CN102362879B - Traditional Chinese herbal medicinal preparation for relieving ulcer by inhibiting gastric acid and preparation method thereof - Google Patents
Traditional Chinese herbal medicinal preparation for relieving ulcer by inhibiting gastric acid and preparation method thereof Download PDFInfo
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- CN102362879B CN102362879B CN201110369040.XA CN201110369040A CN102362879B CN 102362879 B CN102362879 B CN 102362879B CN 201110369040 A CN201110369040 A CN 201110369040A CN 102362879 B CN102362879 B CN 102362879B
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Abstract
The invention discloses a Chinese herbal medicinal preparation for relieving ulcer by inhibiting gastric acid, which is prepared from the following raw materials in part by weight: 200 parts of birch bark and 50 to 100 parts of caramel. The birch bark is bark of white birch which belongs to betulo. In addition, the invention also provides the preparation method of the Chinese herbal medicinal preparation. The Chinese herbal medicinal preparation is prepared by pure Chinese medicines and therefore is from toxic and side effects. The formula of the Chinese herbal medicinal preparation is simple, the treatment effect of the Chinese herbal medicinal preparation is reliable, the preparation process of the Chinese herbal medicinal preparation is simple and the production cost of the Chinese herbal medicinal preparation is low. The Chinese herbal medicinal preparation has the characteristics of quick gastric acid inhibition, short treatment period and low price. The Chinese herbal medicinal preparation has the functions of restraining gastric acid, healing ulcer, soothing stomach, relieving pain, stopping blood and tonifying blood, and is mainly used for treating gastric ulcer, bleeding stomach ulcer, hyperchlorhydria and chronic gastritis. The Chinese herbal medicinal preparation can enter stomach and directly act on lesions and therefore can treat ulcer quickly.
Description
Technical field
The invention belongs to medical technical field, be specifically related to Chinese herbal and crude drugs preparations of a kind of relieving ulcer by inhibiting gastric acid and preparation method thereof.
Background technology
Stomach is positioned under human body diaphragm, above connects esophagus, and lower logical small intestinal is the primary organ of receiving food, digest food.According to data, China's 1,300,000,000 populations, gastroenteropathy patient just has 1.2 hundred million, and wherein middle-aged and elderly people accounts for more than 70%, peptic ulcer rate 10%, chronic gastritis sickness rate 30%.At present the medicine for the treatment of gastropathy is a lot, as Chinese patent medicine has WENWEISHU, YANGWEISHU, SANJIU WEITAI, Veytalo peaceful etc.; Western medicine has ranitidine, cimetidine, gastropine, bismuth aluminate compound etc., but therapeutic effect is all undesirable, the effect that can only play relief of symptoms, eases the pain, and also treatment cycle is long, expense is high, and some patients are compelled against one's will, and have to take operation, and stomach is cut away.The morbidity of stomach, serious harm the mankind's health.
Summary of the invention
Technical problem to be solved by this invention is for above-mentioned the deficiencies in the prior art, and a kind of Chinese herbal and crude drugs preparations hyperchlorhydria, gastric ulcer, gastrorrhagia patient to the relieving ulcer by inhibiting gastric acid of good therapeutical effect is provided.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese herbal and crude drugs preparations of relieving ulcer by inhibiting gastric acid, it is characterized in that, and by the raw material of following weight portion, made: 200 parts of Cortex Betulae Luminiferaes, caramel 50-100 part; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The Chinese herbal and crude drugs preparations of above-mentioned a kind of relieving ulcer by inhibiting gastric acid, the dosage form of described Chinese herbal and crude drugs preparations is capsule, tablet or granule.
The present invention also provides the preparation method of this Chinese herbal and crude drugs preparations, and wherein the preparation method of capsule comprises the following steps:
Step 1, Cortex Betulae Luminiferae is ground into 10～30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6～10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 1 hour～3 hours, amount of water is 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 0.5 hour～1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste; Or it is that 60%～80% reflow of alcohol is extracted twice that Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration, add for the first time ethanol amount for 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour～3 hours, add for the second time ethanol amount for 2～6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour～1.5 hours, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, after being mixed with caramel, the dry extract of Cortex Betulae Luminiferae described in step 3 is ground into 60 order fine powders, in then described fine powder being incapsulated, and the Chinese herbal medicine capsule agent of the gastric acid repairing ulcer that is inhibited.
Described in above-mentioned steps two, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, and amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour; Described in step 2, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, adds for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 1 hour.
The preparation method of tablet comprises the following steps:
Step 1, Cortex Betulae Luminiferae is ground into 10～30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6～10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 1 hour～3 hours, amount of water is 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 0.5 hour～1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste; Or it is that 60%～80% reflow of alcohol is extracted twice that Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration, add for the first time ethanol amount for 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour～3 hours, add for the second time ethanol amount for 2～6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour～1.5 hours, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional tabletting method to carry out tabletting to described fine powder, the Chinese medicinal herbal tablets of the gastric acid repairing ulcer that is inhibited.
Described in above-mentioned steps two, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, and amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour; Described in step 2, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, adds for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 1 hour.
The preparation method of granule comprises the following steps:
Step 1, Cortex Betulae Luminiferae is ground into 10～30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6～10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 1 hour～3 hours, amount of water is 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 0.5 hour～1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste; Or it is that 60%～80% reflow of alcohol is extracted twice that Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration, add for the first time ethanol amount for 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour～3 hours, add for the second time ethanol amount for 2～6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour～1.5 hours, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional method of granulating by described fine powder granulation, the Chinese herbal medicine granule of the gastric acid repairing ulcer that is inhibited.
Described in above-mentioned steps two, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, and amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour; Described in step 2, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, adds for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 1 hour.
Described weight portion can for gram, two, jin, kilogram, Dun Deng weight metering unit.
The present invention be take Cortex Betulae Luminiferae as primary raw material medical material, with decocting, boils or reflow of alcohol method is extracted the effective ingredient of Cortex Betulae Luminiferae, and the Chinese herbal and crude drugs preparations of the treatment hyperchlorhydria being mixed with caramel, gastrorrhagia, gastric ulcer, its dosage form is capsule, tablet or granule.
The present invention compared with prior art has the following advantages:
1, Chinese herbal and crude drugs preparations of the present invention adopts pure traditional Chinese medicine, has no side effect, and formula is simple, curative effect is reliable, preparation technology is simple, production cost is low, has the advantages that gastric acid inhibitory is fast, treatment cycle is short, cheap.
2, the function that Chinese herbal and crude drugs preparations of the present invention has convergence gastric acid, heals ulcer, relaxes stomach and alleviating pain, stops blooding and enrich blood, cures mainly gastric ulcer, gastric hemorrhage, hyperchlorhydria, chronic gastritis.
3, Chinese herbal and crude drugs preparations of the present invention has good therapeutical effect to hyperchlorhydria, gastric ulcer, gastrorrhagia patient, and said preparation (capsule, tablet or granule) can enter stomach, directly acts on focus, plays quick-acting effects.
4, Chinese herbal and crude drugs preparations of the present invention has that cure rate is high, relapse rate is low, stability is strong, the feature for the treatment of both the principal and secondary aspects of a disease, after patient takes, do not develop complications, bad of recurrence etc. should, be applicable to marketing drugs and promote.
The specific embodiment
Embodiment 1
The Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 50kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the capsule of the present embodiment is:
Step 1,200kg Cortex Betulae Luminiferae is ground into 10 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 2 hours, amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 1 hour, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, after being mixed with 50kg caramel, the dry extract of Cortex Betulae Luminiferae described in step 3 is ground into 60 order fine powders, in then described fine powder being incapsulated, and the Chinese herbal medicine capsule agent of the gastric acid repairing ulcer that is inhibited, every capsules is containing fine powder 0.5g.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 2
The present embodiment is identical with embodiment 1, and wherein difference is: amount of water is 10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 1 hour, and amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 0.5 hour.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 3
The present embodiment is identical with embodiment 1, and wherein difference is: amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 3 hours, and amount of water is 4 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1.5 hours.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 4
The Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 100kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the capsule of the present embodiment is:
Step 1,200kg Cortex Betulae Luminiferae is ground into 20 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 3 hours, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, after being mixed with 100kg caramel, the dry extract of Cortex Betulae Luminiferae described in step 3 is ground into 60 order fine powders, in then described fine powder being incapsulated, and the Chinese herbal medicine capsule agent of the gastric acid repairing ulcer that is inhibited, every capsules is containing fine powder 0.5g.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 5
The present embodiment is identical with embodiment 4, and wherein difference is: amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, and amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 6
The present embodiment is identical with embodiment 4, and wherein difference is: amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 1 hour, and amount of water is 4 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 0.5 hour.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 7
The Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 80kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the capsule of the present embodiment is:
Step 1,200kg Cortex Betulae Luminiferae is ground into 30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration is that 80% reflow of alcohol is extracted twice, add for the first time ethanol amount for 8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, add for the second time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, after being mixed with 80kg caramel, the dry extract of Cortex Betulae Luminiferae described in step 3 is ground into 60 order fine powders, in then described fine powder being incapsulated, and the Chinese herbal medicine capsule agent of the gastric acid repairing ulcer that is inhibited, every capsules is containing fine powder 0.5g.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 8
The present embodiment is identical with embodiment 7, wherein difference is: alcohol quality concentration is 70%, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, add for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 9
The present embodiment is identical with embodiment 7, wherein difference is: alcohol quality concentration is 60%, add for the first time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 3 hours, add for the second time ethanol amount for 2 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1.5 hours.
The usage and dosage of the Chinese herbal medicine capsule agent of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 10
The Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 50kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the tablet of the present embodiment is:
Step 1, Cortex Betulae Luminiferae is ground into 20 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration is that 60% reflow of alcohol is extracted twice, add for the first time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 3 hours, add for the second time ethanol amount for 2 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1.5 hours, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional tabletting method to carry out tabletting to described fine powder, the Chinese medicinal herbal tablets of the gastric acid repairing ulcer that is inhibited, every containing fine powder 0.5g.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 11
The present embodiment is identical with embodiment 10, wherein difference is: alcohol quality concentration is 80%, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, add for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 12
The present embodiment is identical with embodiment 10, wherein difference is: alcohol quality concentration is 70%, add for the first time ethanol amount for 8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, add for the second time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 13
The Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 70kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the tablet of the present embodiment is:
Step 1, Cortex Betulae Luminiferae is ground into 10 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration is that 70% reflow of alcohol is extracted twice, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, add for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional tabletting method to carry out tabletting to described fine powder, the Chinese medicinal herbal tablets of the gastric acid repairing ulcer that is inhibited, every containing fine powder 0.5g.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 14
The present embodiment is identical with embodiment 13, wherein difference is: alcohol quality concentration is 80%, add for the first time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, add for the second time ethanol amount for 2 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 15
The present embodiment is identical with embodiment 13, wherein difference is: alcohol quality concentration is 60%, add for the first time ethanol amount for 8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 3 hours, add for the second time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1.5 hours.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 16
The Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 100kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphyllaSuk.).
The preparation method of the tablet of the present embodiment is:
Step 1, Cortex Betulae Luminiferae is ground into 30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 3 hours, amount of water is 4 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional tabletting method to carry out tabletting to described fine powder, the Chinese medicinal herbal tablets of the gastric acid repairing ulcer that is inhibited, every containing fine powder 0.5g.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 17
The present embodiment is identical with embodiment 16, and wherein difference is: amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, and amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 18
The present embodiment is identical with embodiment 16, and wherein difference is: amount of water is 10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 1 hour, and amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 0.5 hour.
The usage and dosage of the Chinese medicinal herbal tablets of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 2～4, three times on the one, warm water is taken after mixing it with water.
Embodiment 19
The Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 100kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the tablet of the present embodiment is:
Step 1, Cortex Betulae Luminiferae is ground into 30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 3 hours, amount of water is 4 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional method of granulating by described fine powder granulation, pack, every bag containing fine powder 1g, the Chinese herbal medicine granule of the gastric acid repairing ulcer that is inhibited.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 20
The present embodiment is identical with embodiment 19, and wherein difference is: amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, and amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 21
The present embodiment is identical with embodiment 19, and wherein difference is: amount of water is 10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 1 hour, and amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 0.5 hour.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 22
The Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 50kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphyllaSuk.).
The preparation method of the tablet of the present embodiment is:
Step 1, Cortex Betulae Luminiferae is ground into 10 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 2 hours, amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 1 hour, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional method of granulating by described fine powder granulation, pack, every bag containing fine powder 1g, the Chinese herbal medicine granule of the gastric acid repairing ulcer that is inhibited.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 23
The present embodiment is identical with embodiment 22, and wherein difference is: amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 1 hour, and amount of water is 4 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 0.5 hour.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 24
The present embodiment is identical with embodiment 22, and wherein difference is: amount of water is 10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 3 hours, and amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1.5 hours.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 25
The Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment, is made by following raw material: Cortex Betulae Luminiferae 200kg, caramel 60kg; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the tablet of the present embodiment is:
Step 1, Cortex Betulae Luminiferae is ground into 20 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration is that 70% reflow of alcohol is extracted twice, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, add for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional method of granulating by described fine powder granulation, pack, every bag containing fine powder 1g, the Chinese herbal medicine granule of the gastric acid repairing ulcer that is inhibited.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 26
The present embodiment is identical with embodiment 25, wherein difference is: alcohol quality concentration is 80%, add for the first time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 3 hours, add for the second time ethanol amount for 2 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1.5 hours.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Embodiment 27
The present embodiment is identical with embodiment 25, wherein difference is: alcohol quality concentration is 60%, add for the first time ethanol amount for 8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, add for the second time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour.
The usage and dosage of the Chinese herbal medicine granule of the relieving ulcer by inhibiting gastric acid of the present embodiment: one time 1～2 bag, three times on the one, warm water is taken after mixing it with water.
Curative effect determinate standard: clinical primary symptom disappears for curing substantially with time disease; Clinical primary symptom all has clear improvement with time disease, or indivedual primary symptoms slight improve but other symptoms all disappearance person be effective; Clinical primary symptom is all improved with time disease, or primary symptom is not improved, but inferior disease all disappears for effectively; Clinical primary symptom is all invalid without being improved as with time disease.
General clinical data: clinical observation case is totally 280 examples, treatment group 200 examples, matched group 80 examples.Wherein, treatment group: take capsule 60 examples of the present invention; Take tablet 60 examples of the present invention; Take granule 80 examples of the present invention.Matched group 80 examples are all taken conventional medicine ranitidine.Treatment group and matched group curative effect comparative result see the following form:
Table 1 treatment group and matched group Comparison of therapeutic
As shown in table 1, clinical observation case 280 examples of the present invention, treatment group 200 examples wherein, matched group 80 examples.Treatment group adopts capsule of the present invention, tablet and granule, wherein takes capsule 60 examples, oral, one time 2～4, three times on the one, warm water takes; Take tablet 60 examples, oral, one time 2～4, three times on the one, warm water takes; Take granule 80 examples, oral, one time 1～2 bag, three times on the one, warm water is taken after mixing it with water; Matched group adopts conventional medicine ranitidine in treating, conventional amount used administration shown in usage by specification.Treatment group and the comparison of matched group general curative effect, its result is: in treatment group, take capsule 60 examples, cure 55 examples, account for 91.7%, effective 5 examples, account for 8.3%, total effective rate 100%; In treatment group, take tablet 60 examples, cure 52 examples, account for 86.7, effective 8 examples, account for 13.3%, total effective rate 100%; In treatment group, take granule 80 examples, cure 78 examples, account for 97.5%, effective 2 examples, account for 2.5%, total effective rate 100%; Matched group 80 examples are all taken ranitidine, cure 50 examples, account for 62.5%, effective 10 examples, account for 12.5%, effective 5 examples, account for 6.25%, invalid 15 examples, account for 18.75%, total effective rate 81.25%, healing be mostly slight patient, and easily recurrence in therapeutic process there is the problems such as aggravation, complication in some patients in therapeutic process.There were significant differences for two groups of comparison curative effects, Chinese medicine composition of the present invention be take Cortex Betulae Luminiferae as primary raw material medical material, be equipped with caramel, cure rate is high, relapse rate is low, stability is strong, have no side effect, treating both the principal and secondary aspects of a disease, after patient takes, do not develop complications, bad of recurrence etc. should, be applicable to marketing drugs and promote.
Model case
Case 1
High mountain, man, 50 years old, peasant.Suffer from stomachache, gastric ulcer 6 years, stomach massive hemorrhage twice, anemic face.Often take sodium bicarbonate and alleviate, once not good with therapeutic effect such as Western medicine.After use Chinese herbal and crude drugs preparations of the present invention treatment January, recovery from illness instead.By stomach radiography, have no niche and occur, gastric mucosa is normal, and appetite, digestion have all recovered normal, and anemia has obtained correction, has rosy cheeks.
Case 2
Model, man, 52 years old, peasant.Regurgitation acid 3 years, stomachache 2 years.Through gastroscopy lesser gastric curvature portion, there is many places ulcer in pyloric cap, once takes ranitidine, cimetidine is effective, but the i.e. recurrence again of drug withdrawal.Taking Chinese herbal and crude drugs preparations of the present invention is that pain relieving, acid regurgitation disappear; The bimester of taking continuously, check ulcer heals completely, and gastric mucosa is normal.
Claims (7)
1. a Chinese herbal and crude drugs preparations for relieving ulcer by inhibiting gastric acid, is characterized in that, by the raw material of following weight portion, is made: 200 parts of Cortex Betulae Luminiferaes, 50-100 parts of caramel; Described Cortex Betulae Luminiferae is the bark of Betula plant Betula platyphylla Suk.; The dosage form of described Chinese herbal and crude drugs preparations is capsule, tablet or granule.
2. a preparation method for Chinese herbal and crude drugs preparations as claimed in claim 1, is characterized in that, the method comprises the following steps:
Step 1, Cortex Betulae Luminiferae is ground into 10～30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6～10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 1 hour～3 hours, amount of water is 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 0.5 hour～1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste; Or it is that 60%～80% reflow of alcohol is extracted twice that Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration, add for the first time ethanol amount for 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour～3 hours, add for the second time ethanol amount for 2～6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour～1.5 hours, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, after being mixed with caramel, the dry extract of Cortex Betulae Luminiferae described in step 3 is ground into 60 order fine powders, in then described fine powder being incapsulated, and the Chinese herbal medicine capsule agent of the gastric acid repairing ulcer that is inhibited.
3. preparation method according to claim 2, it is characterized in that, described in step 2, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour; Described in step 2, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, adds for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 1 hour.
4. a preparation method for Chinese herbal and crude drugs preparations as claimed in claim 1, is characterized in that, the method comprises the following steps:
Step 1, Cortex Betulae Luminiferae is ground into 10～30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6～10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 1 hour～3 hours, amount of water is 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 0.5 hour～1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste; Or it is that 60%～80% reflow of alcohol is extracted twice that Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration, add for the first time ethanol amount for 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour～3 hours, add for the second time ethanol amount for 2～6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour～1.5 hours, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional tabletting method to carry out tabletting to described fine powder, the Chinese medicinal herbal tablets of the gastric acid repairing ulcer that is inhibited.
5. preparation method according to claim 4, it is characterized in that, described in step 2, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour; Described in step 2, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, adds for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 1 hour.
6. a preparation method for Chinese herbal and crude drugs preparations as claimed in claim 1, is characterized in that, the method comprises the following steps:
Step 1, Cortex Betulae Luminiferae is ground into 10～30 object coarse powder;
Step 2, Cortex Betulae Luminiferae after crushed in step 1 is decocted with water and extracted twice, amount of water is 6～10 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, decocting time is 1 hour～3 hours, amount of water is 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, decocting time is 0.5 hour～1.5 hours, merging filtrate after filtering, being concentrated into 50 ℃, to record relative density be 1.30 thick paste; Or it is that 60%～80% reflow of alcohol is extracted twice that Cortex Betulae Luminiferae after crushed in step 1 is added to mass concentration, add for the first time ethanol amount for 4～8 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour～3 hours, add for the second time ethanol amount for 2～6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 0.5 hour～1.5 hours, merging filtrate after filtering, reclaims ethanol, and filtrate is concentrated into 50 ℃, and to record relative density be 1.30 thick paste;
Step 3, thick paste described in step 2 is placed in to vacuum drying tank carries out vacuum drying, obtain Cortex Betulae Luminiferae dry extract;
Step 4, be ground into 60 order fine powders after the dry extract of Cortex Betulae Luminiferae described in step 3 is mixed with caramel, then adopt conventional method of granulating by described fine powder granulation, the Chinese herbal medicine granule of the gastric acid repairing ulcer that is inhibited.
7. preparation method according to claim 6, it is characterized in that, described in step 2, amount of water is 8 times of the Cortex Betulae Luminiferae quality after pulverizing for the first time, and decocting time is 2 hours, amount of water is 6 times of the Cortex Betulae Luminiferae quality after pulverizing for the second time, and decocting time is 1 hour; Described in step 2, add for the first time ethanol amount for 6 times of the Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 2 hours, adds for the second time ethanol amount for 4 times of the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 1 hour.
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