CN109331126A - Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken - Google Patents

Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken Download PDF

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CN109331126A
CN109331126A CN201811511336.9A CN201811511336A CN109331126A CN 109331126 A CN109331126 A CN 109331126A CN 201811511336 A CN201811511336 A CN 201811511336A CN 109331126 A CN109331126 A CN 109331126A
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parts
chicken
raw material
chinese medicine
radix
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孙书华
李海利
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Zhengzhou Saike Pharmaceutical Technology Co ltd
Institute of Animal Husbandry and Veterinary Medicine of Henan Academy of Agricultural Sciences
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Zhengzhou Saike Pharmaceutical Technology Co Ltd
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
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Abstract

Chinese medicine composition of the present invention for treating infectious coryza of chicken is prepared using pure traditional Chinese medicine raw material, there is synergistic effect well between each component, both can suit the medicine to the illness single drug according to symptom, can also effectively can treat infectious coryza of chicken in conjunction with medication;Infectious coryza of chicken is treated using the present invention; it both can be with spice mixed feeding; juice can also be taken to drink water powder decocting; can also gavage, and compared with antibiotic, Chinese medicine have the characteristics that it is pure natural, preventive treatment of disease, have no toxic side effect, noresidue, without drug resistance, thoroughly cure; it is the choice drug for preventing and treating infectious coryza of chicken; and preparation method is simple, is suitble to the needs of large-scale industrial production, is suitable for promoting and applying in husbandry sector.

Description

Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken
Technical field:
The invention belongs to technical field of traditional Chinese medicines, and in particular to for treating the Chinese medicine composition and its system of infectious coryza of chicken Preparation Method.
Background technique:
Infective rhinitis (infectious coryza, IC) is exhaled on one kind as caused by haemophilus paragallinarum is acute Inhale road transmission disease.Main clinic symptoms are the inflammation of nasal cavity and sinus, performance runny nose, facial edema and conjunctivitis.This disease is in the world Property distribution, mainly cause the decline (10%~40%), Growing Chicken growth retardation, broiler chicken air bag inflammation of laying rate of laying hen to cause to butcher Increase etc. is discarded in processing, causes serious financial consequences to poultry husbandry.
Haemophilus paragallinarum (Avibacterium paragallinarum) belongs to bus Bacteriaceae (Pasteurellaceae), fowl Bacillus (Avibacterium).Young age culture is a kind of gram-negative small club Bacterium, bipolar staining do not form gemma, atrichia, no pod membrane, amphimicrobian, life under conditions of containing 5%~10% carbon dioxide It is long preferable.Demand to nutrition is higher, and needing the V factor could well-grown.Blood agar or chocolate agar can meet this The nutritional need of bacterium, culture can form dewdrop sample petite for 24 hours, not haemolysis.Staphylococcus etc. can produce during the growth process V because Son can grow haemophilus paragallinarum bacterium colony when intersecting scribing line culture near staphylococcus bacterium colony.This bacterium azymic gala Sugar, trehalose, no peroxidase.
This bacterium has multiple serotypes, there is A1、A2、A3、A4、B1、C1、C2、C3And C49 serotypes, the epidemic disease of different serotypes Seedling cannot provide cross protection.This bacterium pathogenicity with it is a variety of factor-related.This disease can infect the chicken of various age brackets, 3~4 week old Chicken it is most susceptible, the infection of old chicken is more serious.The infection sources of this disease is mainly diseased chicken and the chicken that carries disease germs.Route of transmission mainly breathes Road and alimentary canal.Communication media is mainly feed, drinking-water, droplet and the dust etc. polluted by this bacterium.The occurrence of this disease is in various Stress inducement it is related, as crowded, all ages and classes the chicken of chicken group mixes group's raising, improper ventilation, sultry or cold wet, ammonia in henhouse Gas concentration is excessively high, abrupt change of climate, the A that is deficient in vitamin, parasitic infection are serious etc. can promote the serious morbidity of chicken group.Chicken group's inoculation General reaction caused by fowl pox vaccine or other vaccines is also often the inducement of this disease.This disease mostly occurs in autumn, two season of winter, and And propagate comparatively fast, this may be related with weather and feeding and management condition.
Nasal cavity and the sinus person of being inflamed often show the thin clear liquid of stream, after switch to slurry viscosity secretion, sneeze sometimes;Eye Week and blepharedema, eye conjunctivitis, blood-shot eye illness and swelling.Feeding and drinking-water are reduced, or have diarrhea, weight loss.Chick undergrowth; Adult hen oviposition, which is reduced, even to be stopped;The common enlargement of cock wattle.If inflammation spreads to lower respiratory tract, then has difficulty in breathing and have Rale;Such as switch to chronic and concurrent other diseases, then issues a kind of stench of dirt in chicken group.Diseased chicken, which is often shaken the head, to be intended to respiratory tract Interior mucus discharge, is finally often choked to death.The infection case fatality rate of virulent strain is higher, and the disease incidence of no accompanying infection is high and sick Dead rate is low.If feeding management is not good at, when lacking nutrition and infection other diseases, then stadium extends, and the state of an illness is even more serious, case fatality rate Also increase.
