CN1927302A - Medicament for animals with heat clearing and detoxicating, detumescence and pus drainage functions and preparing method thereof - Google Patents
Medicament for animals with heat clearing and detoxicating, detumescence and pus drainage functions and preparing method thereof Download PDFInfo
- Publication number
- CN1927302A CN1927302A CN 200510015051 CN200510015051A CN1927302A CN 1927302 A CN1927302 A CN 1927302A CN 200510015051 CN200510015051 CN 200510015051 CN 200510015051 A CN200510015051 A CN 200510015051A CN 1927302 A CN1927302 A CN 1927302A
- Authority
- CN
- China
- Prior art keywords
- herba houttuyniae
- extract
- detumescence
- extraction
- medical material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention involves the veterinary medicine which takes heartleaf houttuynia herb as raw materials and has the function of clearing away the heat-evil and expelling superficial evils, detumescence and purulent discharge and its preparation method. After refining the heartleaf houttuynia herb medicinal substances, wash and cut it into pieces, then extract the ground heartleaf houttuynia herb: extract it with eight times the weight of water of the medicine, the extraction temperature is 95 +- 3DEG C, accommodate its pH to 2-5 with 10% acid for the first extraction, decocte for 2 hours; still add the water to eight times the weight of the medicine for the second extraction and accommodate its pH to 8-9 with 10% alkali, 1.5 hours extraction. Merge the physic liquor after they are filtrated respectively, after drying, pulverization heartleaf houttuynia herb refined powder is obtained.
Description
Technical field
The present invention relates to the technical field of herbal medicine, particularly relating to the Chinese crude drug Herba Houttuyniae is a kind of animal medicament and method for making with heat-clearing and toxic substances removing, detumescence and apocenosis function of raw material.
Background technology
Culture towards intensive and intensive direction and develop along with the animal husbandry of China, the continuous expansion of scale is cultured in animal husbandry, ensures that the quality safety of animal husbandry product has become the present major issue that we need solve.At present, the problem that China's animal product mainly exists has: the one, and the threat of dangerous disease; The 2nd, drug residue.Wherein the drug residue in the animal food has jeopardized people ' s health.Therefore, rationally using animal herbal medicine and health product to control eqpidemic disease and drug residue in the herding production process, is the major issue that needs solution at present.(different name Cen grass comes from Wu Yue spring and autumn not retrieve Herba Houttuyniae at present as yet; The nostril grass comes from Tian Bao book on Chinese herbal medicine) application of extract on livestock and poultry pestilence.Herba Houttuyniae aspect the human medicine mainly is being treatment pneumonia, hematodiarrhoea, edema, gonorrhea.
Herba Houttuyniae has the effect of heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, eliminating carbuncle evacuation of pus as traditional heat-clearing and toxic substances removing herbal medicine material, can be used for treating livestock and poultry, as diseases such as lung abscess, intestinal Huang, dysentery, acute mastitis.But in herbal medicine, directly utilize the Herba Houttuyniae medicinal powder to carry out the oral medication disease at present, though method is simple, but absorb rate variance, most of effective ingredient can not be absorbed fully, has improved cost virtually, and the extracting method of existing Herba Houttuyniae mainly is the extracting method of human preparation, usually adopt steam distillation to extract, lost the fixedness composition in the medicine, veterinary medicine, particularly economic animal such as poultry has increased cost relatively.
Summary of the invention
To the objective of the invention is in order addressing the above problem, a kind of smart powder preparation of Herba Houttuyniae with heat-clearing and toxic substances removing, detumescence and apocenosis function to be provided.Be used for the treatment of diseases such as poultry lung abscess, intestinal Huang, dysentery, acute mastitis, but mixed feeding also can be mixed the drink administration, again can be as the raw material of further preparation.Antibiotherapy is generally adopted in bacillary, the viral infection of treatment domestic animal at present, the heavy dose of antibiotic and the abuse of chemical drugs, cause in the treatment disease, also making the intravital normal flora of machine to suffer to destroy and imbalance, cause producing in the body residual in animal foodstuff of Resistant strain and medicine, indirectly and directly human beings'health has been caused great harmful effect.And the present invention---the smart powder of Herba Houttuyniae is a pure Chinese medicinal preparation, is that therefrom veterinary angle is set out, and adopts Chinese medicine preparation to be used for the treatment of poultry respiratory system, digestive system eqpidemic disease, and evident in efficacy, cost is low, and drug residue free, reaches the effect for the treatment of both the principal and secondary aspects of a disease.
Technical scheme of the present invention is: application and the method for making thereof of the smart powder of the Herba Houttuyniae of a kind of heat-clearing and toxic substances removing, detumescence and apocenosis function on poultry.
The invention provides a kind of have heat-clearing and toxic substances removing, detumescence and apocenosis function animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by Herba Houttuyniae.
Dose processing method: Herba Houttuyniae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Houttuyniae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 1 hour; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 0.5 hour, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Houttuyniae, and yield is 8.4%-12%).
A kind of method for making with animal medicament of heat-clearing and toxic substances removing, detumescence and apocenosis function, comprise the Herba Houttuyniae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Houttuyniae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 1 hour; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 0.5 hour; Medicinal liquid filters the back respectively and merges, and promptly gets Herba Houttuyniae extract, and Herba Houttuyniae extract is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or Herba Houttuyniae extract to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder (yield is 8.4%-12%) of Herba Houttuyniae.
According to described veterinary's medicament and method for making thereof, it is characterized in that described acid is hydrochloric acid or lactic acid with heat-clearing and toxic substances removing, detumescence and apocenosis function; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
Be example below with the infectious bursal disease, the effect of the smart powder of checking Herba Houttuyniae aspect the control livestock and poultry pestilence:
Smart powder test group of Herba Houttuyniae and matched group contrast test: the blue brown commercial chicken in 250 plumages healthy 40 ages in days sea (being provided by Tianjin side's big fowl industry company limited) is divided into 5 groups at random, every group of each 50 plumage, raise respectively in 5 chicken hurdles, feeding environment, temperature, humidity, feedstuff and drinking water are identical.Wherein 1,2,3 group is respectively the smart powder 0.075,0.05 of Herba Houttuyniae, 0.025g/kgd dosage treatment group, and the 4th group is infectivity resistant bursal disease (IBD) high immunity yolk antibody treatment group, and the 5th group is counteracting toxic substances but not administration group.Feeding experiment chicken routinely before the test allows its free choice feeding, and feeding environment, temperature, humidity, feedstuff and drinking water are identical.During test chicken 8 ages in days with the newcastle disease vaccine immunity of drinking water; During 30 ages in days, every bipennate muscle is annotated the 2mLIBDV strong poison of tissue (100 sesquialters are counted infective dose).
Symptom is judged and medication behind the counteracting toxic substances: the bursal disease clinical symptoms all appears in test chicken in various degree behind counteracting toxic substances 24h, show as dysentery, arranges white loose stool, fabricius bursa enlargement, hemorrhage and downright bad.Above-mentioned symptom almost all appears behind the 36h, so the success of decidable inoculation chicken counteracting toxic substances bursal disease. and medication is: 1st, 2,3 groups of test chickens are treated by the smart powder 0.075,0.05 of Herba Houttuyniae, 0.025g/kgd dosage respectively; The 4th group of chest muscle injection high immunity-yolk-antibody 2mL/kg; The 5th group is matched group, the not administration of feeding water behind the counteracting toxic substances.Each organizes chicken administration every day 2 times, and logotype 5d allows it freely drink water, and observes its incidence, clinical symptoms and death condition.
The smart powder clinical trial of Herba Houttuyniae
| Group | The experimental chicken number | Drug dose | Death toll behind the counteracting toxic substances 10d | The survival number | Survival rate (%) |
| 1 | 50 | 0.075g the smart powder of Herba Houttuyniae | 11 | 39 | 78 |
| 2 | 50 | 0.05g the smart powder of Herba Houttuyniae | 8 | 42 | 84 |
| 3 | 50 | 0.025g the smart powder of Herba Houttuyniae | 6 | 44 | 88 |
| 4 | 50 | The 2ml high immunity yolk antibody | 5 | 45 | 90 |
| 5 | 50 | Not medication | 45 | 5 | 11 |
From above table as can be seen, the smart powder test group of Herba Houttuyniae is suitable with high immunity yolk antibody treatment group effect, and infectious bursal disease is had good therapeutical effect.Just can produce effects medication the 2nd day, just controlled the state of an illness on the 3rd day, sick chicken stops death, and survival rate is all more than 78%.Wherein high immunity yolk antibody treatment group survival rate reaches 90%; 3 test group survival rates that gavage 0.025g, 0.05g, the smart powder of 0.075g Herba Houttuyniae are respectively 78%, 84% and 88%; Do not have the matched group survival rate of medication to have only 11%, difference is (P＜0.01) extremely significantly.
Can be inferred that by above-mentioned experiment the smart powder of Herba Houttuyniae can obtained better curative effect aspect alternative antibiotic therapy livestock and poultry virus disease and the bacterial disease, this medicine can not produce Resistant strain simultaneously, in vivo without any residual.
Above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for vapor distillation, leaching process adopts the extracting method of acid back alkali earlier, the effective ingredient that has farthest kept Herba Houttuyniae, be particularly suitable for animal-use drug, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
The invention has the beneficial effects as follows: with reference to the Herba Houttuyniae injectio on the pharmacopeia for animals, the present invention improves extracting method on original basis, on the basis of easy extractive technique, keep the effective ingredient in the medicine to greatest extent, do not used traditional vapor distillation lifting manipulation.The smart powder of the Herba Houttuyniae that extracts with this method has overcome the problem of extract oral absorbance difference in the past, and the effective ingredient in the extract can be absorbed by body rapidly after entering body, and utilization rate is higher.Herba Houttuyniae has the obvious suppression effect to antibacterials such as hemophilus influenza, streptococcus pneumoniae, staphylococcus aureuses, preparation of the present invention can substitute in the above-mentioned pathogenic bacteria of treatment and use antibiotic treatment, can avoid chemical sproof generation when obtaining good effect.
The specific embodiment:
Embodiment 1: get Herba Houttuyniae medical material 100kg, remove impurity afterwash, drying.Decoct with water twice after dried Herba Houttuyniae medical material ground, temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, and the hydrochloric acid with 10% modulates 3 with pH value, decocts 1 hour; Decocting method is the same for the second time, and the sodium hydroxide with 10% decocts pH value modulation 9 0.5 hour.After the decoction decocting liquid is filtered, it is 1.18-1.20g/cm that filtrate is concentrated into relative density
3The clear paste of (70 ℃) is pulverized promptly behind the vacuum drying.Product after the pulverizing is the smart powder of Herba Houttuyniae, can get the smart powder 12kg of Herba Houttuyniae.Be used for the treatment of infectious laryngotracheitis of chicken, 100g converts water 150kg, allows the chicken group freely drink, whole day drinking-water, and 3-5 days is a course of treatment.
Embodiment 2: get Herba Houttuyniae medical material 100kg, method for making embodiment 1.The smart powder 11.7kg of Herba Houttuyniae after the extraction.Be used for the treatment of swine enzootic pneumonia, diseases such as yellow and white dysentery of piglet, 0.05g/kg, once a day, 3-5 days is a course of treatment.
Claims (3)
1, a kind of have heat-clearing and toxic substances removing, a detumescence and apocenosis function animal medicament, it is characterized in that being is the medicament that raw material is made by Herba Houttuyniae
Dose processing method: Herba Houttuyniae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Houttuyniae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 1 hour; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 0.5 hour, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Houttuyniae, and yield is 8.4%-12%.
2, a kind of method for making with animal medicament of heat-clearing and toxic substances removing, detumescence and apocenosis function, comprise the Herba Houttuyniae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Houttuyniae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 1 hour; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 0.5 hour; Medicinal liquid filters the back respectively and merges, and promptly gets Herba Houttuyniae extract, and Herba Houttuyniae extract is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Houttuyniae, and yield is 8.4%-12%.
