CN102805772B - Application of coptis chinensis, amur cork-tree bark, Chinese rhubarb and skullcap dysentery inhibiting particles to preparation of medicines for treating intestinal diseases of poultry, and medicinal composition formed by compounding particles - Google Patents
Application of coptis chinensis, amur cork-tree bark, Chinese rhubarb and skullcap dysentery inhibiting particles to preparation of medicines for treating intestinal diseases of poultry, and medicinal composition formed by compounding particles Download PDFInfo
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- CN102805772B CN102805772B CN201210302245.0A CN201210302245A CN102805772B CN 102805772 B CN102805772 B CN 102805772B CN 201210302245 A CN201210302245 A CN 201210302245A CN 102805772 B CN102805772 B CN 102805772B
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Abstract
The invention belongs to the technical field of veterinary medicines and discloses application of coptis chinensis, amur cork-tree bark, Chinese rhubarb and skullcap dysentery inhibiting particles to preparation of medicines for treating intestinal diseases of poultry, and a medicinal composition formed by compounding the particles. The medicinal composition is formed by compounding the particles and chemical synthetic medicines for treating intestinal diseases of the poultry in a weight ratio of 200:1-5:1. When the particles and the chemical synthetic medicines for treating intestinal diseases of the poultry are compounded, the using amount of chemical synthetic medicines can be effectively reduced, the recovery time of the poultry with intestinal diseases is shortened, and an effect of treating the poultry with intestinal diseases is enhanced.
Description
Technical field
The invention belongs to veterinary drug technical field, particularly four yellow Zhili granules are at the application prepared in treatment birds intestinal tract disease medicine and composite pharmaceutical composition thereof.
Background technology
In modern aviculture, the intestinal tract disease of birds is the greatest problem of puzzlement plant, raiser always.It is annual because intestinal tract disease provisions fowl industry brings huge loss.This kind of disease comprises the pathological conditions such as coccidiosis, colibacillosis, salmonellosis, necrotic enteritis, intestinal toxicity syndrome, also comprises the physiological disorder that the other reasons such as feedstuff or unclean drinking-water that to go mouldy because feeding causes.The cardinal symptom of this kind of disease comprises watery diarrhea, punishment in advance (feedstuff is not because digesting direct discharge) and row's white, yellow, green, redness or Lycoperdon polymorphum Vitt feces etc.
Chemical synthetic drug has played very large effect in this type of disease for the treatment of.Such as diclazuril, sulfaclozine sodium, colistin sulfate, polygynax, enrofloxacin etc.But the animal drug resistance problems that chemosynthesis class drug dependence brings and food-safety problem also become increasingly conspicuous in actual production.Therefore, Chinese medicine particularly extracts through modern crafts the developing direction that the Chinese medicine granules processed becomes veterinary medicine.
Four yellow Zhili granules be by Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae etc. 6 taste Chinese medicine through decocting, filtering, concentrated, granulate, Chinese medicine granules that the technique such as dry is made.There is clearing away heat-fire, the function of dysentery relieving.(Chinese veterinary pharmacopoeia 2010 editions second 587 pages)
Patent CN 102008585 A discloses the purposes of four yellow Zhili granules for chicken colibacillosis, salmonellosis and transmissible gastroenteritis of swine.Patent CN 101590139 A discloses the purposes of four yellow Zhili granules for chicken colibacillosis, necrotic enteritis, intestinal toxicity syndrome.But the report of the disease such as chicken coccidiosis and chicken punishment in advance, watery diarrhea is not used for the treatment of so far about four yellow Zhili granules.
Summary of the invention
The object of the present invention is to provide four yellow Zhili granules at the application prepared in treatment birds intestinal tract disease medicine and composite pharmaceutical composition thereof.
For achieving the above object, the technical scheme taked of the present invention is as follows:
Four yellow Zhili granules are the application in coccidiosis, watery diarrhea or punishment in advance disease medicament in preparation treatment birds intestinal tract disease.
