CN101375931A - Chinese medicine oral liquid with heat-clearing and dampness-draining functions as well as application thereof for livestock and poultry - Google Patents
Chinese medicine oral liquid with heat-clearing and dampness-draining functions as well as application thereof for livestock and poultry Download PDFInfo
- Publication number
- CN101375931A CN101375931A CNA2007100594264A CN200710059426A CN101375931A CN 101375931 A CN101375931 A CN 101375931A CN A2007100594264 A CNA2007100594264 A CN A2007100594264A CN 200710059426 A CN200710059426 A CN 200710059426A CN 101375931 A CN101375931 A CN 101375931A
- Authority
- CN
- China
- Prior art keywords
- oral liquid
- poultry
- medicine
- livestock
- chicken
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
Abstract
The invention relates to a traditional Chinese medicine compound oral liquid with the effects of clearing heat and promoting diuresis, which comprises three medicines of radix isatidis, virgate wormwood herb and liquorice. The compound oral liquid is suitable for liver lesions caused by livestock escherichia coli, salmonella and the like; meanwhile, in combination of the special physical structure that the poultry genital tract is short, and the wood fiber cannot be digested, the medicament is prepared into the oral liquid, and quickly dispersed in fodder water, so that diseased livestock takes the medicine through drinking the water, so that the oral liquid is convenient and favorable for absorption, thereby achieving the quick effect.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of the have Chinese medicine oral liquid of clearing away heat-damp and promoting diuresis effect and the application on poultry thereof.
Background technology
In recent years, along with antibacterials being extensive use of on veterinary clinic, and the abuse of antibacterials, make Resistant strain increase year by year, from clinical more isolated antibacterials, drug resistance has reached 100%.Studies show that Resistant strain is not to a kind of medicine drug resistance, but to multiple medicine or even tens kinds of medicine drug resistances.Simultaneously Resistant strain between the animal, the cross resistance that exists between human-animal's danger of transmitting and the medicine, make the bacterial drug resistance problem become the difficult problem in the veterinary clinic treatment.
Be faced with the increase of Resistant strain on the present veterinary clinic, adopt treatment by Chinese herbs fowl bacterial disease to become one of effective treatment means.The Chinese medicine preparation that uses clinically mostly is powder at present, exists the defective of administration inconvenience, absorption difference, and is short because of the digestive tract of fowl again, can not digest lignocellulose, thereby cause the big problem of drug dose, improved aquaculture cost virtually.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of herbal mixture oral liquid with clearing away heat-damp and promoting diuresis effect.
The object of the present invention is achieved like this: a kind of Chinese traditional compound medicine with clearing away heat-damp and promoting diuresis effect is characterized in that: Radix Isatidis 1-10 part, Herba Artemisiae Scopariae 1-10 part, Radix Glycyrrhizae 0.4-4 part.
Be preferably: 5 parts of Radix Isatidis, 5 parts of Herba Artemisiae Scopariaes, 2 parts in Radix Glycyrrhizae.
A kind of Chinese traditional compound medicine with clearing away heat-damp and promoting diuresis effect is characterized in that: the dosage form of described Chinese traditional compound medicine is an oral liquid.
According to two records of " People's Republic of China's veterinary drug allusion quotation " version in 2005, Radix Isatidis has the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving, and Herba Artemisiae Scopariae has the effect of clearing away damp-heat, jaundice eliminating subcutaneous ulcer, and Radix Glycyrrhizae has the effect of invigorating the spleen and replenishing QI and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription; Be principal agent with Radix Isatidis and Herba Artemisiae Scopariae in the side, Radix Glycyrrhizae is auxilliary, and three herbal medicines share, and clearing away heat-damp and promoting diuresis, jaundice disappears.
The present invention adopts the industry method in common to make: three flavor medical materials decoct with water secondary, 8 times of water gagings for the first time, and 6 times of water gagings for the second time, the back of at every turn boiling keeps little boiling 2 hours, and 200 mesh filter screens filter while hot.Merge filtrate twice, mixing is concentrated into every milliliter and is equivalent to crude drug in whole 1g, cold preservation 24 hours.Pulp board is supplied loss amount after filtering, and cold preservation is 24 hours again, adds the methyl parahydroxybenzoate of 3 ‰ amounts behind the medical filtration, mixing, and flowing steam sterilization 30 minutes, quality inspection, fill, promptly.
Below with concrete description of test effect of the present invention:
1 materials and methods
1.1 trial drug
For the reagent product, main component is Radix Isatidis, Herba Artemisiae Scopariae, Radix Glycyrrhizae, and recommended dose is 0.6ml/, mixes drink; The contrast medicine is 5% enrofloxacin solution.