The depollution of environment is most important to this disease is effectively prevented, and should be noted that the ventilation of henhouse in management, avoids intensive Raising often carries out Continuous disinfection or chlorine-containing disinfectant is added in drinking-water.Usually reinforce the monitoring to breeder flock, positive chicken with When eliminate.Immunity inoculation selects polyvalent inactivation oil-adjuvant vaccine.This bacterium has certain sensibility to Multiple Classes of Antibiotics and sulfa drugs, Common gentamicin, erythromycin, terramycin, Ciprofloxacin etc..Dihydrostreptomycin and some sulfa drugs have synergistic effect.But Antibiotic is easy to remain in meat, egg milk, causes food safety hazards.In order to make infective rhinitis obtain good prevention and control and It solves by having invented a kind of prevention according to Chinese medicine medical knowledge with bring antibiotic residue hidden danger, the present invention is treated with antibiotic prophylaxis With the Chinese medicine composition and preparation method thereof for the treatment of infective rhinitis, infective rhinitis can be effectively controlled.
Summary of the invention:
Aiming at the problem that antibiotic treatment infectious coryza of chicken easily leads to the residual antibiotic in meat, egg, the present invention is provided A kind of Chinese medicine composition and preparation method thereof being not easy remaining treatment infective rhinitis.
In conjunction with the serial symptom that chicken infection infective rhinitis occurs, Chinese veterinarian debates disease and surely belongs to asthenia of pulmonosplenic qi, and weakened defensive QI adds Take good care of oneself accidentally, be affected by the cold repeatedly or the heresy of wind-heat, it is inside and outside to be harmonious.In sick long disease penetrates with, channels is obstructed, the stagnation of the circulation of vital energy Blood stasis, more nose key stop up, obstinate refractory.Clinic distinguishes that disease is broadly divided into two chill, wind-heat disease types.
The present invention solves scheme used by its technical problem: a kind of for treating the Chinese traditional medicine composition of infectious coryza of chicken Object, including following raw material: 5-20 parts of the flower bud of lily magnolia, 4-18 parts of rhizoma anemarrhenae, 7-15 parts of Cortex Phellodendri, 10-18 parts of the root of straight ladybell, 5-12 parts of radix aucklandiae, alum 2-10 parts, 1-10 parts of fructus viticis, 10-25 parts of Rhizoma Et Radix Notopterygii, 5-15 parts of rhizome of chuanxiong, 3-10 parts of schizonepeta, 5-25 parts of chrysanthemum, honeysuckle 10-20 Part, 5-20 parts of Radix Glycyrrhizae, 3-10 parts of Mangnolia officinalis, 5-20 parts of great burdock achene, 8-15 parts of lophatherum gracile.
It is above-mentioned a kind of for treating the Chinese medicine composition of infectious coryza of chicken, including following raw material: 10-15 parts of the flower bud of lily magnolia, 10-18 parts of rhizoma anemarrhenae, 10-15 parts of Cortex Phellodendri, 12-18 parts of the root of straight ladybell, 5-8 parts of radix aucklandiae, 5-10 parts of alum, 1-5 parts of fructus viticis, Rhizoma Et Radix Notopterygii 15- 25 parts, 8-15 parts of rhizome of chuanxiong, 5-10 parts of schizonepeta, 15-25 parts of chrysanthemum, 15-20 parts of honeysuckle, 15-20 parts of Radix Glycyrrhizae, 3-7 parts of Mangnolia officinalis, ox 10-20 parts of burdock, 10-15 parts of lophatherum gracile.
Our heat-clearing enriching yin, dispelling wind are sensible.It cures mainly brain forehead nose purulence symptoms include tears liquid is dilute white or in bean curd slag specimen, stench, nose Swelling, what is kowtowed is in voiced sound, mostly side property.Our disease is brain forehead nose purulence.Sinus frontalis nasal cavity is invaded by the heresy of wound or the six external factors which cause diseases, cult poison It smoulders, changes and form purulence.Rhizoma anemarrhenae bitter cold and moisten, can heat-clearing and enriching yin nutrient solution, rhizoma anemarrhenae it is cold and cool, make its heat-clearing without damage spleen The sun of stomach, altogether at the agent of removing heat with drugs of pungent flavor and cold nature, the pungent of rhizoma anemarrhenae trembles with fear, and eliminates lung gold, then positive bright heat self solves, and rushes down the reason of son actually, clearly Lung enriching yin removing toxic substances, to remove upper heat, Cortex Phellodendri bitter cold is apt to clear damp-heat in lower-JIAO, and consolidating the yin thickness intestines, lower ascarifuge, expel the heat-evil preventing or arresting vomiting, and heat-clearing is dry It is wet.The flower bud of lily magnolia in side, rhizome of chuanxiong, leads to sinus frontalis nasal cavity on great burdock achene at schizonepeta, evacuates cult poison, is monarch drug in a prescription;Minister is with rhizoma anemarrhenae, honeysuckle, henon bamboo Leaf, Cortex Phellodendri uplink and clearing heat and detoxicating, Rhizoma Et Radix Notopterygii, honeysuckle, chrysanthemum let out clearly interior heat;The root of straight ladybell moistening lung, radix aucklandiae regulating functional activities of qi, fructus viticis are dispelled Wind analgesic, alum astringency inducing is adjutant.Radix Glycyrrhizae, Mangnolia officinalis and middle tune medicine are to make medicine.All medicines are harmonious, heat-clearing enriching yin, and dispelling wind is logical Key.We are the dedicated side for controlling brain forehead nose purulence.All nasosinusitis, upper nasosinusitis, maxillary sinus raise steaming person on purulence category lung heat, can take the circumstances into consideration Plus-minus uses.
It is a kind of for treating the Chinese medicine composition of infectious coryza of chicken, including following raw material: 5-20 parts of Chinese ephedra, the root of straight ladybell 5-15 Part, it is 5-10 parts of monkshood, 7-15 parts windproof, 10-20 parts of the achene of Siberian cocklebur, 3-10 parts of radix aucklandiae, 8-20 parts of ramulus cinnamomi, 5-15 parts of fructus viticis, chaste tree 7-12 parts of mustard, 5-15 parts of almond, 2-10 parts of radix bupleuri, 5-15 parts of Radix Angelicae Pubescentis, 5-15 parts of Rhizoma Et Radix Notopterygii, 10-15 parts of Mangnolia officinalis, macleaya cordata 5-10 Part.
Above-mentioned is a kind of for treating the Chinese medicine composition of infectious coryza of chicken, is made of the raw material of following components: fiber crops It is 15-20 parts yellow, it is 5-10 parts of the root of straight ladybell, 5-8 parts of monkshood, 10-15 parts windproof, 10-15 parts of the achene of Siberian cocklebur, 3-8 parts of radix aucklandiae, ramulus cinnamomi 8-15 Part, it is 12-15 parts of fructus viticis, 7-10 parts of schizonepeta, 10-15 parts of almond, 5-10 parts of radix bupleuri, 10-15 parts of Radix Angelicae Pubescentis, 10-15 parts of Rhizoma Et Radix Notopterygii, thick Mend 12-15 parts, 5-8 parts of macleaya cordata.
Our temperature is through sweating, relieving exterior-interior syndrome.The square epheday intermedia diverging sun is monarch in the heresy of table.The few yin of monkshood temperature it is inner it Sun, the root of straight ladybell moistening lung are minister.The achene of Siberian cocklebur cures mainly the cold pain of public attention, rheumatism general arthralgia, and four limbs arrest goldenrain tree pain, wind-dispelling help and Chinese ephedra, monkshood phase 5, supporing yang to deliver, the function of supporing yang cold dispelling is assistant.Windproof dispelling wind pathogens, the analgesic of fructus viticis expelling wind and activating blood flow, radix aucklandiae regulating functional activities of qi are Make, schizonepeta disperses cult poison, ramulus cinnamomi, almond, radix bupleuri, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Mangnolia officinalis, macleaya cordata relieving spasm to stop pain, coordinating the drug actions of a prescription.All medicine phases It is combined into use, interior temperature lacks the sun of yin, and the table of the outgoing sun helps just and eliminating evil, in Wen Jingzhong inducing diaphoresis, in inducing diaphoresis medium temperature sun.Cure mainly kidney The deficiency of yang and affection of exogenous wind-cold, innate deficiency of YANG in the body feel the chronic cough etc. of chill again.
The present invention also provides a kind of for treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, including following step It is rapid:
(1) it weighs each raw material respectively in proportion, raw material is put into medicine decocting tank, 10 times of raw material weight amounts are added into tank Pure water impregnates 2h;
(2) first time decoction is carried out after impregnating, is filtered after decocting 1h, is stayed and is decocted filtrate for the first time;Into filter residue The pure water for adding 10 times of amounts carries out secondary decoction, and second of decoction filtrate is stayed in filtering after decocting 1h;
(3) merge and decoct gained filtrate twice, be condensed into medicinal extract, gained medicinal extract is dried, powder is sprayed into;
(4) filter residue is dried and is crushed, be uniformly mixed with the dry gained powder of filtrate, packing pack.
The present invention also provides a kind of for treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, including following step It is rapid:
(1) it weighs each raw material respectively in proportion, raw material is put into medicine decocting tank, 10 times of raw material weight amounts are added into tank 60% ethyl alcohol impregnates 2h;
(2) first time decoction is carried out after impregnating, is filtered after decocting 1h, is stayed and is decocted filtrate for the first time;Add again into filter residue 60% ethyl alcohol for entering 10 times of amounts carries out secondary decoction, and second of decoction filtrate is stayed in filtering after decocting 1h;
(3) merge and decoct gained filtrate twice, be condensed into medicinal extract, gained medicinal extract is dried, powder is sprayed into;
(4) filter residue is dried and is crushed, be uniformly mixed with the dry gained powder of filtrate, packing pack.
Beneficial effects of the present invention: the present invention is pure Chinese medicinal preparation, compared with antibiotic medicine, Chinese medicine have it is pure natural, Preventive treatment of disease, have no toxic side effect, noresidue, without drug resistance, thoroughly cure the features such as, Chinese medicine composition compatibility of the present invention closes Reason, safely and effectively, and treating both manifestation and root cause of disease, no recurrence, avoid the medicament residue with antibiotic prophylaxis and treatment, it is ensured that food peace It entirely, is suitable for being promoted in husbandry sector.Two kinds of Chinese medicines, which share to prevent and treat infectious coryza of chicken, has preferable treat Effect has preferable treat to the inflammation of nasal cavity and sinus, runny nose, facial edema and conjunctivitis etc. to acute upper respiratory tract infectious disease Effect, has a vast market foreground and biggish economic benefit.
