CN102091138B - Gastrointestinal tablet and preparation process thereof - Google Patents
Gastrointestinal tablet and preparation process thereof Download PDFInfo
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- CN102091138B CN102091138B CN2011100090517A CN201110009051A CN102091138B CN 102091138 B CN102091138 B CN 102091138B CN 2011100090517 A CN2011100090517 A CN 2011100090517A CN 201110009051 A CN201110009051 A CN 201110009051A CN 102091138 B CN102091138 B CN 102091138B
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Abstract
The invention discloses a gastrointestinal tablet and a preparation method thereof, belonging to pure Chinese herbal medicine preparations. The gastrointestinal tablet is prepared from 80-120 parts of rhubarb, 80-120 parts of white peony root and 80-120 parts of liquorice. The invention provides a traditional Chinese medicine preparation for treating various gastrointestinal motility disorders such as gastroparesis syndrome, constipation, chronic gastritis, indigestion, peptic ulcer and the like by coordinating intestines and stomach and dredging functional activities of qi, and the traditional Chinese medicine preparation has better effects on treating the gastrointestinal motility disorders at present.
Description
Technical field the present invention relates to a kind of innerwear Chinese medicine preparation and preparation method thereof.Being specifically related to a kind of is method with regulating gastointestinal, mediation mechanism of qi; Treat the pharmaceutical preparation of various gastrointestinal motility disorder property diseases such as gastroparesis syndrome, constipation, chronic gastritis, dyspepsia, peptic ulcer, the invention still further relates to the method for preparing of this pharmaceutical preparation.
The medicine, particularly Chinese patent medicine of the existing treatment of background technology gastrointestinal motility disorder are very few, and curative effect is not remarkable, and cure rate is low.The similar Chinese patent medicine component that has is various, prescription is complicated, and curative effect is not sure.
Summary of the invention technical problem to be solved by this invention is to improve above-mentioned deficiency, and a kind of gastrointestinal sheet that relaxes is provided, and through regulating gastointestinal, dredge mechanism of qi, more effectively treats gastrointestinal motility disorder, and its preparation method is provided.
The present invention has adopted following technical scheme:
The gastrointestinal sheet that relaxes is characterized in that: get 80～120 parts of Radix Et Rhizoma Rhei, and 80～120 parts of the Radix Paeoniae Albas, 80～120 parts in Radix Glycyrrhizae is formulated; Described part refers to mass parts.
Optimization formula is: get 100 parts of Radix Et Rhizoma Rhei, and 100 parts of the Radix Paeoniae Albas, 100 parts in Radix Glycyrrhizae is formulated.
The preparation technology of the easypro sheet of described gastrointestinal is characterized in that being prepared from according to following steps:
The first, get Radix Et Rhizoma Rhei decoction piece, add the yellow wine of Radix Et Rhizoma Rhei decoction piece quality 20%～40%, stir; Moistening 2 hours is exhausted to yellow wine, in the porcelain enamel barrel of packing into; Place the water decatize 48 hours with porcelain enamel barrel is uncovered, steamed to Radix Et Rhizoma Rhei decoction piece, inside and outsidely all become black in color; Take out, oven dry, it is subsequent use to be ground into 80 order fine powders;
The second, in addition get the Radix Paeoniae Alba, Radix Glycyrrhizae, mix, three times (three times are respectively 45min to decocting, and 30min 30min), filters, and three filtratings merge behind the pressure slag, leave standstill 24 hours, get supernatant, are condensed into thick paste (80 ℃ of following d=1.25g/m
3), put to room temperature, add the Radix Et Rhizoma Rhei fine powder that has crushed, regulate humidity with starch, mixing is processed granule, 80 ℃ of oven dry, granulate is a lubricant with the magnesium stearate, mixing, tabletting.
Chinese herbal medicine of the present invention is according to traditional medicine and modern medicine analysis, and the property of medicine and pharmacological action are following.
Radix Et Rhizoma Rhei: property is bitter, and is cold.Return stomach, large intestine, Liver Channel, spleen channel.Attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, antidotal effect.Pharmacological research shows that Radix Et Rhizoma Rhei contains amaroid, takes low dose and can promote gastric secretion and the digestion-aid effect of being good for the stomach is arranged.
The Radix Paeoniae Alba: its bitter in the mouth, acid is slightly cold, and returns Liver Channel.Have suppressing liver-YANG, nourish blood and receive the effect of the moon.Pharmacological research shows that these article have coronary artery dilator, brings high blood pressure down the effect of hepatoprotective.
The present invention sheerly prepared from traditional Chinese medicines forms, and is a kind of Chinese medicine for oral administration, has the effect of regulating gastointestinal, mediation mechanism of qi.The Chinese herbaceous peony astringe yin that nourishes blood in the side, relieving spasm to stop pain; Rheum officinale is cleansed gastrointestinal retention and is weeded out the old and bring forth the new; The Radix Glycyrrhizae tonifying middle-Jiao and Qi in the sweet mitigation, with Chinese herbaceous peony compatibility sour-sweet herbs nourishing yin, nourishing yin and nourishing blood, relieving spasm to stop pain, makes with the rheum officinale compatibility and to capture and just do not hinder.All medicines share then cloudy liquid and must answer, and the muscle arteries and veins must be supported, and stagnant down, it is logical that internal organs is so incensed that, thereby recover the taste coordination between ascending and descending and reach therapeutic purposes.Modern medicine thinks that the main pathophysiological basis of primary disease is delayed gastric emptying and small intestinal transfer function obstacle.Experiment shows the easypro sheet ability of gastrointestinal accelerate gastrointestinal ahead running, and its mechanism of action is to strengthen the shrinkage amplitude of gastrointestinal smooth muscle spontaneous activity, and contraction frequency is not had obvious influence.The sheet prescription had both met differentiation of tcm so gastrointestinal relaxes, and also met the modern medicine viewpoint.
In addition, the present invention has also that raw material type is few, cost is low, the simple outstanding feature of preparation technology.
The specific embodiment further specifies the present invention in order to understand better and to implement below in conjunction with embodiment.
It below is preparation example.
Preparation example one
Proportioning raw materials: 100 parts of Radix Et Rhizoma Rhei, 100 parts of the Radix Paeoniae Albas, 100 parts in Radix Glycyrrhizae.Described part refers to mass parts.
Method for making:
The first, get Radix Et Rhizoma Rhei decoction piece, add the yellow wine of Radix Et Rhizoma Rhei decoction piece quality 30%, stir moistening 2 hours; Exhausted to yellow wine, in the porcelain enamel barrel of packing into, placed the water decatize 48 hours with porcelain enamel barrel is uncovered, steamed to Radix Et Rhizoma Rhei decoction piece; Inside and outside all become black in color, take out, oven dry, it is subsequent use to be ground into 80 order fine powders;
The second, in addition get the Radix Paeoniae Alba, Radix Glycyrrhizae, mix, three times (three times are respectively 45min to decocting, and 30min 30min), filters, and three filtratings merge behind the pressure slag, leave standstill 24 hours, get supernatant, are condensed into thick paste (80 ℃ of following d=1.25g/m
3), put to room temperature, add the Radix Et Rhizoma Rhei fine powder that has crushed, regulate humidity with starch, mixing is processed granule, 80 ℃ of oven dry, granulate is a lubricant with the magnesium stearate, mixing, tabletting.
Every is equivalent to crude drug 1.5g, and packing promptly gets.
Preparation example two
Proportioning raw materials: 80 parts of Radix Et Rhizoma Rhei, 120 parts of the Radix Paeoniae Albas, 80 parts in Radix Glycyrrhizae.Described part refers to mass parts.
Method for making:
The first, get Radix Et Rhizoma Rhei decoction piece, add the yellow wine of Radix Et Rhizoma Rhei decoction piece quality 20%, stir moistening 2 hours; Exhausted to yellow wine, in the porcelain enamel barrel of packing into, placed the water decatize 48 hours with porcelain enamel barrel is uncovered, steamed to Radix Et Rhizoma Rhei decoction piece; Inside and outside all become black in color, take out, oven dry, it is subsequent use to be ground into 80 order fine powders;
The second, in addition get the Radix Paeoniae Alba, Radix Glycyrrhizae, mix, three times (three times are respectively 45min to decocting, and 30min 30min), filters, and three filtratings merge behind the pressure slag, leave standstill 24 hours, get supernatant, are condensed into thick paste (80 ℃ of following d=1.25g/m
3), put to room temperature, add the Radix Et Rhizoma Rhei fine powder that has crushed, regulate humidity with starch, mixing is processed granule, 80 ℃ of oven dry, granulate is a lubricant with the magnesium stearate, mixing, tabletting.
Every is equivalent to crude drug 1.5g, and packing promptly gets.
Preparation example three
Proportioning raw materials: 120 parts of Radix Et Rhizoma Rhei, 80 parts of the Radix Paeoniae Albas, 120 parts in Radix Glycyrrhizae.Described part refers to mass parts.
Method for making:
The first, get Radix Et Rhizoma Rhei decoction piece, add the yellow wine of Radix Et Rhizoma Rhei decoction piece quality 40%, stir moistening 2 hours; Exhausted to yellow wine, in the porcelain enamel barrel of packing into, placed the water decatize 48 hours with porcelain enamel barrel is uncovered, steamed to Radix Et Rhizoma Rhei decoction piece; Inside and outside all become black in color, take out, oven dry, it is subsequent use to be ground into 80 order fine powders;
The second, in addition get the Radix Paeoniae Alba, Radix Glycyrrhizae, mix, three times (three times are respectively 45min to decocting, and 30min 30min), filters, and three filtratings merge behind the pressure slag, leave standstill 24 hours, get supernatant, are condensed into thick paste (80 ℃ of following d=1.25g/m
3), put to room temperature, add the Radix Et Rhizoma Rhei fine powder that has crushed, regulate humidity with starch, mixing is processed granule, 80 ℃ of oven dry, granulate is a lubricant with the magnesium stearate, mixing, tabletting.
Every is equivalent to crude drug 1.5g, and packing promptly gets.
[proterties] this product is the plain sheet of taupe, and gas is fragrant, bitter.
[discriminating] got 1 of these article, and in small beaker, adding distil water 5ml dissolves, and filters, and hydro-oxidation sodium test solution is 3 in the filtrating, and solution becomes is red.
[inspection] these article meet " pertinent regulations under 2000 editions one appendix ID tablet of Chinese pharmacopoeia (half extractum sheet) item.
[function with cure mainly] regulating gastointestinal, mediation mechanism of qi.Be used to treat various gastrointestinal motility disorder property diseases such as gastroparesis syndrome, constipation, chronic gastritis, dyspepsia, peptic ulcer.
[consumption and usage] is oral, and each 1～3, every day 1～3 time, obey half an hour ante cibum.
Crude drug source is bought by medical material company, and the medical material standard meets the Pharmacopoeia of the People's Republic of China and " the Sanitation Ministry medicine standard " etc.
This invents medicine that preparation adopts, and does not violate " eighteen incompatible medicaments ", " nineteen medicaments of mutual restraint ", mutual compatibility, no mutual inhibition reverse situation.Untoward reaction is not found in clinical practice.
It below is the easypro clinical use curative effect of the sheet situation of the routine gastrointestinal of preparation.Case derives from Hospital Affiliated to Bingzhou Medical Collage.
1, relax clinical observation on the therapeutic effect (the seeing table 1) result of sheet treatment gastroparesis syndrome of gastrointestinal shows, clinical cure and always effectively be superior to motilium (P＜0.01) is not seen untoward reaction.
Easypro sheet of table 1 gastrointestinal and motilium are to the gastroparesis syndrome clinical efficacy relatively
2, clinical observation on the therapeutic effect (the seeing table 2) result of the easypro sheet treatment of gastrointestinal constipation card shows that clinical cure rate is superior to TONGBIAN LING (P＜0.05), does not see untoward reaction.
Easypro sheet of table 2 gastrointestinal and TONGBIAN LING are to constipation card clinical efficacy relatively
3, the gastrointestinal sheet that relaxes shows gynecological's abdominal postoperative gastrointestinal peristalsis functional rehabilitation clinical observation on the therapeutic effect (seeing table 3) result, and the oral gastrointestinal of the postoperative sheet that relaxes shortens 7h than nonacceptor's gastrointestinal tract time average that begins to wriggle, and postoperative evacuation time first on average shortens 13h.And the easypro sheet of gastrointestinal has no adverse effects to gynecologic surgery patient temperature, breathing, pulse, blood pressure, electrocardiogram, hepatic and renal function etc.
Table 3 gastrointestinal relaxes sheet to abdominal postoperative gastrointestinal peristalsis functional rehabilitation clinical efficacy relatively
Claims (3)
1. treat the medicine of gastrointestinal motility disorder property disease, it is characterized in that: get 80～120 parts of Radix Et Rhizoma Rhei, 80～120 parts of the Radix Paeoniae Albas, 80～120 parts in Radix Glycyrrhizae is formulated; Described part refers to mass parts.
2. the medicine of treatment gastrointestinal motility disorder property disease as claimed in claim 1 is characterized in that: get 100 parts of Radix Et Rhizoma Rhei, and 100 parts of the Radix Paeoniae Albas, 100 parts in Radix Glycyrrhizae is formulated.
3. according to the preparation technology of the medicine of claim 1 or 2 described treatment gastrointestinal motility disorder property diseases, it is characterized in that being prepared from according to following steps:
The first, get Radix Et Rhizoma Rhei decoction piece, add the yellow wine of Radix Et Rhizoma Rhei decoction piece quality 20%～40%, stir; Moistening 2 hours is exhausted to yellow wine, in the porcelain enamel barrel of packing into; Place the water decatize 48 hours with porcelain enamel barrel is uncovered, steamed to Radix Et Rhizoma Rhei decoction piece, inside and outsidely all become black in color; Take out, oven dry, it is subsequent use to be ground into 80 order fine powders;
The second, in addition get the Radix Paeoniae Alba, Radix Glycyrrhizae, mix, decocting three times, three times are respectively 45min, 30min, 30min; Filter, three filtratings merge behind the pressure slag, leave standstill 24 hours, get supernatant, are condensed into the thick paste of 80 ℃ of following d=1.25g/m3; Put to room temperature, add the Radix Et Rhizoma Rhei fine powder that has crushed, regulate humidity with starch, mixing is processed granule; 80 ℃ of oven dry, granulate is a lubricant with the magnesium stearate, mixing, tabletting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100090517A CN102091138B (en) | 2011-01-08 | 2011-01-08 | Gastrointestinal tablet and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100090517A CN102091138B (en) | 2011-01-08 | 2011-01-08 | Gastrointestinal tablet and preparation process thereof |
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| CN102091138A CN102091138A (en) | 2011-06-15 |
| CN102091138B true CN102091138B (en) | 2012-07-25 |
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| CN2011100090517A Active CN102091138B (en) | 2011-01-08 | 2011-01-08 | Gastrointestinal tablet and preparation process thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083504A (en) * | 2013-03-07 | 2013-05-08 | 于晓红 | Traditional medical composition for treating constipation |
| CN103919895B (en) * | 2014-04-21 | 2015-10-28 | 陈光敏 | The Chinese medicinal liquor of a kind of the intestines and stomach coordinating, treatment constipation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150904A (en) * | 1995-11-21 | 1997-06-04 | 陕西省中医药研究院 | Kenading muscle and anti-paralysis tablet |
-
2011
- 2011-01-08 CN CN2011100090517A patent/CN102091138B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150904A (en) * | 1995-11-21 | 1997-06-04 | 陕西省中医药研究院 | Kenading muscle and anti-paralysis tablet |
Non-Patent Citations (7)
| Title |
|---|
| 刘孟安 |
| 刘孟安;等.胃肠舒片治疗痞满证临床观察.《中国中医急症》.2006,第15卷(第8期),843-844. * |
| 等.大黄甘草汤在新生儿疾病中的运用.《中国医刊》.1980,(第6期),35－36. |
| 等.胃肠舒片治疗痞满证临床观察.《中国中医急症》.2006,第15卷(第8期),843-844. |
| 虞觐冠 |
| 虞觐冠;等.大黄甘草汤在新生儿疾病中的运用.《中国医刊》.1980,(第6期),35-36. * |
| 赵永德,等.RP-HPLC法测定胃肠舒片中芍药苷的含量.《中国药师》.2005,第8卷(第12期),1007-1008. * |
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| CN102091138A (en) | 2011-06-15 |
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