CN1958022A - Animal use compound medicament with effects for hear-clearing and damp-drying drug, strengthening the spleen and aresting dirrhea, and preparation method - Google Patents
Animal use compound medicament with effects for hear-clearing and damp-drying drug, strengthening the spleen and aresting dirrhea, and preparation method Download PDFInfo
- Publication number
- CN1958022A CN1958022A CNA200510015787XA CN200510015787A CN1958022A CN 1958022 A CN1958022 A CN 1958022A CN A200510015787X A CNA200510015787X A CN A200510015787XA CN 200510015787 A CN200510015787 A CN 200510015787A CN 1958022 A CN1958022 A CN 1958022A
- Authority
- CN
- China
- Prior art keywords
- enteritis
- agrimony
- compound
- hours
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A compound veterinary medicine in the form of powder for treating enteritis, clearing heat and removing toxin is prepared from 6 Chinese-medicinal materials including hairyvien agrimonia herb, coptis root, aucklandia root, ciccada slough, etc. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to and be particularly related to the smart powder of compound agrimony enteritis and the preparation technology's method thereof that a kind of poultry are used in poultry medicine and the field of veterinary.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
The compound agrimony enteritis prescription has the effect of heat clearing and damp drying, invigorating the spleen to arrest diarrhea, be used for the treatment of due to the insufficiency of the spleen retention of damp-heat in the interior have loose bowels urgent, rush down and diseases such as not well or diarrhea, lack of appetite asthenia, abdominal distention stomachache, acute chronic enteritis.2005 editions Pharmacopoeias of the People's Republic of China record the effect that the compound agrimony enteritis capsule has heat clearing and damp drying, invigorating the spleen to arrest diarrhea, and its method for making is Herba Agrimoniae, Rhizoma Coptidis, the Radix Aucklandiae, Periostracum Cicadae, Rhizoma Acori Graminei, Radix Platycodonis Six-element medicine, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil; Aqueous solution behind the extraction volatile oil and four flavors such as medicinal residues and all the other Herba Agrimoniaes decoct with water three times, and 1.5 hours for the first time, each 1 hour of second and third time, decocting liquid filters, filtrate merges, and is concentrated into relative density 1.30-1.35 (25 ℃), adds ethanol and makes and contain the alcohol amount and be about 76%, stir evenly, left standstill 48 hours, filter, filtrate recycling ethanol, and be concentrated in right amount, add an amount of adjuvant, make granule, drying, spray adds volatile oil, airtight 2 hours, incapsulate, promptly.Be used for the treatment of due to the insufficiency of the spleen retention of damp-heat in the interior have loose bowels urgent, rush down and diseases such as not well or diarrhea, lack of appetite asthenia, abdominal distention stomachache, acute chronic enteritis.
The using method of herbal medicine mainly is to carry out mixed feeding or mix drink after directly medicine being pulverized at present, though using method is simple, does not often reach better curative effect.Because the special physiological structure of poultry is directly treated medical material in the mode of crude drug, usually can not get good absorption, major part can be excreted, and the effect of treatment is very little, has wasted a large amount of medical materials simultaneously, has improved aquaculture cost virtually.Do not retrieve at present the application of compound agrimony enteritis prescription on livestock and poultry pestilence as yet.
Summary of the invention
Order of the present invention is exactly in order to address the above problem, and a kind of smart powder of compound agrimony enteritis with heat clearing and damp drying, invigorating the spleen to arrest diarrhea function is provided.Be used for the treatment of due to the insufficiency of the spleen retention of damp-heat in the interior have loose bowels urgent, rush down and diseases such as not well or diarrhea, lack of appetite asthenia, abdominal distention stomachache, acute chronic enteritis.
Technical scheme of the present invention is:
The smart powder of the compound agrimony enteritis that a kind of poultry are used, it is characterized in that: the raw material by following part by weight is made:
Herba Agrimoniae 825-1250g, Rhizoma Coptidis 247-375g, Radix Aucklandiae 247-375g, Periostracum Cicadae 247-375g, Rhizoma Acori Graminei 132-200g, Radix Platycodonis 165-250g
Adopt following method to make:
Described Six-element medicine, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil; Aqueous solution and four Chinese medicines such as medicinal residues and all the other Herba Agrimoniaes behind the extraction volatile oil decoct with water three times, are 1.5 hours for the first time, each 1 hour of second and third time, and decocting liquid filters, and filtrate merges, and being concentrated into relative density is 1.30-1.35g/cm
3(25 ℃) add ethanol and make and contain the alcohol amount and be about 76%, stir evenly, and leave standstill 48 hours, filter, and filtrate recycling ethanol, and be concentrated in right amount, pulverize behind the vacuum drying and promptly get compound agrimony enteritis essence powder.
