CN1136950A - Medicinal composition for curing ulcer and inflammation of gastro-intestinal tract and producing process thereof - Google Patents
Medicinal composition for curing ulcer and inflammation of gastro-intestinal tract and producing process thereof Download PDFInfo
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- CN1136950A CN1136950A CN 96117492 CN96117492A CN1136950A CN 1136950 A CN1136950 A CN 1136950A CN 96117492 CN96117492 CN 96117492 CN 96117492 A CN96117492 A CN 96117492A CN 1136950 A CN1136950 A CN 1136950A
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Abstract
A medicinal composition in the form of tablet or capsule for curing enterogastric ulcer and enterogastritis with distinct curative effect, short course of treatment and less by-effect is prepared from pearl, bletilla tuber, cuttlefish bone, furazolidone, VB6 and corydalis tuber through crushing and proportioning.
Description
The present invention relates to a kind of pharmaceutical composition and production method thereof for the treatment of gastrointestinal disease, particularly a kind of pharmaceutical composition and production method thereof for the treatment of gastroenteritic ulcer, gastroenteritis.
The medicine for the treatment of gastroenteritic ulcer, gastroenteritis at present clinically mostly is single Chinese medicine or single Western medicine, and its drug effect is single.As " bismuth aluminate compound " of Germany's production, " weisen one u ", " capsule for gastropathy " of domestic production that Japan produces, said medicine only has curative effect preferably to gastric duodenal ulcer, and to gastritis, the relatively poor or inefficacy of enteritis curative effect, " SANJIU WEITAI " of domestic production is only effective in cure to gastritis, and to stomach, duodenal ulcer, inefficacy.Clinical practice proves, a kind of gastroenteropathy, and other gastroenteropathy that often occurs together simultaneously is with the single Drug therapy of curative effect, healing is long the course of treatment, and especially Chinese medicine is longer the course of treatment, generally all more than 2-3 month, patient's rehabilitation is slow, has both increased the patient burden, easily recurrence again after the healing.Use single western medicine gastrointestinal disease simultaneously, side effect is big, increases the patient suffering.
The objective of the invention is to overcome the deficiencies in the prior art, provide that a kind of drug effect is wide, short treating period, the treatment gastroenteritic ulcer that curative effect is fast, side effect is little, the pharmaceutical composition and the production method thereof of gastroenteritis.
Solution of the present invention is based on motherland's medical science, doctor trained in Western medicine to gastroenteritic ulcer and pathogenetic understanding of gastroenteritis and Therapeutic Principle, achieve with reference to modern pharmacological research, from Pharmaceuticals, filter out determined curative effect, give full play to the each component synergism, suppress its side effect, enlarge the drug effect scope, shorten the course of treatment, quicken patient's rehabilitation speed, alleviate patient economy burden and the treatment gastroenteritic ulcer of misery and the pharmaceutical composition and the production method thereof of gastroenteritis.
Pharmaceutical composition of the present invention is made up of following component and weight ratio:
Margarita 3-6 part Pseudobulbus Bletillae (Rhizoma Bletillae) 5-9 part Os Sepiae 4-8 part
Furazolidone 3-5 part vitamin B6 0.8-1.2
Rhizoma Corydalis 3-4 part
The preferred weight ratio range of preparation medicine of the present invention is:
Margarita 4-6 part Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7 part Os Sepiae 5-7 part
Furazolidone 4-5 part vitamin B6 0.8-1
Rhizoma Corydalis 3-4 part
The method of above-mentioned each component being made pharmaceutical composition of the present invention is:
1, get Margarita earlier and be ground to the 100-200 order with milling apparatus, also can earlier Margarita be embedded in and boil 8-15 minute in the bean curd, take out Margarita, it is standby to be ground to 100-200 order powder with milling apparatus behind the airing water;
2, get the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae, Rhizoma Corydalis respectively xeraphium grind to 80-120 order powder standby;
3, it is standby furazolidone, vitamin B6 to be ground to 100-200 order powder respectively;
Above-mentioned each component powder is even by described mixed, make the 300mg/ seed lac in incapsulating and wrap up in granule or add an amount of distilled water, it is agglomerating that the mixed dust formulation expert is pinched; unclamp promptly and loose, after 0 mesh sieve is granulated, is pressed into the 300mg/ sheet; under 60-70 ℃ of condition, dry packing again.
The each component that an important feature of the present invention is a medicine is definite to the effect of human body; Margarita has removing toxic substances and promoting granulation; enhance metabolism; endocrine regulation; strengthen body immunity; especially burst soup and boil of gastrointestinal do not held back mouth for a long time unique curative effect is arranged; Pseudobulbus Bletillae (Rhizoma Bletillae) powder has astringing to arrest bleeding; detumescence and promoting granulation; its phlegmatic temperament that contains is to the protection gastrointestinal mucosa, and astringing to arrest bleeding has obvious effect, and the Os Sepiae major function is an astringing to arrest bleeding; relieving gastric hyperacidity to alleviate stomachache; removing dampness is held back skin ulcer, phosphoric acid calcium in its composition; calcium carbonate; colloid; during playing, sodium chloride protects gastroenteritic ulcer face, the effect of anti-inflammatory analgetic with gastric acid; and collaborative with the phlegmatic temperament of the Pseudobulbus Bletillae (Rhizoma Bletillae), the active ingredient long period is stranded in ulcer surface or inflammation part.Furazolidone is the high-efficiency antimicrobial medicine, is used for the treatment of dysentery bacterium, the effectively good effect of the gastrointestinal infection of escherichia coli, helicobacter pylori, and healing also has certain promotion to ulcer surface simultaneously.Certainly it also easily causes pair effect such as polyneuritis and gastrointestinal upset, vomiting, and these pairs effect is told the function releasing by the adjusting function of nervous system of control consumption and Margarita and the town of vitamin B6 powder.
Pharmaceutical composition of the present invention is observed through the clinical use of people more than 10,000, and following advantage is arranged:
1, the each component of the present invention's use is clinical medicine commonly used, each component all meets the pharmaceutical control and administration regulation, and except that furazolidone has certain paying the effect to human body, other each component is harmless, and the furazolidone consumption is controlled at minimum flow, and its side effect is also removed by VB6.
2, pharmaceutical composition of the present invention has made full use of the comprehensive function of each component, thereby curative effect is wide, and removing has curative effect preferably to stomach, duodenal ulcer, and gastritis, enteritis, hemorrhagic gastrointestinal disease are also had curative effect preferably.Curative effect is fast simultaneously, can shorten the course of treatment greatly, and general patient promptly fully recovers one to two course of treatment, and the time is 15-30 days.For a large amount of expenses and time are saved in patient's rehabilitation.
3, pharmaceutical composition dosage of the present invention is little, and taking convenience need be taken one to two (300-600mg gets final product) for each.
4, pharmaceutical composition curative effect of the present invention is reliable, uses statistical results as follows through 10000 routine clinical cases: male's 5480 examples wherein, women's 4520 examples, age 3-76 year.Through clinical definite, acute chronic enteritis 120 examples, acute or chronic gastritis 6277 examples, gastric and duodenal ulcers 3603 examples, the course of disease the shortest half a year, the longest 35 years.Through with recovery from illness medicine composite for curing 1-2 of the present invention course of treatment (distending pain disappear or rush down, melena complete obiteration, appetite weight increase) 8653 examples account for 86.53%, 1009 examples of recovery from illness three courses of treatment (45 days), account for 10.09%, three the above improvements course of treatment and 338 invalid examples, account for 0.338%, obvious effective rate reaches 96.62%.
Model case:
Example 1, man, 45 years old.Go to a doctor in May, 1984, the main suit just began to suffer from gastropathy from 1970, and melena is felt sick, expands, separated to full recently all pains of starving, at acid regurgitation.The inspection of stomach ytterbium is a gastric ulcer, duodenal bulbar ulcer is hemorrhage, taking pharmaceutical composition of the present invention-gastrointestinal health back 15 days (course of treatment) pain disappears, appetite increases, and it is yellow that stool changes, obey ten again surplus day after, appetite is increased to three, four liang by two liang of meals of original every meal, stomach and duodenal bulbar ulcer healing were good after the People's Hospital's gastroscopy of Shihezi, Xinjiang in six months, followed up a case by regular visits to not recurrence again in 10 years.
Example 2, man 48 years old.Go to a doctor in March, 1989, and main suit's Changes in weather or eating and drinking without temperance are all had a stomachache, and often suffer from diarrhoea, through gastroscopy, belong to chronic gastritis, chronic enteritis, obey pharmaceutical composition of the present invention-gastrointestinal health after course of treatment, clinical symptom disappearance, appetite increases, after take two courses of treatment, through gastroscopy, gastric mucosa is full good, and no longer diarrhoea is followed up a case by regular visits to not recurrence again in 5 years.
Instructions of taking: the each consumption two (600mg) three times on the one of being grown up, each one of grown-ups and children weakling, three times on the one, use warm water delivery service, 15 days is a course of treatment.
Below in conjunction with embodiment the present invention is further described:
Embodiment 1 takes by weighing raw material by following proportioning
4 kilograms of 8 kilograms of Os Sepiae of 3 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita
6 kilograms of 0.8 kilogram of Rhizoma Corydalis of 3 kilograms of vitamin Bies of furazolidone
Production method is as follows:
It is standby earlier Margarita to be ground to form 100 order Margarita fine powders with grinder, and the reuse pulverizer is dried and crushed into the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae, Rhizoma Corydalis 100 order fine powders respectively, respectively furazolidone, vitamin B6 is ground to form 150 order fine powders with dismembyator; Then with in the capsule drain pan of packing into behind the abundant mix homogeneously of above-mentioned each component fine powder, every 300mg, and then put a capsule top shell and become the capsule grain.
Embodiment 2:
Take by weighing raw material by following proportioning:
6 kilograms of 5 kilograms of Os Sepiae of 5 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita
3 kilograms of 1 kilogram of Rhizoma Corydalis of 5 kilograms of vitamin Bies of furazolidone
Production method is as follows: Margarita is embedded in boils 8 minutes in the bean curd earlier, take out behind the Margarita airing water that to grind to form 200 order fine powders with dismembyator standby; It is standby that the reuse pulverizer is dried and crushed into the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae, Rhizoma Corydalis respectively 120 order fine powders respectively, it is standby respectively furazolidone, vitamin B6 to be ground to form 200 order fine powders with dismembyator, then with above-mentioned each component in a container fully behind the mixing, adding an amount of distilled water again mixes thoroughly, amount of water is pinched with hands with mixing fine powders can be agglomerating, unclamping to scatter gets final product, and granulates with 0 mesh sieve, is pressed into the tablet of 300mg/ sheet.
Embodiment 3:
Take by weighing raw material by following proportioning:
8 kilograms of 9 kilograms of Os Sepiae of 6 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita
4 kilograms of 1.2 kilograms of Rhizoma Corydalis of 4 kilograms of vitamin Bies of furazolidone
Production method is as follows: will embrace earlier and be embedded in bean curd and boiled 15 minutes, and take out Margarita, behind the airing moisture content, it is standby to grind to form 150 order fine powders with dismembyator; Respectively the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae, Rhizoma Corydalis are dried and crushed into 80 order fine powders respectively with pulverizer, standby, it is standby respectively furazolidone, vitamin B6 to be ground to form 100 order fine powders with dismembyator, then with above-mentioned be equipped with the abundant mixture of component fine powder evenly after, pack in the capsule drain pan, each 300mg, and then put a capsule top shell and become micelle medicine grain.
Claims (6)
1, a kind of pharmaceutical composition for the treatment of gastroenteritic ulcer, gastroenteritis is characterized in that it is the medicament of being made by following component and weight ratio:
Margarita 3-6 part Pseudobulbus Bletillae (Rhizoma Bletillae) 5-9 part Os Sepiae 4-8 part
Furazolidone 3-5 part vitamin B6 0.8-1.2
Rhizoma Corydalis 3-6 part
2,, it is characterized in that the preferred weight proportioning of each component is according to the pharmaceutical composition of the said treatment gastroenteritic ulcer of claim 1, gastroenteritis
Margarita 4-6 part Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7 part Os Sepiae 5-7 part
1 part of furazolidone 4-5 part vitamin B6
Rhizoma Corydalis 3-4 part
3,, it is characterized in that pharmaceutical composition is capsule or any dosage form of tablet according to the pharmaceutical composition of claim 1,2 said treatment gastroenteritic ulcers, gastroenteritis.
4, a kind of process for producing medicine composition for the treatment of gastroenteritic ulcer, gastroenteritis is characterized in that earlier Margarita powder being ground to form the 100-200 fine powder with grinder, and it is standby that the reuse pulverizer is dried and crushed into the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae, Rhizoma Corydalis 80-100 order fine powder respectively.After respectively furazolidone, vitamin B6 being ground to form 100-200 order fine powder with dismembyator, in the capsule drain pan of packing into behind the above-mentioned each component fine powder mix homogeneously, every 300mg, and then cover capsule top shell is made the capsule grain.
5, according to the said a kind of production method for the treatment of the pharmaceutical composition of gastroenteritic ulcer, gastroenteritis of claim 4, it is characterized in that Margarita be embedded in advance boil 8-15 minute in the bean curd after, take out Margarita airing water after the reuse dismembyator grind to form 100-200 order fine powder.
6, according to the said a kind of production method for the treatment of the pharmaceutical composition of gastroenteritic ulcer, gastroenteritis of claim 4, it is characterized in that behind the each component fine powder mix homogeneously, add an amount of distilled water, mix thoroughly, amount of water is pinched with hands with fine powder after mixing can be agglomerating, and unclamping to scatter is advisable, and granulates with 0 mesh sieve, be pressed into the tablet of 300mg/ sheet, 60-70 ℃ of oven dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96117492 CN1136950A (en) | 1996-03-18 | 1996-03-18 | Medicinal composition for curing ulcer and inflammation of gastro-intestinal tract and producing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96117492 CN1136950A (en) | 1996-03-18 | 1996-03-18 | Medicinal composition for curing ulcer and inflammation of gastro-intestinal tract and producing process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1136950A true CN1136950A (en) | 1996-12-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96117492 Pending CN1136950A (en) | 1996-03-18 | 1996-03-18 | Medicinal composition for curing ulcer and inflammation of gastro-intestinal tract and producing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1136950A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063862A1 (en) * | 2002-01-25 | 2003-08-07 | Pharmacia & Upjohn Company | Cotherapy with an oxazolidinone and a vitamin b |
| CN101939024A (en) * | 2007-11-13 | 2011-01-05 | 梅里蒂奇制药公司 | Compositions for the treatment of inflammation of the gastrointestinal tract |
-
1996
- 1996-03-18 CN CN 96117492 patent/CN1136950A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063862A1 (en) * | 2002-01-25 | 2003-08-07 | Pharmacia & Upjohn Company | Cotherapy with an oxazolidinone and a vitamin b |
| CN101939024A (en) * | 2007-11-13 | 2011-01-05 | 梅里蒂奇制药公司 | Compositions for the treatment of inflammation of the gastrointestinal tract |
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