3, describedly have heat-clearing and toxic substances removing, detumescence and apocenosis function animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015051 CN1927302A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, detumescence and pus drainage functions and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015051 CN1927302A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, detumescence and pus drainage functions and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1927302A true CN1927302A (en) | 2007-03-14 |
Family
ID=37857533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510015051 Pending CN1927302A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, detumescence and pus drainage functions and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1927302A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101195013B (en) * | 2007-12-11 | 2011-10-12 | 叶福兰 | Snuffing medicament for treating cold toothache |
| CN103719555A (en) * | 2013-12-31 | 2014-04-16 | 上海朝翔生物技术有限公司 | Houttuynia cordata extract feed additive and preparation method thereof |
-
2005
- 2005-09-09 CN CN 200510015051 patent/CN1927302A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101195013B (en) * | 2007-12-11 | 2011-10-12 | 叶福兰 | Snuffing medicament for treating cold toothache |
| CN103719555A (en) * | 2013-12-31 | 2014-04-16 | 上海朝翔生物技术有限公司 | Houttuynia cordata extract feed additive and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101214311B (en) | Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof | |
| CN102397408B (en) | Compound antiviral oral liquid for poultry and preparation method thereof | |
| CN101810699A (en) | Preparation method of Maxingshigan submicron powder | |
| CN103877229B (en) | A kind of compound Chinese medicine extract and application thereof preventing and treating an avian colibacillosis | |
| CN102091151B (en) | Traditional medicinal composition with wind-dispelling and dampness-removing function and preparation method thereof | |
| CN104739960B (en) | Stomach antibacterial combination, the stomach antibacterials containing said composition and preparation | |
| CN101259160A (en) | Compound preparations for treating birdsvirosis and preparation thereof | |
| CN1927302A (en) | Medicament for animals with heat clearing and detoxicating, detumescence and pus drainage functions and preparing method thereof | |
| CN102210796B (en) | Medicament for treating chicken colibacillosis and preparation method thereof | |
| CN1927272A (en) | Medicament for animals with heat clearing and detoxicating, detumescence and obstruction removing functions and preparing method thereof | |
| CN1939370A (en) | Animal medicament with heat-clearing and dampness-resolving functions and its preparation | |
| CN101376006A (en) | Chinese medicine oral liquid with heat-clearing and detoxicating, cough-suppressing and asthma-relieving functions as well as application thereof for livestock and poultry | |
| CN1935205A (en) | Animal medicament with clearing lung and eliminating phlegm, and regulating stomach, and its preparing method | |
| CN102793869A (en) | Traditional Chinese medicine composition for controlling porcine viral diseases and preparation method thereof | |
| CN1939440A (en) | Animal medicament with anthemorrhagic toxin-removing and dysentery-eliminating functions and its preparation | |
| CN109731044B (en) | Traditional Chinese medicine compound granule for treating intestinal infection of poultry and preparation method thereof | |
| CN1939411A (en) | Animal medicament with heat-clearing, toxin-removing, wind-dispelling and obtundent functions and its making method | |
| CN102648951A (en) | Traditional Chinese herbal medicament for treating laying hen and broiler chicken newcastle diseases | |
| CN1927251B (en) | Medicament for animals with heat clearing and detoxicating functions and preparing method thereof | |
| CN106620211A (en) | Traditional Chinese medicine composition for treating pigeon chlamydiosis | |
| CN101249153A (en) | Chinese and western drugs for curing bird bacillus coli disease and method of preparing the same | |
| CN1939425A (en) | Animal medicament with heat-clearing, toxin-removing, blood-cooling and stasis-dispelling functions and its production | |
| CN1923233A (en) | Medicine for treating fowl bacterial diarrhea and its preparation method | |
| CN105055542A (en) | Traditional Chinese medicine composition for preventing pullorum disease, preparation method thereof, and application thereof to feed | |
| CN1927238A (en) | Medicament for animals with heat clearing and detoxicating, detumescence and pain relieving functions and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |