CN101607061A - A kind of drug regimen of protecting gastric mucosa and preparation method thereof - Google Patents
A kind of drug regimen of protecting gastric mucosa and preparation method thereof Download PDFInfo
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- CN101607061A CN101607061A CNA2008101153437A CN200810115343A CN101607061A CN 101607061 A CN101607061 A CN 101607061A CN A2008101153437 A CNA2008101153437 A CN A2008101153437A CN 200810115343 A CN200810115343 A CN 200810115343A CN 101607061 A CN101607061 A CN 101607061A
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Abstract
The present invention discloses a kind of drug regimen of protecting gastric mucosa and preparation method thereof, and effective ingredient of the present invention is to be formed through extraction by tens medical materials such as Radix Pseudostellariae, Fructus Evodiae, Fructus Gardeniae (parched to brown) core, Fructus Aurantii, Endothelium Corneum Gigeriae Galli, Pericarpium Arecae, the Radix Aucklandiae, Pericarpium Citri tangerinae, Fructus Citri Sarcodactylis, Rhizoma Cyperi, Massa Medicata Fermentata preparata, Radix Glycyrrhizae Preparata, Fructus Amomis.Distinctive active constituents of medicine can effectively be protected the harmonization of the stomach esophageal mucosa membrane injury among the present invention, is used for the treatment of acute or chronic gastritis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen of protecting gastric mucosa and preparation method thereof.
Technical background
Chronic gastritis is meant because the gastric mucosa chronic inflammatory disease due to a variety of causes changes.Be a kind of commonly encountered diseases and frequently-occurring disease clinically.Male's sickness rate is higher than the women, and with the growth at age, the sickness rate of primary disease is warming up of rising.
The feature of chronic gastritis is the chronic inflammatory disease that gastric mucosa takes place repeatedly, and the gastric gland atrophy reduces, and mucous layer shows as specificity regeneration, and clinical manifestation is based on the Pathophysiology of gastric mucosa inflammation stomach function regulating gland atrophy.Chronic gastritis is divided into two kinds of constitutional chronic gastritis and Secondary cases chronic gastritiss.
The Secondary cases chronic gastritis often is secondary to heart failure, liver and gall and other digestive system disease, and the performance of chronic gastritis is the part of protopathy symptom.The constitutional chronic gastritis cause of disease is also not clear fully so far, has fraction to be transformed from acute gastritis, wherein with chronic superficial gastritis and chronic atrophic gastritis for seeing more.
Chronic gastritis its essence is the chronic inflammatory disease or the atrophic lesion of gastric mucosa, after its essence is that gastric epithelial suffers to damage repeatedly, because the special regeneration capacity of portion's film, so that mucosa is reconstructed, and finally cause the atrophy of irreversible intrinsic gastric gland body, even disappear.Go up and to want that symptom characteristic has that epigastrium pain, institute's abdominal distention are asked, glutted, heartburn, nauseating, vomiting and inappetence etc.Primary disease is very common, accounts for to accept gastroscopy patient's 80%～90%, and the male increases with the age growth sickness rate gradually more than the women.Chronic gastritis belong to the traditional Chinese medical science " stomach institute pain ", " the stomach painful abdominal mass ' etc. category.
The sick position of primary disease is at stomach, and is relevant with internal organs such as liver, spleen, stomaches.The generation of primary disease is how relevant with eating and drinking without temperance and disorder of emotion.Can be pungent because of having a liking for food.Drink for a long time, diet raw food, impairing the spleen and stomach; Or because of melancholy impairing the spleen, excessive anger impairing the liver, incoordination between the liver and stomach all can cause primary disease; If further develop, or stagnated QI transforming into fire, injuring stomach-Yin, stomach loses profit and falls; Or a little less than the deficiency of spleen-YANG, lose in warm; Or disease hinders network for a long time, and the blood vessels stasis of blood stagnates; All can cause the taste abnormal ascending-descending of QI.
The present invention is a folk remedy, and the while is prescription in conjunction with the sick research theory of up-to-date digestion, and selects authentic medicinal herbs for use, and ancient method is concocted, and has fully guaranteed the natural sex and the biological activity of medicine.Can effectively protect the harmonization of the stomach esophageal mucosa membrane injury.Wherein contained antipathogenic composition can suppress and kill helicobacter pylori and eliminate mucosal inflammation.
Summary of the invention
One of purpose of the present invention provides a kind of drug regimen of protecting gastric mucosa.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Pseudostellariae 100-200 part Fructus Evodiae 100-200 part Fructus Gardeniae (parched to brown) core 100-200 part
Fructus Aurantii 100-200 part Endothelium Corneum Gigeriae Galli 50-100 part Pericarpium Arecae 100-200 part
Radix Aucklandiae 100-200 part Pericarpium Citri tangerinae 50-100 part Fructus Citri Sarcodactylis 100-200 part
Rhizoma Cyperi 100-200 part Massa Medicata Fermentata preparata 100-200 part Radix Glycyrrhizae Preparata 50-100 part
Fructus Amomi 100-200 part
The active component that preferred following raw materials according is made, curative effect is better:
100 parts of 150 parts of Fructus Gardeniae (parched to brown) core of 200 parts of Fructus Evodiaes of Radix Pseudostellariae
100 parts of 50 parts of Pericarpium Arecae of 150 parts of Endothelium Corneum Gigeriae Galli of Fructus Aurantii
100 parts of 50 portions of Fructus Citri Sarcodactylis of 150 parts of Pericarpium Citri tangerinaes of the Radix Aucklandiae
50 parts of 100 parts of Radix Glycyrrhizae Preparatas of 150 parts of Massa Medicata Fermentata preparatas of Rhizoma Cyperi
100 parts of Fructus Amomis
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology:
(1) Radix Aucklandiae powder is broken into fine powder, sieves;
(2) Radix Pseudostellariae, Fructus Evodiae, Fructus Gardeniae (parched to brown) core, Fructus Aurantii, Endothelium Corneum Gigeriae Galli, Pericarpium Arecae, Pericarpium Citri tangerinae, Fructus Citri Sarcodactylis, Massa Medicata Fermentata preparata, Radix Glycyrrhizae Preparata, Fructus Amomi etc. ten are decocted with water secondary simply, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(3) Rhizoma Cyperi is used 70% ethanol, the heating and refluxing extraction secondary, and each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (2) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(4) with step (3) gained thick paste and Radix Aucklandiae fine powder mixing, granulate, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, fully guaranteed the natural sex and the biological activity of medicine.Can effectively protect the harmonization of the stomach esophageal mucosa membrane injury, be used for the treatment of acute or chronic gastritis.
By the following examples technical scheme of the present invention is described further.
Specific embodiment:
Embodiment 1: the preparation method of granule
1. write out a prescription:
100 parts of 150 parts of Fructus Gardeniae (parched to brown) core of 200 parts of Fructus Evodiaes of Radix Pseudostellariae
100 parts of 50 parts of Pericarpium Arecae of 150 parts of Endothelium Corneum Gigeriae Galli of Fructus Aurantii
100 parts of 50 portions of Fructus Citri Sarcodactylis of 150 parts of Pericarpium Citri tangerinaes of the Radix Aucklandiae
50 parts of 100 parts of Radix Glycyrrhizae Preparatas of 150 parts of Massa Medicata Fermentata preparatas of Rhizoma Cyperi
100 parts of Fructus Amomis
2. preparation technology:
(1) Radix Aucklandiae powder is broken into fine powder, sieves;
(2) Radix Pseudostellariae, Fructus Evodiae, Fructus Gardeniae (parched to brown) core, Fructus Aurantii, Endothelium Corneum Gigeriae Galli, Pericarpium Arecae, Pericarpium Citri tangerinae, Fructus Citri Sarcodactylis, Massa Medicata Fermentata preparata, Radix Glycyrrhizae Preparata, Fructus Amomi etc. ten are decocted with water secondary simply, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(3) Rhizoma Cyperi is used 70% ethanol, the heating and refluxing extraction secondary, and each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (2) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(4) with step (3) gained thick paste and Radix Aucklandiae fine powder mixing, granulate, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
100 parts of 150 parts of Fructus Gardeniae (parched to brown) core of 200 parts of Fructus Evodiaes of Radix Pseudostellariae
100 parts of 50 parts of Pericarpium Arecae of 150 parts of Endothelium Corneum Gigeriae Galli of Fructus Aurantii
100 parts of 50 portions of Fructus Citri Sarcodactylis of 150 parts of Pericarpium Citri tangerinaes of the Radix Aucklandiae
50 parts of 100 parts of Radix Glycyrrhizae Preparatas of 150 parts of Massa Medicata Fermentata preparatas of Rhizoma Cyperi
100 parts of Fructus Amomis
2. preparation technology:
(1) Radix Aucklandiae powder is broken into fine powder, sieves;
(2) Radix Pseudostellariae, Fructus Evodiae, Fructus Gardeniae (parched to brown) core, Fructus Aurantii, Endothelium Corneum Gigeriae Galli, Pericarpium Arecae, Pericarpium Citri tangerinae, Fructus Citri Sarcodactylis, Massa Medicata Fermentata preparata, Radix Glycyrrhizae Preparata, Fructus Amomi etc. ten are decocted with water secondary simply, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(3) Rhizoma Cyperi is used 70% ethanol, the heating and refluxing extraction secondary, and each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (2) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(4) with step (3) gained thick paste and Radix Aucklandiae fine powder mixing, granulate, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
100 parts of 150 parts of Fructus Gardeniae (parched to brown) core of 200 parts of Fructus Evodiaes of Radix Pseudostellariae
100 parts of 50 parts of Pericarpium Arecae of 150 parts of Endothelium Corneum Gigeriae Galli of Fructus Aurantii
100 parts of 50 portions of Fructus Citri Sarcodactylis of 150 parts of Pericarpium Citri tangerinaes of the Radix Aucklandiae
50 parts of 100 parts of Radix Glycyrrhizae Preparatas of 150 parts of Massa Medicata Fermentata preparatas of Rhizoma Cyperi
100 parts of Fructus Amomis
2. preparation technology:
(1) Radix Aucklandiae powder is broken into fine powder, sieves;
(2) Radix Pseudostellariae, Fructus Evodiae, Fructus Gardeniae (parched to brown) core, Fructus Aurantii, Endothelium Corneum Gigeriae Galli, Pericarpium Arecae, Pericarpium Citri tangerinae, Fructus Citri Sarcodactylis, Massa Medicata Fermentata preparata, Radix Glycyrrhizae Preparata, Fructus Amomi etc. ten are decocted with water secondary simply, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(3) Rhizoma Cyperi is used 70% ethanol, the heating and refluxing extraction secondary, and each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (2) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(4) with step (3) gained thick paste and Radix Aucklandiae fine powder mixing, granulate, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen of protecting gastric mucosa is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Pseudostellariae 100-200 part Fructus Evodiae 100-200 part Fructus Gardeniae (parched to brown) core 100-200 part
Fructus Aurantii 100-200 part Endothelium Corneum Gigeriae Galli 50-100 part Pericarpium Arecae 100-200 part
Radix Aucklandiae 100-200 part Pericarpium Citri tangerinae 50-100 part Fructus Citri Sarcodactylis 100-200 part
Rhizoma Cyperi 100-200 part Massa Medicata Fermentata preparata 100-200 part Radix Glycyrrhizae Preparata 50-100 part
Fructus Amomi 100-200 part.
2, a kind of drug regimen of protecting gastric mucosa according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
100 parts of 150 parts of Fructus Gardeniae (parched to brown) core of 200 parts of Fructus Evodiaes of Radix Pseudostellariae
100 parts of 50 parts of Pericarpium Arecae of 150 parts of Endothelium Corneum Gigeriae Galli of Fructus Aurantii
100 parts of 50 portions of Fructus Citri Sarcodactylis of 150 parts of Pericarpium Citri tangerinaes of the Radix Aucklandiae
50 parts of 100 parts of Radix Glycyrrhizae Preparatas of 150 parts of Massa Medicata Fermentata preparatas of Rhizoma Cyperi
100 parts of Fructus Amomis.
3, according to the described a kind of drug regimen of protecting gastric mucosa of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Aucklandiae powder is broken into fine powder, sieves;
(2) Radix Pseudostellariae, Fructus Evodiae, Fructus Gardeniae (parched to brown) core, Fructus Aurantii, Endothelium Corneum Gigeriae Galli, Pericarpium Arecae, Pericarpium Citri tangerinae, Fructus Citri Sarcodactylis, Massa Medicata Fermentata preparata, Radix Glycyrrhizae Preparata, Fructus Amomi etc. ten are decocted with water secondary simply, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(3) Rhizoma Cyperi is used 70% ethanol, the heating and refluxing extraction secondary, and each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (2) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(4) with step (3) gained thick paste and Radix Aucklandiae fine powder mixing, granulate, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of drug regimen of protecting gastric mucosa among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen of protecting gastric mucosa of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101153437A CN101607061A (en) | 2008-06-20 | 2008-06-20 | A kind of drug regimen of protecting gastric mucosa and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101153437A CN101607061A (en) | 2008-06-20 | 2008-06-20 | A kind of drug regimen of protecting gastric mucosa and preparation method thereof |
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| CN101607061A true CN101607061A (en) | 2009-12-23 |
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| CNA2008101153437A Pending CN101607061A (en) | 2008-06-20 | 2008-06-20 | A kind of drug regimen of protecting gastric mucosa and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536874A (en) * | 2013-10-08 | 2014-01-29 | 覃祖仁 | Medicine for treating superficial gastritis |
| CN104524414A (en) * | 2014-12-26 | 2015-04-22 | 山东明仁福瑞达制药股份有限公司 | Traditional Chinese medicine preparation for treating chronic gastritis |
-
2008
- 2008-06-20 CN CNA2008101153437A patent/CN101607061A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536874A (en) * | 2013-10-08 | 2014-01-29 | 覃祖仁 | Medicine for treating superficial gastritis |
| CN104524414A (en) * | 2014-12-26 | 2015-04-22 | 山东明仁福瑞达制药股份有限公司 | Traditional Chinese medicine preparation for treating chronic gastritis |
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| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20091223 |