CN101209304A - Chinese medicinal granule with clearing heat and detoxication, blood-nourishing and dysentery-stopping efficacy - Google Patents
Chinese medicinal granule with clearing heat and detoxication, blood-nourishing and dysentery-stopping efficacy Download PDFInfo
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- CN101209304A CN101209304A CNA2006101305303A CN200610130530A CN101209304A CN 101209304 A CN101209304 A CN 101209304A CN A2006101305303 A CNA2006101305303 A CN A2006101305303A CN 200610130530 A CN200610130530 A CN 200610130530A CN 101209304 A CN101209304 A CN 101209304A
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Abstract
The invention relates to a compound Chinese traditional medicine granules with the efficacies of clearing away heat and toxic material, nourishing the blood and stopping dysentery, including nine Chinese traditional medicines of radix astragali, common andrographis herb, evodia rutaecarpa, rhubarb, sophora flavescens, angelica dahurica, dandelion, Chinese bulbul and liquorice. The invention is mainly used for treating enteritis type and sepsis type colibacillosis. The invention is applicable to the symptoms of avian pericarditis, perihepatitis, peritonitis and chick egg yolk malabsorption, etc. The invention has the efficacies of clearing away heat and toxic material, nourishing the blood and stopping dysentery. By considering the short avian genital tract and the special physiological structure of inability to digest lignocellulose, the medicine is prepared into soluble granules which can quickly be dissolved into drinking water which is absorbed by sick chickens, so as to achieve the purpose of quick effect.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of Chinese medicine granules with heat-clearing and toxic substances removing, blood-nourishing and dysentery-stopping efficacy.
Background technology
At present, because the drug resistance of fowl Escherichia coli and extensively and rapidly propagating makes avian colibacillosis rise to one of the most thorny disease of harm aviculture.Because enteric microorganism antigen and antigenic determinant complexity, immunologic mechanism there are differences, and prevents and treats this disease from the vaccine angle and does not make a breakthrough as yet, so chemicals is still the main means of control primary disease.And the prevention of the abuse of antimicrobial drug and a large amount of inferior therapeutic doses, feedstuff are added medication and are prolonged administration time without limit, have all caused the chemical sproof generation of escherichia coli, propagation, caused drug residue simultaneously and endanger human and livestock health and sanitarian may.
So adopt the treatment by Chinese herbs avian colibacillosis to become one of effective treatment means.Shortcomings such as the Chinese medicine preparation that uses clinically mostly is powder at present, exists the defective of administration inconvenience, and is short because of the digestive tract of chicken again, can not digest lignocellulose, and the drug absorption that causes is poor, and consumption is big.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of herbal mixture granule with heat-clearing and toxic substances removing, blood-nourishing and dysentery-stopping efficacy.
The object of the present invention is achieved like this: a kind of Chinese traditional compound medicine with heat-clearing and toxic substances removing, blood-nourishing and dysentery-stopping efficacy, it is characterized in that: Radix Astragali 2-4 part, Herba Andrographis 8-16 part, Fructus Evodiae 1-2 part, Radix Et Rhizoma Rhei 2-3 part, Radix Sophorae Flavescentis 6-12 part, Radix Angelicae Dahuricae 2-4 part, Herba Taraxaci 2-4 part, Radix Pulsatillae 2-4 part, Radix Glycyrrhizae 2-4 part.
Be preferably: 3 parts of the Radixs Astragali, 12 parts of Herba Andrographis, 1 part of Fructus Evodiae, 2.5 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Sophorae Flavescentiss, 3 parts of the Radixs Angelicae Dahuricae, 3 parts of Herba Taraxacis, 3 parts of the Radix Pulsatillaes, 3 parts in Radix Glycyrrhizae.