Specific embodiment:
Below with reference to embodiment, the present invention is further described.
Embodiment 1: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Treatment chicken anemopyretic infective rhinitis, including following raw material: flower bud of lily magnolia 100g, rhizoma anemarrhenae 100g, Cortex Phellodendri 70g, the root of straight ladybell 100g, radix aucklandiae 50g, Alum 20g, fructus viticis 50g, Rhizoma Et Radix Notopterygii 250g, rhizome of chuanxiong 150g, schizonepeta 30g, chrysanthemum 150g, honeysuckle 150g, Radix Glycyrrhizae 50g, Mangnolia officinalis 100g, great burdock achene 100g, lophatherum gracile 150g.
Preparation method: weighing above-mentioned raw materials respectively, and above-mentioned raw materials are crushed one by one, crosses 200 meshes, is uniformly mixed in being made Medicinal powder end.
Embodiment 2: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Treat chicken anemopyretic infective rhinitis, including following raw material: flower bud of lily magnolia 200g, rhizoma anemarrhenae 40g, Cortex Phellodendri 150g, the root of straight ladybell 120g, radix aucklandiae 120g, alum 50g, fructus viticis 100g, Rhizoma Et Radix Notopterygii 150g, rhizome of chuanxiong 50g, schizonepeta 50g, chrysanthemum 250g, honeysuckle 100g, Radix Glycyrrhizae 150g, Mangnolia officinalis 30g, great burdock achene 50g, lophatherum gracile 80g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are put into medicine decocting tank, and 10 times of raw material weight are added into tank The pure water of amount impregnates 2h, then decocts 1h, filters to decoct filtrate for the first time;The pure water of 10 times of amounts is added into filter residue again 1h is decocted, second of decoction filtrate of filtering gained filtrate will merge twice, and be condensed into medicinal extract, be dried in vacuo, be sprayed into powder; It again by filter residue drying, crushing, is uniformly mixed with powder obtained by filtrate, packing pack.
Embodiment 3: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Treatment chicken anemopyretic infective rhinitis, including following raw material: flower bud of lily magnolia 50g, rhizoma anemarrhenae 180g, Cortex Phellodendri 100g, the root of straight ladybell 180g, radix aucklandiae 80g, Alum 100g, fructus viticis 10g, Rhizoma Et Radix Notopterygii 100g, rhizome of chuanxiong 80g, schizonepeta 100g, chrysanthemum 50g, honeysuckle 200g, Radix Glycyrrhizae 200g, Mangnolia officinalis 70g, great burdock achene 200g, lophatherum gracile 100g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are put into medicine decocting tank, and it is total that raw material is then added into tank 60% ethyl alcohol of 10 times of weight amounts impregnates 2h, then decocts 1h, filters to decoct filtrate for the first time;10 times are added into filter residue again 60% ethyl alcohol of amount continues to decoct 1h, second of decoction filtrate of filtering;Filtrate merging twice is condensed into medicinal extract, vacuum is dry It is dry, it is sprayed into powder;Again by filter residue dries pulverizing, mixed with the dry gained powder of filtrate, packing pack.
Embodiment 4: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Treat chicken anemopyretic infective rhinitis, including following raw material: flower bud of lily magnolia 150g, rhizoma anemarrhenae 100g, Cortex Phellodendri 100g, the root of straight ladybell 120g, radix aucklandiae 80g, alum 50g, fructus viticis 100g, Rhizoma Et Radix Notopterygii 150g, rhizome of chuanxiong 80g, schizonepeta 50g, chrysanthemum 150g, honeysuckle 200g, Radix Glycyrrhizae 150g, Mangnolia officinalis 30g, great burdock achene 50g, lophatherum gracile 80g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are put into medicine decocting tank, and 10 times of raw material weight are added into tank The pure water of amount impregnates 2h, then decocts 1h, filters to decoct filtrate for the first time;The pure water of 10 times of amounts is added into filter residue again 1h is decocted, second of decoction filtrate of filtering gained filtrate will merge twice, and be condensed into medicinal extract, be dried in vacuo, be sprayed into powder; It again by filter residue drying, crushing, is uniformly mixed with powder obtained by filtrate, packing pack.
Embodiment 5: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Treat chicken anemopyretic infective rhinitis, including following raw material: flower bud of lily magnolia 120g, rhizoma anemarrhenae 150g, Cortex Phellodendri 130g, the root of straight ladybell 160g, radix aucklandiae 60g, alum 70g, fructus viticis 30g, Rhizoma Et Radix Notopterygii 180g, rhizome of chuanxiong 110g, schizonepeta 70g, chrysanthemum 210g, honeysuckle 170g, Radix Glycyrrhizae 180g, Mangnolia officinalis 50g, great burdock achene 130g, lophatherum gracile 120g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are put into medicine decocting tank, and it is total that raw material is then added into tank 60% ethyl alcohol of 10 times of weight amounts impregnates 2h, then decocts 1h, filters to decoct filtrate for the first time;10 times are added into filter residue again 60% ethyl alcohol of amount continues to decoct 1h, second of decoction filtrate of filtering;Filtrate merging twice is condensed into medicinal extract, vacuum is dry It is dry, it is sprayed into powder;Again by filter residue dries pulverizing, mixed with the dry gained powder of filtrate, packing pack.
