CN106265983A - A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases - Google Patents
A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases Download PDFInfo
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- CN106265983A CN106265983A CN201610874857.5A CN201610874857A CN106265983A CN 106265983 A CN106265983 A CN 106265983A CN 201610874857 A CN201610874857 A CN 201610874857A CN 106265983 A CN106265983 A CN 106265983A
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- 239000003814 drug Substances 0.000 title claims abstract description 47
- 201000010099 disease Diseases 0.000 title claims abstract description 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 36
- 229940079593 drug Drugs 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 241000628997 Flos Species 0.000 claims abstract description 14
- 239000008187 granular material Substances 0.000 claims description 15
- 230000000694 effects Effects 0.000 abstract description 17
- 239000003640 drug residue Substances 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 44
- 239000000843 powder Substances 0.000 description 24
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- 239000006071 cream Substances 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 239000012567 medical material Substances 0.000 description 8
- 239000002244 precipitate Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
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- 239000006228 supernatant Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 240000005001 Paeonia suffruticosa Species 0.000 description 5
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
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- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
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- 229910001220 stainless steel Inorganic materials 0.000 description 4
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- 238000010025 steaming Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 241000251468 Actinopterygii Species 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
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- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
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- 241000411851 herbal medicine Species 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
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- 241000195493 Cryptophyta Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of Chinese herbal and crude drugs preparations preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Herba Artemisiae Scopariae 12 22 parts, Radix Bupleuri 16 20 parts, Radix Sophorae Flavescentis 12 18, Fructus Forsythiae 8 12 parts, Cortex Moutan 12 18 parts, Folium Perillae 12 18 parts, Radix Achyranthis Bidentatae 26 parts, Flos Lonicerae 8 11 parts, Galla Chinensis 26 parts.By Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect extremely notable, provide a kind of pond culture effective medicine of Carnis Rapanae thomasianae Common Diseases for culture fishery, have instant effect, curative effect really, no drug residue, feature without any side effects.The Chinese herbal and crude drugs preparations of the application present invention, can effectively control pond culture Carnis Rapanae thomasianae Common Diseases, reduces the M & M of Common Diseases.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating pond culture Carnis Rapanae thomasianae particularly to one
Chinese herbal and crude drugs preparations of Common Diseases and preparation method thereof.
Background technology
The shellfish biologies such as Carnis Rapanae thomasianae are oviparity or ovoviviparous animal, the term of Carnis Rapanae thomasianae probably 5～August, this period marine site
The life procreations such as water temperature is higher, suitable Carnis Rapanae thomasianae.The kind that Carnis Rapanae thomasianae has is mainly collective's ovulation row's essence, being subject to of after fertilization in sea water
Essence ovum swims in water as plankton, runs into reef and just adheres to, waits to hatch in reef gap, and some kinds are at body
Hatch the most voluntarily, be similar to the breeding of Limax etc..
Carnis Rapanae thomasianae is improved seeds of development seawater pond culture.
Carnis Rapanae thomasianae cultivation mainly stable breeding, shared pond area is little, belongs to intensity cultivation, and the seed amount of every mu should control
About 1.2 ten thousand, after the Mid-autumn Festival can with discontinuity catch stay greatly little.Harvest time does not reaches the Carnis Rapanae thomasianae of specification, should be put in circular groove
In support temporarily, next year can be made seed and also can list in advance.Sum it up, Carnis Rapanae thomasianae cultivation is that of polycultured ponds is attached, it also it is fall
One condition of low polycultured ponds risk.Although less demanding to growing environment of Carnis Rapanae thomasianae, but it is raw in comfortable environment
Long speed is relatively fast, and other breed varieties of polycultured ponds are also required to a comfortable growing environment, so in breeding process
The change of water quality must be grasped, keep the bacterium algae balance in pond, control substrate change, routine cleaning purse seine, appropriate bait throwing in, protect
Dissolved oxygen in card water.To go to a doctor in time when having disease to occur, prevent cross infection.The Common Diseases of pond culture Carnis Rapanae thomasianae, one
The four seasons in year all can occur, and treatment difficulty is big, and the preventing and treating for this disease must adhere to the former of " putting prevention first, anti-overweighting is controlled "
Then.If shrimp body surface festers, treating the pathogenic bacterium in such disease water body to be killed, more important point is to kill skin
The antibacterial of skin rotten position, takes the pathogenic bacterium in antibacterials purged body orally simultaneously.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate
The most extremely serious by situation so that the treatment difficulty of pond culture Carnis Rapanae thomasianae strengthens, and drug residue problem is more and more heavier, pacify to food
Full problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, by rationally screening Chinese medicine and prescription, as preventing and treating
Pond culture Carnis Rapanae thomasianae Common Diseases is first-selected, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine
Preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, increasingly by attention and the favor of people, is increasingly widely accepted, and is unique with it
Mechanism of action, model of action and advantage inseparable, put it briefly, herbal control disease has Accommodation, righting is dispelled
Evil, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and there is not antibiolics
The residue problem of thing, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has low price, wide material sources,
The advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, is prepared by the Chinese crude drug of following weight portion
Form: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Cortex Moutan 12-18 part, Folium Perillae 12-18 part,
Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, by following weight portion
Chinese crude drug is prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Cortex Moutan 16 parts, Folium Perillae 14 parts, Radix Achyranthis Bidentatae 4 parts,
Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
It is further preferred that described is granule for preventing and treating the Chinese herbal and crude drugs preparations of pond culture Carnis Rapanae thomasianae Common Diseases.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
The consumption of above-mentioned preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases Chinese medicine granules is by the ratio of 50-80g/100kg body weight
Example mixes pharmaceutical chemistry, allows pond culture Carnis Rapanae thomasianae be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats pond culture Carnis Rapanae thomasianae Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result, and application
The Chinese herbal and crude drugs preparations of the present invention can effectively control pond culture Carnis Rapanae thomasianae Common Diseases, reduces sending out of pond culture Carnis Rapanae thomasianae Common Diseases
Sick rate and mortality rate, but also do not produce drug resistance.The present invention is by Chinese medicine reasonable formula, anti-inflammation, enhancing immunity
Effect extremely notable, provide effective medicine of a kind of pond culture Carnis Rapanae thomasianae Common Diseases for culture fishery, have
Instant effect, curative effect are certain, no drug residue, feature without any side effects；Its preparation method is simple, is suitable for large-scale industrial and produces
Needs.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and
It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention
Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Forsythiae, Paeonia suffruticosa
Skin, Folium Perillae, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg, Paeonia suffruticosa
Skin 16kg, Folium Perillae 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, concrete preparation process is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg, Cortex Moutan 16kg, Folium Perillae 14kg,
Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Forsythiae, Paeonia suffruticosa
Skin, Folium Perillae, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Cortex Moutan
14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, concrete preparation process is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, cattle
Knee joint 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Forsythiae, Paeonia suffruticosa
Skin, Folium Perillae, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentis 18kg, Fructus Forsythiae 12kg, Paeonia suffruticosa
Skin 18kg, Folium Perillae 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Galla Chinensis 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, concrete preparation process is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, cattle
Knee joint 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases is the ratio in 60g/100kg body weight
Mixing pharmaceutical chemistry, oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the pond culture Carnis Rapanae thomasianae that area, Rongcheng, Shandong Province certain pond culture Carnis Rapanae thomasianae raiser raises sends out
Disease, clinical symptoms: ill pond culture Carnis Rapanae thomasianae fish tail shank, trunk or skin of head fester, and necrosis comes off, severe patient is burst
Rotten being deep into Musclar layer, the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then with Chinese medicine described in the embodiment of the present invention 2
Granules in Treating, after medication 2 days, the state of an illness is clearly better, and substantially, mortality rate reduces the change of health color by sky, mortality rate after 5 days
It is 0, is almost recovered.
Inventor prevents and treats pond culture Carnis Rapanae thomasianae Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result, is no matter
Prevention, or treatment, evident in efficacy, but also do not produce drug resistance, through test of many times and little area popularization and application, achieve good
Good effect, makes fishing ground economic benefit significantly improve.
Claims (3)
1. the Chinese herbal and crude drugs preparations being used for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases, it is characterised in that: by following weight portion
Chinese crude drug is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Cortex Moutan 12-18 part, purple
Soviet Union 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases the most according to claim 1, it is characterised in that:
It is prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Cortex Moutan 16 parts, purple
Revive 14 parts, Radix Achyranthis Bidentatae 4 parts, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
Chinese herbal and crude drugs preparations for preventing and treating pond culture Carnis Rapanae thomasianae Common Diseases the most according to claim 1 and 2, its feature exists
In: it is granule.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745049A (en) * | 2010-02-26 | 2010-06-23 | 山东省海水养殖研究所 | Herbal preparation for aquaculture, preparation method and application |
-
2016
- 2016-09-30 CN CN201610874857.5A patent/CN106265983A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745049A (en) * | 2010-02-26 | 2010-06-23 | 山东省海水养殖研究所 | Herbal preparation for aquaculture, preparation method and application |
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