A kind of Chinese traditional compound medicine with heat-clearing and toxic substances removing, blood-nourishing and dysentery-stopping efficacy is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
Control according to the dialectical opinion of Chinese veterinarian, colibacillosis can be considered in the epidemic disease poison invades exuberant lung-stomach heat, stagnation of QI and blood.The poultry dysentery mainly by the epidemic disease poison, invade in damp and hot due to, the major lesions position is at taste and intestine and small intestine.The rule of treatment is with heat-clearing and toxic substances removing, replenishing QI to invigorate the spleen.Based on Herba Andrographis, Radix Sophorae Flavescentis, Radix Pulsatillae heat-clearing and toxic substances removing, be aided with the Radix Astragali, Fructus Evodiae, Radix Angelicae Dahuricae replenishing QI to invigorate the spleen, detumescence and apocenosis in the side, assistant is attacked long-pending blood stasis dispelling with Radix Et Rhizoma Rhei, Herba Taraxaci; Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription, all medicines share have blood-nourishing and dysentery-stopping, effect such as dysentery relieving, antidiarrheal, hemostasis, antiulcer.
The present invention adopts the industry method in common to make: with nine flavor medical materials, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Below with concrete description of test effect of the present invention:
1 materials and methods
1.1 trial drug
For reagent product medicine main component of the present invention is the Radix Astragali, Herba Andrographis, Fructus Evodiae, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, the Radix Angelicae Dahuricae, Herba Taraxaci, the Radix Pulsatillae, Radix Glycyrrhizae, and recommended dose is a 1g/L drinking-water; The contrast medicine is 2.5% polygynax soluble powder, and polygynax is available from the pharmaceutical factory, Zhejiang, and lot number is 030315.
1.2 430 AA mixing of experimental animal meat young bird available from the Nanjing company of raising chickens, is transported in this laboratory pouity dwelling place and raises in cages, Routine Management is fed to complete feed to 14 age in days, and colibacillosis does not take place on inspection, can be shown to test and use chicken.Wherein 80 are used for doing trial test, all the other 350 tests are divided into 7 groups with healthy chicken, wherein 1,2,3 group is respectively the high, medium and low treatment group of counteracting toxic substances medicine of the present invention, 4 group of 2.5% polygynax soluble powder matched group, 5 groups of negative matched groups (counteracting toxic substances is not treated matched group), 6 groups of positive matched groups (not counteracting toxic substances do not treat normal healthy controls group), safe matched group (being used in healthy test chicken) according to 10 times of medicine recommended dose of the present invention.
1.3 determining of colibacillus artificial challenge dosage
1.3.1 strain chicken colon bacillus reference culture (O
78Serotype)
1.3.2 the preparation of test organisms liquid is with standard lyophilization bacterium O
78Be inoculated on the maconkey agar after adding the dissolving of 0.5ml meat soup, separate single bacterium colony.Smooth, circular, the red bacterium colony 2-3 of picking diameter 1-2mm is inoculated in the 2ml ordinary broth, cultivates 18h for 37 ℃.After the rejuvenation of broth culture inoculation chicken, separating Escherichia coli from dead chicken liver, renewed vaccination as stated above.After gram stain microscopy does not have varied bacteria growing, as test organisms liquid.Carry out count plate with plate dilution method and be about 6 * 10
9CFU/ml.
1.3.3 definite (trial test) 80 healthy chickens of counteracting toxic substances dosage are divided into 4 groups, 20 every group, 3 groups is infected group, and 1 group is matched group.Infected group is divided high dose group (every chicken inoculation 1.2 hundred million bacterium), middle dosage group (every chicken inoculation 0.9 hundred million bacterium) and low dose group (every chicken inoculation 0.6 hundred million bacterium) again; Matched group intramuscular injection 0.5ml normal saline.According to morbidity, pathological changes and deadly situation, determine 1.2 hundred million chicken source property escherichia coli O at last
78Type strain is test counteracting toxic substances amount.
1.4 test method is except that positive controls and safe matched group, every chicken muscle is injected 1.2 hundred million escherichia coli.Behind the counteracting toxic substances 4 hours, chickling performance lassitude, stop eating, necking down, close one's eyes, lie still on the ground, face downwards and symptom such as bradykinesia.Be diagnosed as colibacillosis with the bacteriology checking method, after this medication was at once used five days continuously, observed therapeutic effect.
Table 1 test grouping and drug treating
1.5 curative effect determinate standard
1.5.1 death is also dead at the classical symptom that chicken colibacillosis appears in duration of test, necropsy has typical characteristics of lesion, and goes out the chicken colon bacillus from liver, spleen and heart separation and Culture, is judged to be to infect this bacterium and death.Calculate the mortality rate of each group according to dead chicken number.
Recover normal 1.5.2 cure, clinical symptoms such as row's loose stool no longer occur, all belong to and curing in the duration of test refreshing state of chicken essence, appetite after administration for oral administration.The ratio that accounts for the test chicken number according to the healing chicken calculates cure rate.
1.5.3 effectively after administration for oral administration, the chicken of Zhi Yuing and do not have death but the clinical symptoms shower is arranged is effective fully; During off-test, the percentage rate that the chicken number of every group of survival accounts for the test chicken number is an effective percentage.
1.5.4 the body weight of weightening finish every chicken during according to on-test and off-test is calculated the gain in weight of every chicken, calculates the average weight gain of every group of test chicken then in view of the above.The relative weight gain rate is to calculate by the ratio of each medication treatment group with the weightening finish of normal healthy controls group, and wherein normal healthy controls group chicken rate of body weight gain is made as 100%.
1.6 the analysis of data and processing
Carry out the significance test of data, wherein mortality rate, effective percentage and cure rate X 2 test with biometrics; The t check is adopted in weightening finish.
2 result of the tests
Each experimental group sees Table 2 to the curative effect of chicken colibacillosis
Each medicine of table 2 compares the curative effect of chicken colibacillosis
2.1 mortality rate
Each medication group is compared, and medicine height of the present invention, middle dosage group, 2.5% polygynax soluble powder mortality rate are lower, be respectively 22%, 24% and, 30%.Statistical analysis shows that the mortality rate of medicine height of the present invention, middle dosage group and 2.5% polygynax soluble powder extremely significantly is lower than the mortality rate (p＜0.01) of negative control group (infection matched group).
2.2 cure rate and effective percentage
Medicine height of the present invention, middle dosage group cure rate are higher, all above 70%.Above-mentioned two groups effective percentage is also higher, all above 70%.Cure rate, the effective percentage of medicine low dose group of the present invention, 2.5% polygynax soluble powder group are relatively low.
2.3 rate of body weight gain
The rate of body weight gain of medicine height of the present invention, the middle dosage group difference extremely significantly (p＜0.01) of comparing with negative control group.Medicine low dose group of the present invention, the weightening finish of 2.5% polygynax soluble powder all significantly are lower than medicine height of the present invention, middle dosage group.(p＜0.05)。
3 discuss
3.1 curative effect of medication of the present invention
The curative effect of dosage group is variant in medicine high dose group of the present invention and the medicine of the present invention, but not obvious, considers raiser's economic interests, the medicine of the present invention of dosage group during suggestion is used
3.2 safety testing
During the medication of safety testing group, chicken essence is refreshing active, and it is normal, full-fledged to search for food, and cuts open inspection back internal organs and organizes no abnormality seen, proves that medicine of the present invention is safe to chicken.
Beneficial effect of the present invention: prescription of the present invention has heat-clearing and toxic substances removing, the effect of blood-nourishing and dysentery-stopping.In conjunction with birds reproductive tract weak point, can not digest the special physiological structure of wood fibre, medicine is made soluble granule, dissolving rapidly in feeding drinking-water after the trouble chicken passes through the drinking-water absorption, can reach the purpose of rapid onset.