Embodiment 6: of the invention a kind of for treating the Chinese medicine composition of chicken anemopyretic infective rhinitis in order to verify Beneficial effect, using the Chinese medicine composition respectively to one plant of standard haemophilus paragallinarum bacterial strain and 9 plants of Clinical isolations most Low Mlc and minimum bactericidal concentration are tested.Test method is as follows:
(1) flower bud of lily magnolia 10g, rhizoma anemarrhenae 10g, Cortex Phellodendri 10g, the root of straight ladybell 12g, radix aucklandiae 8g, alum 5g, fructus viticis 5g, Qiang are accurately weighed 15g, rhizome of chuanxiong 8g, schizonepeta 5g living, chrysanthemum 15g, honeysuckle 15g, Radix Glycyrrhizae 15g, Mangnolia officinalis 7g great burdock achene 10g, lophatherum gracile 10g;It will be upper State raw material and be uniformly mixed and be put into medicine decocting tank, be added into tank 8 times of raw material weight amounts distilled water decoct boiling after use instead and be cooked by slow fire During which 1h remains 8 times of amount water, with 4 layers of filtered through gauze: residue adds 6 times of amount water with filtering after method decoction 1h, and merging is filtered twice Liquid is concentrated under reduced pressure, makes its concentration 1g/ml.
(2) haemophilus paragallinarum is seeded to culture medium by the preparation of bacterium solution, and 37 DEG C of stationary cultures are for 24 hours.With sterilizing blank training It supports base and corrects bacterial concentration, make viable count 1-2 × 108CFU/ml, it is spare.
(3) minimum inhibitory concentration (minimal inhibition concentration, MIC) measures
It is carried out using test tube doubling dilution, determines Chinese medicine minimum inhibitory concentration (minimal inhibition concentration,MIC).25, sterile test tube is taken to be numbered, every pipe adds culture medium 2mL, in the first pipe in addition Medical fluid 2mL takes out 2mL and is put into the second pipe, and so on, it is discarded until the 23rd pipe takes out 2.0ml;Medical fluid is not added in 24th pipe, makees For positive control, the 25th pipe takes out 2.0ml and discards, be not added as negative control, the 25th pipe plus tested medical fluid 2.0ml after mixing Bacterium respectively manages parallel 3 parts as negative control.I.e. the concentration of drug is (1g/mL, 500mg/mL, 250mg/mL, 125mg/ mL、62.5mg/mL、31.25mg/m L、15.63mg/mL、7.81mg/mL、3.95mg/mL、1.98mg/mL、0.99mg/mL、 0.49mg/mL、0.25mg/mL、0.12mg/mL、0.06mg/mL、0.03mg/mL、15.43μg/mL、7.71μg/mL、3.86μ G/mL, 1.93 μ g/mL, 0.97 μ g/mL, 0.48 μ g/mL, 0.24 μ g/mL), 10 μ L (10 of bacterium solution is added in 1~24 pipe8CFU/m L), every kind of medicine does 3 and takes its average value in parallel, be placed in 37 DEG C of constant incubators and cultivate 24-48h, observes result.Sterile life Long region is the smallest Mlc (MIC) of the medicine.
(4) minimum bactericidal concentration (minimal bacteriocidal concentration, MBC) measures
Culture in each dilution tube for more than MIC endpoint concentration not growing bacterium is inoculated with aseptic cotton carrier streaking inoculation It is cultivated for 24 hours on culture medium, being placed in 37 DEG C of constant incubators, observes result.3 tests are averaged.
(5) it the results are shown in Table 1.
A kind of Chinese medicine composition test result for treating chicken anemopyretic infective rhinitis of table 1
As shown in Table 1, the Chinese medicine composition for treating chicken anemopyretic infective rhinitis of the invention is to the bloodthirsty bar of secondary chicken Bacterium tool has a better effect.
Embodiment 7: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Chicken wind-cold type infective rhinitis is treated, including following raw material: Chinese ephedra 150g, the root of straight ladybell 50g, monkshood 80g, windproof 150g, the achene of Siberian cocklebur 100g, radix aucklandiae 100g, ramulus cinnamomi 200g, fructus viticis 50g, schizonepeta 100g, almond 100g, radix bupleuri 100g, Radix Angelicae Pubescentis 100g, Rhizoma Et Radix Notopterygii 150g, Mangnolia officinalis 100g, macleaya cordata 80g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are crushed one by one, crosses 200 meshes, is uniformly mixed in being made Medicinal powder end.
Embodiment 8: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Chicken wind-cold type infective rhinitis is treated, including following raw material: Chinese ephedra 50g, the root of straight ladybell 150g, monkshood 100g, windproof 70g, the achene of Siberian cocklebur 200g, radix aucklandiae 80g, ramulus cinnamomi 80g, fructus viticis 150g, schizonepeta 120g, almond 50g, radix bupleuri 50g, Radix Angelicae Pubescentis 150g, Rhizoma Et Radix Notopterygii 50g are thick Mend 150g, macleaya cordata 100g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are put into medicine decocting tank, raw material weight is added into medicine decocting tank The pure water of 10 times of amounts impregnates 2h, then decocts 1h, filters to decoct filtrate for the first time;The pure of 10 times of amounts is added into filter residue again Water purification decocts 1h, and second of decoction filtrate of filtering gained filtrate will merge twice, and be condensed into medicinal extract, be dried in vacuo, be sprayed into powder End;It again by filter residue drying, crushing, is uniformly mixed with powder obtained by filtrate, packing pack.
Embodiment 9: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, the medicine is for controlling Chicken wind-cold type infective rhinitis is treated, including following raw material: Chinese ephedra 200g, the root of straight ladybell 100g, monkshood 50g, windproof 100g, the achene of Siberian cocklebur 150g, radix aucklandiae 30g, ramulus cinnamomi 150g, fructus viticis 120g, schizonepeta 70g, almond 150g, radix bupleuri 20g, Radix Angelicae Pubescentis 50g, Rhizoma Et Radix Notopterygii 100g are thick Mend 120g, macleaya cordata 50g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are put into medicine decocting tank, is then added 10 times of raw material gross weight 60% ethyl alcohol of amount impregnates 2h, then decocts 1h, filters to decoct filtrate for the first time;The 60% of 10 times of amounts is added into filter residue again Ethyl alcohol continues to decoct 1h, second of decoction filtrate of filtering;Filtrate merging twice is condensed into medicinal extract, is dried in vacuo, is sprayed into powder End;Again by filter residue dries pulverizing, mixed with the dry gained powder of filtrate, packing pack.
Embodiment 10: a kind of for treating the Chinese medicine composition of infectious coryza of chicken described in the present embodiment, which is used for Chicken wind-cold type infective rhinitis is treated, including following raw material: Chinese ephedra 170g, the root of straight ladybell 70g, monkshood 65g, windproof 120g, the achene of Siberian cocklebur 130g, radix aucklandiae 60g, ramulus cinnamomi 120g, fructus viticis 130g, schizonepeta 90g, almond 120g, radix bupleuri 70g, Radix Angelicae Pubescentis 130g, Rhizoma Et Radix Notopterygii 130g, Mangnolia officinalis 140g, macleaya cordata 70g.
Preparation method: weighing above-mentioned raw materials respectively, and all raw materials are put into medicine decocting tank, raw material weight is added into medicine decocting tank The pure water of 10 times of amounts impregnates 2h, then decocts 1h, filters to decoct filtrate for the first time;The pure of 10 times of amounts is added into filter residue again Water purification decocts 1h, and second of decoction filtrate of filtering gained filtrate will merge twice, and be condensed into medicinal extract, be dried in vacuo, be sprayed into powder End;It again by filter residue drying, crushing, is uniformly mixed with powder obtained by filtrate, packing pack.
Embodiment 11: of the invention a kind of for treating the Chinese medicine composition of chicken wind-cold type infective rhinitis in order to verify Beneficial effect, using the Chinese medicine composition respectively to one plant of standard haemophilus paragallinarum bacterial strain and 9 plants of Clinical isolations most Low Mlc and minimum bactericidal concentration are tested.Test method is as follows:
(1) Chinese ephedra 10g is accurately weighed, the root of straight ladybell 10g, monkshood 8g, windproof 10g, achene of Siberian cocklebur 15g, radix aucklandiae 8g, ramulus cinnamomi 15g are climing Jing Zi 12g, schizonepeta 10g, almond 10g, radix bupleuri 5g, Radix Angelicae Pubescentis 10g, Rhizoma Et Radix Notopterygii 10g, Mangnolia officinalis 12g, macleaya cordata 8g;Above-mentioned raw materials are mixed Conjunction is uniformly put into medicine decocting tank, uses instead after the distilled water decoction boiling of 8 times of raw material weight amounts of addition into tank and is cooked by slow fire 1h, during which begins 8 times of amount water are kept eventually, and with 4 layers of filtered through gauze: residue adds 6 times of amount water with filtering after method decoction 1h, merges filtrate twice, depressurizes dense Contracting, makes its concentration 1g/ml.
(2) haemophilus paragallinarum is seeded to culture medium by the preparation of bacterium solution, and 37 DEG C of stationary cultures are for 24 hours.With sterilizing blank training It supports base and corrects bacterial concentration, make viable count 1-2 × 108CFU/ml, it is spare.
(3) minimum inhibitory concentration (minimal inhibition concentration, MIC) measures
It is carried out using test tube doubling dilution, determines Chinese medicine minimum inhibitory concentration (minimal inhibition concentration,MIC).25, sterile test tube is taken to be numbered, every pipe adds culture medium 2mL, in the first pipe in addition Medical fluid 2mL takes out 2mL and is put into the second pipe, and so on, it is discarded until the 23rd pipe takes out 2.0ml;Medical fluid is not added in 24th pipe, makees For positive control, the 25th pipe takes out 2.0ml and discards, be not added as negative control, the 25th pipe plus tested medical fluid 2.0ml after mixing Bacterium respectively manages parallel 3 parts as negative control.I.e. the concentration of drug is (1g/mL, 500mg/mL, 250mg/mL, 125mg/ mL、62.5mg/mL、31.25mg/m L、15.63mg/mL、7.81mg/mL、3.95mg/mL、1.98mg/mL、0.99mg/mL、 0.49mg/mL、0.25mg/mL、0.12mg/mL、0.06mg/mL、0.03mg/mL、15.43μg/mL、7.71μg/mL、3.86μ G/mL, 1.93 μ g/mL, 0.97 μ g/mL, 0.48 μ g/mL, 0.24 μ g/mL), 10 μ L (10 of bacterium solution is added in 1~24 pipe8CFU/m L), every kind of medicine does 3 and takes its average value in parallel, be placed in 37 DEG C of constant incubators and cultivate 24-48h, observes result.Sterile life Long region is the smallest Mlc (MIC) of the medicine.
(4) minimum bactericidal concentration (minimal bacteriocidal concentration, MBC) measures
Culture in each dilution tube for more than MIC endpoint concentration not growing bacterium is inoculated with aseptic cotton carrier streaking inoculation It is cultivated for 24 hours on culture medium, being placed in 37 DEG C of constant incubators, observes result.3 tests are averaged.
(5) 2 be the results are shown in Table.
A kind of Chinese medicine composition test result for treating chicken wind-cold type infective rhinitis of table 2
As shown in Table 2, a kind of Chinese medicine composition for treating chicken wind-cold type infective rhinitis of the invention is thermophilic to secondary chicken Blood bacillus tool has a better effect.
Embodiment 12: clinical application effect
Case 1:2017 June 19, there are 10 30,000 laying hens in Henan Province chicken farm, wherein 235 days of 2 henhouses Age 6000 laying hens morbidity, describes according to chicken house technical superintendent, morbidity in first day only more than 20, on disease incidence is unexpected within second day It rising, third day involves full group, disease incidence 100%, and dead more than 150.Morbidity chicken eyelid swelled, there is a head swelling;Nasal cavity Inside there is slurries sexual secretion, chicken, which gets rid of head, secretion outflow, and night can hear sound of stridulating in henhouse, and diseased chicken arranges yellow-white or yellowish green Color loose stool, appetite stimulator;Laying rate decline.Dissect changes visible nasal cavity and congestion of nasal sinus, redness, there is a large amount of viscous secretions; Oral cavity, larynx, tunica mucosa tracheae are congested, have volume mucus, air bag muddy, thicken, some has cheesy object;Lungs extravasated blood, darkly It is red;Liver enlargement, matter are crisp.Haemophilus paragallinarum, wind-cold rhinitis are diagnosed as through pathogen separation, identification.With one kind of the invention For treating the Chinese medicine composition 500g of chicken wind-cold type infective rhinitis, 2 tons are watered, twice a day, chicken is allowed freely to drink, is used in conjunction 5 days, medication the 2nd day chicken group's state of an illness mitigated, and diet is intended to increase, and the state of an illness is controlled within the 4th day, and egg production bottom out is to normal.
Case 2:2017 November 21,6000 50 age in days chickens morbidity of Henan Province's chicken house raising.Diseased chicken is stridulated Sound is coveted drink and is intended to, and body temperature increases, and sneezing, morbidity third day disease incidence only, is diagnosed as chronic respiratory up to 60%, dead more than 70 Disease.It separated, be accredited as haemophilus paragallinarum, anemopyretic.It is a kind of for treating chicken anemopyretic infective rhinitis's with the present invention Chinese medicine powder 200g is watered 1 ton, is used in conjunction 5 days, and symptom disappears after 5 days, and chicken group restores normal.
Case 3:2018 September 11 days, the 18000 95 age in days chickens morbidities of Henan Province's chicken house.Diseased chicken just starts to flow slurries Property nose liquid, subsequent apocenosis nose liquid, facial edema.It separated, cultivate and be diagnosed as infective rhinitis, anemopyretic.With the present invention one Kind is watered 4 tons for treating the Chinese medicine powder 1kg of chicken anemopyretic infective rhinitis, is used in conjunction 5 days, and symptom disappears after 4 days, Chicken group restores normal.
The above be preferred embodiments of the invention, all equivalent variationss done according to scope of the present invention patent with repair Decorations, all should belong to protection scope of the present invention.

Claims (6)

1. a kind of for treating the Chinese medicine composition of infectious coryza of chicken, which is characterized in that including following raw material: flower bud of lily magnolia 5-20 Part, 4-18 parts of rhizoma anemarrhenae, 7-15 parts of Cortex Phellodendri, 10-18 parts of the root of straight ladybell, 5-12 parts of radix aucklandiae, 2-10 parts of alum, 1-10 parts of fructus viticis, Rhizoma Et Radix Notopterygii 10-25 parts, 5-15 parts of rhizome of chuanxiong, 3-10 parts of schizonepeta, 5-25 parts of chrysanthemum, 10-20 parts of honeysuckle, 5-20 parts of Radix Glycyrrhizae, 3-10 parts of Mangnolia officinalis, 5-20 parts of great burdock achene, 8-15 parts of lophatherum gracile.
