CN1923233A - Medicine for treating fowl bacterial diarrhea and its preparation method - Google Patents
Medicine for treating fowl bacterial diarrhea and its preparation method Download PDFInfo
- Publication number
- CN1923233A CN1923233A CNA2005100149233A CN200510014923A CN1923233A CN 1923233 A CN1923233 A CN 1923233A CN A2005100149233 A CNA2005100149233 A CN A2005100149233A CN 200510014923 A CN200510014923 A CN 200510014923A CN 1923233 A CN1923233 A CN 1923233A
- Authority
- CN
- China
- Prior art keywords
- radix pulsatillae
- medicament
- preparation
- hours
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y02A50/475—
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a traditional medicine for treating bacillary dysentery of animal, while its material is Chinese bulbul. Wherein, its production comprises that removing foreign from Chinese bulbul, washing, cutting, breaking and extracting; extracting with the water eight times of medicine, at 95+-3Deg. C, that adjusting pH with 10% acid to 2-5 and boiling for 2hours, and adding water to eight times of medicine and adjusting pH with 10% alkali to 8-9, and extracting for 1.5 hours; filtering drug and combining, drying and breaking to obtain the Chinese bulbul fine powder. The invention can keep the effective component of drug, to reduce the cost.
Description
Technical field
The present invention relates to technical field of Chinese medicine for animals, particularly relating to the Radix Pulsatillae is a kind of medicament for the treatment of poultry antibacterial dysentery of raw material and preparation method thereof.
Background technology
In domestic animal, poultry farming field, bacterial diarrhea is comparatively common at present.Poultry is common in Pullorum Disease, and that pig then is common in is red, white, yellow scours etc.Above-mentioned disease is often sent out in chickling and piglet, and is higher because of M ﹠ M, usually can cause bigger loss to the raiser so in a single day fall ill.Present this type of disease of prevention, the raiser adopts and adds antibiotic method prevent administration in drinking-water in chickling, the piglet back of just being born usually, after the morbidity then with the antibiotic of heavy dose or directly adopt Chinese medicine to treat.The method of doing so often causes antibiotic intravital residual in a large number poultry, influences the quality of animal foodstuff; Adopt the Chinese medicine of not doing any processed usually to treat in addition and can not obtain good curative effect.Do not retrieve the Radix Pulsatillae (the wild father-in-law of different name, Hu king envoy are come from herbal classic, and hoary hair's public affairs the come from Collective Notes to Canon of Materia Medica) application of smart powder on livestock and poultry pestilence at present as yet.The Radix Pulsatillae is normally adopted compound preparation mainly being treatment toxic-heat and blood stasis, pudendal pruritus leukorrhagia aspect the human medicine, as Radix Pulsatillae Decoction, is made up of the Radix Pulsatillae, Cortex Phellodendri, Rhizoma Coptidis and Cortex Fraxini.The extracting method of the existing Radix Pulsatillae mainly is the extracting method of human preparation.Usually adopt the decocting in water alcohol deposition method, removed the compositions such as protein in the medicine, and generally after water is carried, also will adopt organic solvents such as ether, chloroform to extract, in the poultry body, easily cause residually like this, influence the quality of animal foodstuff, human body is worked the mischief.And said method is higher for the extraction cost of animal drug, and technology is comparatively complicated, and the extraction that is applied to animal drug is also uneconomical.
Summary of the invention
Purpose of the present invention is exactly in order to overcome above-mentioned defective, it is medicament and preparation method thereof of the preparation treatment fowl bacterial diarrhea of raw material that a kind of Radix Pulsatillae is provided, be provided for treating the pure Chinese medicinal preparation of domestic animal, poultry bacterial dysentery, and on technology, improve to some extent, kept the effective ingredient in the medicine and do not suffered a loss.Therefrom veterinary angle is set out, and adopts Chinese medicine preparation to be used for the treatment of bacterial diarrhea, and evident in efficacy, cost is low, and drug residue free, the effect that reaching takes stopgap measures effects a permanent cure.
Technical scheme of the present invention is: a kind of medicament for the treatment of fowl bacterial diarrhea is characterized in that this medicament is is the medicament that raw material is made by the Radix Pulsatillae.
The medicament preparation method: Radix Pulsatillae herb is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Radix Pulsatillae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and extracting for the first time and being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder of the Radix Pulsatillae, yield is 16.8%-24%.
A kind of medicaments preparation method for the treatment of fowl bacterial diarrhea, comprise Radix Pulsatillae herb is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Radix Pulsatillae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, extracting for the first time and being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours.Medicinal liquid filters the back respectively and merges, and promptly gets Radix Pulsatillae extract, and Radix Pulsatillae extract is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder (yield is 16.8%-24%) of the Radix Pulsatillae.
Medicament of described treatment fowl bacterial diarrhea and preparation method thereof is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
For verifying the curative effect of this medicine, carry out following test, experimental result is as follows:
Laboratory animal is 150 200 age in days Luo Man laying hens, is provided by Tianjin side's big fowl industry company limited.The sealing hen house is raised in cages, and the complete feedstuff of feeding is freely drunk water, and laying rate is 95% before the test.Test chicken is divided into three groups at random, 50 every group.0.2ml Pullorum Disease bacterial infection material (being provided by animal medicine institute of Agricultural University Of Nanjing infectious disease group) is provided preceding two groups every chicken per nasal, the 3rd group of counteracting toxic substances not.First group is the smart powder test group of the Radix Pulsatillae, and test chicken is drunk this medicine by the 0.3g/ plumage after clinical symptoms appears in 30h behind the counteracting toxic substances, connect to drink 5 days.Second group is the antibiotic matched group, and 30h presses 0.4g/ plumage oral dose amoxicillin behind the counteracting toxic substances, and method is the same.The 3rd group is the safe dose matched group, connects with ten times of recommended dose of the smart powder of the Radix Pulsatillae and drinks 5 days.Duration of test, every day, observed and recorded was added up effective percentage, mortality rate and the relative weight gain rate after the course of treatment.After the drug withdrawal 3 days, the administration experimental chicken did not have obvious clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing; Sx, anti-chicken excessively are effective in the therapeutic process.
| Group | Medication sequela number | Sickness rate | The survival number | Effective percentage | Laying rate before the counteracting toxic substances | Laying rate after the medication |
| Radix Pulsatillae group | 20 | 40 | 46 | 92 | 95.4 | 92.2 |
| The antibiotic group | 38 | 76 | 26 | 52 | 94.9 | 80.2 |
| Safe matched group | - | - | 50 | - | 94.7 | 95.1 |
Annotate: chicken number * 100 before effective percentage (%)=treatment back survival chicken number/dispensing
Morbidity chicken number in sickness rate (%)=treatment/dispensing back chicken number * 100
Laying rate (%)=test chicken laying rate every day/50 * 100
30-35h behind the counteracting toxic substances, clinical symptoms appears in the full group of other two groups of chickens except that the safety matched group, as can be seen from the above table: Radix Pulsatillae group chicken sickness rate is starkly lower than the antibiotic group, and effective percentage is significantly higher than the antibiotic group, prove that medicine of the present invention is evident in efficacy to Pullorum Disease, and help the recovery of laying rate.Show through safety testing, do not see clinical unusual performance between the operating period, healthy chicken is not had obvious influence, illustrate that this preparation is evident in efficacy, safe in utilization, do not have any drug residue healthy chicken.
Above-mentioned preparation method has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept the Radix Pulsatillae, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
The invention has the beneficial effects as follows: by zoopery, confirmed Radix Pulsatillae preparation for treating domestic animal, poultry, played the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery because of bacterial dysentery has excellent curative.
Confirmed the purposes of the Radix Pulsatillae on preparation treatment livestock and poultry diarrhea medicine.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Radix Pulsatillae crude drug.After water is carried, do not adopt alcohol extracting method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, poultry because of bacterial dysentery has excellent curative, played the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.
The specific embodiment is as follows:
Embodiment 1: get Radix Pulsatillae herb 150kg, remove impurity afterwash, cutting, grind then, cross 60 mesh sieves.Extract: extracting temperature is 95 ± 3 ℃, and amount of water is for extracting 8 times of medical material, and being adjusted to pH with 10% hydrochloric acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, the sodium hydroxide adjusting pH with 10% is 8-9, and extraction time is 1.5 hours.Medicinal liquid filters the back respectively and merges, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3The thick paste of (70 ℃), thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly obtains the smart powder 27kg (yield is 18%) of the Radix Pulsatillae.Get and extract the smart powder of the good Radix Pulsatillae, be used for the treatment of Pullorum Disease, 100g converts water 150kg, whole day drinking-water, and 3-5 days is a course of treatment.