The smart powder of the compound agrimony that these poultry are used is made by the raw material of following weight preferred proportion: Herba Agrimoniae 825g, Rhizoma Coptidis 247g, Radix Aucklandiae 247g, Periostracum Cicadae 247g, Rhizoma Acori Graminei 132g, Radix Platycodonis 165g
Adopt following method to make: described Six-element medicine, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil; Aqueous solution and four Chinese medicines such as medicinal residues and all the other Herba Agrimoniaes behind the extraction volatile oil decoct with water three times, are 1.5 hours for the first time, each one hour of second and third time, and decocting liquid filters, and filtrate merges, and being concentrated into relative density is 1.30-1.35g/cm
3(25 ℃) add ethanol and make and contain the alcohol amount and be about 76%, stir evenly, and leave standstill 48 hours, filter, and filtrate recycling ethanol, and be concentrated in right amount, pulverize behind the vacuum drying and promptly get compound agrimony enteritis essence powder.
Using method of the present invention is: be used for the treatment of poultry urgent because of having loose bowels due to the insufficiency of the spleen retention of damp-heat in the interior, rush down not well or diseases such as diarrhea, lack of appetite asthenia, abdominal distention stomachache, acute chronic enteritis.Usage is spice or mixes drink, horse, cattle: 10.5-13.5g/ head/sky, and sheep, pig: 2.5-4.5g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.04-0.08//day, mix drink, 3-5 days is a course of treatment.
Effect of the present invention is:
The reference man is with officinal compound agrimony enteritis capsule, the present invention improves at the special physiological structure of domestic animal on the basis of existing dosage form, and for example big domestic animal mostly is many stomaches plant-eating animal, directly the former prescription medicinal powder of mixed feeding compound agrimony enteritis, often be difficult for absorbing, cause waste.The present invention has effectively improved the original preparation cost of compound agrimony enteritis height, has been difficult for the shortcoming of absorption, be made into the smart powder of compound agrimony enteritis, active component in the medicine has overcome the problem of the direct oral absorption rate variance of Chinese drugs powder, reduce aquaculture cost on the whole, effectively improved cure rate.The present invention be used for the treatment of domestic animal, poultry urgent because of being used for the treatment of because of having loose bowels due to the insufficiency of the spleen retention of damp-heat in the interior, rush down not well or diseases such as diarrhea, lack of appetite asthenia, abdominal distention stomachache, acute chronic enteritis, can play the effect of heat clearing and damp drying, invigorating the spleen to arrest diarrhea.This medicine is a pure Chinese medicinal preparation simultaneously, without any toxic and side effects.
For verifying effect of the present invention, carry out following test:
Trial drug: trial drug is the smart powder of compound agrimony enteritis, and control drug is that the compound agrimony enteritis powder (according to the weight proportion of various medical materials in the described compound agrimony enteritis prescription, is pulverized voluntarily after preparing and is the compound agrimony enteritis powder.Crude drug is purchased pharmacy, Jinshi City on daytime).
Experimental animal: 350 AA mixing meat young birds, purchase Jinshi City side on daytime big fowl industry company limited.Test chicken is without the Pullorum Disease vaccine immunity, and male and female has concurrently, transports laboratory immediately back after going out shell, raises routinely on adjustable temperature control net cage, feeds complete feedstuff, free choice feeding and drinking-water, and carry out clinical observation.Artificial challenge's white diarrhea disease during raising to 7 age in days infects the back and observed 15 days.Test chicken body weight and grouping situation see Table 1.
Manual-induced Pullorum Disease
Strain: the Pullorum Disease Salmonella is provided by microorganism teaching and research room of animal medicine institute of Agricultural University Of Nanjing.Before the use, the virulent strain of preservation is the inoculation ordinary flat earlier.Cultivate after 24 hours, select colonies typical in meat soup, cultivate after 18 hours for 37 ℃ and take out.Calculating turbidity unit with the Maxwell turbidimetry, is 5 * 10
6Bacterium/ml.
