CN106420966A - Chinese herbal medicine preparation for preventing common diseases of pond-cultured Fenneropenaeus chinensiss - Google Patents
Chinese herbal medicine preparation for preventing common diseases of pond-cultured Fenneropenaeus chinensiss Download PDFInfo
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- CN106420966A CN106420966A CN201610961748.7A CN201610961748A CN106420966A CN 106420966 A CN106420966 A CN 106420966A CN 201610961748 A CN201610961748 A CN 201610961748A CN 106420966 A CN106420966 A CN 106420966A
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- 201000010099 disease Diseases 0.000 title claims abstract description 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 35
- 241000995704 Fenneropenaeus chinensis Species 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 241000411851 herbal medicine Species 0.000 title abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 43
- 241000746375 Andrographis Species 0.000 claims abstract description 14
- 229940079593 drug Drugs 0.000 claims description 23
- 239000008187 granular material Substances 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 13
- 238000005303 weighing Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 18
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 235000008216 herbs Nutrition 0.000 abstract 2
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241000427159 Achyranthes Species 0.000 abstract 1
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000003097 Artemisia absinthium Nutrition 0.000 abstract 1
- 240000001851 Artemisia dracunculus Species 0.000 abstract 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 abstract 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 abstract 1
- 244000236521 Bupleurum rotundifolium Species 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 240000005001 Paeonia suffruticosa Species 0.000 abstract 1
- 235000003889 Paeonia suffruticosa Nutrition 0.000 abstract 1
- 235000014220 Rhus chinensis Nutrition 0.000 abstract 1
- 240000003152 Rhus chinensis Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 238000009360 aquaculture Methods 0.000 abstract 1
- 244000144974 aquaculture Species 0.000 abstract 1
- 239000001138 artemisia absinthium Substances 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 44
- 239000000843 powder Substances 0.000 description 24
- 241000238557 Decapoda Species 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000006071 cream Substances 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 12
- 229920002472 Starch Polymers 0.000 description 8
- 239000012141 concentrate Substances 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 239000012567 medical material Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 7
- 206010013786 Dry skin Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 241000251468 Actinopterygii Species 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 241000238421 Arthropoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000927735 Penaeus Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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Abstract
The invention discloses a Chinese herbal medicine preparation for preventing common diseases of pond-cultured Fenneropenaeus chinensiss. The Chinese herbal medicine preparation is prepared from traditional Chinese medicinal materials in parts by weight as follows: 12-22 parts of virgate wormwood herbs, 16-20 parts of Chinese thorowax roots, 12-18 parts of lightyellow sophora roots, 8-12 parts of forsythia, 12-18 parts of tree peony bark, 12-18 parts of common andrographis herbs, 2-6 parts of bidentate achyranthes roots, 8-11 parts of honeysuckle flowers and 2-6 parts of Chinese gall. Traditional Chinese medicines are reasonably matched, the effects of resisting bacteria, diminishing inflammations and enhancing immunity are very remarkable, an effective treatment medicine for preventing common diseases of the pond-cultured Fenneropenaeus chinensiss is provided for the aquaculture industry, and the preparation has the characteristics of taking effect quickly and being exact in curative effect and free of agent residues and toxic and side effects. With the adoption of the Chinese herbal medicine preparation, the common diseases of the pond-cultured Fenneropenaeus chinensiss can be effectively controlled, and the incidence and dearth rate caused by the common diseases can be reduced.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, more particularly to a kind of for preventing and treating pond culture China
Chinese herbal and crude drugs preparationses of bright prawn Common Diseases and preparation method thereof.
Background technology
Fenneropenaeus chinensis Osbeck is once called as Chinese prawn also known as oriental prawn, belongs to Arthropoda, Crustachia, Decapoda, prawn
Section, Penaeus.Past is often because selling in pairs, therefore claims prawn.Chinese prawn, it is male prawn that prawn, inclined yellow prawn are caught in sea, partially
Cyan prawn is female prawn, and the past is often because selling in pairs, therefore claims prawn, and also known as oriental prawn, the China that non-cultivation is caught in sea is right
Shrimp is typically at 30 grams -50 grams, and specification is more big more rare.Chinese prawn is one of important aquatic resources of China, its natural population
It is distributed mainly on Chinese Yellow Coast of Bohai Sea marine site and Korea peninsula marine site.
