CN102836417B - Drug composition for treating white scour of piglets and preparation method thereof - Google Patents
Drug composition for treating white scour of piglets and preparation method thereof Download PDFInfo
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- CN102836417B CN102836417B CN201210367930.1A CN201210367930A CN102836417B CN 102836417 B CN102836417 B CN 102836417B CN 201210367930 A CN201210367930 A CN 201210367930A CN 102836417 B CN102836417 B CN 102836417B
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Abstract
The invention discloses a drug composition for treating white scour of piglets and a preparation method thereof. The drug composition mainly comprises the following raw materials in parts by weight: 200 parts of radix isatidis, 200 parts of baical skullcap root, 200 parts of amur corktree bark, 100 parts of rheum officinale, 200 parts of rhizoma coptidis, 100 parts of liquorice, 10-20 parts of tannalbin and 10-20 parts of montmorillonite. The drug composition is obtained through extraction, concentration and drying. The drug has the advantages of quick effect, good prevention and treatment effects, low cost and simple preparation method and is easy to popularize and apply.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition being used for the treatment of piglet pujos blancos and preparation method thereof, belong to veterinary drug technical field.
Background technology
Piglet pujos blancos is the infectious disease that a kind of piglet caused by pathogenic colon bacillus often sends out, and is multiplely born in 10 ~ 30 age in days piglets, and sickness rate is high, and mortality rate is low, has a strong impact on the growth promoter of piglet.If treatment time not in time or Therapeutic Method imappropriate, then very easily form cad pig, thus reduce the price of deed, affect the economic benefit of raising pigs.At present, when there is no effective vaccine and preventing and treating this disease, Drug therapy is still the Main Means of this disease of control, and great majority use antibiotic, but due to antibacterials abuse clinically, causes Resistant strain to produce in a large number.Traditional Chinese veterinary medicine thinks that primary disease is that carcass is subject to damp and hot invasion and attack, and taste are not normal, invade in epidemic disease poison, cause intestinal clear QI being mixed up with turbid QI, the wet bet of water and rawly to have loose bowels.Theoretical and the clinical treatment by Chinese herbs practice according to traditional Chinese veterinary medicine; filter out with heat-clearing and toxic substances removing, anti-inflammation, the solid intestinal of dysentery relieving for master be that treatment by Chinese herbs disease is except antibacterial; also can reach by other approach; as resist colon bacillus the enterotoxin that produces; with the mucoprotein formation protecting film in intestinal mucosa surface, the physiological Mechanism of adjustment biological organs.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition being used for the treatment of piglet pujos blancos.
Another object of the present invention is also to provide a kind of preparation method being used for the treatment of the pharmaceutical composition of piglet pujos blancos.
To achieve these goals, the present invention is by the following technical solutions:
Treat a pharmaceutical composition for piglet pujos blancos, comprise the raw material of following parts by weight: Radix Isatidis 200 parts, Radix Scutellariae 200 parts, Cortex Phellodendri 200 parts, Radix Et Rhizoma Rhei 100 parts, Rhizoma Coptidis 200 parts, 100 parts, Radix Glycyrrhizae, tannalbin 10 ~ 20 parts, Montmorillonitum 10 ~ 20 parts.
Parts by weight the best of primary raw material is: Radix Isatidis 200 parts, Radix Scutellariae 200 parts, Radix Et Rhizoma Rhei 100 parts, Rhizoma Coptidis 200 parts, Cortex Phellodendri 200 parts, 100 parts, Radix Glycyrrhizae, tannalbin 10 parts, Montmorillonitum 15 parts.
The preparation method of medicament composition granule agent of the present invention is:
Weigh Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Isatidis, Radix Scutellariae, Radix Glycyrrhizae 6 kinds of raw materials, decoct with water 2 times, 2 ~ 3 hours first times, second time 1 ~ 2 hour, collecting decoction, filter, filtrate is concentrated into thick paste, adds tannalbin, Montmorillonitum, white sugar 700 parts and 200 parts, dextrin, makes granule, drying, to obtain final product.
Montmorillonitum of the present invention is to pathogenic bacterium, viruses (especially rotavirus) such as Escherichia coli, golden Portugal mattress, V.cholerae, helicobacter pylori, jejunum campylobacter mattresses. and toxin, gas etc. that they produce have extremely strong absorption, fixing, inhibitory action, the alimentary canal mucous membrane epithelium regeneration making it lose pathogenic Montmorillonitum also can to promote to damage. repair the intercellular bridge of damage, impel cell tight junction: reduce the movement disorder of enterocyte. recover the normal rhythm of enterokinesia. safeguard conveying and the absorption function of intestinal; Alleviate child due to the normal mattress group of osmotic diarrhea balance intestinal that disaccharidase in intestinal reduces or shortage causes glycolipid dyspepsia and causes, improve gastral immunologic function.Do not change at gastric after Montmorillonitum is for oral administration, also do not present effect, enter enteral and meet alkaline intestinal juice, be then gradually decomposed into tannic acid and albumen, and present convergence antiinflammatory, anti-diarrhea effect; Leukocyte and adjustment immunologic function can be improved; Convergence protection Chang wall Zu Zhi ﹑ coagulated protein, reduces rheuminess, thus improves intestinal resistance, protection intestinal mucosa.This effect is relatively more lasting, can reach intestinal rear portion.Four yellow Zhili granules are mainly based on antibacterial, auxiliary with intestinal regeneration agent tannalbin, and Montmorillonitum reaches treating both the principal and secondary aspects of a disease effect jointly to the absorption of bacterial virus.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described.
Embodiment 1
Raw material forms: Radix Isatidis 200g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g, Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Glycyrrhizae 100g, tannalbin 10g, Montmorillonitum 15g.
Preparation method is as follows:
Radix Isatidis 200g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g, Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Glycyrrhizae 100g decoct with water 2 times, 2 hours first times, second time 1 hour, collecting decoction, filter, filtrate is concentrated into thick paste, adds tannalbin, Montmorillonitum, white sugar 700g and dextrin 200g, make granule, be drying to obtain.
Embodiment 2
Raw material forms: Radix Isatidis 200g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g, Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Glycyrrhizae 100g, tannalbin 20g, montmorillonite 2 0g.
Preparation method is as follows:
Radix Isatidis 200g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g, Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Glycyrrhizae 100g decoct with water 2 times, 3 hours first times, second time 2 hours, collecting decoction, filter, filtrate is concentrated into thick paste, adds tannalbin, Montmorillonitum, white sugar 700g and dextrin 200g, make granule, be drying to obtain.
Embodiment 3
Raw material forms: Radix Isatidis 200g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g, Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Glycyrrhizae 100g, tannalbin 15g, Montmorillonitum 10g.
Preparation method is as follows:
Radix Isatidis 200g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g, Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Glycyrrhizae 100g decoct with water 2 times, 2.5 hours first times, second time 1.5 hours, collecting decoction, filter, filtrate is concentrated into thick paste, adds tannalbin, Montmorillonitum, white sugar 700g and dextrin 200g, make granule, be drying to obtain.
Animal experiment
1 materials and methods
1.1 trial drug
Trial drug: test group 1: add the yellow Zhili granule of taste four, the medicine prepared by above-described embodiment 1;
Test group 2: add the yellow Zhili granule of taste four, the medicine prepared by above-described embodiment 2;
Test group 3: add the yellow Zhili granule of taste four, the medicine prepared by above-described embodiment 3;
Control drug
Matched group 1: enrofloxacin soluble powder is produced by Zhengzhou Houyi Pharmaceutical Co., Ltd., lot number: 20090110;
The yellow Zhili granule of matched group 2: four is produced by Zhengzhou Houyi Pharmaceutical Co., Ltd., lot number: 20090316.Preparation method: Radix Isatidis 200g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g, Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Glycyrrhizae 100g decoct with water 2 times, 2.5 hours first times, second time 1.5 hours, collecting decoction, filter, filtrate is concentrated into thick paste, adds white sugar 700g and dextrin 200g, make granule, be drying to obtain.
1.2 Antigen isolation and identification
Gather feces with disinfecting silk or cotton swab from the frank sick pig rectum of Hakuri, be inoculated on Mai Kangkai flat board, cultivate 24 ~ 48h for 37 DEG C, the brick-red bacterium colony that picking is smooth, after several separation and purification, is inoculated on ordinary broth culture fluid and nutrient agar panel.
