CN106266005A - A kind of Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester - Google Patents

A kind of Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester Download PDF

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CN106266005A
CN106266005A CN201610874798.1A CN201610874798A CN106266005A CN 106266005 A CN106266005 A CN 106266005A CN 201610874798 A CN201610874798 A CN 201610874798A CN 106266005 A CN106266005 A CN 106266005A
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parts
disease
coastal waters
cage culture
paralichthys olivaceus
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王培亮
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Weihai Hongrun Ocean Technology Co Ltd
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Weihai Hongrun Ocean Technology Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a kind of Chinese herbal and crude drugs preparations preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Herba Artemisiae Scopariae 12 22 parts, Radix Bupleuri 16 20 parts, Rhizoma Coptidis 12 18, Radix Isatidis 8 12 parts, Cortex Moutan 12 18 parts, Rhizoma Polygoni Cuspidati 12 18 parts, Radix Achyranthis Bidentatae 26 parts, Flos Lonicerae 8 11 parts, 26 parts of Radix Glycyrrhizae.By Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect the most notable, provide a kind of coastal waters cage culture effective medicine of Paralichthys olivaceus Disease of skin fester for culture fishery, have instant effect, curative effect really, no drug residue, feature without any side effects.The Chinese herbal and crude drugs preparations of the application present invention, can effectively control coastal waters cage culture Paralichthys olivaceus Disease of skin fester, reduces the M & M of Disease of skin fester.