The artificial challenge: per os gavaged Pullorum Disease Salmonella liquid 1ml when chickling was supported to 7 ages in days, contained 500,000,000 bacterium approximately.Cardinal symptom for depressed, the appetite of spirit descends, the feather pine disorderly, sagging, the lethargy of closing one's eyes of both wings, drop-head stays and stands, draws white or kermesinus loose stool.The visible lung of postmortem is kermesinus, and liver has a large amount of point-like or striated hemorrhage, and there is turbid liquid in the thoracic cavity, and pericardium has the cellulose calmness, and kidney is pale, urate deposition is arranged, and caseous substance is arranged in the caecum.Part night blindness enteral is mixed with blood, and is all separable to a large amount of Pullorum Disease Salmonellas by liver, spleen, lung.The proof experimental chicken is infected chicken Hakuri Salmonella.
Therapeutic evaluation
Mortality rate: the Pullorum Disease classical symptom occurs and death in that duration of test is all, necropsy has the characteristic pathological changes, and separation and Culture goes out Pullorum Disease Salmonella person from liver, spleen, is judged to infect deadly, calculates mortality rate of each group.
Cure rate: allly recover normal person and be judged to healing, account for the ratio calculating cure rate of this group test chicken according to curing chicken at duration of test various transference cures after the drinking-water medication.
Weightening finish: the body weight of every plumage chicken during according to on-test and end, the weightening finish of calculating every plumage chicken.With the weightening finish of normal healthy controls (negative control) group is 100%, and each group weightening finish is compared with the weightening finish of normal healthy controls group, calculates the relative weight gain rate of each group.
The analysis of data and processing: the significance test that carries out data with biometrics
The grouping of table 1 test chicken and processing (unit: plumage)
| Numbering | Group | Drug dose (g//day) | Quantity (only) | Body weight (g) | Handle |
| 1 2 3 4 | Normal healthy controls infects dosage group among the contrast A high dose group A | 0.08 0.06 | 50 50 50 50 | 88.32±13.44 81.47±13.98 84.31±11.21 84.47±11.68 | Do not infect, not administration is infected, not administration mixes drink, infect and mix drink, infect |
| 5 6 7 | A low dose group B medicine contrasts safe matched group | 0.04 0.5 0.8 | 50 50 50 | 81.36±11.83 82.13±10.65 85.36±10.68 | Mix drink, infect mixed feeding, infect mixed drink, do not infect |
Annotate: the smart powder B of A compound agrimony enteritis compound agrimony enteritis powder
Result of the test: each is organized the test chicken result of the test and sees Table 2
The various medicines of table 2 are to the curative effect of the white scour of chicken
| Numbering | Group | Death toll (only) | Mortality rate (%) | Cure rate (%) | Weightening finish (g) | The relative weight gain rate (%) |
| 1 2 3 4 5 6 | Normal healthy controls infects dosage A low dosage B medicine contrast among the contrast A high dose A | 0 14 0 3 8 6 | 0 28 0 6 16 12 | ---- 100 94 84 88 | 324.86 242.27 317.42 296.81 276.03 268.98 | 100 74.6 97.7 91.4 84.9 82.8 |
Annotate: the smart powder B of A compound agrimony enteritis compound agrimony enteritis powder
By table 2 statistical results show, the basic, normal, high dosage of the smart powder of compound agrimony enteritis, medicine matched group mortality rate all extremely significantly are lower than the infection matched group.The cure rate utmost point is significantly higher than the infection matched group, illustrates that smart powder of compound agrimony enteritis and medicine matched group have curative effect preferably to white diarrhea disease.The mortality rate and the cure rate of smart powder group of basic, normal, high dosage compound agrimony enteritis and medicine matched group comparison shows that best with the smart powder group of high, middle dosage compound agrimony enteritis, its mortality rate significantly is lower than low dose group and medicine matched group.
Safety testing
During the medication of safety testing group, chicken essence is refreshing active, and it is normal, full-fledged to search for food, and cuts open inspection back internal organs and organizes no abnormality seen, proves that the smart powder of compound agrimony enteritis is safe to chicken.
