CN106344699A - Traditional Chinese herbal medicine preparation for preventing and treating common diseases of factory-like bred California sea cucumber - Google Patents
Traditional Chinese herbal medicine preparation for preventing and treating common diseases of factory-like bred California sea cucumber Download PDFInfo
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- 201000010099 disease Diseases 0.000 title claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 241000411851 herbal medicine Species 0.000 title claims abstract description 14
- 241000251511 Holothuroidea Species 0.000 title abstract 7
- 239000003814 drug Substances 0.000 claims description 31
- 241000965254 Apostichopus japonicus Species 0.000 claims description 27
- 238000012986 modification Methods 0.000 claims description 24
- 230000004048 modification Effects 0.000 claims description 24
- 241000196324 Embryophyta Species 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 22
- 241000746375 Andrographis Species 0.000 claims description 13
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 241000251468 Actinopterygii Species 0.000 claims description 2
- 244000025254 Cannabis sativa Species 0.000 claims 1
- 235000020995 raw meat Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 13
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 241000218176 Corydalis Species 0.000 abstract 1
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000013717 Houttuynia Nutrition 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 230000017448 oviposition Effects 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 44
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- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
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- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- QTCANKDTWWSCMR-UHFFFAOYSA-N costic aldehyde Natural products C1CCC(=C)C2CC(C(=C)C=O)CCC21C QTCANKDTWWSCMR-UHFFFAOYSA-N 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
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- 230000002708 enhancing effect Effects 0.000 description 1
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- ISTFUJWTQAMRGA-UHFFFAOYSA-N iso-beta-costal Natural products C1C(C(=C)C=O)CCC2(C)CCCC(C)=C21 ISTFUJWTQAMRGA-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Abstract
The invention discloses a traditional Chinese herbal medicine preparation for preventing and treating common diseases of factory-like bred California sea cucumber. The traditional Chinese herbal medicine preparation is prepared from the following traditional Chinese medicines in parts by weight: 16-20 parts of rhizoma coptidis, 16-20 parts of cape jasmine, 12-18 parts of radix sophorae flavescentis, 8-12 parts of herba andrographitis, 12-18 parts of cordate houttuynia, 12-18 parts of polygonum cuspidatum, 2-6 parts of roots of bidentate achyranthes, 8-11 parts of corydalis raddeana, 2-6 parts of gallnut and 8-20 parts of liquorice. As traditional Chinese herbal medicines are reasonably matched, common diseases of the factory-like bred California sea cucumber can be prevented through sterilization and disinfection, and meanwhile due to the adoption of the traditional Chinese herbal medicine preparation, no toxic or harmful chemical reagent can be retained in pool water or bodies of the factory-like bred California sea cucumber. By adopting the traditional Chinese herbal medicine preparation, common diseases of the factory-like bred California sea cucumber can be effectively prevented and treated, the survival rate and the egg laying rate of the factory-like bred California sea cucumber can be increased, and the traditional Chinese herbal medicine preparation has great significances for factory-like breeding of the California sea cucumber.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, it is used for preventing and treating plant modification particularly to one kind and add
Chinese herbal and crude drugs preparationses of Li Funiya Stichopus japonicuss Common Diseases and preparation method thereof.
Background technology
California Stichopus japonicuss, originate in east coast of the United States, California to Alaska Costal, morphological characteristic: growth
Phase is long, individual big, and body wall thorniness easily sends out system, and meat is thick, in good taste, and rise 4 times that the rate of sending out is weight, is covered with Stichopus japonicuss in body wall
Muscle (is commonly called as Flos Osmanthi Fragrantis rod), high in nutritive value.
Radix Morinae Bulleyanae is one of economic breed variety of northern China coastal area, has been enter into the large-scale production stage in the last few years
And obtain good benefit.However, in recent years due to factors such as marine pollutions, in the industrialized culture of Radix Morinae Bulleyanae produces, frequently
Occur in that the common disease such as " mouthpart festers ", " bark rot " leads to Radix Morinae Bulleyanae dead, cause to Industrialized stichopus japonicus culture larger
Loss；Wherein " mouthpart ulcer disease " is presently the most disease popular and that impact is the most serious.So-called " mouthpart ulcer disease " is disease
Radix Morinae Bulleyanae membrana perisomialis blackening, can not ingest when sb.'s illness took a turn for the worse, adhere to, and Spina jujubae is dead after gradually coming off.This sick initial stage is no any
Abnormal, but examine and can find that Radix Morinae Bulleyanae ingestion ability gradually weakens.Its mortality rate is very high, and economic loss is extremely serious.So
How effectively to prevent industrialized culture Radix Morinae Bulleyanae " mouthpart ulcer disease " it is particularly important.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine
Preventing and treating Stichopus japonicuss plant modification Common Diseases are increasingly subject to attention and the favor of people, are increasingly widely accepted, are only with it
The mechanism of action of spy, model of action and advantage are inseparable, put it briefly, herbal control disease has Accommodation, righting
Eliminating evil, have no drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and there is not antibiotic
The residue problem of medicine, breeds products export to the Aquatic product of China highly beneficial.In addition, Chinese herbal medicine also has low price, source
Extensively, the advantages of easy to use, it is one of developing direction of fish medicine from now on.
Content of the invention
It is an object of the invention to provide a kind of for preventing and treating in the Stichopus japonicuss Common Diseases of plant modification California
Herbal medicinal product.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparationses for preventing and treating plant modification California Stichopus japonicuss Common Diseases, by following weight portion
Chinese crude drug be prepared from: Rhizoma Coptidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentiss 12-18, Herba Andrographis 8-12 part, Herba Houttuyniae 12-18
Part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Galla Chinensiss 2-6 part, Radix Glycyrrhizae 8-20 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating plant modification California Stichopus japonicuss Common Diseases, by
The Chinese crude drug of following weight portion is prepared from: 18 parts of Rhizoma Coptidis, 18 parts of Fructus Gardeniae, Radix Sophorae Flavescentiss 16,10 parts of Herba Andrographis, 16 parts of Herba Houttuyniae, tiger
14 parts of cane, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Herba crotalariae albidae, 4 parts of Galla Chinensiss, 11 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal medicine system for preventing and treating plant modification California Stichopus japonicuss Common Diseases
Agent is granule.
The preparation method of the Chinese herbal and crude drugs preparationses that above-mentioned each Chinese crude drug preparation cost is invented, comprises the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaning up by recipe quantity, pulverize, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
The consumption of above-mentioned preventing and treating California Stichopus japonicuss plant modification Common Diseases Chinese medicine granules is by 60-80g/
The ratio of 100kg body weight mixes pharmaceutical chemistry, allows Stichopus japonicuss to be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats California Stichopus japonicuss plant modification Common Diseases with Chinese herbal and crude drugs preparationses, from our experiment
Result is seen, application the present invention Chinese herbal and crude drugs preparationses can effective control California Stichopus japonicuss plant modification Common Diseases, reduce
The M ＆ M of California Stichopus japonicuss plant modification Common Diseases, but also do not produce drug resistance.The present invention will
Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect extremely notable, be that Aquatic product is bred industry and provided a kind of plus profit
The effectively treatment medicine of Fu Niya Stichopus japonicuss plant modification Common Diseases, has instant effect, curative effect really, no drug residue, no any
The feature of toxic and side effects；Its preparation method is simple, the needs of suitable large-scale production.
Specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for the present invention is described, and
It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is broadly fallen into the simple modifications of preparation method of the present invention
Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese herbal and crude drugs preparationses for preventing and treating plant modification California Stichopus japonicuss Common Diseases, by Rhizoma Coptidis, Fructus Gardeniae,
Radix Sophorae Flavescentiss, Herba Andrographis, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Rhizoma Coptidis 18kg, Fructus Gardeniae 18kg,
Radix Sophorae Flavescentiss 16kg, Herba Andrographis 10kg, Herba Houttuyniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Galla Chinensiss 4kg, Radix Glycyrrhizae
11kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating California Stichopus japonicuss plant modification Common Diseases, concrete system
Standby step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Rhizoma Coptidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentiss 16kg, Herba Andrographis 10kg, Herba Houttuyniae 16kg, Rhizoma Polygoni Cuspidati
14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Galla Chinensiss 4kg, Radix Glycyrrhizae 11kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 2
A kind of Chinese herbal and crude drugs preparationses for preventing and treating plant modification California Stichopus japonicuss Common Diseases, by Rhizoma Coptidis, Fructus Gardeniae,
Radix Sophorae Flavescentiss, Herba Andrographis, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Rhizoma Coptidis 19kg, Fructus Gardeniae 17kg,
Radix Sophorae Flavescentiss 15kg, Herba Andrographis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae
13kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating California Stichopus japonicuss plant modification Common Diseases, concrete system
Standby step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Rhizoma Coptidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 13kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 3
A kind of Chinese herbal and crude drugs preparationses for preventing and treating plant modification California Stichopus japonicuss Common Diseases, by Rhizoma Coptidis, Fructus Gardeniae,
Radix Sophorae Flavescentiss, Herba Andrographis, Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Rhizoma Coptidis 20kg, Fructus Gardeniae 20kg,
Radix Sophorae Flavescentiss 18kg, Herba Andrographis 12kg, Herba Houttuyniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Herba crotalariae albidae 11kg, Galla Chinensiss 6kg, Radix Glycyrrhizae
15kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating California Stichopus japonicuss plant modification Common Diseases, concrete system
Standby step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Rhizoma Coptidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis 9kg, Herba Houttuyniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 15kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating California Stichopus japonicuss plant modification Common Diseases is by 60g/
The ratio of 100kg body weight mixes pharmaceutical chemistry, is administered orally, and being used in conjunction 5 days is a course for the treatment of.After oral, treatment disease is reached by intestinal absorption
Purpose.
Inventor prevents and treats California Stichopus japonicuss plant modification Common Diseases with Chinese herbal and crude drugs preparationses, from our experiment knot
Fruit sees, no matter being prevention, or treatment, evident in efficacy, but also do not produce drug resistance, promoting through test of many times and small area should
With achieving good effect, so that nursery economic benefit is significantly improved.
Claims (3)
1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating plant modification California Stichopus japonicuss Common Diseases it is characterised in that: by
The Chinese crude drug of following weight portion is prepared from: Rhizoma Coptidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentiss 12-18, Herba Andrographis 8-12 part, fish
Raw meat grass 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Galla Chinensiss 2-6 part, Radix Glycyrrhizae 8-20 part.
2. the Chinese herbal medicine system for preventing and treating plant modification California Stichopus japonicuss Common Diseases according to claim 1
Agent it is characterised in that: be prepared from by the Chinese crude drug of following weight portion: 18 parts of Rhizoma Coptidis, 18 parts of Fructus Gardeniae, Radix Sophorae Flavescentiss 16, Herba Andrographis 10
Part, 16 parts of Herba Houttuyniae, 14 parts of Rhizoma Polygoni Cuspidati, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Herba crotalariae albidae, 4 parts of Galla Chinensiss, 11 parts of Radix Glycyrrhizae.
3. the Chinese herbal medicine for preventing and treating plant modification California Stichopus japonicuss Common Diseases according to claim 1 and 2
Preparation it is characterised in that: it be granule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610962476.2A CN106344699A (en) | 2016-11-04 | 2016-11-04 | Traditional Chinese herbal medicine preparation for preventing and treating common diseases of factory-like bred California sea cucumber |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610962476.2A CN106344699A (en) | 2016-11-04 | 2016-11-04 | Traditional Chinese herbal medicine preparation for preventing and treating common diseases of factory-like bred California sea cucumber |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106344699A true CN106344699A (en) | 2017-01-25 |
Family
ID=57864400
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610962476.2A Withdrawn CN106344699A (en) | 2016-11-04 | 2016-11-04 | Traditional Chinese herbal medicine preparation for preventing and treating common diseases of factory-like bred California sea cucumber |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106344699A (en) |
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2016
- 2016-11-04 CN CN201610962476.2A patent/CN106344699A/en not_active Withdrawn
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170125 |
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