The 1.3 external mattresses that press down are tested
1.3.1 the preparation of pharmaceutical composition of the present invention
Add the yellow Zhili granule of taste four and four yellow Zhili granules, add equivalent water dissolution, be loaded in clean triangular flask, sterilizing is for subsequent use.
1.3.2 the extracorporeal bacteria inhibitor test of herbal mixture
Criterion: antibacterial circle diameter≤10mm is drug resistance, 10 ~ 15mm is medium sensitivity, and >=15mm is extremely sensitive.
The agar culture medium being coated with pathogen punches, and at the bottom of hole, add the sterilizing agar dissolved a little, to seal at the bottom of hole, the solution that the four yellow Zhili granules that prepare shake up is added respectively in hole, be advisable to fill it up with not overflow, put after cultivating 24h in 37 DEG C of incubators, measure antibacterial circle diameter.Test result is in table 1.
Four yellow Zhili granules are respectively 11.0mm and 12.5mm with the average diameter of inhibition zone adding the yellow Zhili granule of taste four, and establishing criteria is judged to be medium sensitivity, four yellow Zhili granules are described and add the yellow Zhili granule of taste four have certain inhibitory action to colon bacillus.
1.3.3 the drug sensitive test of antimicrobial drug
Enrofloxacin, ciprofloxacin, ceftazidime, rifampicin, cephazolin, furazolidone, ampicillin, ceftriaxone sodium, spectinomycin, norfloxacin is selected to carry out drug sensitive test.Result of the test is in table 1.
Enrofloxacin, ceftriaxone sodium, ring receive the third husky star, cephazolin is Gao Min; Ceftazidime, ampicillin, spectinomycin, norfloxacin are quick in being; Rifampicin is drug resistance.Therefore select enrofloxacin medicine as a control group.
1.4 animal experiment
1.4.1 Antigen isolation and identification is through test for identification, and the antibacterial be separated to from morbidity piglet feces is pathogenic colon bacillus.
1.4.2 test method
Add the therapeutic test of the yellow Zhili granule of taste four to piglet pujos blancos and choose 10 ~ 30 age in days generation Hakuri and the obvious piglet of clinical symptoms 140, according to the principle that disease time, age in days, severity extent, body condition are relatively consistent, adopt the method for grouping in nest, the piglet suffering from Hakuri is divided into 4 groups at random, often organizes 70.Test group 1 pig gavages the medicine prepared by embodiment 1, and every each 10g, is dissolved in 5mL warm water and gavages, and every day 2 times, is used in conjunction 3d; Test group 1 pig gavages medicine prepared by embodiment 2, and every each 5g, is dissolved in 5mL warm water and gavages, and every day 2 times, is used in conjunction 3d; Test group 1 pig gavages medicine prepared by embodiment 3, and every each 2.5g, is dissolved in 5mL warm water and gavages, and every day 2 times, is used in conjunction 3d.
The specific drug enrofloxacin soluble powder treatment of matched group 1 pig, every pig 1.2g, is dissolved in 5mL warm water and gavages, and every day 2 times, is used in conjunction 3d.
The yellow Zhili granule of matched group 2: four, every each 10g, is dissolved in 5mL warm water and gavages, and every day 2 times, is used in conjunction 3d.1.4.3 curative effect determinate standard
After testing 1 course for the treatment of of disease pig medication, feces, spirit, appetite recover normal.Effective: after testing 1 course for the treatment of of disease pig medication, pellet morphology takes a turn for the better, and number of times of having loose bowels reduces, and appetite takes a turn for the better.Invalid: after testing 1 course for the treatment of of disease pig medication, symptom is not improved, even to increase the weight of or dead.
1.4.4 date processing
The significance test of data is carried out, cure rate, total effective rate X 2 test with statistical method.
The therapeutic test of medicine of the present invention to piglet pujos blancos the results are shown in Table 2, although the total effective rate of test group and matched group 1, matched group 2 is all without difference, with regard to cure rate, the two difference extremely significantly (P<0.01).Test group dosetest group effective percentage and cure rate are without difference.