2. according to claim 1 a kind of for treating the Chinese medicine composition of infectious coryza of chicken, which is characterized in that including Following raw material: 10-15 parts of the flower bud of lily magnolia, 10-18 parts of rhizoma anemarrhenae, 10-15 parts of Cortex Phellodendri, 12-18 parts of the root of straight ladybell, 5-8 parts of radix aucklandiae, alum 5-10 Part, it is 1-5 parts of fructus viticis, 15-25 parts of Rhizoma Et Radix Notopterygii, 8-15 parts of rhizome of chuanxiong, 5-10 parts of schizonepeta, 15-25 parts of chrysanthemum, 15-20 parts of honeysuckle, sweet It is 15-20 parts careless, 3-7 parts of Mangnolia officinalis, 10-20 parts of great burdock achene, 10-15 parts of lophatherum gracile.
3. a kind of for treating the Chinese medicine composition of infectious coryza of chicken, which is characterized in that including following raw material: Chinese ephedra 5-20 Part, it is 5-15 parts of the root of straight ladybell, 5-10 parts of monkshood, 7-15 parts windproof, 10-20 parts of the achene of Siberian cocklebur, 3-10 parts of radix aucklandiae, 8-20 parts of ramulus cinnamomi, wild pepper It is 5-15 parts sub-, 7-12 parts of schizonepeta, 5-15 parts of almond, 2-10 parts of radix bupleuri, 5-15 parts of Radix Angelicae Pubescentis, 5-15 parts of Rhizoma Et Radix Notopterygii, 10-15 parts of Mangnolia officinalis, 5-10 parts of macleaya cordata.
4. according to claim 3 a kind of for treating the Chinese medicine composition of infectious coryza of chicken, which is characterized in that including Following raw material: it is 15-20 parts of Chinese ephedra, 5-10 parts of the root of straight ladybell, 5-8 parts of monkshood, 10-15 parts windproof, 10-15 parts of the achene of Siberian cocklebur, radix aucklandiae 3-8 Part, 8-15 parts of ramulus cinnamomi, 12-15 parts of fructus viticis, 7-10 parts of schizonepeta, 10-15 parts of almond, 5-10 parts of radix bupleuri, 10-15 parts of Radix Angelicae Pubescentis, Qiang It is 10-15 parts, 12-15 parts of Mangnolia officinalis, 5-8 parts of macleaya cordata living.
5. a kind of according to any one of claims 1-4 for treating the preparation side of the Chinese medicine composition of infectious coryza of chicken Method, which comprises the following steps:
(1) it weighs each raw material respectively in proportion, raw material is put into medicine decocting tank, the pure of 10 times of raw material weight amounts is added into tank Water impregnates 2h;
(2) first time decoction is carried out after impregnating, is filtered after decocting 1h, is stayed and is decocted filtrate for the first time;Add again into filter residue The pure water for entering 10 times of amounts carries out secondary decoction, and second of decoction filtrate is stayed in filtering after decocting 1h;
(3) merge and decoct gained filtrate twice, be condensed into medicinal extract, gained medicinal extract is dried, powder is sprayed into;
(4) filter residue is dried and is crushed, be uniformly mixed with the dry gained powder of filtrate, packing pack.
6. a kind of according to any one of claims 1-4 for treating the preparation side of the Chinese medicine composition of infectious coryza of chicken Method, which comprises the following steps:
(1) it weighs each raw material respectively in proportion, raw material is put into medicine decocting tank, the 60% of 10 times of raw material weight amounts is added into tank Ethyl alcohol impregnates 2 h;
(2) first time decoction is carried out after impregnating, is filtered after decocting 1h, is stayed and is decocted filtrate for the first time;10 are added into filter residue again 60% ethyl alcohol of amount carries out secondary decoction again, and second of decoction filtrate is stayed in filtering after decocting 1h;
(3) merge and decoct gained filtrate twice, be condensed into medicinal extract, gained medicinal extract is dried, powder is sprayed into;
(4) filter residue is dried and is crushed, be uniformly mixed with the dry gained powder of filtrate, packing pack.
CN201811511336.9A 2018-12-11 2018-12-11 Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken Pending CN109331126A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1958023A (en) * 2005-10-31 2007-05-09 天津市润拓生物技术有限公司 Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method
CN101007133A (en) * 2007-01-23 2007-08-01 天津生机集团有限公司 Drug for treating infectious rhinitis of avian and its preparation method
CN101757314A (en) * 2008-10-30 2010-06-30 天津生机集团股份有限公司 Traditional Chinese medicine composition for preventing and treating infectious coryza of chicken and preparation method thereof
CN103181970A (en) * 2011-12-27 2013-07-03 瑞普(天津)生物药业有限公司 Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method for same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1958023A (en) * 2005-10-31 2007-05-09 天津市润拓生物技术有限公司 Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method
CN101007133A (en) * 2007-01-23 2007-08-01 天津生机集团有限公司 Drug for treating infectious rhinitis of avian and its preparation method
CN101757314A (en) * 2008-10-30 2010-06-30 天津生机集团股份有限公司 Traditional Chinese medicine composition for preventing and treating infectious coryza of chicken and preparation method thereof
CN103181970A (en) * 2011-12-27 2013-07-03 瑞普(天津)生物药业有限公司 Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method for same

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