CN106266167A - A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases - Google Patents

A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases Download PDF

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CN106266167A
CN106266167A CN201610963825.2A CN201610963825A CN106266167A CN 106266167 A CN106266167 A CN 106266167A CN 201610963825 A CN201610963825 A CN 201610963825A CN 106266167 A CN106266167 A CN 106266167A
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stichopus japonicus
australia
plant modification
common diseases
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王培亮
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Weihai Hongrun Ocean Technology Co Ltd
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Weihai Hongrun Ocean Technology Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
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Abstract

The invention discloses a kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Rhizoma Coptidis 16 20 parts, Fructus Gardeniae 16 20 parts, Radix Sophorae Flavescentis 12 18, Herba Andrographis 8 12 parts, Herba Houttuyniae 12 18 parts, Rhizoma Polygoni Cuspidati 12 18 parts, Radix Achyranthis Bidentatae 26 parts, Herba crotalariae albidae 8 11 parts, Flos Lonicerae 26 parts, 8 20 parts of Radix Glycyrrhizae.Utilize traditional Chinese herbal medicine reasonably combined, can be by sterilization, the Common Diseases problem of the Australian Stichopus japonicus plant modification of sterilization prevention, the present invention uses Chinese herbal and crude drugs preparations simultaneously, it is ensured that do not remain poisonous and hazardous chemical agent in water and Australia's Radix Morinae Bulleyanae body.The present invention is used can effectively to prevent and treat Australia's Stichopus japonicus plant modification Common Diseases, the Australian Stichopus japonicus plant modification survival rate of raising, spawning rate, significant to Australia's Stichopus japonicus plant modification.

Description

A kind of Chinese herbal medicine for preventing and treating plant modification Australia Stichopus japonicus Common Diseases Preparation
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating plant modification Australia particularly to one Chinese herbal and crude drugs preparations of big Leah Stichopus japonicus Common Diseases and preparation method thereof.
Background technology
Australia Stichopus japonicus, is to originate from a kind of Stichopus japonicus of Australia, and meat is thick, in light calvus after boiling peeling, Therefore also known as bald ginseng, in bald ginseng body wall, Stichopus japonicus protein content is 50%, and wherein Stichopus japonicus mucopolysaccharide content is up to 25.2%, for institute Having the one that glycosaminoglycan content in Stichopus japonicus is the highest, its food therapy value is more than 2 times of equal quality Radix Morinae Bulleyanae.Bald ginseng Saponin sulphation Degree is low, and osteocomma is moderate, therefore mouthfeel stick-slip, and meat is thick, and glue sense is tangible, in good taste, is top grade in Stichopus japonicus. temperature compensation autumn and winter First-selection, is also your YIN nourishing, marine superfine product of looks improving and the skin nourishing, good merchantable brand of giving a present.
Radix Morinae Bulleyanae is one of economic breed variety of northern China coastal area, has been enter into the large-scale production stage in the last few years And obtain good benefit.But, in recent years due to factors such as marine pollutions, in the industrialized culture of Radix Morinae Bulleyanae produces, frequently Occur in that the common disease such as " mouthpart festers ", " bark rot " causes Radix Morinae Bulleyanae dead, cause to Industrialized stichopus japonicus culture bigger Loss；Wherein " mouthpart ulcer disease " is presently the most popular and that impact is the most serious disease.So-called " mouthpart ulcer disease " is disease Radix Morinae Bulleyanae membrana perisomialis blackening, can not ingest when sb.'s illness took a turn for the worse, adhere to, and Spina jujubae is dead after gradually coming off.This disease initial stage is without any Abnormal, but examine and can find that Radix Morinae Bulleyanae ingestion ability gradually weakens.Its mortality rate is the highest, and economic loss is extremely serious.So The most effectively prevent industrialized culture Radix Morinae Bulleyanae " mouthpart ulcer disease " it is particularly important.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine Preventing and treating Stichopus japonicus plant modification Common Diseases, increasingly by attention and the favor of people, is increasingly widely accepted, is only with it Special mechanism of action, model of action and advantage are inseparable, put it briefly, and herbal control disease has Accommodation, righting Eliminating evil, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and there is not antibiotic The residue problem of medicine, breeds products export to the Aquatic product of China highly beneficial.It addition, Chinese herbal medicine also has low price, source Extensively, the advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of medium-height grass for preventing and treating plant modification Australia Stichopus japonicus Common Diseases Medicine preparation.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases, by following weight portion Chinese crude drug is prepared from: Rhizoma Coptidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Herba Andrographis 8-12 part, Herba Houttuyniae 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Flos Lonicerae 2-6 part, Radix Glycyrrhizae 8-20 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases, by such as The Chinese crude drug of lower weight portion is prepared from: Rhizoma Coptidis 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Herba Andrographis 10 parts, Herba Houttuyniae 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Achyranthis Bidentatae 4 parts, Herba crotalariae albidae 9 parts, Flos Lonicerae 4 parts, 11 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases It it is granule.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
The consumption of above-mentioned preventing and treating Australia Stichopus japonicus plant modification Common Diseases Chinese medicine granules is by 60-80g/ The ratio of 100kg body weight mixes pharmaceutical chemistry, allows Stichopus japonicus be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor, with the Australian Stichopus japonicus plant modification Common Diseases of Chinese herbal and crude drugs preparations preventing and treating, ties from our experiment Fruit sees, the Chinese herbal and crude drugs preparations of the application present invention can effectively control Australia's Stichopus japonicus plant modification Common Diseases, reduces Australia big The M & M of Leah Stichopus japonicus plant modification Common Diseases, but also do not produce drug resistance.The present invention is by tradition Medicine reasonable formula, anti-inflammation, enhancing immunity effect extremely notable, breed industry for Aquatic product and provide a kind of Australia sea Effective medicine of ginseng plant modification Common Diseases, have instant effect, curative effect really, no drug residue, without any side effects Feature；Its preparation method is simple, is suitable for the needs of large-scale production.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases, by Rhizoma Coptidis, Fructus Gardeniae, hardship Ginseng, Herba Andrographis, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Rhizoma Coptidis 18kg, Fructus Gardeniae 18kg, hardship Ginseng 16kg, Herba Andrographis 10kg, Herba Houttuyniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Flos Lonicerae 4kg, Radix Glycyrrhizae 11kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating Australia Stichopus japonicus plant modification Common Diseases, specifically prepares Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Rhizoma Coptidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentis 16kg, Herba Andrographis 10kg, Herba Houttuyniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Flos Lonicerae 4kg, Radix Glycyrrhizae 11kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 2
A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases, by Rhizoma Coptidis, Fructus Gardeniae, hardship Ginseng, Herba Andrographis, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Rhizoma Coptidis 19kg, Fructus Gardeniae 17kg, hardship Ginseng 15kg, Herba Andrographis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Flos Lonicerae 5kg, Radix Glycyrrhizae 13kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating Australia Stichopus japonicus plant modification Common Diseases, specifically prepares Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Rhizoma Coptidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Herba Andrographis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Flos Lonicerae 5kg, Radix Glycyrrhizae 13kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 3
A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases, by Rhizoma Coptidis, Fructus Gardeniae, hardship Ginseng, Herba Andrographis, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Rhizoma Coptidis 20kg, Fructus Gardeniae 20kg, hardship Ginseng 18kg, Herba Andrographis 12kg, Herba Houttuyniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Herba crotalariae albidae 11kg, Flos Lonicerae 6kg, Radix Glycyrrhizae 15kg。
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating Australia Stichopus japonicus plant modification Common Diseases, specifically prepares Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Rhizoma Coptidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Herba Andrographis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Flos Lonicerae 5kg, Radix Glycyrrhizae 15kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating Australia Stichopus japonicus plant modification Common Diseases is by 60g/100kg The ratio of body weight mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
Inventor is with the Australian Stichopus japonicus plant modification Common Diseases of Chinese herbal and crude drugs preparations preventing and treating, from our experimental result See, no matter be prevention, or treatment, evident in efficacy, but also do not produce drug resistance, promoting through test of many times and little area should With, achieve good effect, make nursery economic benefit significantly improve.

Claims (3)

1. the Chinese herbal and crude drugs preparations being used for preventing and treating plant modification Australia Stichopus japonicus Common Diseases, it is characterised in that: by such as The Chinese crude drug of lower weight portion is prepared from: Rhizoma Coptidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Herba Andrographis 8-12 part, fish raw meat Grass 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Flos Lonicerae 2-6 part, Radix Glycyrrhizae 8-20 part.
Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases the most according to claim 1, It is characterized in that: be prepared from by the Chinese crude drug of following weight portion: Rhizoma Coptidis 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Herba Andrographis 10 parts, Herba Houttuyniae 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Achyranthis Bidentatae 4 parts, Herba crotalariae albidae 9 parts, Flos Lonicerae 4 parts, 11 parts of Radix Glycyrrhizae.
Chinese herbal medicine system for preventing and treating plant modification Australia Stichopus japonicus Common Diseases the most according to claim 1 and 2 Agent, it is characterised in that: it is granule.
CN201610963825.2A 2016-11-04 2016-11-04 A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Australia Stichopus japonicus Common Diseases Withdrawn CN106266167A (en)

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Application publication date: 20170104