CN1085798A

CN1085798A - Composite pill for curing ulcer and preparation method thereof

Info

Publication number: CN1085798A
Application number: CN 93115764
Authority: CN
Inventors: 刘宗汉
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-08-20
Filing date: 1993-08-20
Publication date: 1994-04-27

Abstract

A kind of Chinese medicine compound pill for curing ulcer that is used for the treatment of stomach and duodenal ulcer, this medicine each component is respectively: Endoconcha Sepiae, dried Alumen, Rhizoma Corydalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Glycyrrhizae, Mel, Semen daturae extractum, except that Mel, each component that will clean mixes and pulverized 120 mesh sieves, makes pill with the Mel mixing and be finished product.This medicine is relief of symptoms rapidly, and it is fast to relieve the pain, and does not have diarrhoea, side effect such as hepatic and renal functions such as constipation, headache, dizzy, xerostomia, thirsty, blurred vision, dysuria are impaired, in having and effects such as the gastric acid ability is strong, nutrition ulcer surface, its preparation method is simple, easily operation.

Description

Composite pill for curing ulcer and preparation method thereof

The present invention relates to a kind of medicine pill and preparation method for the treatment of gastric and duodenal ulcers.

At present both at home and abroad the medicine of treatment gastric and duodenal ulcers is a lot, but weak point is respectively arranged, and the curative effect that has is relatively poor, relief of symptoms rapidly, and the side effect that has is big and relapse rate is high.Toxic and side effects such as headache, dizzy, myalgia, hepatic and renal function be impaired appear as Western medicine cimetidine clothes back.

The purpose of this invention is to provide a kind of composite pill for curing ulcer and preparation method thereof, this Chinese medicine is relief of symptoms rapidly, it is fast to relieve the pain, there is not diarrhoea, side effect such as hepatic and renal functions such as constipation, headache, dizzy, xerostomia, thirsty, blurred vision, dysuria are impaired, in having and effects such as the gastric acid ability is strong, nutrition ulcer surface, its preparation method is simple, easily operation.

The object of the present invention is achieved like this: the weight ratio of this Chinese medicine each component is: Endoconcha Sepiae: dried Alumen: Rhizoma Corydalis: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Glycyrrhizae: Mel: Semen daturae soaks lamb=(0.5-5): (0.2-2): (0.5-3): (0.5-3): (0.5-3): (5-9.5): (1/4500-1/2500).

Preparation method is as follows: take by weighing each component according to the above ratio.Endoconcha Sepiae is chosen decontamination, goes into clear water rinsing 2-3 time, cold drying; It is that Alumen is gone out dried Alumen loose, pure white, cellular, light weight with infrared ray baking oven calcine under 250-300 ℃ of temperature that dried Alumen is produced; Rhizoma Corydalis is by pharmacopeia rice vinegar big gun moxibustion, and other each component makes by pharmacopeia, and it is main that Mel adopts tilia nectar, and its specific gravity control is 1.44, and water content is below 4%.Except that Mel, all the other each components are mixed pulverizing, cross 120 mesh sieves, make pill with the Mel mixing and be finished product.

Pill of the present invention is a principal agent with Endoconcha Sepiae, dried Alumen, and the two is in having and the gastric acid effect, and dried Alumen also has collaborative Endoconcha Sepiae astringing to arrest bleeding and antipepsin active function; Rhizoma Corydalis except that pain relieving, and can blood circulation promoting and blood stasis dispelling, remove the gastrointestinal blood stasis, have the inhibition gastric secretion, reduce the effect of gastric acidity; The Pseudobulbus Bletillae (Rhizoma Bletillae) is assisted the principal agent hemostasis, and regeneration of the gastric mucosa of promotion and ulcer surface healing effect are arranged; Radix Glycyrrhizae 12 warps that pass through can directly adsorb gastric juice, and the enzymatic activity that reduces pepsin also has spasmolysis; Though Mel is accessory drugs, also nutritious ulcer surface and healing effect, and play the seasoning effect; Semen daturae can be accelerated analgesic effect.Above-mentioned all medicines share rapidly that relief of symptoms, pain relieving are fast, 13-15 minute can relieve the pain; convergence, antiacid, pain relieving, hemostasis, nutrition and the effect of protection ulcer surface are arranged; be applied to gastric and duodenal ulcers, toxic and side effects such as no Liver and kidney is impaired, gastroscopy is evident in efficacy.This medicament preparation is simple.

Acute toxicity test

Choose 18-22 gram 10 of healthy mices (male and female half and half), divide two dosage groups, every group 5, test fasting in preceding 8 hours, once irritate stomach respectively, give the water diluent of various dose 25-50g/kg, observed 3-7 days, each treated animal does not all have death, and does not see other unusual performance, proves that this medicine has no side effect.

The invention will be further described below in conjunction with embodiment.

Embodiment one

Take by weighing 0.5 kilogram of Endoconcha Sepiae, 0.2 kilogram of dried Alumen, 0.5 kilogram of Rhizoma Corydalis, 0.5 kilogram of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.5 kilogram in Radix Glycyrrhizae, 5 kilograms of Mel, Semen daturae and soak lamb 0.2 gram, preparation process is as follows: Endoconcha Sepiae is chosen decontamination with clear water rinsing 2-3 time, cold drying; Dried Alumen is produced: alum powder is broken into the chest nut size, is tiled in the stainless steel disc, thick about 1.5cm forges into loose, pure white, inside with the infrared ray baking oven and is dried Alumen cellular, light weight under 250-300 ℃ of temperature; Mel is selected for use based on tilia nectar, and its specific gravity control is 1.44, and water content is below 4%.Other each component is produced by pharmacopeia.Rhizoma Corydalis is by pharmacopeia rice vinegar big gun moxibustion.Except that Mel, all the other each medicines mix to be pulverized, and crosses 120 mesh sieves, makes pill with the Mel mixing, about every ball 10 grams, is patent medicine.

Embodiment two

Take by weighing 1 kilogram of Endoconcha Sepiae, 0.5 kilogram of dried Alumen, 1 kilogram of Rhizoma Corydalis, 0.7 kilogram of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.8 kilogram in Radix Glycyrrhizae, 6 kilograms of Mel, Semen daturae and soak lamb 0.25 gram, following steps are with embodiment one.

Embodiment three

Take by weighing 2.5 kilograms of Endoconcha Sepiaes, 0.8 kilogram of dried Alumen, 1.5 kilograms of Rhizoma Corydalis, 1 kilogram of the Pseudobulbus Bletillae (Rhizoma Bletillae), 1 kilogram in Radix Glycyrrhizae, 7 kilograms of Mel, Semen daturae and soak lamb 0.29 gram, following steps are with embodiment one.

Embodiment four

Take by weighing 3 kilograms of Endoconcha Sepiaes, 1 kilogram of dried Alumen, 2 kilograms of Rhizoma Corydalis, 2 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 1.5 kilograms in Radix Glycyrrhizae, 7.5 kilograms of Mel, Semen daturae and soak lamb 0.4 gram, following steps are with embodiment one.

Embodiment five

Take by weighing 5 kilograms of Endoconcha Sepiaes, 2 kilograms of dried Alumens, 3 kilograms of Rhizoma Corydalis, 3 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 2 kilograms in Radix Glycyrrhizae, 8 kilograms of Mel, Semen daturae and soak lamb 0.4 gram, following steps are with embodiment one.

Usage and consumption: 2-3 time on the 1st, each ball, 30 days is a course of treatment.

Curative effect determinate standard:

1, cure: the gastroscope check, ulcer surface heals fully.

2, take a turn for the better: the gastroscope check, the ulcer area dwindles, pain relief or disappearance.

3, invalid: the gastroscope check, the ulcer area does not have significant change.

Cure 215 examples in the 270 routine cases, account for sum 79.6%, 49 examples that take a turn for the better, some sum 18.15%, invalid 6 examples account for sum 2.22%, and total effective rate 97.78%, Average of hospital stay are 38.47 days, see the following form:

Ulcer spot is cured the invalid subtotal that takes a turn for the better

Example number percentage rate example number percentage rate example number percentage rate example number percentage rate

Gastric ulcer 14 5.19 1 0.37 1 0.37 16 5.93

Duodenal bulbar ulcer 185 68.52 41 15.19 5 1.85 231 85.56

Complex ulcer 16 5.92 7 2.59 23 8.51

Add up to 215 79.63 49 18.15 6 2.22 170 100.00

Claims

1, a kind of Chinese medicine compound pill for curing ulcer that is used for the treatment of gastric and duodenal ulcers is characterized in that the each component weight ratio is: Endoconcha Sepiae: dried Alumen: Rhizoma Corydalis: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Glycyrrhizae: Mel: Semen daturae soaks lamb=(0.5-5): (0.2-2): (0.5-3): (0.5-3): (0.5-3): (5-9.5): (1/4500-1/2500).

2, a kind of preparation method according to the described composite pill for curing ulcer of claim 1, it is characterized in that pressing the column weight amount and take by weighing each component: Endoconcha Sepiae: dried Alumen: Rhizoma Corydalis: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Glycyrrhizae: Mel: Semen daturae soaks lamb=(0.5-5): (0.2-2): (0.5-3): (0.5-3): (0.5-3): (5-9.5): (1/4500-1/2500), except that Mel, 120 mesh sieves were pulverized in the each component mixing that cleans, make pill with the Mel mixing, be finished product.

3, preparation method according to claim 2 is characterized in that dried Alumen adopts Alumen to form at 250-300 ℃ of infrared ray baking oven calcine.

4, preparation method according to claim 2 is characterized in that the Mel specific gravity control 1.44, and water content is below 4%.