Embodiment 2: get Radix Pulsatillae herb 150kg, preparation method can get the smart powder 25.5kg (yield is 17%) of the Radix Pulsatillae with embodiment 1.Get the smart powder of the Radix Pulsatillae that makes, be used for the treatment of the piglet pujos blancos that is caused by escherichia coli, spice uses, the 1g/kg feedstuff, and free choice feeding, 3-5 days is a course of treatment.
Claims (3)
1, a kind of medicament for the treatment of fowl bacterial diarrhea is characterized in that this medicament is is the medicament that raw material is made by the Radix Pulsatillae
The medicament preparation method: Radix Pulsatillae herb is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Radix Pulsatillae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder of the Radix Pulsatillae, yield is 16.8%-24%.
2, a kind of medicaments preparation method for the treatment of fowl bacterial diarrhea, comprise that general/father-in-law's herb removes impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first to after handling/father-in-law extracts: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets Radix Pulsatillae extract, and Radix Pulsatillae extract is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder of the Radix Pulsatillae, yield is 16.8%-24%.
3, according to medicament of claim 1 and 2 described treatment fowl bacterial diarrheas and preparation method thereof, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100149233A CN1923233A (en) | 2005-08-31 | 2005-08-31 | Medicine for treating fowl bacterial diarrhea and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100149233A CN1923233A (en) | 2005-08-31 | 2005-08-31 | Medicine for treating fowl bacterial diarrhea and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1923233A true CN1923233A (en) | 2007-03-07 |
Family
ID=37816175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005100149233A Pending CN1923233A (en) | 2005-08-31 | 2005-08-31 | Medicine for treating fowl bacterial diarrhea and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1923233A (en) |
-
2005
- 2005-08-31 CN CNA2005100149233A patent/CN1923233A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101698024B (en) | Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof | |
| CN104435023B (en) | A kind of Chinese medical extract and its application | |
| CN102671011B (en) | Traditional Chinese medicine compound powder for preventing and treating yellow and white scour of piglets and preparation method thereof | |
| CN104739960B (en) | Stomach antibacterial combination, the stomach antibacterials containing said composition and preparation | |
| CN100367989C (en) | Medication for treating disease of alimentary tract of livestock husbandry and birds | |
| CN102641354B (en) | Veterinary compound pure traditional Chinese medicine preparation for treating coccidium and preparing method and application thereof | |
| CN104825700A (en) | Traditional Chinese medicine composition for resisting bacteria and diminishing inflammation | |
| CN101664485B (en) | Traditional Chinese medicine for treating respiratory disease of livestock and preparation method thereof | |
| CN1927272A (en) | Medicament for animals with heat clearing and detoxicating, detumescence and obstruction removing functions and preparing method thereof | |
| CN1939370A (en) | Animal medicament with heat-clearing and dampness-resolving functions and its preparation | |
| CN107789394B (en) | Composition for treating livestock and poultry diarrhea | |
| CN1923233A (en) | Medicine for treating fowl bacterial diarrhea and its preparation method | |
| CN1927302A (en) | Medicament for animals with heat clearing and detoxicating, detumescence and pus drainage functions and preparing method thereof | |
| CN101376006A (en) | Chinese medicine oral liquid with heat-clearing and detoxicating, cough-suppressing and asthma-relieving functions as well as application thereof for livestock and poultry | |
| CN1939440A (en) | Animal medicament with anthemorrhagic toxin-removing and dysentery-eliminating functions and its preparation | |
| CN1935205A (en) | Animal medicament with clearing lung and eliminating phlegm, and regulating stomach, and its preparing method | |
| CN109731044B (en) | Traditional Chinese medicine compound granule for treating intestinal infection of poultry and preparation method thereof | |
| CN1927251B (en) | Medicament for animals with heat clearing and detoxicating functions and preparing method thereof | |
| CN110237113B (en) | Plant extract additive for resisting mixed infection of escherichia coli and coccidian and application | |
| CN1939411A (en) | Animal medicament with heat-clearing, toxin-removing, wind-dispelling and obtundent functions and its making method | |
| CN1927238A (en) | Medicament for animals with heat clearing and detoxicating, detumescence and pain relieving functions and preparing method thereof | |
| CN106880686B (en) | Traditional Chinese medicine premix for preventing and treating piglet diarrhea and preparation method thereof | |
| CN1939401A (en) | Animal medicament with liverfire-clearing and digesting functions and its making method | |
| CN101396438A (en) | Traditional Chinese medicine oral liquid capable of relieving cough and asthma and use thereof in livestock and poultry | |
| CN105055542A (en) | Traditional Chinese medicine composition for preventing pullorum disease, preparation method thereof, and application thereof to feed |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |