CN106265965A - A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester - Google Patents
A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester Download PDFInfo
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- CN106265965A CN106265965A CN201610874796.2A CN201610874796A CN106265965A CN 106265965 A CN106265965 A CN 106265965A CN 201610874796 A CN201610874796 A CN 201610874796A CN 106265965 A CN106265965 A CN 106265965A
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Abstract
The invention discloses a kind of Chinese herbal and crude drugs preparations preventing and treating industrialized culture black porgy Disease of skin fester, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Herba Artemisiae Scopariae 12 22 parts, Radix Bupleuri 16 20 parts, Radix Sophorae Flavescentis 12 18, Radix Isatidis 8 12 parts, Cortex Moutan 12 18 parts, Rhizoma Polygoni Cuspidati 12 18 parts, Folium Perillae 26 parts, Flos Lonicerae 8 11 parts, 26 parts of Radix Glycyrrhizae.By Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect the most notable, provide a kind of industrialized culture effective medicine of black porgy Disease of skin fester for culture fishery, have instant effect, curative effect really, no drug residue, feature without any side effects.The Chinese herbal and crude drugs preparations of the application present invention, can effectively control industrialized culture black porgy Disease of skin fester, reduces the M & M of Disease of skin fester.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating industrialized culture particularly to one black
Chinese herbal and crude drugs preparations of Channa argus Disease of skin fester and preparation method thereof.
Background technology
The skin of industrialized culture black porgy includes epidermis and corium two-layer, and possibly together with a kind of special body of gland, can secrete
Go out substantial amounts of mucus, make skin be rich in mucosity, also can form effective physical protection barrier simultaneously in fish surface, protect fish
Body is from the invasion and attack of pathogenic microorganism.Industrialized culture black porgy once skin sustains damage, easily bacterial infection and produce dead
Die.Skin ulceration is industrialized culture black porgy dermatosis more typically, is typically due to parasite parasitism or fish body by machinery
Property damage secondary bacterial, fungus etc. infect and cause the inflammation of skin histology, affected area is the most downright bad, and tissue loss forms defect,
Shallow defect is rotten to the corn, and deep is ulcer.The antibacterial majority that can cause industrialized culture black porgy skin ulceration at present belongs to leather orchid
Family name's negative bacterium, mainly has pseudomonas, Aeromonas, tarda, vibrio etc..Industrialized culture black porgy body surface festers
After, basis of microscopic observation, it is possible to find infecting the necrosis of fish body surface meat fiber, dissolve, muscle fiber interstitial is the most broadening, sends out
Unboiled water swells, simultaneously also with the infiltration of the inflammatory cell such as lymphocyte and mononuclear cell.This disease is often concurrent with fish molds.Low
In warm rainy season, position of festering is easy to long fish molds.Rotten afterbody continues development and then may result in bacterial septicemia, each internal organs
Pathological changes in various degree occurs.
The Disease of skin fester of industrialized culture black porgy, the most all can occur, and treatment difficulty is big, prevents for this disease
Control the principle that must adhere to " putting prevention first, anti-overweighting is controlled ".If fish body surface festers, treat such disease and not only to kill
Pathogenic bacterium in water body, more important point is to kill the antibacterial at skin ulceration, takes orally in antibacterials purged body simultaneously
Pathogenic bacterium.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate
The most extremely serious by situation so that the treatment difficulty of industrialized culture black porgy strengthens, and drug residue problem is more and more heavier, to food
Safety problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, by rationally screening Chinese medicine and prescription, as anti-
Control industrialized culture black porgy Disease of skin fester first-selected, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine
Preventing and treating industrialized culture black porgy Disease of skin fester, increasingly by attention and the favor of people, is increasingly widely accepted, is and it
Unique mechanism of action, model of action and advantage are inseparable, put it briefly, and herbal control disease has Accommodation, holds up
The most eliminating evil, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and there is not antibiosis
The residue problem of element medicine, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has low price, source
Extensively, the advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester, by the Chinese crude drug of following weight portion
It is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Radix Isatidis 8-12 part, Cortex Moutan 12-18 part, Rhizoma Polygoni Cuspidati 12-
18 parts, Folium Perillae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester, by following weight
The Chinese crude drug of part is prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Radix Isatidis 10 parts, Cortex Moutan 16 parts, Rhizoma Polygoni Cuspidati 14 parts, purple
Revive 4 parts, Flos Lonicerae 9 parts, 4 parts of Radix Glycyrrhizae.
It is further preferred that described is granule for preventing and treating the Chinese herbal and crude drugs preparations of industrialized culture black porgy Disease of skin fester
Agent.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
The consumption of above-mentioned preventing and treating industrialized culture black porgy Disease of skin fester Chinese medicine granules is by 50-80g/100kg body weight
Ratio mix pharmaceutical chemistry, allow industrialized culture black porgy be administered orally, being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats industrialized culture black porgy Disease of skin fester with Chinese herbal and crude drugs preparations, in terms of our experimental result,
The Chinese herbal and crude drugs preparations of the application present invention can effectively control industrialized culture black porgy Disease of skin fester, reduces industrialized culture black porgy skin
The M & M of skin ulcer disease, but also do not produce drug resistance.The present invention, by Chinese medicine reasonable formula, antibacterial disappears
Effect scorching, enhancing immunity is extremely notable, provides a kind of industrialized culture black porgy Disease of skin fester for culture fishery
Effectively medicine, have instant effect, curative effect really, no drug residue, feature without any side effects；Its preparation method is simple,
It is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and
It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention
Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating industrialized culture black porgy Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Radix Isatidis,
Cortex Moutan, Rhizoma Polygoni Cuspidati, Folium Perillae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Radix Isatidis 10kg,
Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati 14kg, Folium Perillae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture black porgy Disease of skin fester, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Radix Isatidis 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati
14kg, Folium Perillae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating industrialized culture black porgy Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Radix Isatidis,
Cortex Moutan, Rhizoma Polygoni Cuspidati, Folium Perillae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Radix Isatidis 9kg, male
Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Folium Perillae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture black porgy Disease of skin fester, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg,
Folium Perillae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating industrialized culture black porgy Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Radix Isatidis,
Cortex Moutan, Rhizoma Polygoni Cuspidati, Folium Perillae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentis 18kg, Radix Isatidis 12kg,
Cortex Moutan 18kg, Rhizoma Polygoni Cuspidati 18kg, Folium Perillae 6kg, Flos Lonicerae 11kg, Radix Glycyrrhizae 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture black porgy Disease of skin fester, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg,
Folium Perillae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture black porgy Disease of skin fester is by 60g/100kg body weight
Ratio mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the industrialized culture that area, Rongcheng, Shandong Province certain industrialized culture black porgy raiser raises is black
Channa argus falls ill, clinical symptoms: ill industrialized culture black porgy fish tail shank, trunk or skin of head fester, and necrosis comes off, sternly
Severe one is festered and is deep into Musclar layer, and the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then with the embodiment of the present invention 2 institute
Stating Chinese medicine granules treatment, after medication 2 days, the state of an illness is clearly better, and substantially, mortality rate reduces the change of health color by sky, after 5 days
Mortality rate is 0, is almost recovered.
Inventor prevents and treats industrialized culture black porgy Disease of skin fester with Chinese herbal and crude drugs preparations, in terms of our experimental result, no
Pipe is prevention, or treatment, evident in efficacy, but also does not produce drug resistance, through test of many times and little area popularization and application, obtains
Good effect, makes the fishing ground economic benefit significantly improve.
Claims (3)
1. the Chinese herbal and crude drugs preparations being used for preventing and treating industrialized culture black porgy Disease of skin fester, it is characterised in that: by following weight
The Chinese crude drug of part is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Radix Isatidis 8-12 part, Cortex Moutan 12-18
Part, Rhizoma Polygoni Cuspidati 12-18 part, Folium Perillae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester the most according to claim 1, its feature
It is: be prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Radix Isatidis 10 parts, Cortex Moutan
16 parts, Rhizoma Polygoni Cuspidati 14 parts, Folium Perillae 4 parts, Flos Lonicerae 9 parts, 4 parts of Radix Glycyrrhizae.
Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester the most according to claim 1 and 2, it is special
Levy and be: it is granule.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435292A (en) * | 2014-12-29 | 2015-03-25 | 杨成胜 | Chinese herbal medicine preparation for preventing leech ulcer disease |
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2016
- 2016-09-30 CN CN201610874796.2A patent/CN106265965A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435292A (en) * | 2014-12-29 | 2015-03-25 | 杨成胜 | Chinese herbal medicine preparation for preventing leech ulcer disease |
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Application publication date: 20170104 |