CN106266146A - A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases - Google Patents
A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases Download PDFInfo
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- CN106266146A CN106266146A CN201610986658.3A CN201610986658A CN106266146A CN 106266146 A CN106266146 A CN 106266146A CN 201610986658 A CN201610986658 A CN 201610986658A CN 106266146 A CN106266146 A CN 106266146A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Radix Isatidis 16 20 parts, Fructus Gardeniae 16 20 parts, Radix Sophorae Flavescentis 12 18, Herba Andrographis 8 12 parts, Herba Artemisiae Scopariae 12 18 parts, Folium Perillae 12 18 parts, Radix Achyranthis Bidentatae 26 parts, Herba crotalariae albidae 8 11 parts, Cortex Phellodendri 26 parts, 8 20 parts of Radix Glycyrrhizae.Utilize traditional Chinese herbal medicine reasonably combined, can be by sterilization, the Common Diseases problem of sterilization prevention plant modification Concha Tridacna squamosa, the present invention uses Chinese herbal and crude drugs preparations simultaneously, it is ensured that do not remain poisonous and hazardous chemical agent in water and Concha Tridacna squamosa body.Use the present invention can effectively prevent and treat plant modification Concha Tridacna squamosa Common Diseases, improve plant modification Concha Tridacna squamosa survival rate, spawning rate, plant modification Concha Tridacna squamosa is bred significant.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating plant modification Che particularly to one
Chinese herbal and crude drugs preparations of giant clam Common Diseases and preparation method thereof.
Background technology
Concha Tridacna squamosa (Tridacnidae spp.): be the marine animal of Mollusca Bivalvia.Have 1 section 2 and belong to 9 kinds, be
Bivalve shellfish maximum in ocean, is referred to as " shellfish king ", and largest body length is up to more than 1 meter, and weight reaches more than 300 kilograms.Shell
Matter is thick and heavy, shell edge such as tooth, two shell sizableness, the pure white smoothness of inner shell, pale as beautiful.External ligament, generally has a big byssus
Hole.Hinge has a main tooth and 1～2 posterior lateral tooth.Overcoat trace is complete, and anterior adductor muscle disappears, and posterior adductor muscle is the most central.All
For noble cane, generally it is attached on coral reef life with byssus.For maximum shellfish individual in Bivalve, the biggest Concha Tridacna squamosa
(Tridacna gigas) shell length is up to 1 meter.There is substantial amounts of zooxanthellae in Concha Tridacna squamosa outer embrane, by vitreous body optically focused in film, make
Zooxanthellae amount reproduction and as self nutrient, the two forms the special relationship of Mutualism, have good market prospect and
Value of exploiting and utilizing.
In recent years, China's Coastal Areas cultivated shellfish massive mortality event frequently occurs, and the shellfish kind related to is with foster
Grow area and scope is continuously increased, make shellfishery suffer great economic loss.Cultivated shellfish massive mortality problem is
Cause the extensive attention at aquaculture family.The cultivated shellfish bionosis cause of death, mainly has: virus, antibacterial, parasitic former
Worm, rickettsia-like organism, class chlamydia, mycoplasma-like organism(MLO) etc..
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine
Preventing and treating plant modification Concha Tridacna squamosa Common Diseases, increasingly by attention and the favor of people, is increasingly widely accepted, is only with it
Special mechanism of action, model of action and advantage are inseparable, put it briefly, and herbal control disease has Accommodation, righting
Eliminating evil, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and there is not antibiotic
The residue problem of medicine, breeds products export to the Aquatic product of China highly beneficial.It addition, Chinese herbal medicine also has low price, source
Extensively, the advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases, by the Chinese crude drug system of following weight portion
For forming: Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Herba Andrographis 8-12 part, Herba Artemisiae Scopariae 12-18 part, Folium Perillae 12-18
Part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Cortex Phellodendri 2-6 part, Radix Glycyrrhizae 8-20 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases, by following weight portion
Chinese crude drug be prepared from: Radix Isatidis 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Herba Andrographis 10 parts, Herba Artemisiae Scopariae 16 parts, Folium Perillae 14 parts, Radix Achyranthis Bidentatae
4 parts, Herba crotalariae albidae 9 parts, Cortex Phellodendri 4 parts, 11 parts of Radix Glycyrrhizae.
It is further preferred that described is granule for preventing and treating the Chinese herbal and crude drugs preparations of plant modification Concha Tridacna squamosa Common Diseases
Agent.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
The consumption of above-mentioned preventing and treating plant modification Concha Tridacna squamosa Common Diseases Chinese medicine granules is by 60-80g/100kg body weight
Ratio mixes pharmaceutical chemistry, allows plant modification Concha Tridacna squamosa be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats plant modification Concha Tridacna squamosa Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result, and should
Can effectively control plant modification Concha Tridacna squamosa Common Diseases with the Chinese herbal and crude drugs preparations of the present invention, reduce plant modification Concha Tridacna squamosa commonly encountered diseases
The M & M of evil, but also do not produce drug resistance.The present invention is by Chinese medicine reasonable formula, anti-inflammation, enhancing
Effect of immunity is extremely notable, breeds industry for Aquatic product and provides effective curative of a kind of plant modification Concha Tridacna squamosa Common Diseases
Thing, have instant effect, curative effect really, no drug residue, feature without any side effects；Its preparation method is simple, is suitable for scale
The needs produced.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and
It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention
Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating plant modification Concha Tridacna squamosa Common Diseases, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentis, Herba Andrographis,
Herba Artemisiae Scopariae, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentis 16kg, punching
Lotus 10kg, Herba Artemisiae Scopariae 16kg, Folium Perillae 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Cortex Phellodendri 4kg, Radix Glycyrrhizae 11kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating plant modification Concha Tridacna squamosa Common Diseases, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentis 16kg, Herba Andrographis 10kg, Herba Artemisiae Scopariae 16kg, Folium Perillae
14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Cortex Phellodendri 4kg, Radix Glycyrrhizae 11kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating plant modification Concha Tridacna squamosa Common Diseases, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentis, Herba Andrographis,
Herba Artemisiae Scopariae, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, punching
Lotus 9kg, Herba Artemisiae Scopariae 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 13kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating plant modification Concha Tridacna squamosa Common Diseases, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Herba Andrographis 9kg, Herba Artemisiae Scopariae 14kg, Folium Perillae 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 13kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating plant modification Concha Tridacna squamosa Common Diseases, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentis, Herba Andrographis,
Herba Artemisiae Scopariae, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 20kg, Fructus Gardeniae 20kg, Radix Sophorae Flavescentis 18kg, punching
Lotus 12kg, Herba Artemisiae Scopariae 18kg, Folium Perillae 18kg, Radix Achyranthis Bidentatae 6kg, Herba crotalariae albidae 11kg, Cortex Phellodendri 6kg, Radix Glycyrrhizae 15kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating plant modification Concha Tridacna squamosa Common Diseases, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Herba Andrographis 9kg, Herba Artemisiae Scopariae 14kg, Folium Perillae 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 15kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating plant modification Concha Tridacna squamosa Common Diseases is by the ratio of 60g/100kg body weight
Example mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On July 20th, 2016, the plant modification Concha Tridacna squamosa morbidity that Weihai City, Shandong Province nursery is bred, clinical condition
Shape: ill plant modification Concha Tridacna squamosa tentacle, trunk or skin of head fester, and necrosis comes off, and severe patient festers and is deep into flesh
Sarcocyte.It is typical case's ulcer disease after diagnosing.Then with Chinese medicine granules treatment described in the embodiment of the present invention 2, after medication 2 days, the state of an illness is bright
Aobvious improvement, substantially, mortality rate reduces the change of health color by sky, and after 7 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats plant modification Concha Tridacna squamosa Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result, no matter
It is prevention, or treatment, evident in efficacy, but also do not produce drug resistance, through test of many times and little area popularization and application, achieve
Good effect, makes breeding field economic benefit significantly improve.
Claims (3)
1. the Chinese herbal and crude drugs preparations being used for preventing and treating plant modification Concha Tridacna squamosa Common Diseases, it is characterised in that: by following weight portion
Chinese crude drug be prepared from: Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Herba Andrographis 8-12 part, Herba Artemisiae Scopariae 12-18
Part, Folium Perillae 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Cortex Phellodendri 2-6 part, Radix Glycyrrhizae 8-20 part.
Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases the most according to claim 1, its feature exists
In: it is prepared from by the Chinese crude drug of following weight portion: Radix Isatidis 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Herba Andrographis 10 parts, Herba Artemisiae Scopariae 16
Part, Folium Perillae 14 parts, Radix Achyranthis Bidentatae 4 parts, Herba crotalariae albidae 9 parts, Cortex Phellodendri 4 parts, 11 parts of Radix Glycyrrhizae.
Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases the most according to claim 1 and 2, its feature
It is: it is granule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11434255B2 (en) * | 2016-09-16 | 2022-09-06 | Lcb Pharma Inc. | Nucleoside and nucleotide analogues bearing a quaternary all-carbon stereogenic center at the 2′ position and methods of use as a cardioprotective agent |
-
2016
- 2016-11-10 CN CN201610986658.3A patent/CN106266146A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11434255B2 (en) * | 2016-09-16 | 2022-09-06 | Lcb Pharma Inc. | Nucleoside and nucleotide analogues bearing a quaternary all-carbon stereogenic center at the 2′ position and methods of use as a cardioprotective agent |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170104 |