1.2 experimental animal
430 AA mixing meat young birds available from the Tianjin suburban district company of raising chickens, are transported in this laboratory pouity dwelling place and raise in cages, and Routine Management is fed to complete feed to 14 age in days, and colibacillosis does not take place on inspection, can be shown to test and use chicken.Wherein 80 are used for doing trial test, all the other 350 tests are divided into 7 groups with chicken, wherein 1,2,3 group is respectively the high, medium and low treatment group of counteracting toxic substances medicine of the present invention, 4 groups of enrofloxacin water soluble powder matched groups, 5 groups of positive matched groups (counteracting toxic substances is not treated matched group), 6 groups of negative matched groups (not counteracting toxic substances do not treat normal healthy controls group), safe matched group (being used in healthy test chicken) according to 5 times of medicine recommended dose of the present invention.
1.3 determining of colibacillus artificial challenge dosage
1.3.1 strain chicken colon bacillus reference culture (O
78Serotype)
1.3.2 the preparation of test organisms liquid is with standard lyophilization bacterium O
78Be inoculated on the maconkey agar after adding the dissolving of 0.5ml meat soup, separate single bacterium colony.Smooth, circular, the red bacterium colony 2-3 of picking diameter 1-2mm is inoculated in the 2ml ordinary broth, cultivates 18h for 37 ℃.After the rejuvenation of broth culture inoculation chicken, separating Escherichia coli from dead chicken liver, renewed vaccination as stated above.After gram stain microscopy does not have varied bacteria growing, as test organisms liquid.Carry out count plate with plate dilution method and be about 6 * 10
9CFU/ml.
1.3.3 definite (trial test) 80 healthy chickens of counteracting toxic substances dosage are divided into 4 groups, 20 every group, 3 groups is infected group, and 1 group is matched group.Infected group is divided high dose group (every chicken inoculation 1.2 hundred million bacterium), middle dosage group (every chicken inoculation 0.9 hundred million bacterium) and low dose group (every chicken inoculation 0.6 hundred million bacterium) again; Matched group intramuscular injection 0.5ml normal saline.According to morbidity, pathological changes and deadly situation, determine 1.2 hundred million chicken source property escherichia coli O at last
78Type strain is test counteracting toxic substances amount.
1.4 test method is except that positive controls and safe matched group, every chicken muscle is injected 1.2 hundred million escherichia coli.Behind the counteracting toxic substances 4 hours, chickling performance lassitude, stop eating, necking down, symptom such as close one's eyes.Be diagnosed as colibacillosis with the bacteriology checking method, after this medication was at once used five days continuously, observed therapeutic effect.
Table 1 test grouping and drug treating
1.5 curative effect determinate standard
1.5.1 death is also dead at the classical symptom that chicken colibacillosis appears in duration of test, necropsy has typical characteristics of lesion, and goes out the chicken colon bacillus from liver, spleen and heart separation and Culture, is judged to be to infect this bacterium and death.Calculate the mortality rate of each group according to dead chicken number.
Recover normal 1.5.2 cure, clinical symptoms such as row's loose stool no longer occur, all belong to and curing in the duration of test refreshing state of chicken essence, appetite after administration for oral administration.The ratio that accounts for the test chicken number according to the healing chicken calculates cure rate.
1.5.3 effectively after administration for oral administration, the chicken of Zhi Yuing and do not have death but the clinical symptoms shower is arranged is effective fully; During off-test, the percentage rate that the chicken number of every group of survival accounts for the test chicken number is an effective percentage.
1.5.4 the body weight of weightening finish every chicken during according to on-test and off-test is calculated the gain in weight of every chicken, calculates the average weight gain of every group of test chicken then in view of the above.The relative weight gain rate is to calculate by the ratio of each medication treatment group with the weightening finish of normal healthy controls group, and wherein normal healthy controls group chicken rate of body weight gain is made as 100%.
1.6 the analysis of data and processing
Carry out the significance test of data with biometrics.
2 result of the tests
Each experimental group sees Table 2 to the curative effect of chicken colibacillosis
Each medicine of table 2 compares the curative effect of chicken colibacillosis
2.1 mortality rate
Each medication group is compared, and medicine height of the present invention, middle dosage group, enrofloxacin water soluble powder matched group mortality rate are lower, are respectively 14%, 16% and 30%.Statistical analysis shows that the mortality rate of medicine height of the present invention, middle dosage group and enrofloxacin water soluble powder matched group extremely significantly is lower than the mortality rate (p＜0.01) of positive controls (infection matched group).
