CN106937966B - Stomach nourishing paste and preparation method thereof - Google Patents

Stomach nourishing paste and preparation method thereof Download PDF

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CN106937966B
CN106937966B CN201710306886.6A CN201710306886A CN106937966B CN 106937966 B CN106937966 B CN 106937966B CN 201710306886 A CN201710306886 A CN 201710306886A CN 106937966 B CN106937966 B CN 106937966B
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mixing
baking soda
alum
honey
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常桂秋
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/288—Taraxacum (dandelion)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A—HUMAN NECESSITIES
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention relates to the field of traditional Chinese medicines, and in particular relates to stomach nourishing paste and a preparation method thereof. The stomach nourishing paste is prepared from various raw materials. The raw materials comprise, by weight, 15-25 parts of honey, 0.5-0.8 part of alum, 0.8-1.5 parts of baking soda, 1-2 parts of kudzu root, 0.5-1.5 parts of tuckahoe and 0.8-1.2 parts of liquorice. The stomach nourishing paste has the advantages of regulating stomach function, regulating gastric acid secretion, protecting gastric mucosa, promoting gastrointestinal peristalsis, protecting stomach, promoting normal gastric acid secretion, inhibiting growth of pathogenic bacteria, and improving immunity.

Description

Stomach nourishing paste and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to stomach nourishing paste and a preparation method thereof.
Background
Gastropathy is the general term for many stomach related diseases. They have similar symptoms such as epigastric discomfort, pain, fullness after meals, eructation, acid regurgitation, even nausea, vomiting, etc. The common stomach diseases clinically include acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastroduodenal complex ulcer, gastric polyp, gastric calculus, benign and malignant tumors of stomach, prolapse of gastric mucosa, acute gastric dilatation, pyloric obstruction and the like.
In life, because food eaten by human bodies contains a plurality of pathogenic bacteria, the food can not be completely removed by cleaning or high temperature, and meanwhile, the stomach illness is difficult to recover and easy to relapse because the Chinese people are not used to use public chopsticks and the tableware of one family. The existing medicine for treating the gastropathy only can relieve single symptoms of the gastropathy, but cannot relieve multiple symptoms by one medicine, and meanwhile, the treatment effect is poor.
Disclosure of Invention
The invention aims to provide stomach nourishing paste which has obvious curative effects on nausea, vomiting, regurgitation, fullness, pain, eructation and the like caused by gastric mucosa injury, helicobacter pylori flora superstandard, hyperacidity and the like.
The invention also aims to provide a preparation method of the stomach nourishing paste, and the stomach nourishing paste can be quickly prepared by the preparation method.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
the invention provides a stomach nourishing paste which is prepared from a plurality of raw materials. The raw materials comprise, by weight, 15-25 parts of honey, 0.5-0.8 part of alum, 0.8-1.5 parts of baking soda, 1-2 parts of kudzu root, 0.5-1.5 parts of tuckahoe and 0.8-1.2 parts of liquorice.
The invention provides a preparation method of stomach nourishing paste, which comprises the following steps:
1-2 parts of kudzuvine root, 0.5-1.5 parts of tuckahoe and 0.8-1.2 parts of liquorice are decocted and concentrated to obtain concentrated solution.
Under the heating condition, 0.5 to 0.8 portion of alum, water and concentrated solution are mixed and then mixed with 15 to 25 portions of honey, and 0.8 to 1.5 portions of baking soda are added in batches and mixed evenly.
The stomach nourishing paste has the beneficial effects that: the stomach nourishing paste provided by the invention utilizes the combined action of 15-25 parts of honey, 0.5-0.8 part of alum, 0.8-1.5 parts of baking soda, 1-2 parts of kudzu root, 0.5-1.5 parts of tuckahoe and 0.8-1.2 parts of liquorice to regulate stomach function, regulate gastric acid secretion, protect gastric mucosa, promote gastrointestinal tract peristalsis, protect stomach, promote normal gastric acid secretion, inhibit germ growth and improve human immunity. Meanwhile, the mutual action of the raw materials can offset the toxic and side effects of the raw materials or other raw materials, reduce the adverse symptoms after the stomach nourishing paste is taken, and reduce the occurrence probability of the adverse symptoms.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
In the description of the present invention, it should be noted that the terms "first", "second", and the like are used only for distinguishing the description, and are not intended to indicate or imply relative importance.
The stomach nourishing paste and the preparation method thereof according to the embodiment of the present invention will be specifically described below.
The stomach nourishing paste provided by the embodiment of the invention is prepared from various raw materials. The raw materials comprise, by weight, 15-25 parts of honey, 0.5-0.8 part of alum, 0.8-1.5 parts of baking soda, 1-2 parts of kudzu root, 0.5-1.5 parts of tuckahoe and 0.8-1.2 parts of liquorice. Preferably, the raw materials comprise 18-22 parts of honey, 0.5-0.6 part of alum, 1-1.2 parts of baking soda, 1-1.5 parts of kudzu root, 0.8-1.2 parts of tuckahoe and 0.8-1.2 parts of liquorice.
When the raw materials in the stomach nourishing paste are in the proportion, the synergistic effect among the components can achieve the best effect, and the effect or the function of each component is reduced and the synergistic effect among the components is reduced or even disappears when the proportion is more than or less than the proportion recorded in the embodiment of the invention. The alum can react with the baking soda to generate aluminum hydroxide, and the aluminum hydroxide can neutralize gastric acid by using the alkalinity of the aluminum hydroxide, so that the problem of excessive gastric acid secretion is reduced, and the stomach pain is relieved. Meanwhile, the alum has the bacteriostatic effect and can inhibit the growth of helicobacter pylori, so that the symptom of stomachache is relieved. The baking soda also has the effect of neutralizing gastric acid, and further inhibits gastric acid secretion. But the alum has slight toxicity, the liquorice can detoxify and reduce the toxicity and side effect of the stomach nourishing paste, and meanwhile, the liquorice has the similar adrenocortical hormone-like effect and has the inhibition effect on hyperacidity caused by histamine; it also has antacid and spasmodic effects on smooth muscle of stomach and intestine. Therefore, it can further alleviate the symptoms of gastric discomfort. Meanwhile, the sodium bicarbonate can generate carbon dioxide after the reaction of a human body and acid, and the carbon dioxide stimulates gastric mucosa to trigger excessive gastric acid secretion. The added honey can form a protective layer on gastric mucosa and prevent the stimulation of carbon dioxide on the gastric mucosa. The kudzu root, the tuckahoe and the like can also interact with the raw materials to relieve the side effect of a single medicament, and simultaneously play a role in treating stomach diseases or relieving stomach discomfort. The synergistic effect of the raw materials can play the effect of the traditional Chinese medicine, simultaneously reduce the toxic and side effects of other medicines, increase the treatment effect of other medicines, and relieve and even treat various stomach symptoms or stomach diseases through the interaction of various raw materials.
The honey is yellow white sticky liquid which is obtained by collecting nectar from bees and naturally fermenting. The honey has effects of improving blood components, promoting heart and brain and blood vessel, maintaining liver, promoting liver regeneration, and sterilizing. In the embodiment of the invention, the honey has the functions of inhibiting bacteria and preventing infection, and meanwhile, the honey can enhance enterokinesia, shorten defecation time, regulate gastrointestinal tract function and promote normal gastric acid secretion. And various enzymes and minerals in the honey act synergistically, so that the immunity of a human body can be improved, the resistance of the human body to germs can be improved, and the damage of carbon dioxide to gastric mucosa can be reduced.
Alum is crystal extracted from mineral alunite. The main chemical component is aluminum potassium sulfate dodecahydrate. Mineral Chinese medicine, can detoxify and kill parasites, eliminate dampness and relieve itching by external use; internal use can stop bleeding, check diarrhea and resolve phlegm. Alum is sour and astringent in taste, cold, slightly toxic and edible in small amount. In the embodiment of the invention, the alum mainly plays a role in inhibiting the growth of helicobacter pylori, and simultaneously reacts with sodium bicarbonate to generate aluminum hydroxide so as to neutralize gastric acid.
Baking soda, also known as sodium bicarbonate, is an acid salt generated by neutralizing a strong base with a weak acid, and is weakly alkaline when dissolved in water. It is easily decomposed by heating and slowly decomposed in humid air. Can be directly used as raw material in pharmaceutical industry for treating hyperacidity. In the embodiment of the invention, the medicine reacts with gastric acid to relieve symptoms such as pain, heartburn and vomiting caused by the gastric hyperacidity. Meanwhile, the aluminum hydroxide is generated by the reaction with the alum to further neutralize the gastric acid.
Pueraria lobata (Willd.) Ohwi is dry root of Pueraria lobata Ohwi of Leguminosae, and is called as Pueraria lobata Ohwi. It has effects of relieving muscles and fever, promoting eruption, promoting fluid production to quench thirst, invigorating yang and relieving diarrhea, and can be used for treating fever due to exterior syndrome, neck and back pain, measles without adequate eruption, fever thirst, yin deficiency wasting thirst, heat diarrhea and dysentery, and spleen deficiency diarrhea. The kudzu root has the effects of promoting metabolism, strengthening the detoxification function of the liver and protecting gastric mucosa from being damaged to a certain extent.
Poria is dried sclerotium of Wolf of Poria cocos (Schw.) belonging to Polyporaceae. It has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. In the embodiment of the invention, the tuckahoe can invigorate the stomach, extract water retention in the stomach, improve gastric motility and simultaneously has a protective effect on gastric mucosa injury.
Licorice, academic name: glycyrrhiza uralensis Fisch alias: radix Angelicae Dahuricae, radix Glycyrrhizae, and radix Glycyrrhizae. Leguminous and glycyrrhiza herbs belong to perennial herbs, and the roots and the rhizomes are thick and strong, so that the Chinese herbal medicine is a good tonifying Chinese herbal medicine for human bodies, and the medicinal parts are roots and rhizomes. Licorice root has the similar effect of adrenocortical hormone. Has inhibitory effect on hyperacidity caused by histamine; it also has antacid and spasmodic effects on smooth muscle of stomach and intestine. The glycyrrhiza extract and glycyrrhizic acid have detoxifying effect similar to that of glucuronic acid on certain toxicants. In the practice of the present invention, licorice is mainly used to neutralize the property and effect of each herb. Meanwhile, the composition can inhibit gastric acid secretion, relieve toxicity of each medicament, relieve pain and protect gastric mucosa.
Further preferably, the plurality of raw materials further comprise 0.8-1.2 parts of ginseng. The meat root of ginseng (Panax ginseng c.a.mey) is a well-known tonic, suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects. In the embodiment of the invention, the ginseng can mainly increase the detoxification capability of the liver, thereby enhancing the tolerance of the body to various chemical substances. Meanwhile, the repair of gastric mucosa is promoted, and the damage of gastric acid to mucosa is reduced.
Further preferably, the plurality of raw materials further comprise 0.8-1.2 parts of dandelion. Taraxacum mongolicum hand-Mazz (Taraxacum mongolicum hand.) Taraxacum Mongolicum hand-Mazz (Taraxacum mongolicum hand-Mazz.) Compositae, Taraxacum perennial herb. The dandelion plant contains various health nutritional components such as taraxol, taraxacin, choline, organic acid, inulin, etc., and can be used for treating gastritis, toxic heat, toothache, and conjunctival congestion. The invention is mainly used for sterilizing and diminishing inflammation, relieving stomach pain and protecting gastric mucosa in the embodiment of the invention.
The invention also provides a method for preparing the stomach nourishing paste, which comprises the following steps:
s1, decocting;
according to the weight portion, 1-2 portions of kudzuvine root, 0.5-1.5 portions of tuckahoe and 0.8-1.2 portions of liquorice are respectively crushed into blocks, so that the subsequent extraction of solvent-water to dissolve the effective components in the raw materials is facilitated, and the extraction efficiency and the extraction speed are further improved. Then mixing the crushed raw materials with 120 parts of 100-85 parts of water, and decocting for 2-3 hours at the temperature of 60-85 ℃. Heating is carried out, the dissolving efficiency of the effective components in water is improved, and the extraction speed is accelerated. However, the active ingredient may contain a heat-sensitive substance, and extraction is performed at a medium temperature in order to prevent the heat-sensitive substance from being deteriorated at a high temperature.
It should be noted that the decoction of the kudzu root, the tuckahoe and the liquorice can be carried out after three raw materials are mixed, or 3 raw materials are respectively decocted and then mixed together, and the types and the quantities of the substances extracted by the two decoction modes are basically consistent, so the treatment effects are consistent.
Further preferably, the three raw materials are extracted for a plurality of times to ensure the extraction effect, and preferably, the extraction times are 2-3 times.
Preferably, the decoction obtained by decocting the three raw materials is concentrated by 1/4-1/6 times of the total amount of the decoction. The decoction is concentrated to ensure the content of effective components in the decoction of radix puerariae, poria cocos and liquorice, so that the curative effect of the stomach nourishing paste is improved.
S2, mixing;
mixing 0.5-0.8 part of alum, water and the concentrated solution at 40-60 ℃, wherein the specific mixing mode is to dissolve the alum in the water and then mix the concentrated solution. As the alum is solid, the alum must be dissolved firstly, and then the alum is mixed with the concentrated solution to obtain the mixed solution. Or mixing Alumen with the concentrated solution and mixing with water. Because alum is easy to hydrolyze to obtain aluminum ions after being dissolved in water, the aluminum ions and water form colloidal strong aluminum oxide, and the aluminum hydroxide colloid has strong adsorption capacity, is easy to adsorb suspended substances in water and forms precipitates. The concentrated solution may contain some water-insoluble active ingredients, or active substances which are dissolved out with the temperature being lowered and are partially soluble in water but not high in solubility. If the alum is mixed with the concentrated solution, the alum easily causes insoluble substances in the concentrated solution to settle, and the effective components in the concentrated solution are damaged. If the alum is mixed with the water and then mixed with the concentrated solution, the alum is dissolved in the water firstly to precipitate impurities possibly contained in the water, so that the subsequent effect of the alum and the effective components in the concentrated solution is reduced, and the content of the effective components in the whole mixed solution is ensured.
Then mixing the mixed solution with 15-25 parts of honey, and then adding baking soda in batches. The honey is not easy to be mixed with other substances uniformly due to the large viscosity. If the honey is mixed with other substances, uneven mixing is easily caused, and the effect of the stomach nourishing paste is further reduced. The water has high fluidity, and can be easily mixed with honey. Meanwhile, the baking soda and the alum are mixed and then react to generate carbon dioxide, so that the mixed solution generates a large amount of bubbles, and the uniform mixing of the baking soda is not facilitated, therefore, the baking soda is added in batches, and the uniform mixing of all the raw materials is ensured. The viscosity of the mixture of honey and water is reduced compared with that of honey, but the viscosity is still high on the whole, the baking soda added in batches can only be uniformly mixed with the mixture on the upper layer, meanwhile, a large amount of bubbles are generated, in order to ensure the treatment effect of the stomach nourishing paste, the uniformly mixed liquid on the upper layer is transferred to another container, then the baking soda is added, and then stirring and transferring are carried out. The liquid after multiple transfers also needs to be stirred continuously after being mixed, and the uniform mixing of all the substances is ensured.
Further, the baking soda is added in portions by adding 0.015 to 0.03 part of baking soda to the honey and mixed solution and stirring, at which time a large amount of bubbles are generated, transferring the upper layer liquid to another storage container along with the bubbles, then adding 0.015 to 0.03 part of baking soda and repeating the above steps. The mixture of the upper layer liquid in the storage vessel was stirred until the bubble was small, and natural cooling was performed. Furthermore, the whole heating process lasts for 1-3 hours, the heating time can evenly mix the alum, the water, the concentrated solution, the honey and the baking soda, and simultaneously, the content of effective components contained in the stomach nourishing paste is ensured, and the effect is optimal.
The stomach nourishing paste provided by the invention can effectively regulate stomach function, promote normal gastric acid secretion, inhibit growth of pathogenic bacteria and improve human immunity by using honey as a basic substance. Meanwhile, through the interaction of honey, alum, sodium bicarbonate, kudzu root, tuckahoe and liquorice, the gastric acid secretion is regulated, gastric mucosa is protected, gastrointestinal peristalsis is promoted, and the stomach is protected. Meanwhile, the mutual action of the raw materials can offset the toxic and side effects of the raw materials or other raw materials, reduce the adverse symptoms after the stomach nourishing paste is taken, and reduce the occurrence probability of the adverse symptoms.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The stomach nourishing paste provided by the embodiment is prepared from various raw materials. The raw materials include 20g Mel, 0.8g Alumen, 1g sodium bicarbonate, 1g radix Puerariae, 0.5g Poria and 1g Glycyrrhrizae radix.
The preparation method of the stomach nourishing paste provided by the embodiment comprises the following steps:
pulverizing radix Puerariae 1g, Poria 0.5g and Glycyrrhrizae radix 1g respectively, mixing with water 100g, and decocting at 75 deg.C for 2 hr. Decocting for 2 times. Mixing the decoctions obtained by the two times, and concentrating to 1/4 times of the total amount of the decoctions.
Dissolving 0.8g Alumen in water at 40 deg.C, mixing with the above concentrated solution, and mixing with 20g Mel. Baking soda was then added in portions, 0.025g each, and then the upper layer of liquid was transferred to another storage vessel along with air bubbles. And continuously mixing the upper layer liquid in the container until all the raw materials in the reaction container are completely transferred, and naturally cooling the storage container after the bubbles in the storage container completely disappear. The time for the entire heating process was 2 hours.
Example 2
The stomach nourishing paste provided by the embodiment is prepared from various raw materials. The raw materials include honey 15g, alum 0.6g, baking soda 1.5g, kudzu vine root 1.2g, tuckahoe 1g, liquorice 0.8g and ginseng 1 g.
The preparation method of the stomach nourishing paste provided by the embodiment comprises the following steps:
pulverizing radix Puerariae 1.2g, Poria 1g, Glycyrrhrizae radix 0.8g and Ginseng radix 1g respectively, mixing with 110g water, and decocting at 80 deg.C for 2.5 hr for 3 times. Mixing the decoctions, and concentrating to 1/5 times of total amount.
Dissolving 0.6g Alumen in water at 60 deg.C, mixing with the above concentrated solution, and mixing with 15g Mel. Baking soda was then added in portions, 0.03g each, and then the upper layer of liquid was transferred to another storage vessel along with air bubbles. And continuously mixing the upper layer liquid in the container until all the raw materials in the reaction container are completely transferred, and naturally cooling the storage container after the bubbles in the storage container completely disappear. The time for the entire heating process was 1 hour.
Example 3
The stomach nourishing paste provided by the embodiment is prepared from various raw materials. The raw materials include honey 25g, alum 0.7g, sodium bicarbonate 0.8g, kudzu vine root 2g, tuckahoe 1.2g, liquorice 0.9g, ginseng 0.8g and dandelion 1.2 g.
The preparation method of the stomach nourishing paste provided by the embodiment comprises the following steps:
pulverizing radix Puerariae 2g, Poria 1.2g, Glycyrrhrizae radix 0.9g, Ginseng radix 0.8g and herba Taraxaci 1.2g respectively, mixing with water 120g, decocting at 60 deg.C for 3 hr, and decocting for 3 times respectively. Mixing the decoctions, and concentrating to 1/6 times of total amount.
