CN101209306A - Chinese medicine granule for treating colibacillosis of avian - Google Patents
Chinese medicine granule for treating colibacillosis of avian Download PDFInfo
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- CN101209306A CN101209306A CNA2006101305286A CN200610130528A CN101209306A CN 101209306 A CN101209306 A CN 101209306A CN A2006101305286 A CNA2006101305286 A CN A2006101305286A CN 200610130528 A CN200610130528 A CN 200610130528A CN 101209306 A CN101209306 A CN 101209306A
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Abstract
The invention relates to a compound Chinese traditional medicine granules used for treating avian colibacillosis, including thirteen Chinese traditional medicines of Chinese goldthread, phellodendron, honeysuckle, chrysanthemum, Chinese bulbul, rhizoma atractylodis, pomegranate rind, dandelion, sanguisorba, radix isatidis, common andrographis herb, Indian buead and galla chinensis. The invention is mainly used for treating enteritis type and sepsis type colibacillosis. The invention is applicable to the symptoms of avian pericarditis, perihepatitis, peritonitis and chick egg yolk malabsorption, etc. The invention has the efficacies of clearing away heat and toxic material, reinforcing the spleen, improving appetite, nourishing the blood and stopping dysentery. By considering the short avian genital tract and the special physiological structure of inability to digest lignocellulose, the medicine is prepared into soluble granules which can quickly be dissolved into drinking water which is absorbed by sick chicken so as to achieve the purpose of quick effect.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of Chinese medicine granules that is used for the treatment of avian colibacillosis.
Background technology
The drug resistance of fowl Escherichia coli and propagating extensively and rapidly makes avian colibacillosis rise to one of the most thorny disease of harm aviculture.Because enteric microorganism antigen and antigenic determinant complexity, immunologic mechanism there are differences, and prevents and treats this disease from the vaccine angle and does not make a breakthrough as yet, so chemicals is still the main means of control primary disease.And the prevention of the abuse of antimicrobial drug and a large amount of inferior therapeutic doses, feedstuff are added medication and are prolonged administration time without limit, have all caused the chemical sproof generation of escherichia coli, propagation, caused drug residue simultaneously and endanger human and livestock health and sanitarian may.
The colibacillosis traditional Chinese medical science is also referred to as " intestinal Huang ", is one of commonly encountered diseases of chicken, the pathogenesis of primary disease be damp-heat accumulation in large intestine, cause QI and blood being obstructed, conduction dereliction of duty.Make damp and hot malicious heresy act on large intestine and produce the enteral SHENGHUANG, see stomachache is arranged, dysentery, after then watery diarrhea.Damp and hot heresy and the blood knot of fighting is obstructed the intestinal network.See have in the excrement that pus and blood mixes, its flavor is stench.So the intenseness of heat impairment of body fluid is the sign of thirsty greedy drink.The rule of treatment is with heat clearing and damp drying, removing pathogenic heat from blood and toxic substance from the body.China's tradition Chinese herbal medicine is in heat clearing and damp drying, and the outstanding classical prescription of removing pathogenic heat from blood and toxic substance from the body aspect is a lot.In recent years, domestic scholars is studied the antibiotic mechanism of Chinese medicine from the modern pharmacology angle, for the reasonable use of Chinese herbal medicine provides the modern theory basis.
Shortcomings such as the Chinese medicine preparation that uses clinically mostly is powder at present, has administration inconvenience, and is short because of the digestive tract of chicken again, can not digest lignocellulose, and the drug absorption that causes is poor, and consumption is big.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of herbal mixture granule that is used for the treatment of avian colibacillosis.
The object of the present invention is achieved like this: a kind of Chinese traditional compound medicine that is used for the treatment of avian colibacillosis is characterized in that: Rhizoma Coptidis 3-5 part, Cortex Phellodendri 3-5 part, Flos Lonicerae 4-6 part, Flos Chrysanthemi 3-5 part, Radix Pulsatillae 3-5 part, Rhizoma Atractylodis 3-5 part, Pericarpium Granati 3-5 part, Herba Taraxaci 3-5 part, Radix Sanguisorbae 3-5 part, Radix Isatidis 3-5 part, Herba Andrographis 4-6 part, Poria 2-3 part, Galla Chinensis 3-5 part.
Be preferably: 4 parts of Rhizoma Coptidis, 4 parts of Cortex Phellodendris, 4.5 parts of Flos Loniceraes, 4 parts of Flos Chrysanthemis, 4 parts of the Radix Pulsatillaes, 4 parts of Rhizoma Atractylodis, 4 parts of Pericarpium Granatis, 4 parts of Herba Taraxacis, 4 parts of Radix Sanguisorbaes, 4 parts of Radix Isatidis, 4.5 parts of Herba Andrographis, 2.5 parts in Poria, 4 parts of Galla Chinensiss.
A kind of Chinese traditional compound medicine that is used for the treatment of avian colibacillosis is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
Control according to the dialectical opinion of Chinese veterinarian, colibacillosis can be considered in the epidemic disease poison invades, exuberant lung-stomach heat, and stagnation of QI and blood is controlled suitable heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis.Rhizoma Coptidis, Cortex Phellodendri, Flos Lonicerae heat-clearing and toxic substances removing in the side, the removing heat from blood detumescence is main, Herba Taraxaci, Flos Chrysanthemi, Radix Isatidis, the Radix Pulsatillae, Herba Andrographis heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, reducing swelling and alleviating pain, Pericarpium Granati, Rhizoma Atractylodis astringing intestine to stop diarrhea, dampness-eliminating and dysentery-stopping are accessory drugs, Radix Sanguisorbae, Galla Chinensis astringing to arrest bleeding are adjuvant drug, and Poria eliminating dampness by diuresis spleen invigorating is a messenger drug.Cortex Phellodendri clearing away damp-heat, asthenic fire are adjuvant drug.Each medicine share and amounts to the relieve inflammation or internal heat effect of dysentery relieving of heat-clearing and toxic substances removing, removing heat from blood.
The present invention adopts the industry method in common to make: with 13 flavor medical materials, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Below with concrete description of test effect of the present invention:
1 materials and methods
1.1 trial drug
For the reagent product is medicine of the present invention, and main component is Rhizoma Coptidis, Cortex Phellodendri, Flos Lonicerae, Flos Chrysanthemi, the Radix Pulsatillae, Rhizoma Atractylodis, Pericarpium Granati, Herba Taraxaci, Radix Sanguisorbae, Radix Isatidis, Herba Andrographis, Poria, Galla Chinensis, and recommended dose is a 0.5g/L drinking-water; Contrast medicine 2% norfloxacin soluble powder, hydrochloric acid norfloxacin be available from the pharmaceutical factory, Zhejiang, lot number 030107.
1.2 experimental animal
430 AA mixing meat young birds available from the Nanjing company of raising chickens, are transported in the pouity dwelling place and raise in cages, and Routine Management is fed to complete feed to 14 age in days, and colibacillosis does not take place on inspection, can be shown to test and use chicken.Wherein 80 are used for doing trial test, all the other 350 tests are divided into 7 groups with healthy chicken, wherein 1,2,3 group is respectively the high, medium and low treatment group of counteracting toxic substances medicine of the present invention, 4 groups is norfloxacin soluble powder matched group, 5 groups of negative matched groups (counteracting toxic substances is not treated matched group), 6 groups of positive matched groups (not counteracting toxic substances do not treat normal healthy controls group), safe matched group (being used in healthy test chicken) according to 10 times of medicine recommended dose of the present invention.
1.3 determining of colibacillus artificial challenge dosage
1.3.1 strain chicken colon bacillus reference culture (O
78Serotype) provide by animal medicine institute of Agricultural University Of Nanjing
1.3.2 the preparation of test organisms liquid is with standard lyophilization bacterium O
78Be inoculated on the maconkey agar after adding the dissolving of 0.5ml meat soup, separate single bacterium colony.Smooth, circular, the red bacterium colony 2-3 of picking diameter 1-2mm is inoculated in the 2ml ordinary broth, cultivates 18h for 37 ℃.After the rejuvenation of broth culture inoculation chicken, separating Escherichia coli from dead chicken liver, renewed vaccination as stated above.After gram stain microscopy does not have varied bacteria growing, as test organisms liquid.Carry out count plate with plate dilution method and be about 6 * 10
9CFU/ml.
1.3.3 definite (trial test) 80 healthy chickens of counteracting toxic substances dosage are divided into 4 groups, 20 every group, 3 groups is infected group, and 1 group is matched group.Infected group is divided high dose group (every chicken inoculation 1.2 hundred million bacterium), middle dosage group (every chicken inoculation 0.9 hundred million bacterium) and low dose group (every chicken inoculation 0.6 hundred million bacterium) again; Matched group intramuscular injection 0.5ml normal saline.According to morbidity, pathological changes and deadly situation, determine 1.2 hundred million chicken source property escherichia coli O at last
78Type strain is test counteracting toxic substances amount.
1.4 test method is except that positive controls and safe matched group, every chicken muscle is injected 1.2 hundred million escherichia coli.Behind the counteracting toxic substances 4 hours, chickling performance lassitude, stop eating, necking down, close one's eyes, lie still on the ground, face downwards and symptom such as bradykinesia.Be diagnosed as colibacillosis with the bacteriology checking method, after this medication was at once used five days continuously, observed therapeutic effect.
Table 1 test grouping and drug treating
1.5 curative effect determinate standard
1.5.1 death is also dead at the classical symptom that chicken colibacillosis appears in duration of test, necropsy has typical characteristics of lesion, and goes out the chicken colon bacillus from liver, spleen and heart separation and Culture, is judged to be to infect this bacterium and death.Calculate the mortality rate of each group according to dead chicken number.
Recover normal 1.5.2 cure, clinical symptoms such as row's loose stool no longer occur, all belong to and curing in the duration of test refreshing state of chicken essence, appetite after administration for oral administration.The ratio that accounts for the test chicken number according to the healing chicken calculates cure rate.
1.5.3 effectively after administration for oral administration, the chicken of Zhi Yuing and do not have death but the clinical symptoms shower is arranged is effective fully; During off-test, the percentage rate that the chicken number of every group of survival accounts for the test chicken number is an effective percentage.
1.5.4 the body weight of weightening finish every chicken during according to on-test and off-test is calculated the gain in weight of every chicken, calculates the average weight gain of every group of test chicken then in view of the above.The relative weight gain rate is to calculate by the ratio of each medication treatment group with the weightening finish of normal healthy controls group, and wherein normal healthy controls group chicken rate of body weight gain is made as 100%.
1.6 the analysis of data and processing
Carry out the significance test of data, wherein mortality rate, effective percentage and cure rate X 2 test with biometrics; The t check is adopted in weightening finish.
2 result of the tests
Each experimental group sees Table 2 to the curative effect of chicken colibacillosis
Each medicine of table 2 compares the curative effect of chicken colibacillosis
2.1 mortality rate
Each medication group is compared, and medicine height of the present invention, middle dosage group mortality rate are lower, are respectively 10%, 16%.Statistical analysis shows that medicine height of the present invention, middle dosage group mortality rate extremely significantly are lower than the mortality rate (p＜0.01) of negative control group (infection matched group).
2.2 cure rate and effective percentage
Medicine height of the present invention, middle dosage group cure rate are higher, all above 75%.Above-mentioned two groups effective percentage is also higher, all above 80%.Cure rate, the effective percentage of medicine low dose group of the present invention, norfloxacin soluble powder group are relatively low.
The difference extremely significantly (p＜0.01) 2.3 the rate of body weight gain of rate of body weight gain medicine height of the present invention, middle dosage group is compared with negative control group.Medicine low dose group of the present invention, the weightening finish of norfloxacin soluble powder group all significantly are lower than medicine height of the present invention, middle dosage group matched group (p＜0.05).
By above-mentioned experiment as can be seen, the effective percentage of medicine of the present invention, cure rate, rate of body weight gain all are significantly higher than control drug.
Beneficial effect of the present invention: prescription of the present invention has heat-clearing and toxic substances removing, spleen reinforcing appetizing, the effect of blood-nourishing and dysentery-stopping.In conjunction with birds reproductive tract weak point, can not digest the special physiological structure of wood fibre, medicine is made soluble granule, dissolving rapidly in feeding drinking-water after the trouble chicken passes through the drinking-water absorption, can reach the purpose of rapid onset.
The specific embodiment
Embodiment 1: 3 parts of Rhizoma Coptidis, 3 parts of Cortex Phellodendris, 4 parts of Flos Loniceraes, 3 parts of Flos Chrysanthemis, 3 parts of the Radix Pulsatillaes, 3 parts of Rhizoma Atractylodis, 3 parts of Pericarpium Granatis, 3 parts of Herba Taraxacis, 3 parts of Radix Sanguisorbaes, 3 parts of Radix Isatidis, 4 parts of Herba Andrographis, 2 parts in Poria, 3 parts of Galla Chinensiss.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat enteritis type and septic colibacillosis.Be applicable to diseases such as fowl pericarditis, perihepatitis, peritonitis, chickling absorption of yolk at its be bad.Mix drink, poultry: add this product 1.0 grams in per 2 premium on currency, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used.
Embodiment 2: 5 parts of Rhizoma Coptidis, 5 parts of Cortex Phellodendris, 6 parts of Flos Loniceraes, 5 parts of Flos Chrysanthemis, 5 parts of the Radix Pulsatillaes, 5 parts of Rhizoma Atractylodis, 5 parts of Pericarpium Granatis, 5 parts of Herba Taraxacis, 5 parts of Radix Sanguisorbaes, 5 parts of Radix Isatidis, 6 parts of Herba Andrographis, 3 parts in Poria, 5 parts of Galla Chinensiss.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat enteritis type and septic colibacillosis.Be applicable to diseases such as fowl pericarditis, perihepatitis, peritonitis, chickling absorption of yolk at its be bad.Mix drink, poultry: add this product 1.0 grams in per 2 premium on currency, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used.
Embodiment 3: 4 parts of Rhizoma Coptidis, 4 parts of Cortex Phellodendris, 4.5 parts of Flos Loniceraes, 4 parts of Flos Chrysanthemis, 4 parts of the Radix Pulsatillaes, 4 parts of Rhizoma Atractylodis, 4 parts of Pericarpium Granatis, 4 parts of Herba Taraxacis, 4 parts of Radix Sanguisorbaes, 4 parts of Radix Isatidis, 4.5 parts of Herba Andrographis, 2.5 parts in Poria, 4 parts of Galla Chinensiss.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat enteritis type and septic colibacillosis.Be applicable to diseases such as fowl pericarditis, perihepatitis, peritonitis, chickling absorption of yolk at its be bad.Mix drink, poultry: add this product 1.0 grams in per 2 premium on currency, a twice-daily is freely drunk, and logotype 3-5 days, the serious symptom doubled amount was used.
Claims (3)
1. a compound Chinese medicinal preparation that is used for the treatment of avian colibacillosis is characterized in that: Rhizoma Coptidis 3-5 part, Cortex Phellodendri 3-5 part, Flos Lonicerae 4-6 part, Flos Chrysanthemi 3-5 part, Radix Pulsatillae 3-5 part, Rhizoma Atractylodis 3-5 part, Pericarpium Granati 3-5 part, Herba Taraxaci 3-5 part, Radix Sanguisorbae 3-5 part, Radix Isatidis 3-5 part, Herba Andrographis 4-6 part, Poria 2-3 part, Galla Chinensis 3-5 part.
2. a kind of compound Chinese medicinal preparation that is used for the treatment of avian colibacillosis according to claim 1 is characterized in that optimizing prescriptions of the present invention is: 4 parts of Rhizoma Coptidis, 4 parts of Cortex Phellodendris, 4.5 parts of Flos Loniceraes, 4 parts of Flos Chrysanthemis, 4 parts of the Radix Pulsatillaes, 4 parts of Rhizoma Atractylodis, 4 parts of Pericarpium Granatis, 4 parts of Herba Taraxacis, 4 parts of Radix Sanguisorbaes, 4 parts of Radix Isatidis, 4.5 parts of Herba Andrographis, 2.5 parts in Poria, 4 parts of Galla Chinensiss.
3. a kind of compound Chinese medicinal preparation that is used for the treatment of avian colibacillosis according to claim 1 is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006101305286A CN101209306A (en) | 2006-12-25 | 2006-12-25 | Chinese medicine granule for treating colibacillosis of avian |
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| CNA2006101305286A CN101209306A (en) | 2006-12-25 | 2006-12-25 | Chinese medicine granule for treating colibacillosis of avian |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006792A (en) * | 2012-12-27 | 2013-04-03 | 北京大北农动物保健科技有限责任公司 | Veterinary drug for preventing livestock bowel diseases, preparation method of drug, and feed |
-
2006
- 2006-12-25 CN CNA2006101305286A patent/CN101209306A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006792A (en) * | 2012-12-27 | 2013-04-03 | 北京大北农动物保健科技有限责任公司 | Veterinary drug for preventing livestock bowel diseases, preparation method of drug, and feed |
| CN103006792B (en) * | 2012-12-27 | 2017-12-12 | 北京大北农动物保健科技有限责任公司 | A kind of herbal medicine for preventing and treating livestock and poultry intestinal canal diseases and preparation method thereof and feed |
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Open date: 20080702 |