2.2 cure rate and effective percentage
Medicine height of the present invention, middle dosage group cure rate are higher, all above 70%.Above-mentioned two groups effective percentage is also higher, all above 80%.Cure rate, the effective percentage of medicine low dose group of the present invention, enrofloxacin water soluble powder matched group are relatively low.
2.3 rate of body weight gain
The rate of body weight gain of medicine height of the present invention, middle dosage group significantly is lower than the height of medicine of the present invention, middle dosage group (p＜0.05) apparently higher than the rate of body weight gain of medicine low dose group of the present invention, enrofloxacin water soluble powder matched group.
Beneficial effect of the present invention: medicine of the present invention is pure Chinese medicine preparation, has effectively suppressed the generation of bacterial drug resistance, and it is intravital residual poultry also to have reduced medicine, simultaneously, in conjunction with the special physiological structure of poultry, the dosage form of medicine is decided to be oral liquid, convenient drug administration is convenient to absorb.
The specific embodiment
Embodiment 1: 1 part of Radix Isatidis, and 1 part of Herba Artemisiae Scopariae, 0.4 part in Radix Glycyrrhizae, three flavor medical materials decoct with water secondary, 8 times of water gagings for the first time, 6 times of water gagings for the second time, the back of at every turn boiling keeps little boiling 2 hours, and 200 mesh filter screens filter while hot.Merge filtrate twice, mixing is concentrated into every milliliter and is equivalent to crude drug in whole 1g, cold preservation 24 hours.Pulp board is supplied loss amount after filtering, and cold preservation is 24 hours again, adds the methyl parahydroxybenzoate of 3 ‰ amounts behind the medical filtration, mixing, and flowing steam sterilization 30 minutes, quality inspection, fill, promptly.
Clearing away heat-damp and promoting diuresis.Be applicable to the hepatic lesions that poultry escherichia coli, Salmonella etc. cause.Poultry: 0.6ml/, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used; Domestic animal: the 0.2ml/kg body weight, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used.
Embodiment 2: 5 parts of Radix Isatidis, and 5 parts of Herba Artemisiae Scopariaes, 2 parts in Radix Glycyrrhizae, three flavor medical materials decoct with water secondary, 8 times of water gagings for the first time, 6 times of water gagings for the second time, the back of at every turn boiling keeps little boiling 2 hours, and 200 mesh filter screens filter while hot.Merge filtrate twice, mixing is concentrated into every milliliter and is equivalent to crude drug in whole 1g, cold preservation 24 hours.Pulp board is supplied loss amount after filtering, and cold preservation is 24 hours again, adds the methyl parahydroxybenzoate of 3 ‰ amounts behind the medical filtration, mixing, and flowing steam sterilization 30 minutes, quality inspection, fill, promptly.
Clearing away heat-damp and promoting diuresis.Be applicable to the hepatic lesions that poultry escherichia coli, Salmonella etc. cause.Poultry: 0.6ml/, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used; Domestic animal: the 0.2ml/kg body weight, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used.
Embodiment 3: 10 parts of Radix Isatidis, and 10 parts of Herba Artemisiae Scopariaes, 4 parts in Radix Glycyrrhizae, three flavor medical materials decoct with water secondary, 8 times of water gagings for the first time, 6 times of water gagings for the second time, the back of at every turn boiling keeps little boiling 2 hours, and 200 mesh filter screens filter while hot.Merge filtrate twice, mixing is concentrated into every milliliter and is equivalent to crude drug in whole 1g, cold preservation 24 hours.Pulp board is supplied loss amount after filtering, and cold preservation is 24 hours again, adds the methyl parahydroxybenzoate of 3 ‰ amounts behind the medical filtration, mixing, and flowing steam sterilization 30 minutes, quality inspection, fill, promptly.
Clearing away heat-damp and promoting diuresis.Be applicable to the hepatic lesions that poultry escherichia coli, Salmonella etc. cause.Poultry: 0.6ml/, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used; Domestic animal: the 0.2ml/kg body weight, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used.
Claims (3)
1, a kind of compound Chinese medicinal preparation with clearing away heat-damp and promoting diuresis effect is characterized in that: Radix Isatidis 1-10 part, Herba Artemisiae Scopariae 1-10 part, Radix Glycyrrhizae 0.4-4 part.
2, a kind of compound Chinese medicinal preparation with clearing away heat-damp and promoting diuresis effect according to claim 1 is characterized in that optimizing prescriptions of the present invention is: 5 parts of Radix Isatidis, 5 parts of Herba Artemisiae Scopariaes, 2 parts in Radix Glycyrrhizae.