Dissolving 0.7g of Alumen in water at 50 deg.C, mixing with the above concentrated solution, and mixing with 25g of Mel. Baking soda was then added in portions, 0.015g each, and then the upper layer of liquid was transferred to another storage vessel along with the bubbles. And continuously mixing the upper layer liquid in the container until all the raw materials in the reaction container are completely transferred, and naturally cooling the storage container after the bubbles in the storage container completely disappear. The time for the entire heating process was 3 hours.
Example 4
The stomach nourishing paste provided by the embodiment is prepared from various raw materials. The raw materials include honey 17g, Alumen 0.5g, sodium bicarbonate 1.2g, radix Puerariae 1.5g, Poria 1.5g, Glycyrrhrizae radix 1.2g, Ginseng radix 1.2g and herba Taraxaci 0.8 g.
The preparation method of the stomach nourishing paste provided by the embodiment comprises the following steps:
pulverizing radix Puerariae 1.5g, Poria 1.5g, Glycyrrhrizae radix 1.2g, Ginseng radix 1.2g and herba Taraxaci 0.8g respectively, mixing with water 115g, and decocting at 65 deg.C for 2.5 hr for 2 times. Mixing the decoctions, and concentrating to 1/4 times of total amount.
Dissolving 0.5g Alumen in water at 55 deg.C, mixing with the above concentrated solution, and mixing with 17g Mel. The baking soda was then added in portions, 0.02g each, and then the liquid in the upper layer was transferred to another storage vessel along with air bubbles. And continuously mixing the upper layer liquid in the container until all the raw materials in the reaction container are completely transferred, and naturally cooling the storage container after the bubbles in the storage container completely disappear. The time for the entire heating process was 2.5 hours.
Example 5
The stomach nourishing paste provided by the embodiment is prepared from various raw materials. The raw materials include 22g Mel, 0.65g Alumen, 0.9g sodium bicarbonate, 1.8g radix Puerariae, 0.7g Poria, 1.1g Glycyrrhrizae radix, 0.9g Ginseng radix and 1g herba Taraxaci.
The preparation method of the stomach nourishing paste provided by the embodiment comprises the following steps:
pulverizing radix Puerariae 1.8g, Poria 0.7g, Glycyrrhrizae radix 1.1g, Ginseng radix 0.9g and herba Taraxaci 1g respectively, mixing with 105g water, decocting at 70 deg.C for 3 hr, and decocting for 2 times respectively. Mixing the decoctions, and concentrating to 1/6 times of total amount.
Dissolving 0.65g of Alumen in water at 45 deg.C, mixing with the above concentrated solution, and mixing with 22g of Mel. Baking soda was then added in portions, 0.03g each, and then the upper layer of liquid was transferred to another storage vessel along with air bubbles. And continuously mixing the upper layer liquid in the container until all the raw materials in the reaction container are completely transferred, and naturally cooling the storage container after the bubbles in the storage container completely disappear. The time for the entire heating process was 1.5 hours.
Experimental example 1
The test tube two-fold dilution method was used to perform the in vitro helicobacter pylori inhibition test in examples 1 to 5.
Culture medium: brucella broth: according to the newly compiled culture manual for bacterial examination [ Dupinghua, Lvwen and the newly compiled culture manual for bacterial examination [ M ]. Qingdao; ocean university Press, 1994,106 ]. After Skirrow culture medium is sterilized, TMP antibacterial mixed liquor is added: TMP (sulfa synergist) 5mg, vancomycin 10mg, polymyxin mu and cefuroxime 15 mg.
Separating and culturing helicobacter pylori: uniformly coating gastric mucosa tissue on the prepared Skirrow double discs, and placing the Skirrow double discs in a microaerobic environment at 37 ℃ (adding a catalyst into the German bio-meerieux generdox to form a microaerobic environment with 5% -8% CO2,33.6％H2O). After incubation for 48 hours, the shape, characteristics, color and biochemical reaction of the colony are observed, and a rapid urease experiment is simultaneously carried out.
Preparing bacterial liquid: enriching the identified helicobacter pylori with Brookfield broth for 48 hours, and diluting with 10% glucose solution to 10%-5(about 1000 bacteria per ml).
Preparing a liquid medicine: 10g of the stomach nourishing paste of example 1 to example 5 was weighed out and mixed with 50ml of water to be dissolved, and then transferred to a 100ml volumetric flask, and the volume was determined (1 g of the drug per ml). Sterilizing for 20 minutes for later use.
The method comprises the following steps: 13 sterile test tubes are taken in each group, 1ml of Brookfield broth is added into each test tube, and the liquid medicine of the embodiment is added into the first test tube1ml, sucking 1ml after mixing, adding into a second tube, diluting to a twelfth tube in the same way, taking 1ml from the twelfth tube as a blank control, and adding a bacterium solution 10 into each tube-40.1ml (about 1000 bacteria), mixing, placing in 37 ℃ micro oxygen environment to culture 48 hours, and observing the results. The turbidity of the liquid indicates the presence of bacteria; the liquid is clear, and the liquid still can be clear after shaking up and can grow aseptically. The concentration for sterile growth is the lowest drug concentration. And sequentially taking 1ml of each tube without bacterial growth, adding the tubes into a double-disc, injecting Skirrow culture medium, shaking up, placing the tubes in a microaerobic environment at 37 ℃ for culturing for 72 hours, and observing whether bacteria grow or not, wherein the concentration of the drug with the minimum dilution with the colony count of less than 5 on a plate is the minimum bactericidal concentration. Specific results are shown in table 1.
TABLE 1 results of bacteriostasis
Figure BDA0001285970020000141
Figure BDA0001285970020000151
As can be seen from Table 1, the MIC, MBC and MBC of the stomach nourishing paste of examples 1 to 5 are 1:64, 1:64 and 1:64 respectively for helicobacter pylori, which indicates that the stomach nourishing paste has good bactericidal and bacteriostatic effects on helicobacter pylori.
Experimental example 2
Selecting 300 patients with gastropathy of 40-50 years old, dividing into 5 groups, and administering the same amount of the stomach nourishing paste for each group at the same time; the medicine is taken 2 times daily at 8 am and 21 pm, respectively, and 5ml each time. The edible effect is filled in 28 days and 56 days respectively.
Wherein, the relieving of symptoms of nausea, vomiting, acid regurgitation, satiety, pain, eructation and the like is judged to be effective, the disappearance of at least one symptom of symptoms of nausea, vomiting, acid regurgitation, satiety, pain, eructation and the like is judged to be effective, and the disappearance of symptoms of nausea, vomiting, acid regurgitation, satiety, pain, eructation and the like is judged to be recovery. The specific results are shown in Table 2.
TABLE 2 improvement of patients with gastropathy
Figure BDA0001285970020000152
Figure BDA0001285970020000161
As can be seen from table 2, the stomach-nourishing ointments provided in examples 1 to 5 of the present invention have a good therapeutic effect on stomach diseases. Wherein, all the drugs are effective after being taken for 56 days, at least 35 percent of patients are cured, and the significant efficiency is as high as 55 percent.
In conclusion, the components of the stomach nourishing paste of the embodiments 1 to 5 of the invention have synergistic effect, and the honey can kill and inhibit bacteria, and can promote normal secretion of gastric acid. The alum and the baking soda can react to generate the aluminum hydroxide to neutralize gastric acid, the alum can also sterilize, the baking soda can also neutralize gastric acid, and the honey can also promote liver detoxification, enhance human immunity, reduce toxic and side effects of the stomach nourishing paste, and improve the curative effect of the stomach nourishing paste. The kudzu root, the poria cocos and the liquorice can also relieve stomach discomfort, and meanwhile, the toxic and side effects of other raw materials are reduced, so that the treatment effect of the stomach nourishing paste is integrally enhanced. The stomach nourishing paste for treating the stomach illness can be quickly prepared by the preparation method.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (4)

1. The stomach nourishing paste is characterized by being prepared from the following raw material medicines in parts by weight: 15-25 parts of honey, 0.5-0.8 part of alum, 0.8-1.5 parts of baking soda, 1-2 parts of kudzu root, 0.5-1.5 parts of tuckahoe and 0.8-1.2 parts of liquorice; pulverizing radix Puerariae, Poria and Glycyrrhrizae radix, mixing with 120 parts of 100-85 deg.C water, decocting at 60-85 deg.C, mixing decoctions, and concentrating to 1/4-1/6 times of total amount of the decoctions;
under the heating condition, dissolving alum in water, mixing with the concentrated solution, and then mixing with honey to form a mixture;
then adding baking soda into the mixture according to the addition amount of 0.015-0.03 part per batch and stirring, wherein a large amount of bubbles are generated, transferring the upper layer liquid into another storage container along with the bubbles, then adding 0.015-0.03 part of baking soda and repeating the steps; the mixture of the upper layer liquid in the storage container was stirred until the bubbles disappeared and allowed to cool naturally.
2. The stomach nourishing paste as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 18-22 parts of honey, 0.5-0.6 part of alum, 1-1.2 parts of baking soda, 1-1.5 parts of kudzu root, 0.8-1.2 parts of tuckahoe and 0.8-1.2 parts of liquorice.
3. The stomach nourishing paste is characterized by being prepared from the following raw material medicines in parts by weight: 15-25 parts of honey, 0.5-0.8 part of alum, 0.8-1.5 parts of baking soda, 1-2 parts of kudzu root, 0.5-1.5 parts of tuckahoe, 0.8-1.2 parts of liquorice and 0.8-1.2 parts of ginseng; pulverizing radix Puerariae, Poria, Glycyrrhrizae radix and Ginseng radix, mixing with 120 parts of 100-85 deg.C water, decocting at 60-85 deg.C, mixing decoctions, and concentrating to 1/4-1/6 times of total amount of the decoctions;
under the heating condition, dissolving alum in water, mixing with the concentrated solution, and then mixing with honey to form a mixture;
then adding baking soda into the mixture according to the addition amount of 0.015-0.03 part per batch and stirring, wherein a large amount of bubbles are generated, transferring the upper layer liquid into another storage container along with the bubbles, then adding 0.015-0.03 part of baking soda and repeating the steps; the mixture of the upper layer liquid in the storage container was stirred until the bubbles disappeared and allowed to cool naturally.
4. The stomach nourishing paste is characterized by being prepared from the following raw material medicines in parts by weight: 15-25 parts of honey, 0.5-0.8 part of alum, 0.8-1.5 parts of baking soda, 1-2 parts of kudzu root, 0.5-1.5 parts of tuckahoe, 0.8-1.2 parts of liquorice, 0.8-1.2 parts of ginseng and 0.8-1.2 parts of dandelion; pulverizing radix Puerariae, Poria, Glycyrrhrizae radix, Ginseng radix and herba Taraxaci, mixing with 120 parts of 100-85 deg.C water, decocting at 60-85 deg.C, mixing decoctions, and concentrating to 1/4-1/6 times of total amount of the decoctions;
under the heating condition, dissolving alum in water, mixing with the concentrated solution, and then mixing with honey to form a mixture;
then adding baking soda into the mixture according to the addition amount of 0.015-0.03 part per batch and stirring, wherein a large amount of bubbles are generated, transferring the upper layer liquid into another storage container along with the bubbles, then adding 0.015-0.03 part of baking soda and repeating the steps; the mixture of the upper layer liquid in the storage container was stirred until the bubbles disappeared and allowed to cool naturally.
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