The specific embodiment
Embodiment 1: 2 parts of the Radixs Astragali, 8 parts of Herba Andrographis, 1 part of Fructus Evodiae, 2 parts of Radix Et Rhizoma Rhei, 6 parts of Radix Sophorae Flavescentiss, 2 parts of the Radixs Angelicae Dahuricae, 2 parts of Herba Taraxacis, Radix Pulsatillae 2-part, Radix Glycyrrhizae 2-part.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat enteritis type and septic colibacillosis.Be applicable to diseases such as fowl pericarditis, perihepatitis, peritonitis, chickling absorption of yolk at its be bad.Mix drink.Poultry: add this product 1.0 grams in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 2: 3 parts of the Radixs Astragali, 12 parts of Herba Andrographis, 1 part of Fructus Evodiae, 2.5 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Sophorae Flavescentiss, 3 parts of the Radixs Angelicae Dahuricae, 3 parts of Herba Taraxacis, 3 parts of the Radix Pulsatillaes, 3 parts in Radix Glycyrrhizae.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat enteritis type and septic colibacillosis.Be applicable to diseases such as fowl pericarditis, perihepatitis, peritonitis, chickling absorption of yolk at its be bad.Mix drink.Poultry: add this product 1.0 grams in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 3: 4 parts of the Radixs Astragali, 16 parts of Herba Andrographis, 2 parts of Fructus Evodiaes, 3 parts of Radix Et Rhizoma Rhei, 12 parts of Radix Sophorae Flavescentiss, 4 parts of the Radixs Angelicae Dahuricae, 4 parts of Herba Taraxacis, 4 parts of the Radix Pulsatillaes, 4 parts in Radix Glycyrrhizae.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat enteritis type and septic colibacillosis.Be applicable to diseases such as fowl pericarditis, perihepatitis, peritonitis, chickling absorption of yolk at its be bad.Mix drink.Poultry: add this product 1.0 grams in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Claims (3)
1. the compound Chinese medicinal preparation with heat-clearing and toxic substances removing, blood-nourishing and dysentery-stopping efficacy is characterized in that: Radix Astragali 2-4 part, Herba Andrographis 8-16 part, Fructus Evodiae 1-2 part, Radix Et Rhizoma Rhei 2-3 part, Radix Sophorae Flavescentis 6-12 part, Radix Angelicae Dahuricae 2-4 part, Herba Taraxaci 2-4 part, Radix Pulsatillae 2-4 part, Radix Glycyrrhizae 2-4 part.
2. a kind of compound Chinese medicinal preparation with heat-clearing and toxic substances removing, blood-nourishing and dysentery-stopping efficacy according to claim 1 is characterized in that optimizing prescriptions of the present invention is: 3 parts of the Radixs Astragali, 12 parts of Herba Andrographis, 1 part of Fructus Evodiae, 2.5 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Sophorae Flavescentiss, 3 parts of the Radixs Angelicae Dahuricae, 3 parts of Herba Taraxacis, 3 parts of the Radix Pulsatillaes, 3 parts in Radix Glycyrrhizae.
3. a kind of compound Chinese medicinal preparation with heat-clearing and toxic substances removing, blood-nourishing and dysentery-stopping efficacy according to claim 1 is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
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| CNA2006101305303A CN101209304A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal granule with clearing heat and detoxication, blood-nourishing and dysentery-stopping efficacy |
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| CNA2006101305303A CN101209304A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal granule with clearing heat and detoxication, blood-nourishing and dysentery-stopping efficacy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225018A (en) * | 2014-07-24 | 2014-12-24 | 扬中牧乐药业有限公司 | Medicine preparation for preventing botryomycosis of poultry |
| CN108837023A (en) * | 2018-08-24 | 2018-11-20 | 河南牧翔动物药业有限公司 | A kind of preparation method for animals for wearing bitter particle |
| CN109106783A (en) * | 2018-10-30 | 2019-01-01 | 河南后羿实业集团有限公司 | A kind of preparation method for wearing bitter particle |
| CN109432389A (en) * | 2018-12-28 | 2019-03-08 | 河北肽都生物科技有限公司 | A kind of Chinese medicine peptide for treating bovine viral diarrhoea, drug and preparation method thereof |
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2006
- 2006-12-25 CN CNA2006101305303A patent/CN101209304A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225018A (en) * | 2014-07-24 | 2014-12-24 | 扬中牧乐药业有限公司 | Medicine preparation for preventing botryomycosis of poultry |
| CN108837023A (en) * | 2018-08-24 | 2018-11-20 | 河南牧翔动物药业有限公司 | A kind of preparation method for animals for wearing bitter particle |
| CN108837023B (en) * | 2018-08-24 | 2021-08-24 | 河南牧翔动物药业有限公司 | Preparation method of veterinary Chuanqian granules |
| CN109106783A (en) * | 2018-10-30 | 2019-01-01 | 河南后羿实业集团有限公司 | A kind of preparation method for wearing bitter particle |
| CN109432389A (en) * | 2018-12-28 | 2019-03-08 | 河北肽都生物科技有限公司 | A kind of Chinese medicine peptide for treating bovine viral diarrhoea, drug and preparation method thereof |
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Open date: 20080702 |