CN1958023A - Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method - Google Patents
Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method Download PDFInfo
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- CN1958023A CN1958023A CN 200510015795 CN200510015795A CN1958023A CN 1958023 A CN1958023 A CN 1958023A CN 200510015795 CN200510015795 CN 200510015795 CN 200510015795 A CN200510015795 A CN 200510015795A CN 1958023 A CN1958023 A CN 1958023A
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Abstract
A compound veterinary medicine in the form of powder for replenishing qi, consolidating superficies, expelling wind and relieving stuffy nose is prepared from 10 Chinese-medicinal materials including asarum herb, scutellaria root, astragalus root, cinnamon twig, etc. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to and be particularly related to the smart powder of XINQIN and the preparation technology's method thereof that a kind of poultry are used in poultry medicine and the field of veterinary.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
The XINQIN prescription has the effect of benefiting QI for strengthening the superficies, expelling pathogenic wind and restoring the functions of orifices in face.2005 editions Pharmacopoeias of the People's Republic of China record this prescription and are used for the treatment of diseases such as rhinocnesmus due to insufficiency of lung-QI, the ailment said due to cold or exposure appearance, sneeze, snivel, allergic rhinitis, have the effect of benefiting QI for strengthening the superficies, expelling pathogenic wind and restoring the functions of orifices in face.Wherein the particulate method for making of XINQIN is: Herba Asari, Radix Scutellariae, Herba Schizonepetae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Fructus Xanthii, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Rhizoma Acori Graminei ten flavor medicines, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, decocting liquid filtered, filtrate merges, be concentrated in right amount, add suitable amount of sucrose powder and dextrin, make granule, dry below 80 ℃, promptly; Or filtrate is concentrated in right amount, and spray drying adds an amount of dextrin and correctives, makes granule, and drying promptly, has the effect of benefiting QI for strengthening the superficies, expelling pathogenic wind and restoring the functions of orifices in face.
The using method of herbal medicine mainly is to carry out mixed feeding or mix drink after directly medicine being pulverized at present, though using method is simple, does not often reach better curative effect.Because the special physiological structure of poultry is directly treated medical material in the mode of crude drug, usually can not get good absorption, major part can be excreted, and the effect of treatment is very little, has wasted a large amount of medical materials simultaneously, has improved aquaculture cost virtually.Do not retrieve at present the application of the smart powder of XINQIN on livestock and poultry pestilence as yet.
Summary of the invention
Technical problem to be solved by this invention is the smart powder of the XINQIN with benefiting QI for strengthening the superficies, expelling pathogenic wind and restoring the functions of orifices in face function that provides a kind of poultry to use and preparation technology's method thereof.Be used for the treatment of poultry because of diseases such as the rhinocnesmus due to insufficiency of lung-QI, the ailment said due to cold or exposure appearance, sneeze, snivel, allergic rhinitises.
Technical scheme of the present invention is:
The smart powder of the XINQIN that a kind of poultry are used, it is characterized in that: the raw material by following part by weight is made:
Herba Asari 100-200g, Radix Scutellariae 100-200g, Herba Schizonepetae 100-200g, Radix Saposhnikoviae 100-200g, Radix Angelicae Dahuricae 100-200g, Fructus Xanthii 100-200g, Radix Astragali 100-200g, Rhizoma Atractylodis Macrocephalae 100-200g, Ramulus Cinnamomi 100-200g, Rhizoma Acori Graminei 100-200g.
Adopt following method to make:
Described ten flavor medicines decoct with water twice, and 1.5 hours for the first time, 1 hour for the second time, decocting liquid filtered, and filtrate merges, and are concentrated in right amount, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste promptly gets the smart powder of XINQIN after the spray drying.
The smart powder of the XINQIN that these poultry are used, it is characterized in that: the raw material by following weight preferred proportion is made: Herba Asari 100g, Radix Scutellariae 100g, Herba Schizonepetae 100g, Radix Saposhnikoviae 100g, Radix Angelicae Dahuricae 100g, Fructus Xanthii 100g, Radix Astragali 100g, Rhizoma Atractylodis Macrocephalae 100g, Ramulus Cinnamomi 100g, Rhizoma Acori Graminei 100g.