3, a kind of compound Chinese medicinal preparation with clearing away heat-damp and promoting diuresis effect according to claim 1, it is characterized in that: the dosage form of described Chinese traditional compound medicine is an oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100594264A CN101375931A (en) | 2007-08-31 | 2007-08-31 | Chinese medicine oral liquid with heat-clearing and dampness-draining functions as well as application thereof for livestock and poultry |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100594264A CN101375931A (en) | 2007-08-31 | 2007-08-31 | Chinese medicine oral liquid with heat-clearing and dampness-draining functions as well as application thereof for livestock and poultry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101375931A true CN101375931A (en) | 2009-03-04 |
Family
ID=40419778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100594264A Pending CN101375931A (en) | 2007-08-31 | 2007-08-31 | Chinese medicine oral liquid with heat-clearing and dampness-draining functions as well as application thereof for livestock and poultry |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101375931A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849980A (en) * | 2010-06-08 | 2010-10-06 | 江西中成药业集团有限公司 | Particle for treating liver and gall diseases and preparation method thereof |
| CN103127209A (en) * | 2013-03-01 | 2013-06-05 | 栾福起 | Antiviral drug |
-
2007
- 2007-08-31 CN CNA2007100594264A patent/CN101375931A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849980A (en) * | 2010-06-08 | 2010-10-06 | 江西中成药业集团有限公司 | Particle for treating liver and gall diseases and preparation method thereof |
| CN103127209A (en) * | 2013-03-01 | 2013-06-05 | 栾福起 | Antiviral drug |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103689296B (en) | Feed for ewe at later pregnancy and lactation period and preparation method thereof | |
| CN103006792A (en) | Veterinary drug for preventing livestock bowel diseases, preparation method of drug, and feed | |
| CN101209307A (en) | Chinese medicinal oral liquid with heat-clearing and detoxication, dampness-eliminating and dysentery-stopping efficacy | |
| CN102028795A (en) | Chinese pulsatilla root granules for preventing and treating livestock and poultry bacterial diseases and preparation method and premix thereof | |
| CN101209297A (en) | Compound Chinese medicinal granule for treating chicken coccidiosis | |
| CN101209330A (en) | Compound Chinese medicinal granule with heat-clearing and detoxication, worm-expelling and liver-protecting efficacy | |
| CN101940634A (en) | Chinese medicinal composition for treating avian colibacillosis and application thereof | |
| CN101780227A (en) | Traditional Chinese medicine composition for treating acute stroke and preparation method thereof | |
| CN1686501A (en) | Compound Chinese medicine for treating child diarrhea and its preparation method | |
| CN1957997A (en) | Animal use compound medicament with effects of relieving the muscles and skin, clearing away heat, relieving darrhea, and relieving dysentery, and preparation method | |
| CN101209304A (en) | Chinese medicinal granule with clearing heat and detoxication, blood-nourishing and dysentery-stopping efficacy | |
| CN101375931A (en) | Chinese medicine oral liquid with heat-clearing and dampness-draining functions as well as application thereof for livestock and poultry | |
| CN1180806C (en) | Pure Chinese medicine preparation | |
| CN109432287B (en) | Traditional Chinese medicine oral liquid for preventing and treating excessive heat syndrome of poultry qi system and preparation method thereof | |
| CN101209305A (en) | Chinese medicinal oral liquid for treating colibacillosis of avian | |
| CN104147165A (en) | Traditional Chinese medicine for control of animal Escherichia coli disease and preparation method thereof | |
| CN104971124A (en) | New application of medicine composition | |
| CN103610768B (en) | Composition for treating colibacillosis | |
| CN101209303A (en) | Chinese medicinal oral liquid with heat-clearing and detoxication, antimicrobial and anti-inflammation efficacy | |
| CN103191264A (en) | Traditional Chinese veterinary medicine oral solution for preventing and treating colibacillosis of poultry | |
| CN103536879B (en) | A kind of pharmaceutical composition and preparation method for the treatment of diabetes | |
| CN106344523A (en) | Preparation method and application of polydatin phospholipid complex granule | |
| CN101209315A (en) | Chinese medicinal injection with antimicrobial and anti-inflammation, milk-smoothing and mass-dissipating efficacy | |
| CN101829257B (en) | Traditional Chinese medicine oral liquid for treating chicken colibacillosis and preparation method thereof | |
| CN101375934A (en) | Chinese medicine oral liquid with heat-clearing and detoxicating, antibiotic and anti-dysentery functions as well as application thereof for livestock and poultry |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090304 |