Description

A kind of Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating coastal waters cage culture particularly to one Chinese herbal and crude drugs preparations of Paralichthys olivaceus Disease of skin fester and preparation method thereof.
Background technology
The skin of coastal waters cage culture Paralichthys olivaceus includes epidermis and corium two-layer, and possibly together with a kind of special body of gland, can divide Secrete substantial amounts of mucus, make skin be rich in mucosity, also can form effective physical protection barrier in fish surface simultaneously, protection Fish body is from the invasion and attack of pathogenic microorganism.Coastal waters cage culture Paralichthys olivaceus once skin sustains damage, easily bacterial infection and produce Dead.Skin ulceration is coastal waters cage culture Paralichthys olivaceus dermatosis more typically, is typically due to parasite parasitism or fish body is subject to Mechanical injuries secondary bacterial, fungus etc. infect the inflammation causing skin histology, and affected area is the most downright bad, and tissue loss is formed scarce Damaging, shallow defect is rotten to the corn, and deep is ulcer.The antibacterial majority that can cause coastal waters cage culture Paralichthys olivaceus skin ulceration at present belongs to Gram negative bacteria, mainly has pseudomonas, Aeromonas, tarda, vibrio etc..Cage culture Paralichthys olivaceus body surface in coastal waters is sent out After life is festered, basis of microscopic observation, it is possible to find infecting the necrosis of fish body surface meat fiber, dissolve, muscle fiber interstitial is to some extent Broadening, there is edema, simultaneously also with the infiltration of the inflammatory cell such as lymphocyte and mononuclear cell.This disease is often with fish molds also Send out.In low temperature rainy season, position of festering is easy to long fish molds.Rotten afterbody continues development and then may result in bacterial septicemia, respectively Internal organs all may occur in which pathological changes in various degree.
The Disease of skin fester of coastal waters cage culture Paralichthys olivaceus, the most all can occur, and treatment difficulty is big, for this disease Preventing and treating must adhere to the principle of " putting prevention first, anti-overweighting is controlled ".If fish body surface festers, treat such disease and not only to kill Going out the pathogenic bacterium in water body, more important point is to kill the antibacterial at skin ulceration, takes orally in antibacterials purged body simultaneously Pathogenic bacterium.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate The most extremely serious by situation so that the treatment difficulty of coastal waters cage culture Paralichthys olivaceus strengthens, and drug residue problem is more and more heavier, feeding Product safety problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, by Chinese medicine is rationally screened and prescription, as Preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester is first-selected, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine Preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester increasingly by attention and the favor of people, be increasingly widely accepted, be with The mechanism of action of its uniqueness, model of action and advantage are inseparable, put it briefly, herbal control disease have Accommodation, Strengthening vital QI to eliminate pathogenic factors, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and do not exist anti- The residue problem of raw element medicine, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has low price, come The advantages such as source is extensive, easy to use, are one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal medicine system for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester Agent.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, by the Chinese medicine of following weight portion Material is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Rhizoma Coptidis 12-18, Radix Isatidis 8-12 part, Cortex Moutan 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, by weighing as follows Amount part Chinese crude drug be prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Rhizoma Coptidis 16, Radix Isatidis 10 parts, Cortex Moutan 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Achyranthis Bidentatae 4 parts, Flos Lonicerae 9 parts, 4 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester is Granule.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
The consumption of above-mentioned preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester Chinese medicine granules is by 50-80g/100kg body The ratio of weight mixes pharmaceutical chemistry, allows cage culture Paralichthys olivaceus in coastal waters be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats coastal waters cage culture Paralichthys olivaceus Disease of skin fester with Chinese herbal and crude drugs preparations, from our experimental result Seeing, the Chinese herbal and crude drugs preparations of the application present invention can effectively control coastal waters cage culture Paralichthys olivaceus Disease of skin fester, reduces coastal waters net cage and supports Grow the M & M of Paralichthys olivaceus Disease of skin fester, but also do not produce drug resistance.The present invention by Chinese medicine reasonable formula, Anti-inflammation, enhancing immunity effect extremely notable, provide a kind of coastal waters cage culture Paralichthys olivaceus skin for culture fishery Effective medicine of ulcer disease, have instant effect, curative effect really, no drug residue, feature without any side effects；Its preparation side Method is simple, is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Rhizoma Coptidis, Baphicacanthus cusia Root, Cortex Moutan, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Rhizoma Coptidis 16kg, Radix Isatidis 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, concrete preparation process As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Rhizoma Coptidis 16kg, Radix Isatidis 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Rhizoma Coptidis, Baphicacanthus cusia Root, Cortex Moutan, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Rhizoma Coptidis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, concrete preparation process As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Rhizoma Coptidis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Rhizoma Coptidis, Baphicacanthus cusia Root, Cortex Moutan, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Rhizoma Coptidis 18kg, Radix Isatidis 12kg, Cortex Moutan 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Radix Glycyrrhizae 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, concrete preparation process As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Rhizoma Coptidis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester is by 60g/100kg body weight Ratio mix pharmaceutical chemistry, oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the coastal waters net cage that area, Rongcheng, Shandong Province certain coastal waters cage culture Paralichthys olivaceus raiser raises is supported Grow Paralichthys olivaceus morbidity, clinical symptoms: ill coastal waters cage culture Paralichthys olivaceus caudal peduncle portion, trunk or skin of head fester, necrosis Coming off, severe patient festers and is deep into Musclar layer, and the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then real by the present invention Executing described in example 2 Chinese medicine granules treatment, after medication 2 days, the state of an illness is clearly better, and substantially, mortality rate drops the change of health color by sky Low, after 5 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats coastal waters cage culture Paralichthys olivaceus Disease of skin fester with Chinese herbal and crude drugs preparations, in terms of our experimental result, No matter it is prevention, or treatment, evident in efficacy, but also do not produce drug resistance, through test of many times and little area popularization and application, take Obtained good effect, and made fishing ground economic benefit significantly improve.

Claims (3)

1. the Chinese herbal and crude drugs preparations being used for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester, it is characterised in that: by weighing as follows The Chinese crude drug of amount part is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Rhizoma Coptidis 12-18, Radix Isatidis 8-12 part, Cortex Moutan 12- 18 parts, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester the most according to claim 1, it is special Levy and be: be prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Rhizoma Coptidis 16, Radix Isatidis 10 parts, Paeonia suffruticosa Skin 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Achyranthis Bidentatae 4 parts, Flos Lonicerae 9 parts, 4 parts of Radix Glycyrrhizae.
Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester the most according to claim 1 and 2, its It is characterised by: it is granule.
CN201610874798.1A 2016-09-30 2016-09-30 A kind of Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester Withdrawn CN106266005A (en)

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