Table 1 antibacterials are to the fungistatic effect being separated Enteropathogenic Escherichia coli
The clinical effectiveness of table 2 piglet pujos blancos
Piglet pujos blancos is primarily of caused by pathogenic colon bacillus, and the source of infection normally carries disease germs sow, and pathogenic colon bacillus is after sow excretes, intersperse among colony house, pollute nipple and the skin of sow, when piglet is sucked the breast or licks sow skin, direct oral cavity infects.Add taste four yellow Zhili granule In Vitro Bacteriostasis result to show, they have certain inhibitory action to pathogenic colon bacillus.From fungistatic effect, the effect of trial drug compositions is not as enrofloxacin, but cure rate is apparently higher than enrofloxacin (P<0.01).Its reason may be that to control its reason may be that treatment by Chinese herbs disease is except antibacterial to Chinese medicine; also can reach by other approach; as resist colon bacillus the enterotoxin that produces, with the mucoprotein formation protecting film in intestinal mucosa surface, the physiological Mechanism etc. of adjustment biological organs.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical composition of piglet pujos blancos, it is characterized in that: the raw material comprising following parts by weight: Radix Isatidis 200 parts, Radix Scutellariae 200 parts, Cortex Phellodendri 200 parts, Radix Et Rhizoma Rhei 100 parts, Rhizoma Coptidis 200 parts, 100 parts, Radix Glycyrrhizae, tannalbin 10 parts, Montmorillonitum 15 parts.
2. a kind of pharmaceutical composition being used for the treatment of piglet pujos blancos as claimed in claim 1, is characterized in that: the dosage form product dosage form of described pharmaceutical composition can be acceptable dosage form on oral liquid, powder, tablet, granule, injection or other pharmaceutics.
3. a kind of pharmaceutical composition being used for the treatment of piglet pujos blancos as claimed in claim 1, is characterized in that: the dosage form of described pharmaceutical composition is granule.
4. one kind is used for the treatment of the preparation method of the pharmaceutical composition of piglet pujos blancos as claimed in claim 3, it is characterized in that: preparation method is: weigh Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Isatidis, Radix Scutellariae, Radix Glycyrrhizae 6 kinds of raw materials, decoct with water 2 times, 2 ~ 3 hours first times, second time 1 ~ 2 hour, collecting decoction, filter, filtrate is concentrated into thick paste, add tannalbin, Montmorillonitum, white sugar 700 parts and 200 parts, dextrin, make granule, dry, to obtain final product.
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| CN101138572A (en) * | 2006-09-08 | 2008-03-12 | 周伯根 | Medicament for treating children lax |
| CN101590139A (en) * | 2008-05-30 | 2009-12-02 | 天津生机集团股份有限公司 | A kind of preparation method of preventing and treating the Chinese medicine compound four yellow dysentery stopping preparations of livestock and poultry intestinal canal diseases |
| CN102008585A (en) * | 2009-09-08 | 2011-04-13 | 河南惠通天下动物药业有限公司 | Sihuang anti-dysentery effervescent particle and preparation method thereof |
| CN102406659A (en) * | 2011-09-30 | 2012-04-11 | 广东紫金正天药业有限公司 | Medical composition for treating piglet diarrhea |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138572A (en) * | 2006-09-08 | 2008-03-12 | 周伯根 | Medicament for treating children lax |
| CN101590139A (en) * | 2008-05-30 | 2009-12-02 | 天津生机集团股份有限公司 | A kind of preparation method of preventing and treating the Chinese medicine compound four yellow dysentery stopping preparations of livestock and poultry intestinal canal diseases |
| CN102008585A (en) * | 2009-09-08 | 2011-04-13 | 河南惠通天下动物药业有限公司 | Sihuang anti-dysentery effervescent particle and preparation method thereof |
| CN102406659A (en) * | 2011-09-30 | 2012-04-11 | 广东紫金正天药业有限公司 | Medical composition for treating piglet diarrhea |
Non-Patent Citations (1)
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| 蒙脱石-安全高效的止泻药;赵民生;《药物与人》;20070701;29 * |
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Address after: 451162 Zhengzhou economic comprehensive experimentation area, Zhengzhou air port, Henan, Xingang Province Patentee after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451162 Xingang, Henan, Zhengzhou, Hong Kong airport on the eastern side of the road on the eastern side of Zhengzhou Patentee before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |