CN106361866A - Chinese herbal medicine preparation for preventing and curing common diseases of sinonovacula constricta cultured in earth pond - Google Patents

Chinese herbal medicine preparation for preventing and curing common diseases of sinonovacula constricta cultured in earth pond Download PDF

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CN106361866A
CN106361866A CN201610963842.6A CN201610963842A CN106361866A CN 106361866 A CN106361866 A CN 106361866A CN 201610963842 A CN201610963842 A CN 201610963842A CN 106361866 A CN106361866 A CN 106361866A
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chinese herbal
herbal medicine
sinonovacula constricta
common diseases
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王培亮
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Weihai Hongrun Ocean Technology Co Ltd
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Weihai Hongrun Ocean Technology Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/315—Isatis, e.g. Dyer's woad
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/756—Phellodendron, e.g. corktree

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Abstract

The invention discloses a Chinese herbal medicine preparation for preventing and curing common diseases of sinonovacula constricta cultured in an earth pond. The Chinese herbal medicine preparation is prepared from, by weight, 16-20 parts of radix isatidis, 16-20 parts of cape jasmine, 12-18 parts of forsythia suspense, 8-12 parts of andrographis paniculata, 12-18 parts of tree peony bark, 12-18 parts of purple perilla, 2-6 parts of radix achyranthis bidentatae, 8-11 parts of taraxacum mongolicum, 2-6 parts of golden cypress and 8-20 parts of licorice root. According to the Chinese herbal medicine preparation, the common diseases of the sinonovacula constricta cultured in the earth pond can be prevented through the reasonable match of traditional Chinese herbal medicine preparations, disinfection and sterilization, at the same time, through the adoption of the Chinese herbal medicine preparations, it can be guaranteed that no toxic and harmful chemical agent remains in the pond water and the body of the sinonovacula constricta. By adopting the Chinese herbal medicine preparation, the common diseases of the sinonovacula constricta cultured in the earth pond can be effectively prevented and cured, and the survival rate and spawning rate of the sinonovacula constricta cultured in the earth pond are improved; the Chinese herbal medicine preparation has great significance for the pond culture of the sinonovacula constricta.

Description

A kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases
Technical field
The invention belongs to fishery practical technique field, specifically, it is used for preventing and treating pond culture Sinonovacula constricta particularly to one kind Chinese herbal and crude drugs preparationses of Common Diseases and preparation method thereof.
Background technology
Sinonovacula constricta, another name " person of low position is celestial " belongs to Mollusca, is Bivalvia curtain clam mesh shell-fish, lives among ocean, be Common seafood food materials.Shell crisp and thin in long flat-square-shaped, from shell top to ventral margin, have the chase of one diagonal, therefore named Sinonovacula constricta.Rather The many beach in ripple region following the line of the sea, have advantageous advantage to cultivation razor clam, are the popular sea in Ningbo special products, and Ninghai Chang Jie mono- carries, face Face Sanmen Wan, have a large amount of fresh water injections throughout the year, the sea water degree of saltiness is suitable, and bait enriches, and applies matter based on silt, thus razor clam growth Hurry up, individual big, meat tenderness and fertile, color is delicious in vain, therefore long street razor clam of gaining the name.Record according to clear " Ninghai county annals ": razor clam, freshwater mussel belong to, with field kind Kind meaning razor clam farm, shape narrow and long as middle finger, a Mactraantiquata Spengler, Yan Qimei., flavour deliciousness, it is of high nutritive value, there is qi-restoratives Function.In sum, Sinonovacula constricta is a kind of high protein of high-quality, low-fat food, and it is of high nutritive value, delicious flavour, has Good market prospect and value of exploiting and utilizing.
In recent years, China's Coastal Areas cultivated shellfish massive mortality event frequently occurs, the shellfish kind being related to and support Grow area and scope is continuously increased, make shellfishery suffer great economic loss.Cultivated shellfish massive mortality problem is Cause the extensive attention at aquaculture family.The cultivated shellfish bionosis cause of death, mainly has: virus, antibacterial, parasitism are former Worm, rickettsia-like organism, class chlamydia, mycoplasma-like organism(MLO) etc..
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine Preventing and treating pond culture Sinonovacula constricta Common Diseases are increasingly subject to attention and the favor of people, are increasingly widely accepted, and are unique with it Mechanism of action, model of action and advantage inseparable, put it briefly, herbal control disease has Accommodation, righting is dispelled Evil, have no drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and there are not antibiolicss The residue problem of thing, the aquaculture products outlet to China is highly beneficial.In addition, Chinese herbal medicine also has low price, source is wide General, the advantages of easy to use, it is one of developing direction of fish medicine from now on.
Content of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases, by the Chinese crude drug preparation of following weight portion Form: Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Fructus Forsythiae 12-18, Herba Andrographis 8-12 part, Cortex Moutan 12-18 part, Folium Perillae 12-18 Part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Cortex Phellodendri 2-6 part, Radix Glycyrrhizae 8-20 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases, by following weight portion Chinese crude drug is prepared from: 18 parts of Radix Isatidis, 18 parts of Fructus Gardeniae, Fructus Forsythiae 16,10 parts of Herba Andrographis, 16 parts of Cortex Moutan, 14 parts of Folium Perillae, Radix Achyranthis Bidentatae 4 parts, 9 parts of Herba crotalariae albidae, 4 parts of Cortex Phellodendri, 11 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases are granules.
The preparation method of the Chinese herbal and crude drugs preparationses that above-mentioned each Chinese crude drug preparation cost is invented, comprises the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaning up by recipe quantity, pulverize, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator, Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place, Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule Agent.
The consumption of above-mentioned preventing and treating pond culture Sinonovacula constricta Common Diseases Chinese medicine granules is the ratio by 60-80g/100kg body weight Example mixes pharmaceutical chemistry, allows pond culture Sinonovacula constricta to be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats pond culture Sinonovacula constricta Common Diseases with Chinese herbal and crude drugs preparationses, in terms of our experimental result, application The Chinese herbal and crude drugs preparationses of the present invention can effective control pond culture Sinonovacula constricta Common Diseases, reduce pond culture Sinonovacula constricta Common Diseases send out Sick rate and mortality rate, but also do not produce drug resistance.The present invention is by Chinese medicine reasonable formula, anti-inflammation, enhancing immunity Effect extremely notable, be that culture fishery provides a kind of effectively treatment medicine of pond culture Sinonovacula constricta Common Diseases, have Instant effect, curative effect really, no drug residue, feature without any side effects；Its preparation method is simple, the need of suitable large-scale production Will.
Specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for the present invention is described, and It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is broadly fallen into the simple modifications of preparation method of the present invention Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules of preventing and treating pond culture Sinonovacula constricta Common Diseases, by Radix Isatidis, Fructus Gardeniae, Fructus Forsythiae, Herba Andrographis, male Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 18kg, Fructus Gardeniae 18kg, Fructus Forsythiae 16kg, punching Lotus 10kg, Cortex Moutan 16kg, Folium Perillae 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Cortex Phellodendri 4kg, Radix Glycyrrhizae 11kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Sinonovacula constricta Common Diseases, concrete preparation process is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Radix Isatidis 18kg, Fructus Gardeniae 18kg, Fructus Forsythiae 16kg, Herba Andrographis 10kg, Cortex Moutan 16kg, Folium Perillae 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Cortex Phellodendri 4kg, Radix Glycyrrhizae 11kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator, Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place, Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule Agent.
Embodiment 2
A kind of Chinese medicine granules of preventing and treating pond culture Sinonovacula constricta Common Diseases, by Radix Isatidis, Fructus Gardeniae, Fructus Forsythiae, Herba Andrographis, male Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 19kg, Fructus Gardeniae 17kg, Fructus Forsythiae 15kg, punching Lotus 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 13kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Sinonovacula constricta Common Diseases, concrete preparation process is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Fructus Forsythiae 15kg, Herba Andrographis 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 13kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator, Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place, Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule Agent.
Embodiment 3
A kind of Chinese medicine granules of preventing and treating pond culture Sinonovacula constricta Common Diseases, by Radix Isatidis, Fructus Gardeniae, Fructus Forsythiae, Herba Andrographis, male Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 20kg, Fructus Gardeniae 20kg, Fructus Forsythiae 18kg, punching Lotus 12kg, Cortex Moutan 18kg, Folium Perillae 18kg, Radix Achyranthis Bidentatae 6kg, Herba crotalariae albidae 11kg, Cortex Phellodendri 6kg, Radix Glycyrrhizae 15kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Sinonovacula constricta Common Diseases, concrete preparation process is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Fructus Forsythiae 15kg, Herba Andrographis 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 15kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator, Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place, Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating pond culture Sinonovacula constricta Common Diseases is the ratio in 60g/100kg body weight Mix pharmaceutical chemistry, be administered orally, being used in conjunction 5 days is a course for the treatment of.Reach the purpose for the treatment of disease by intestinal absorption after oral.
On July 20th, 2016, the pond culture Sinonovacula constricta morbidity of Shandong Province Weihai City nursery cultivation, clinical symptoms: The pond culture Sinonovacula constricta tentacle of illness, trunk or skin of head fester, and necrosis comes off, and severe patient festers and is deep into Musclar layer. It is typical ulcer disease after diagnosing.Then, after using Chinese medicine granules treatment, medication 2 days described in the embodiment of the present invention 2, the state of an illness is substantially good Turn, substantially, mortality rate reduces body color change by sky, and after 7 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats pond culture Sinonovacula constricta Common Diseases with Chinese herbal and crude drugs preparationses, in terms of our experimental result, no matter being Prevention, or treatment, evident in efficacy, but also do not produce drug resistance, through test of many times and small area popularization and application, achieve good Good effect, makes plant's economic benefit significantly improve.

Claims (3)

1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases it is characterised in that: by following weight portion Chinese crude drug is prepared from: Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Fructus Forsythiae 12-18, Herba Andrographis 8-12 part, Cortex Moutan 12-18 Part, Folium Perillae 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Cortex Phellodendri 2-6 part, Radix Glycyrrhizae 8-20 part.
2. the Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases according to claim 1 it is characterised in that: It is prepared from by the Chinese crude drug of following weight portion: 18 parts of Radix Isatidis, 18 parts of Fructus Gardeniae, Fructus Forsythiae 16,10 parts of Herba Andrographis, Cortex Moutan 16 Part, 14 parts of Folium Perillae, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Herba crotalariae albidae, 4 parts of Cortex Phellodendri, 11 parts of Radix Glycyrrhizae.
3. the Chinese herbal and crude drugs preparationses for preventing and treating pond culture Sinonovacula constricta Common Diseases according to claim 1 and 2, its feature exists In: it is granule.
CN201610963842.6A 2016-11-04 2016-11-04 Chinese herbal medicine preparation for preventing and curing common diseases of sinonovacula constricta cultured in earth pond Withdrawn CN106361866A (en)

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Application publication date: 20170201