The specific embodiment
Embodiment 1: get Herba Agrimoniae 1250g, Rhizoma Coptidis 375g, Radix Aucklandiae 375g, Periostracum Cicadae 375g, Rhizoma Acori Graminei 200g, Radix Platycodonis 250g
Described Six-element medicine, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil; Aqueous solution and four Chinese medicines such as medicinal residues and all the other Herba Agrimoniaes behind the extraction volatile oil decoct with water three times, are 1.5 hours for the first time, each one hour of second and third time, and decocting liquid filters, and filtrate merges, and being concentrated into relative density is 1.30-1.35g/cm
3(25 ℃) add ethanol and make and contain the alcohol amount and be about 76%, stir evenly, and leave standstill 48 hours, filter, and filtrate recycling ethanol, and be concentrated in right amount, pulverize behind the vacuum drying and promptly get compound agrimony enteritis essence powder.
Embodiment 2: get Herba Agrimoniae 825g, Rhizoma Coptidis 247g, Radix Aucklandiae 247g, Periostracum Cicadae 247g, Rhizoma Acori Graminei 132g, Radix Platycodonis 165g
Described Six-element medicine, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil; Aqueous solution and four Chinese medicines such as medicinal residues and all the other Herba Agrimoniaes behind the extraction volatile oil decoct with water three times, are 1.5 hours for the first time, each one hour of second and third time, and decocting liquid filters, and filtrate merges, and being concentrated into relative density is 1.30-1.35g/cm
3(25 ℃) add ethanol and make and contain the alcohol amount and be about 76%, stir evenly, and leave standstill 48 hours, filter, and filtrate recycling ethanol, and be concentrated in right amount, pulverize behind the vacuum drying and promptly get compound agrimony enteritis essence powder.
Be used for the treatment of poultry urgent because of having loose bowels due to the insufficiency of the spleen retention of damp-heat in the interior, rush down not well or diseases such as diarrhea, lack of appetite asthenia, abdominal distention stomachache, acute chronic enteritis, can play the effect of heat clearing and damp drying, invigorating the spleen to arrest diarrhea.Usage is spice or mixes drink, horse, cattle: 10.5-13.5g/ head/sky, and sheep, pig: 2.5-4.5g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.04-0.08//day, mix drink, 3-5 days is a course of treatment.
Claims (2)
1, the smart powder of a kind of compound agrimony enteritis of poultry use, it is characterized in that: the raw material by following part by weight is made:
Herba Agrimoniae 825-1250g, Rhizoma Coptidis 247-375g, Radix Aucklandiae 247-375g, Periostracum Cicadae 247-375g, Rhizoma Acori Graminei 132-200g, Radix Platycodonis 165-250g
Adopt following method to make: described Six-element medicine, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil; Aqueous solution and four Chinese medicines such as medicinal residues and all the other Herba Agrimoniaes behind the extraction volatile oil decoct with water three times, are 1.5 hours for the first time, each one hour of second and third time, and decocting liquid filters, and filtrate merges, and being concentrated into relative density is 1.30-1.35g/cm
3(25 ℃) add ethanol and make and contain the alcohol amount and be about 76%, stir evenly, and leave standstill 48 hours, filter, and filtrate recycling ethanol, and be concentrated in right amount, pulverize behind the vacuum drying and promptly get compound agrimony enteritis essence powder.
