CN106361873A - Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in inshore net cage - Google Patents
Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in inshore net cage Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in an inshore net cage. The Chinese herbal medicine preparation is prepared from, by weight, 12-22 parts of artemisiacapillaris thumb, 16-20 parts of radix burpleuri, 12-18 parts of radix sophorae flavescentis, 8-12 parts of radix isatidis, 12-18 parts of herba houttuyniae, 12-18 parts of rhizoma polygoni cuspidate, 2-6 parts of purple perilla, 8-11 parts of lonicera japonica and 2-6 parts of radix glycyrrhizae. According to the Chinese herbal medicine preparation, the reasonable formula of the traditional Chinese medicines has very significant effects of antisepsis and anti-inflammation and immunological enhancement, provides a medicine for effectively treating the skin fester disease of the black sea bream cultured in the inshore net cage for aquaculture industry, and has the advantages of taking effect fast, being good in curative effect, free of medicinal residues, free of any toxic and side effects. The Chinese herbal medicine preparation can effectively control the skin fester disease of the black sea bream cultured in the inshore net cage and reduce the morbidity and death rate of the skin fester disease.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, it is used for preventing and treating coastal waters cage culture particularly to one kind
Chinese herbal and crude drugs preparationses of black porgy Disease of skin fester and preparation method thereof.
Background technology
The skin of coastal waters cage culture black porgy includes epidermis and corium two-layer, and also contains a kind of special body of gland, can divide
Secrete substantial amounts of mucus, make skin be rich in mucosity, also can form effective physical protection barrier on fish body surface simultaneously, protection
Fish body is from the invasion and attack of pathogenic microorganism.Once cage culture black porgy skin in coastal waters sustains damage, easily bacterial infection and produce
Dead.Skin ulceration is coastal waters cage culture black porgy dermatosiss more typically, is typically due to parasite parasitism or fish body is subject to
The infection such as mechanical injuries secondary bacterial, funguses causes the inflammation of skin histology, and affected area is then downright bad, and tissue loss forms scarce
Damage, erosion, deep is ulcer to shallow defect.The antibacterial majority that coastal waters cage culture black porgy skin ulceration can be caused at present belongs to
Gram negative bacteria, mainly has pseudomonass, Aeromonass, tarda, vibrio etc..Cage culture black porgy body surface in coastal waters is sent out
After life is festered, basis of microscopic observation, it is possible to find infection fish body table meat fiber necrosis, dissolving, muscle fiber interstitial is to some extent
Broadening, there is edema, simultaneously also with the infiltration of the inflammatory cells such as lymphocyte and mononuclear cell.This disease is often with fish molds simultaneously
Send out.In low temperature rainy season, position of festering is easy to long fish moldss.Rotten afterbody continues development and then may result in bacterial septicemia, respectively
Internal organs all may occur in which different degrees of pathological changes.
The Disease of skin fester of coastal waters cage culture black porgy, all can occur throughout the year, and it is big, for this disease to treat difficulty
Preventing and treating must adhere to the principle of " putting prevention first, anti-overweighting is controlled ".If fish body table festers, treat such disease and not only will kill
The pathogenic bacterium gone out in water body, more important point is the antibacterial killed at skin ulceration, takes antibacterials simultaneously orally and removes in vivo
Pathogenic bacterium.
How to be treated using western medicine antibiotics at this stage, although aquatic medicine controls relatively strictly, western medicine antibiotics are indiscriminate
With situation still extremely serious so that the treatment difficulty of coastal waters cage culture black porgy increases, medicament residue problem is more and more heavier, to food
Product safety problem causes seriously to threaten.China's natural resources of Chinese medicinal materials enriches, by rationally being screened and prescription to Chinese medicine, as
Preventing and treating coastal waters cage culture black porgy Disease of skin fester is first-selected, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine
Preventing and treating coastal waters cage culture black porgy Disease of skin fester is increasingly subject to the attention of people and favor, is increasingly widely accepted, be with
Its unique mechanism of action, model of action and advantage are inseparable, put it briefly, herbal control disease have Accommodation,
Strengthening vital QI to eliminate pathogenic factors, have no drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and does not exist anti-
The residue problem of raw element medicine, highly beneficial to the animal husbandry products export of China.In addition, Chinese herbal medicine also has low price, come
Source extensively, the advantages of easy to use, is one of developing direction of fish medicine from now on.
Content of the invention
It is an object of the invention to provide a kind of Chinese herbal medicine system for preventing and treating coastal waters cage culture black porgy Disease of skin fester
Agent.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparationses for preventing and treating coastal waters cage culture black porgy Disease of skin fester, by the Chinese medicine of following weight portion
Material is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentiss 12-18, Radix Isatidis 8-12 part, Herba Houttuyniae 12-18 part, Rhizoma Polygoni Cuspidati
12-18 part, Folium Perillae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating coastal waters cage culture black porgy Disease of skin fester, by weighing as follows
Amount part Chinese crude drug be prepared from: 18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Radix Sophorae Flavescentiss 16,10 parts of Radix Isatidis, 16 parts of Herba Houttuyniae, 14 parts of Rhizoma Polygoni Cuspidati,
4 parts of Folium Perillae, 9 parts of Flos Lonicerae, 4 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparationses for preventing and treating coastal waters cage culture black porgy Disease of skin fester are
Granule.
The preparation method of the Chinese herbal and crude drugs preparationses that above-mentioned each Chinese crude drug preparation cost is invented, comprises the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaning up by recipe quantity, pulverize, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
The consumption of above-mentioned preventing and treating coastal waters cage culture black porgy Disease of skin fester Chinese medicine granules is by 50-80g/100kg body
The ratio of weight mixes pharmaceutical chemistry, allows cage culture black porgy in coastal waters to be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats coastal waters cage culture black porgy Disease of skin fester with Chinese herbal and crude drugs preparationses, from our experimental result
See, the Chinese herbal and crude drugs preparationses of the application present invention can effective control coastal waters cage culture black porgy Disease of skin fester, reduce coastal waters net cage and support
Grow the M ＆ M of black porgy Disease of skin fester, but also do not produce drug resistance.The present invention by Chinese medicine reasonable formula,
Anti-inflammation, enhancing immunity effect extremely notable, be that culture fishery provides a kind of coastal waters cage culture black porgy skin
The effectively treatment medicine of ulcer disease, has the characteristics that instant effect, curative effect really, no drug residue, without any side effects；Its preparation side
Method is simple, the needs of suitable scale industrial production.
Specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for the present invention is described, and
It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is broadly fallen into the simple modifications of preparation method of the present invention
Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules of preventing and treating coastal waters cage culture black porgy Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, Baphicacanthus cusia
Root, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Folium Perillae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentiss 16kg, Radix Isatidis
10kg, Herba Houttuyniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Folium Perillae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture black porgy Disease of skin fester, concrete preparation process
As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentiss 16kg, Radix Isatidis 10kg, Herba Houttuyniae 16kg, Rhizoma Polygoni Cuspidati
14kg, Folium Perillae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules of preventing and treating coastal waters cage culture black porgy Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, Baphicacanthus cusia
Root, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Folium Perillae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Radix Isatidis
9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Folium Perillae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture black porgy Disease of skin fester, concrete preparation process
As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Radix Isatidis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Folium Perillae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules of preventing and treating coastal waters cage culture black porgy Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, Baphicacanthus cusia
Root, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Folium Perillae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentiss 18kg, Radix Isatidis
12kg, Herba Houttuyniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Folium Perillae 6kg, Flos Lonicerae 11kg, Radix Glycyrrhizae 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture black porgy Disease of skin fester, concrete preparation process
As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Radix Isatidis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Folium Perillae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture black porgy Disease of skin fester is by 60g/100kg body weight
Ratio mix pharmaceutical chemistry, be administered orally, be used in conjunction 5 days be a course for the treatment of.Reach the purpose for the treatment of disease by intestinal absorption after oral.
On June 28th, 2013, the coastal waters net cage that Shandong Province Rongcheng area certain coastal waters cage culture black porgy raiser raises is supported
Grow black porgy morbidity, clinical symptoms: the coastal waters cage culture black porgy fish tail shank of illness, trunk or skin of head fester, necrosis
Come off, severe patient festers and is deep into Musclar layer, fester in some disease fish kiss ends.It is typical ulcer disease after diagnosing.Then real with the present invention
Apply described in example 2 Chinese medicine granules treatment, after medication 2 days, the state of an illness is clearly better, and substantially, mortality rate drops body color change by sky
Low, after 5 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats coastal waters cage culture black porgy Disease of skin fester with Chinese herbal and crude drugs preparationses, in terms of our experimental result,
No matter being prevention, or treatment, evident in efficacy, but also do not produce drug resistance, through test of many times and small area popularization and application, take
Obtained good effect, and so that fishing ground economic benefit is significantly improved.
Claims (3)
1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating coastal waters cage culture black porgy Disease of skin fester it is characterised in that: by weighing as follows
The Chinese crude drug of amount part is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentiss 12-18, Radix Isatidis 8-12 part, Herba Houttuyniae 12-
18 parts, Rhizoma Polygoni Cuspidati 12-18 part, Folium Perillae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
2. the Chinese herbal and crude drugs preparationses for preventing and treating coastal waters cage culture black porgy Disease of skin fester according to claim 1, it is special
Levy and be: be prepared from by the Chinese crude drug of following weight portion: 18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Radix Sophorae Flavescentiss 16,10 parts of Radix Isatidis, fish raw meat
16 parts of grass, 14 parts of Rhizoma Polygoni Cuspidati, 4 parts of Folium Perillae, 9 parts of Flos Lonicerae, 4 parts of Radix Glycyrrhizae.
3. the Chinese herbal and crude drugs preparationses for preventing and treating coastal waters cage culture black porgy Disease of skin fester according to claim 1 and 2, its
It is characterised by: it is granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610961728.XA CN106361873A (en) | 2016-11-04 | 2016-11-04 | Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in inshore net cage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610961728.XA CN106361873A (en) | 2016-11-04 | 2016-11-04 | Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in inshore net cage |
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| Publication Number | Publication Date |
|---|---|
| CN106361873A true CN106361873A (en) | 2017-02-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610961728.XA Withdrawn CN106361873A (en) | 2016-11-04 | 2016-11-04 | Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in inshore net cage |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106361873A (en) |
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2016
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| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170201 |