Described ten flavor medicines decoct with water twice, and 1.5 hours for the first time, 1 hour for the second time, decocting liquid filtered, and filtrate merges, and are concentrated in right amount, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste promptly gets the smart powder of XINQIN after the spray drying.
Using method of the present invention is: be used for the treatment of poultry because of diseases such as the rhinocnesmus due to insufficiency of lung-QI, the ailment said due to cold or exposure appearance, sneeze, snivel, allergic rhinitises.Usage is spice or mixes drink, horse, cattle: 19.5-25.5g/ head/sky, and sheep, pig: 6.5-8.5g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.05-0.15g//day, mix drink, 3-5 days is a course of treatment.
Effect of the present invention is:
The reference man improves at the special physiological structure of poultry on the basis of existing dosage form with officinal XINQIN granule, the present invention, and for example big domestic animal mostly is many stomaches plant-eating animal, and directly mixed feeding XINQIN crude drug prescription powder often is difficult for absorbing, and causes waste.The present invention has effectively improved the original preparation cost of XINQIN height, has been difficult for the shortcoming of absorption, be made into the smart powder of XINQIN, active component in the medicine has overcome the problem of the direct oral absorption rate variance of Chinese drugs powder, has reduced aquaculture cost on the whole, has effectively improved cure rate.The present invention is used for the treatment of domestic animal, poultry because of diseases such as the rhinocnesmus due to insufficiency of lung-QI, the ailment said due to cold or exposure appearance, sneeze, snivel, allergic rhinitises, can play the effect of benefiting QI for strengthening the superficies, expelling pathogenic wind and restoring the functions of orifices in face.This medicine is a pure Chinese medicinal preparation simultaneously, without any toxic and side effects.
For verifying effect of the present invention, carry out following test: trial drug: trial drug is the smart powder of XINQIN, control drug be the XINQIN powder (available from weight proportion, pulverize after preparing, sieve according to various medical materials in the described XINQIN prescription, mixing is the XINQIN powder.Crude drug is available from the pharmacy, Tianjin).
Experimental animal: 370 of extra large blue laying hens of non-immunity are provided by the Tianjin chicken house.Raise in cages in the pouity dwelling place, feed to complete feed, Routine Management is divided into 7 groups when raising to 70 ages in days and is for experiment.
Seed culture of viruses: infective rhinitis A, C type bacterial strain, being the TanJin Agricultural College animal science is that the infectious disease group is preserved.
Test method
Antibacterial culturing: the secondary haemophilus of chicken is inoculated in and contains in the red proteic chicken serum broth bouillon of 2% Sanguis caprae seu ovis, cultivates 24h, count plate according to a conventional method for 37 ℃.
Counteracting toxic substances dosimetry: get 20 of test chickens, divide 4 groups at random, through the secondary haemophilus bacterium of rhinovaccination chicken liquid 0.2ml, 0.4ml, 0.6ml, 0.8ml, observe the chicken incidence behind the counteracting toxic substances respectively, determine that counteracting toxic substances dosage is 0.4ml.
The artificial onset: adopt at present in two serotypes of haemophilus gallinarum A, the C of China's pilosity as the counteracting toxic substances strain, through toxicity test, determine to the chicken inoculation amount is 0.5mL/ only, route of inoculation is the collunarium counteracting toxic substances, raises by normal feeding and management program behind the counteracting toxic substances.
The test grouping: 350 the 70 blue laying hens in age in days sea are divided into 7 groups.The 1st group is the smart powder high dose group of XINQIN (0.15g/ only mixes drink); The 2nd group of smart powder of XINQIN is middle dosage group (0.1g/ only mixes drink); The 3rd group is the smart powder low dose group of XINQIN (0.05g/ only mixes drink); The 4th group is XINQIN powder matched group (2g/ only mixes drink); The 5th group for infecting matched group, not administration of counteracting toxic substances; The 6th group is the normal healthy controls group, not administration of counteracting toxic substances; The 7th group is the safe dose matched group, and counteracting toxic substances is not pressed ten times of recommended dose administrations of the smart powder of XINQIN.Grouping sees Table 1.
Clinical trial: behind the counteracting toxic substances second day by drinking-water administration, successive administration 5 days.Observe prevention effect after the medication, observe once every 2h, observe continuously in case of necessity, write down disease time, symptom, lapse to projects such as situation, death condition, feed intake variation, weightening finish, mental status, to the prevention effect that the chicken group infects the infective rhinitis, efficacy result sees Table 2 to count " the smart powder of XINQIN ".
The grouping of table 1 test chicken
| Group | Test chicken number (only) | For the reagent thing | Drug level (g//day) | The medication natural law (my god) |
| 1 2 3 4 5 6 7 | 50 50 50 50 50 50 50 | The hot a kind of reed mentioned in ancient books powder contrast of the hot a kind of reed mentioned in ancient books fine powder of dosage group low dose group medicine group infects the hot a kind of reed mentioned in ancient books fine powder safe dose control group of control group normal healthy controls (not infecting) group in the hot a kind of reed mentioned in ancient books fine powder of hot a kind of reed mentioned in ancient books fine powder high dose group | 0.15, mix drink 0.1, mix drink 0.05, mix drink 2, mixed feeding 00 1.5 is mixed drink | 5 5 5 5 5 |
The smart powder of table 2 XINQIN is to the therapeutic effect of test chicken
| Group | Body weight (gram) before the medication | Sickness rate (%) | Survival chicken number (only) | Effective percentage (%) | The relative weight gain rate (%) |
| Dosage group low dose group medicine matched group infects matched group in the high dose group | 782.5 779.5 778.7 780.6 783.2 | 24 26 30 34 62 | 46 44 42 43 39 | 92 88 84 86 78 | 96.7 96.2 91.5 88.7 77.9 |
| Normal healthy controls group safe dose matched group | 782.8 781.9 | 0 0 | 50 50 | - - | 100 104.7 |
The smart powder efficacy result of XINQIN
Significantly be lower than the control drug group and infected matched group by the visible chicken group sickness rate of throwing the smart powder height of clothes XINQIN, middle dosage group of table 2, effective percentage is significantly higher than XINQIN powder group and infects matched group.The effective percentage that the smart powder height of XINQIN, middle dosage group and XINQIN powder group compare infectious coryza of chicken does not have significant difference, but sickness rate significantly is lower than XINQIN powder group, and the relative weight gain rate also is higher than XINQIN powder group.
The safety testing of the smart powder of XINQIN
Show through safety testing (10 times of recommended dose drinking-water, logotype 5 days), do not see clinical unusual performance between the operating period, healthy chicken is not had obvious influence healthy chicken.
The curative effect of the smart powder of XINQIN
By result of the test as can be seen, 3 dosage groups of the smart powder of XINQIN effectively reduce the sickness rate of infectious coryza of chicken, and effective percentage reaches 92%, 88% and 84% respectively, and the sickness rate reduction obviously is better than XINQIN powder group.
According to result of the test, the clinical recommended dose of the smart powder of XINQIN is 0.1g/, mixes drink, and logotype 3-5 days, the serious symptom doubled amount was used.
The specific embodiment
Embodiment 1: get Herba Asari 200g, Radix Scutellariae 200g, Herba Schizonepetae 200g, Radix Saposhnikoviae 200g, Radix Angelicae Dahuricae 200g, Fructus Xanthii 200g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 200g, Ramulus Cinnamomi 200g, Rhizoma Acori Graminei 200g, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, decocting liquid filtered, and filtrate merges, be concentrated in right amount, filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste promptly gets the smart powder of XINQIN after the spray drying.
Embodiment 2: get Herba Asari 100g, Radix Scutellariae 100g, Herba Schizonepetae 100g, Radix Saposhnikoviae 100g, Radix Angelicae Dahuricae 100g, Fructus Xanthii 100g, Radix Astragali 100g, Rhizoma Atractylodis Macrocephalae 100g, Ramulus Cinnamomi 100g, Rhizoma Acori Graminei 100g, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, decocting liquid filtered, and filtrate merges, be concentrated in right amount, filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste promptly gets the smart powder of XINQIN after the spray drying.
Be used for the treatment of poultry because of diseases such as the rhinocnesmus due to insufficiency of lung-QI, the ailment said due to cold or exposure appearance, sneeze, snivel, allergic rhinitises.Usage is spice or mixes drink, horse, cattle: 19.5-25.5g/ head/sky, and sheep, pig: 6.5-8.5g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.05-0.15g//day, mix drink, 3-5 days is a course of treatment.
Claims (2)
1, the smart powder of a kind of XINQIN of poultry use, it is characterized in that: the raw material by following part by weight is made:
Herba Asari 100-200g, Radix Scutellariae 100-200g, Herba Schizonepetae 100-200g, Radix Saposhnikoviae 100-200g, Radix Angelicae Dahuricae 100-200g, Fructus Xanthii 100-200g, Radix Astragali 100-200g, Rhizoma Atractylodis Macrocephalae 100-200g, Ramulus Cinnamomi 100-200g, Rhizoma Acori Graminei 100-200g.
Adopt following method to make: above-mentioned ten flavor medicines, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, decocting liquid filtered, and filtrate merges, and is concentrated in right amount, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of XINQIN.
2, the smart powder of the XINQIN of poultry use according to claim 1, it is characterized in that: the raw material by following weight preferred proportion is made: Herba Asari 200g, Radix Scutellariae 200g, Herba Schizonepetae 200g, Radix Saposhnikoviae 200g, Radix Angelicae Dahuricae 200g, Fructus Xanthii 200g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 200g, Ramulus Cinnamomi 200g, Rhizoma Acori Graminei 200g.
Adopt following method to make: above-mentioned ten flavor medicines, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, decocting liquid filtered, and filtrate merges, and is concentrated in right amount, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of XINQIN.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015795 CN1958023A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method |
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| CN 200510015795 CN1958023A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526552A (en) * | 2010-12-09 | 2012-07-04 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition with function of improving production performance of poultry, and preparation method thereof |
| CN104547357A (en) * | 2015-02-10 | 2015-04-29 | 中国人民解放军第三军医大学第二附属医院 | Chinese herbal compound tablet for treating allergic rhinitis and preparation method of Chinese herbal compound |
| CN107595938A (en) * | 2017-11-03 | 2018-01-19 | 天津瑞贝特科技发展有限公司 | Treat scorching Chinese medicine composition of hog snout and preparation method thereof |
| CN109331126A (en) * | 2018-12-11 | 2019-02-15 | 郑州赛科药业科技有限公司 | Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken |
-
2005
- 2005-10-31 CN CN 200510015795 patent/CN1958023A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526552A (en) * | 2010-12-09 | 2012-07-04 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition with function of improving production performance of poultry, and preparation method thereof |
| CN104547357A (en) * | 2015-02-10 | 2015-04-29 | 中国人民解放军第三军医大学第二附属医院 | Chinese herbal compound tablet for treating allergic rhinitis and preparation method of Chinese herbal compound |
| CN104547357B (en) * | 2015-02-10 | 2018-10-26 | 中国人民解放军第三军医大学第二附属医院 | A kind of Chinese medicine compound prescription that treating allergic rhinitis, tablet and preparation method thereof |
| CN107595938A (en) * | 2017-11-03 | 2018-01-19 | 天津瑞贝特科技发展有限公司 | Treat scorching Chinese medicine composition of hog snout and preparation method thereof |
| CN109331126A (en) * | 2018-12-11 | 2019-02-15 | 郑州赛科药业科技有限公司 | Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken |
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