Be used for the treatment of a pharmaceutical composition for birds intestinal tract disease, formed so that the weight ratio of 200:1 ~ 5:1 is composite by the chemical synthetic drug of four yellow Zhili granules and treatment birds intestinal tract disease.Wherein, four yellow Zhili granules (get Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Et Rhizoma Rhei 100g, Radix Scutellariae 200g, Radix Isatidis 200g, Radix Glycyrrhizae 100g according to the preparation method preparation of Chinese veterinary pharmacopoeia 2010 editions second.Above 6 tastes decoct with water 2 times, 2 hours first times, second time 1 hour, collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.32-1.35, appropriate with sucrose and dextrin, makes granule, dry, make 1000g, to obtain final product), comprise all business-like preparations including but not limited to the commercially available veterinary formulations being common name with four yellow Zhili granules.
Birds intestinal tract disease refers to the pathological conditions such as colibacillosis, salmonellosis, intestinal toxicity syndrome, necrotic enteritis, coccidiosis and punishment in advance, the watery diarrhea that reason causes such as to be not good at, to have loose bowels because of feeding and management.Birds intestinal tract disease preferred pin of the present invention is to coccidiosis, watery diarrhea or punishment in advance.Punishment in advance: make because of animal intestinal digestion or malabsorption the phenomenon that Nutrient feces is discharged together in breeding process, the feedstuff granules such as Semen Maydis larger as seen in feces, feces, containing a large amount of moisture, may be the result of single paathogenic factor or multiple paathogenic factor comprehensive function.
When described birds intestinal tract disease is coccidiosis, chemical synthetic drug is diclazuril, Toltrazuril, sulfaclozine sodium or sulfachlorpyridazine sodium; When described birds intestinal tract disease be watery diarrhea or punishment in advance time, conventional chemical synthetic drug is gentamycin, ofloxacin, norfloxacin, ciprofloxacin, colistin sulfate or polygynax.
Pharmaceutical composition of the present invention is used for the treatment of birds intestinal tract disease, particularly extra large blue laying hen, Roman egghen, capital red eggs chicken, capital powder laying hen, white meat-type chickens, the Sanhuang chicken such as any kind chicken, duck, goose, Carnis Coturnicis japonicae, Columba livia and can treats with pharmaceutical composition of the present invention.
Using method: pharmaceutical composition of the present invention with the mode administration of freely drinking water, also by the mode administration of spice, preferably with the mode administration of freely drinking water, can be used in conjunction 3 ~ 4 days.Preferably 0.5 ~ 1g pharmaceutical composition is dissolved in 0.1 ~ 20kg water, more preferably 0.5 ~ 1g pharmaceutical composition is dissolved in 0.5 ~ 5kg water, and most preferably 0.5 ~ 1g pharmaceutical composition is dissolved in 1 ~ 2kg water.
When the yellow Zhili granule of the present invention four and chemical synthetic drug share, effectively can reduce the consumption of chemical synthetic drug, shorten the recovery time of disease simultaneously, strengthen the therapeutic effect to birds intestinal tract disease.
Accompanying drawing explanation
Fig. 1 is the recovery extent curve of laying rate.
Detailed description of the invention
Embodiment one: to the therapeutical effect of Eimeria species
The object of this research is the therapeutical effect of test pharmaceutical composition of the present invention for Eimeria species.
Test egg capsule: Eimeria Tenella egg capsule is preserved by Mu Yi engineering college of Agricultural University Of He'nan parasitology laboratory.
Test medicine: four yellow Zhili granules, Henan Xinzhenghao Bio-Engineering Co., Ltd. produces (lot number 20120503).
Ball bit (effective ingredient diclazuril mass content 0.5%), Henan Xinzhenghao Bio-Engineering Co., Ltd. produces (lot number 20120402).
Above-mentioned two kinds of medicines are all according to Chinese veterinary pharmacopoeia 2010 editions standard production, and Toltrazuril, sulfachlorpyridazine sodium, sulfaclozine sodium are the former powder of medicine.
EXPERIMENTAL DESIGN: test chicken (extra large blue laying hen) 220 is divided into 11 groups at random in 7 ages in days, often organizes 20.Grouping situation is as follows:
Except the 1st group, the blunt nosed syringe per oral inoculation 1.0 × 10 of all the other 10 groups of chicken every chickens
5individual E. pubescens Msxim.Latter 4th day of inoculation, 2-10 group is by water way administration.Administration concentration is respectively: the 2nd group, and the yellow Zhili granule of 1g tetra-converts 1.5kg water; 3rd group, 1g ball bit converts 1.5kg water; 4th group, 0.1g Toltrazuril converts 1.5kg water; 5th group, 0.2g sulfachlorpyridazine sodium converts 1.5kg water; 6th group, 0.2g sulfaclozine sodium converts 1.5kg water; 7th group, 0.5g tetra-yellow Zhili granule+0.5g ball bit converts 1.5kg water; 8th group, 0.5g tetra-yellow Zhili granule+0.04g Toltrazuril converts 1.5kg water; 9th group, 0.5g tetra-yellow Zhili granule+0.1g sulfachlorpyridazine sodium converts 1.5kg water; 10th group, 0.5g tetra-yellow Zhili granule+0.1g sulfaclozine sodium converts 1.5kg water, and above 10 groups of equal administrations 3 days, freely drink water.1st, 11 groups of normal water.
Testing index: searching for food and drinking-water situation, the mental status, feces character and death condition of every day entry chicken.Within after infecting 5-8 days, collect feces and carry out egg capsule counting, within the 8th day, weigh, cut off the water supply before weighing fracture 2 h, then puts to death and cut open inspection, carries out caecum lesion and score and content egg capsule counting.
Evaluating drug effect standard: measure following index with reference to correlation technique: anticoccidial Index A CI=(body weight increase rate+survival rate) × 100-(pathological changes value+egg capsule value), wherein body weight increase rate=administration group or infect not administration group rate of body weight gain/do not infect not administration group rate of body weight gain × 100%; Survival rate=survival chicken number/total chicken number × 100%.ACI>180 person, is judged to efficient anticoccidial drug; ACI is 160-, is judged to middle effect anticoccidial drug; ACI is 120-160 person, is judged to poor efficiency anticoccidial drug; ACI<120 person, is judged to invalid anticoccidial drug.
The caecum average lesion of pathological changes value=often organize chicken scores × and 10, carry out lesion score by 4 points of systems: 0 point, lose pathological changes; 1 point, caecum mucosa has a small amount of petechia; 2 points, intestinal wall thickens, and mucosa has volume petechia; 3 points, caecum swelling, content containing volume blood, or forms hard intestinal core admittedly; 4 points, caecum extremely swelling, outward appearance is aubergine, and content containing blood clot, or dies from coccidiosis patient.
Egg capsule value: calculate egg capsule number (OPG) contained in every gram of feces by Mike's geneva method.Then according to the form below is converted into egg capsule value.
Result of the test:
This research found four yellow Zhili granules and anticoccidial chemical synthetic drug as diclazuril, Toltrazuril, sulfachlorpyridazine sodium, sulfaclozine sodium share time, effectively can reduce the consumption of anticoccidial chemical synthetic drug, strengthen the therapeutic effect to Eimeria species simultaneously.
Embodiment two is for the field test of the pathogenic disorders such as laying hen punishment in advance, watery diarrhea.
The plant of a livestock on hand 4000 adult extra large blue laying hens.Laying hen 170 age in days.Due to the feedstuff that part is gone mouldy of having fed, cause having continued since one week to occur the symptom such as punishment in advance (feed granules does not digest direct discharge), clear watery diarrhea.Laying rate drops to 55% by 92%, without dead chicken.
Because 4000 chickens cultivate respectively in 2 hen houses, 2000 every.So design following testing program:
First: change fresh feed, (Henan Xinzhenghao Bio-Engineering Co., Ltd. produces to add four yellow Zhili granules in drinking-water, lot number 20120503) and gentamycin sulfate and bismuth subcarbonate capsules (effective ingredient colistin sulfate mass content 10%, Henan Xinzhenghao Bio-Engineering Co., Ltd.'s production, lot number 20120403.Concentration is that 50g tetra-yellow Zhili granule+50g gentamycin sulfate and bismuth subcarbonate capsules is watered 150kg.Freely drink water, be used in conjunction 4 days.
Second: change fresh feed, in drinking-water, add gentamycin sulfate and bismuth subcarbonate capsules (effective ingredient colistin sulfate mass content 10%, Henan Xinzhenghao Bio-Engineering Co., Ltd. produces, lot number 20120403).Concentration is that 100g gentamycin sulfate and bismuth subcarbonate capsules is watered 150kg.Freely drink water, be used in conjunction 4 days.
Result of the test: judge medication effect, as Fig. 1 by the recovery extent of laying rate.This test describe four yellow Zhili granules and antibiotic medicine drug combination be used for the pathogenic disorders such as punishment in advance, watery diarrhea for the treatment of laying hen time, effectively can treat the disease of above-mentioned symptom, reduce antibiotic using dosage, shorten the recovery time of disease simultaneously.
Claims (3)
1. be used for the treatment of a pharmaceutical composition for birds intestinal tract disease, it is characterized in that: formed so that the weight ratio of 200:1 ~ 5:1 is composite by the chemical synthetic drug of four yellow Zhili granules and treatment birds intestinal tract disease; Described birds intestinal tract disease is coccidiosis, watery diarrhea or punishment in advance; When described birds intestinal tract disease is coccidiosis, chemical synthetic drug is diclazuril, Toltrazuril, sulfaclozine sodium or sulfachlorpyridazine sodium; When described birds intestinal tract disease be watery diarrhea or punishment in advance time, chemical synthetic drug is gentamycin, ofloxacin, norfloxacin, ciprofloxacin, colistin sulfate or polygynax.
2. be used for the treatment of the pharmaceutical composition of birds intestinal tract disease as claimed in claim 1, it is characterized in that: described birds is any kind chicken, duck, goose, Carnis Coturnicis japonicae or Columba livia.
3. be used for the treatment of the pharmaceutical composition of birds intestinal tract disease as claimed in claim 2, it is characterized in that: described birds is extra large blue laying hen, Roman egghen, capital red eggs chicken, capital powder laying hen, white meat-type chickens or Sanhuang chicken.
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| CN201210302245.0A CN102805772B (en) | 2012-08-23 | 2012-08-23 | Application of coptis chinensis, amur cork-tree bark, Chinese rhubarb and skullcap dysentery inhibiting particles to preparation of medicines for treating intestinal diseases of poultry, and medicinal composition formed by compounding particles |
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| CN103271921B (en) * | 2013-05-10 | 2015-04-29 | 华南农业大学 | Preparation method of compound solution of toltrazuril and diclazuril and application thereof |
| CN107412425A (en) * | 2017-08-09 | 2017-12-01 | 福建中农牧生物药业有限公司 | A kind of plant additive for preventing and treating transmissible gastroenteritis of swine and preparation method thereof |
| CN114468171A (en) * | 2020-10-23 | 2022-05-13 | 河北科星药业有限公司 | Feed additive for preventing and treating quail coccidiosis, preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062171A (en) * | 2007-05-18 | 2007-10-31 | 湛江市第一兽药厂 | Method for producing bacterial virus element medicine for preventing bacterial virus mixed infection for critter, fowl and aquatic animals |
| CN101590139A (en) * | 2008-05-30 | 2009-12-02 | 天津生机集团股份有限公司 | A kind of preparation method of preventing and treating the Chinese medicine compound four yellow dysentery stopping preparations of livestock and poultry intestinal canal diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101062171A (en) * | 2007-05-18 | 2007-10-31 | 湛江市第一兽药厂 | Method for producing bacterial virus element medicine for preventing bacterial virus mixed infection for critter, fowl and aquatic animals |
| CN101590139A (en) * | 2008-05-30 | 2009-12-02 | 天津生机集团股份有限公司 | A kind of preparation method of preventing and treating the Chinese medicine compound four yellow dysentery stopping preparations of livestock and poultry intestinal canal diseases |
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