The Common Diseases of pond culture Fenneropenaeus chinensis Osbeck, can all occur throughout the year, and treat difficulty greatly, for the disease
Preventing and treating must adhere to the principle of " putting prevention first, anti-overweighting is controlled ".If shrimp body surface festers, treat such disease and will not only kill
The pathogenic bacterium that goes out in water body, more important point is to kill the antibacterial at skin ulceration, while take antibacterials orally removing in vivo
Pathogenic bacterium.
How to be treated using western medicine antibiotics at this stage, although aquatic medicine control is relatively strict, but western medicine antibiotics are indiscriminate
Still extremely serious with situation so that the treatment difficulty of pond culture Fenneropenaeus chinensis Osbeck is increased, and medicament residue problem is increasingly weighed, and is given
Food-safety problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, and by rationally being screened to Chinese medicine and prescription, makees
For preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases first-selection, will be with very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine come
Preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases are increasingly widely accepted increasingly by attention and the favor of people, be with
Its unique mechanism of action, model of action and advantage are inseparable, put it briefly, herbal control disease have Accommodation,
Strengthening vital QI to eliminate pathogenic factors, have no drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and does not exist anti-
The residue problem of raw element medicine, highly beneficial to the animal husbandry products export of China.In addition, Chinese herbal medicine also has low price, come
Source is extensive, the advantages of easy to use, is one of developing direction of fish medicine from now on.
Content of the invention
It is an object of the invention to provide a kind of Chinese herbal medicine system for preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases
Agent.
The object of the present invention is achieved like this：
A kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases, by the Chinese medicine of following weight portion
Material is prepared from：Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentiss 12-18, Fructus Forsythiae 8-12 part, Cortex Moutan 12-18 part, Herba Andrographis
12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensiss 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases, by weighing as follows
The Chinese crude drug of amount part is prepared from：18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Radix Sophorae Flavescentiss 16,10 parts of Fructus Forsythiae, 16 parts of Cortex Moutan, 14 parts of Herba Andrographis,
4 parts of Radix Achyranthis Bidentatae, 9 parts of Flos Lonicerae, 4 parts of Galla Chinensiss.
It is further preferred that the described Chinese herbal and crude drugs preparationses for preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases are
Granule.
By the preparation method of the Chinese herbal and crude drugs preparationses of above-mentioned each Chinese crude drug preparation cost invention, comprise the steps：
The first step, prepares clear paste powder：
1) get the raw materials ready：The above-mentioned Chinese crude drug for cleaning up is weighed by recipe quantity, is crushed, standby；
2) decoct：Add water to cook, first decocts 8 times for adding water as medical material total amount per tank, is kept for 2 hours, carry after ebuillition of heated
Taking liquid entrance settling tank is filtered through 200 mesh filters；Second decocts the water heating extraction for adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution is filtered through 200 mesh filters and enters settling tank；
3) precipitate：Liquid precipitate being extracted 12 hours in settling tank, extracts supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of measure) in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered in suction vacuum decompressioning and concentrating tank, is added ethanol to alcohol content 60% (v/v), place,
Filtration；It is to go out cream when 1.10～1.22 (90 DEG C of measure) to concentrate and mix to relative density, to storage cream bucket, standby；
5) dry：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) powder is beaten：80 mesh sieve of smashing fineness, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, is stirred 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, is taken out, is cooled and obtain final product described granule
Agent.
The consumption of above-mentioned preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases Chinese medicine granules be by 50-80g/100kg body
The ratio of weight mixes pharmaceutical chemistry, allows pond culture Fenneropenaeus chinensis Osbeck to be administered orally, and is used in conjunction 5-7 days for a course for the treatment of.
The present inventor prevents and treats pond culture Fenneropenaeus chinensis Osbeck Common Diseases with Chinese herbal and crude drugs preparationses, from our experimental result
See, apply the present invention Chinese herbal and crude drugs preparationses can effective control pond culture Fenneropenaeus chinensis Osbeck Common Diseases, reduce pond culture in
The M ＆ M of the bright prawn Common Diseases of state, but also do not produce drug resistance.The present invention by Chinese medicine reasonable formula,
Anti-inflammation, enhancing immunity effect extremely notable, be culture fishery provide a kind of pond culture Fenneropenaeus chinensis Osbeck normal
See the effectively treatment medicine of disease, have the characteristics that instant effect, curative effect really, no drug residue, without any side effects；Its preparation side
Method is simple, the needs of suitable scale industrial production.
Specific embodiment
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for the present invention is described, and
It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is belonged to the simple modifications of preparation method of the present invention
Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases Chinese medicine granules, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, Fructus Forsythiae,
Cortex Moutan, Herba Andrographis, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensiss composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentiss 16kg, Fructus Forsythiae
10kg, Cortex Moutan 16kg, Herba Andrographis 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensiss 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases, concrete preparation process
As follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentiss 16kg, Fructus Forsythiae 10kg, Cortex Moutan 16kg, Herba Andrographis
14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensiss 4kg are raw material, and wash clean Chinese crude drug is crushed, standby；
2) decoct：Add water to cook, first decocts 8 times for adding water as medical material total amount per tank, is kept for 2 hours, carry after ebuillition of heated
Taking liquid entrance settling tank is filtered through 200 mesh filters；Second decocts the water heating extraction for adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution is filtered through 200 mesh filters and enters settling tank；
3) precipitate：Liquid precipitate being extracted 12 hours in settling tank, extracts supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of measure) in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered in suction vacuum decompressioning and concentrating tank, is added ethanol to alcohol content 60% (v/v), place,
Filtration；It is to go out cream when 1.10～1.22 (90 DEG C of measure) to concentrate and mix to relative density, to storage cream bucket, standby；
5) dry：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) powder is beaten：80 mesh sieve of smashing fineness, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, is stirred 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, is taken out, is cooled and obtain final product described granule
Agent.
Embodiment 2
A kind of preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases Chinese medicine granules, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, Fructus Forsythiae,
Cortex Moutan, Herba Andrographis, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensiss composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Fructus Forsythiae 9kg,
Cortex Moutan 14kg, Herba Andrographis 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensiss 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases, concrete preparation process
As follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Fructus Forsythiae 9kg, Cortex Moutan 14kg, Herba Andrographis 13kg,
Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensiss 5kg are raw material, and wash clean Chinese crude drug is crushed, standby；
2) decoct：Add water to cook, first decocts 8 times for adding water as medical material total amount per tank, is kept for 2 hours, carry after ebuillition of heated
Taking liquid entrance settling tank is filtered through 200 mesh filters；Second decocts the water heating extraction for adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution is filtered through 200 mesh filters and enters settling tank；
3) precipitate：Liquid precipitate being extracted 12 hours in settling tank, extracts supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of measure) in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered in suction vacuum decompressioning and concentrating tank, is added ethanol to alcohol content 60% (v/v), place,
Filtration；It is to go out cream when 1.10～1.22 (90 DEG C of measure) to concentrate and mix to relative density, to storage cream bucket, standby；
5) dry：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) powder is beaten：80 mesh sieve of smashing fineness, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, is stirred 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, is taken out, is cooled and obtain final product described granule
Agent.
Embodiment 3
A kind of preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases Chinese medicine granules, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, Fructus Forsythiae,
Cortex Moutan, Herba Andrographis, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensiss composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentiss 18kg, Fructus Forsythiae
12kg, Cortex Moutan 18kg, Herba Andrographis 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Galla Chinensiss 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases, concrete preparation process
As follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Fructus Forsythiae 9kg, Cortex Moutan 14kg, Herba Andrographis 13kg,
Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensiss 5kg are raw material, and wash clean Chinese crude drug is crushed, standby；
2) decoct：Add water to cook, first decocts 8 times for adding water as medical material total amount per tank, is kept for 2 hours, carry after ebuillition of heated
Taking liquid entrance settling tank is filtered through 200 mesh filters；Second decocts the water heating extraction for adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution is filtered through 200 mesh filters and enters settling tank；
3) precipitate：Liquid precipitate being extracted 12 hours in settling tank, extracts supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of measure) in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered in suction vacuum decompressioning and concentrating tank, is added ethanol to alcohol content 60% (v/v), place,
Filtration；It is to go out cream when 1.10～1.22 (90 DEG C of measure) to concentrate and mix to relative density, to storage cream bucket, standby；
5) dry：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) powder is beaten：80 mesh sieve of smashing fineness, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, is stirred 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, is taken out, is cooled and obtain final product described granule
Agent.
4 clinical trial of embodiment
The consumption of the Chinese medicine granules of above-mentioned preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases be by 60g/100kg body weight
Ratio mix pharmaceutical chemistry, be administered orally, be used in conjunction 5 days for a course for the treatment of.The purpose for the treatment of disease is reached after oral by intestinal absorption.
On June 28th, 2013, the pond culture that Shandong Province Rongcheng area certain pond culture Fenneropenaeus chinensis Osbeck raiser raises
Fenneropenaeus chinensis Osbeck is fallen ill, clinical symptoms：The pond culture Fenneropenaeus chinensis Osbeck fish tail shank of illness, trunk or skin of head are burst
Rotten, necrosis comes off, and severe patient festers and is deep into Musclar layer, and some disease fish kiss ends are festered.It is typical ulcer disease after diagnosing.Then with this
After Chinese medicine granules treatment, medication 2 days described in inventive embodiments 2, the state of an illness is clearly better, and body color change is obvious, mortality rate
Reduce by day, after 5 days, mortality rate is 0, to be almost recovered.
Inventor prevents and treats pond culture Fenneropenaeus chinensis Osbeck Common Diseases with Chinese herbal and crude drugs preparationses, from terms of our experimental result,
No matter it is prevention, or treatment, evident in efficacy, but also drug resistance is not produced, through test of many times and small area popularization and application, take
Good effect was obtained, significantly improves fishing ground economic benefit.
Claims (3)
1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases, it is characterised in that：By weighing as follows
The Chinese crude drug of amount part is prepared from：Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentiss 12-18, Fructus Forsythiae 8-12 part, Cortex Moutan 12-18
Part, Herba Andrographis 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensiss 2-6 part.
2. Chinese herbal and crude drugs preparationses for preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases according to claim 1, which is special
Levy and be：It is prepared from by the Chinese crude drug of following weight portion：18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Radix Sophorae Flavescentiss 16,10 parts of Fructus Forsythiae, Cortex Moutan
16 parts, 14 parts of Herba Andrographis, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Flos Lonicerae, 4 parts of Galla Chinensiss.
3. Chinese herbal and crude drugs preparationses for preventing and treating pond culture Fenneropenaeus chinensis Osbeck Common Diseases according to claim 1 and 2, its
It is characterised by：It is granule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260948A (en) * | 2017-06-27 | 2017-10-20 | 宁国市仙之居家庭农场 | The Chinese herbal feed additive and preparation method of a kind of rice shrimp aquaculture |
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2016
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260948A (en) * | 2017-06-27 | 2017-10-20 | 宁国市仙之居家庭农场 | The Chinese herbal feed additive and preparation method of a kind of rice shrimp aquaculture |
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Application publication date: 20170222 |