2, the smart powder of the compound agrimony enteritis of poultry use according to claim 1, it is characterized in that: the raw material by following weight preferred proportion is made:
Herba Agrimoniae 825g, Rhizoma Coptidis 247g, Radix Aucklandiae 247g, Periostracum Cicadae 247g, Rhizoma Acori Graminei 132g, Radix Platycodonis 165g
Adopt following method to make: described Six-element medicine, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil; Aqueous solution and four Chinese medicines such as medicinal residues and all the other Herba Agrimoniaes behind the extraction volatile oil decoct with water three times, are 1.5 hours for the first time, each one hour of second and third time, and decocting liquid filters, and filtrate merges, and being concentrated into relative density is 1.30-1.35g/cm
3(25 ℃) add ethanol and make and contain the alcohol amount and be about 76%, stir evenly, and leave standstill 48 hours, filter, and filtrate recycling ethanol, and be concentrated in right amount, pulverize behind the vacuum drying and promptly get compound agrimony enteritis essence powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200510015787XA CN1958022A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects for hear-clearing and damp-drying drug, strengthening the spleen and aresting dirrhea, and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200510015787XA CN1958022A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects for hear-clearing and damp-drying drug, strengthening the spleen and aresting dirrhea, and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1958022A true CN1958022A (en) | 2007-05-09 |
Family
ID=38069974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200510015787XA Pending CN1958022A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects for hear-clearing and damp-drying drug, strengthening the spleen and aresting dirrhea, and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1958022A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645137A (en) * | 2015-03-05 | 2015-05-27 | 于巧媛 | Traditional Chinese medicine for treating scouring disease caused by spleen deficiency |
| CN111671776A (en) * | 2020-07-20 | 2020-09-18 | 石家庄红专科技有限公司 | Preparation method and application of traditional Chinese medicine cicada slough micro-ecological freeze-dried powder |
-
2005
- 2005-10-31 CN CNA200510015787XA patent/CN1958022A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645137A (en) * | 2015-03-05 | 2015-05-27 | 于巧媛 | Traditional Chinese medicine for treating scouring disease caused by spleen deficiency |
| CN111671776A (en) * | 2020-07-20 | 2020-09-18 | 石家庄红专科技有限公司 | Preparation method and application of traditional Chinese medicine cicada slough micro-ecological freeze-dried powder |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102341114A (en) | Plant extract compositions for prevention and treatment of influenza | |
| CN101836691A (en) | Chinese medicinal herb feed additive | |
| CN101690811B (en) | Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof | |
| CN103169773A (en) | Traditional Chinese medicine compound preparation for enhancing livestock immunity and preparation method | |
| CN1957997A (en) | Animal use compound medicament with effects of relieving the muscles and skin, clearing away heat, relieving darrhea, and relieving dysentery, and preparation method | |
| CN101690812B (en) | Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease-infectious bursal disease and preparation process thereof | |
| CN103202908B (en) | Chinese herbal medicine feed additive for preventing and curing colibacillosis | |
| CN107661416A (en) | A kind of traditional Chinese medicine extraction compound pharmaceutical for preventing and treating livestock and birds respiratory disease | |
| CN1958008A (en) | Animal use compound medicament with effects of removing toxic heat, and preparation method | |
| CN1958022A (en) | Animal use compound medicament with effects for hear-clearing and damp-drying drug, strengthening the spleen and aresting dirrhea, and preparation method | |
| CN1957994A (en) | Animal use compound medicament with effect for clearing away the heat-evil and expelling superficial evils, and preparation method | |
| CN101209304A (en) | Chinese medicinal granule with clearing heat and detoxication, blood-nourishing and dysentery-stopping efficacy | |
| CN1958023A (en) | Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method | |
| CN113908149A (en) | Application of formononetin in preparation of medicine for preventing and treating acute lung injury | |
| CN109432287B (en) | Traditional Chinese medicine oral liquid for preventing and treating excessive heat syndrome of poultry qi system and preparation method thereof | |
| CN103251691A (en) | Chinese medicine formula for treating bovine mastitis as well as extract and preparation thereof | |
| CN103417653B (en) | Veterinary-use compound pure Chinese herbal medicine for treating coccidium and preparation method of oral liquid of same | |
| CN101829257B (en) | Traditional Chinese medicine oral liquid for treating chicken colibacillosis and preparation method thereof | |
| CN1939370A (en) | Animal medicament with heat-clearing and dampness-resolving functions and its preparation | |
| CN101085048B (en) | Traditional Chinese medicine for detoxicating for animals and preparation method thereof | |
| CN104352582A (en) | Medicine for preventing and treating colibacillosis of chickens and preparation method thereof | |
| CN103610768A (en) | Composition for treating colibacillosis | |
| CN1314421C (en) | Cordate houttuynia mixture for preventing and treating livestock bird infectious disease | |
| CN101375931A (en) | Chinese medicine oral liquid with heat-clearing and dampness-draining functions as well as application thereof for livestock and poultry | |
| CN101209303A (en) | Chinese medicinal oral liquid with heat-clearing and detoxication, antimicrobial and anti-inflammation efficacy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |