CN101607074A - A kind of drug regimen for the treatment of chronic gastritis and preparation method thereof - Google Patents
A kind of drug regimen for the treatment of chronic gastritis and preparation method thereof Download PDFInfo
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- CN101607074A CN101607074A CNA2008101153418A CN200810115341A CN101607074A CN 101607074 A CN101607074 A CN 101607074A CN A2008101153418 A CNA2008101153418 A CN A2008101153418A CN 200810115341 A CN200810115341 A CN 200810115341A CN 101607074 A CN101607074 A CN 101607074A
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Abstract
The present invention discloses a kind of drug regimen for the treatment of chronic gastritis and preparation method thereof, and effective ingredient of the present invention is to be formed through extraction by tens medical materials such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Fructus Amomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, the Radix Astragali, Endothelium Corneum Gigeriae Galli.Distinctive active constituents of medicine can effectively be protected the harmonization of the stomach esophageal mucosa membrane injury and can suppress and kill helicobacter pylori and eliminate mucosal inflammation among the present invention, clinically is used for the treatment of disease such as acute or chronic gastritis.
Description
Technical field:
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen for the treatment of chronic gastritis and preparation method thereof.
Technical background
Chronic gastritis comprises chronic atrophic gastritis, chronic superficial gastritis (bile reflux gastritis), antral gastritis, gastritis verrucosa (claiming erosive gastritis, gastritis varioliformis, polypoid gastritis again).
Chronic gastritis is chronic inflammation pathological changes or the atrophic lesion that gastric mucosa is taken place under various paathogenic factor effects.At present its name and classification are still lacked unified understanding, generally be divided into chronic superficial gastritis and chronic atrophic gastritis, wherein atrophic gastritis is divided into A type (body of stomach pathological changes) and Type B (gastric antrum pathological changes) again.The category that also belongs to chronic gastritis as for specific types such as gastritis verrucosa, partial gastritis.
Chronic gastritis does not have typical case and special clinical symptoms, most patient shows as dyspeptic symptom, glutted or pain, belch, pantothenic acid etc., especially atrophic gastritis patient as feed aftersensation epigastrium, mainly showing as stomach seemingly has thing to stop up sense, but the void of pressing is soft.The primary disease sickness rate is high, occupy the first in various gastropathy, can't accurately add up, and account for and accept more than 90% of gastroscopy patient, and its sickness rate has with age growth trend of rising to some extent.
Above distention and fullness in the abdomen of primary disease or pain are cardinal symptom, belong to the category of Chinese medicine " stomach painful abdominal mass ", " stomachache ".
Chronic gastritis does not have typical case and specific clinical symptoms, clinical symptoms can be not consistent with the degree of pathological changes yet, show as repeatedly or persistence epigastric discomfort, glutted, dull pain, burning pain, no obvious rhythmicity, heavier after the general feed, secondly be appetite decline, belch, pantothenic acid, indigestion symptom such as nauseating.These symptoms can not be alleviated with antacid and spasmolytic.There is the part patient not have clinical symptoms.The person can occur hemorrhage on a small quantity and row's melena the gastric mucosal erosion, and long-term person especially atrophic gastritis then has Anemia.In addition, dissimilar its clinical manifestations of chronic gastritis emphasize particularly on different fields.
(1) chronic superficial gastritis is main person with gastric antrum portion inflammation especially, shows as epigastrium distending pain, dull pain, dull pain or causalgia mostly, and the pain majority occurs after the meal, because of anxious state of mind, overwork, climate change and diet are careless etc., and factor increases the weight of.Gastrointestinal tract excitation symptoms such as it is undesired to cause nausea when upper abdominal pain exacerbates, vomit, defecate.Also there is some cases can show as Peptic Ulcers sample symptom, gastric cancer sample symptom, pyloric obstruction sample symptom, also can merges hemorrhage and cause a series of symptoms.
(2) chronic atrophic gastritis mainly shows as the epigastrium feeling of repletion, feel that all day stomach is glutted and little with the relation of whether taking food, have no appetite, appetite reduces, refer to that to containing protein the more food of fat is difficult to digestion, and cause diarrhoea easily, indigested fat granule, muscle fiber and dish slag etc. are often arranged in the stool.Many have pale complexion, health to become thin, symptom such as body is tired, weak, dizzy, insomnia.
(3) gastritis verrucosa claims chronic erosive gastritis, gastritis varioliformis, polypoid gastritis etc. again.Most patients feel epigastrium pain, and its character is similar to Peptic Ulcers, also with inappetence, nausea and vomiting, lose weight, symptom such as malaise, also can merge hemorrhage.
(4) anastomositis, partial gastritis are pathological changes common behind the gastrectomy, can occur in behind the stomach operation in the recent period with at a specified future date.Show as mainly that the epigastrium big gun expands, pain, more than increasing the weight of after meal, even take place to feel sick, vomiting bile, the patient's inappetence that has loses weight, fatigue and asthenia etc., part patient can arrange melena.
The present invention is a folk remedy, and the while is prescription in conjunction with the sick research theory of up-to-date digestion, and selects authentic medicinal herbs for use, and ancient method is concocted, and has fully guaranteed the natural sex and the biological activity of medicine.The harmonization of the stomach esophageal mucosa membrane injury can be effectively protected and helicobacter pylori elimination mucosal inflammation can be suppressed and kill.
Summary of the invention
One of purpose of the present invention provides a kind of drug regimen for the treatment of chronic gastritis.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1, prescription:
Radix Codonopsis 50-150 part Rhizoma Atractylodis Macrocephalae 50-150 part Poria 50-150 part
Radix Paeoniae Alba 50-150 part Rhizoma Chuanxiong 50-150 part Pericarpium Citri Reticulatae 50-150 part
Fructus Amomi 50-150 part Radix Aconiti Lateralis Preparata 50-150 part Rhizoma Zingiberis 50-150 part
Radix Glycyrrhizae 50-150 part Cortex Magnoliae Officinalis 50-150 part Radix Astragali 50-150 part
Endothelium Corneum Gigeriae Galli 50-150 part
The active component that preferred following raw materials according is made, curative effect is better:
100 parts in 100 parts of Poria of 150 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis
150 parts of 100 parts of Pericarpium Citri Reticulataes of 100 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
50 parts of 100 portions of Rhizoma Zingiberiss of 50 parts of Radix Aconiti Lateralis Preparatas of Fructus Amomi
100 parts of 100 parts of Radixs Astragali of 50 parts of Cortex Magnoliae Officinalis of Radix Glycyrrhizae
50 parts of Endothelium Corneum Gigeriae Galli
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2, preparation technology:
(1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Fructus Amomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Radix Glycyrrhizae, the Radix Astragali, Endothelium Corneum Gigeriae Galli are decocted with water secondary, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(2) Cortex Magnoliae Officinalis 70% ethanol, the heating and refluxing extraction secondary, each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (1) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(3) with gained thick paste drying in the step (2), be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
By the following examples technical scheme of the present invention is described further.
Specific embodiment
Embodiment 1: the preparation method of granule
1, prescription:
100 parts in 100 parts of Poria of 150 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis
150 parts of 100 parts of Pericarpium Citri Reticulataes of 100 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
50 parts of 100 portions of Rhizoma Zingiberiss of 50 parts of Radix Aconiti Lateralis Preparatas of Fructus Amomi
100 parts of 100 parts of Radixs Astragali of 50 parts of Cortex Magnoliae Officinalis of Radix Glycyrrhizae
50 parts of Endothelium Corneum Gigeriae Galli
2, preparation technology:
(1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Fructus Amomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Radix Glycyrrhizae, the Radix Astragali, Endothelium Corneum Gigeriae Galli are decocted with water secondary, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(2) Cortex Magnoliae Officinalis 70% ethanol, the heating and refluxing extraction secondary, each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (1) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(3) with gained thick paste drying in the step (2), be ground into fine powder, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1, prescription:
100 parts in 100 parts of Poria of 150 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis
150 parts of 100 parts of Pericarpium Citri Reticulataes of 100 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
50 parts of 100 portions of Rhizoma Zingiberiss of 50 parts of Radix Aconiti Lateralis Preparatas of Fructus Amomi
100 parts of 100 parts of Radixs Astragali of 50 parts of Cortex Magnoliae Officinalis of Radix Glycyrrhizae
50 parts of Endothelium Corneum Gigeriae Galli
2, preparation technology:
(1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Fructus Amomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Radix Glycyrrhizae, the Radix Astragali, Endothelium Corneum Gigeriae Galli are decocted with water secondary, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(2) Cortex Magnoliae Officinalis 70% ethanol, the heating and refluxing extraction secondary, each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (1) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(3) with gained thick paste drying in the step (2), be ground into fine powder, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1, prescription:
100 parts in 100 parts of Poria of 150 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis
150 parts of 100 parts of Pericarpium Citri Reticulataes of 100 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
50 parts of 100 portions of Rhizoma Zingiberiss of 50 parts of Radix Aconiti Lateralis Preparatas of Fructus Amomi
100 parts of 100 parts of Radixs Astragali of 50 parts of Cortex Magnoliae Officinalis of Radix Glycyrrhizae
50 parts of Endothelium Corneum Gigeriae Galli
2, preparation technology:
(1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Fructus Amomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Radix Glycyrrhizae, the Radix Astragali, Endothelium Corneum Gigeriae Galli are decocted with water secondary, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(2) Cortex Magnoliae Officinalis 70% ethanol, the heating and refluxing extraction secondary, each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (1) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(3) with gained thick paste drying in the step (2), be ground into fine powder, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen for the treatment of chronic gastritis is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Codonopsis 50-150 part Rhizoma Atractylodis Macrocephalae 50-150 part Poria 50-150 part
Radix Paeoniae Alba 50-150 part Rhizoma Chuanxiong 50-150 part Pericarpium Citri Reticulatae 50-150 part
Fructus Amomi 50-150 part Radix Aconiti Lateralis Preparata 50-150 part Rhizoma Zingiberis 50-150 part
Radix Glycyrrhizae 50-150 part Cortex Magnoliae Officinalis 50-150 part Radix Astragali 50-150 part
Endothelium Corneum Gigeriae Galli 50-150 part.
2, a kind of drug regimen for the treatment of chronic gastritis according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
100 parts in 100 parts of Poria of 150 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis
150 parts of 100 parts of Pericarpium Citri Reticulataes of 100 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
50 parts of 100 portions of Rhizoma Zingiberiss of 50 parts of Radix Aconiti Lateralis Preparatas of Fructus Amomi
100 parts of 100 parts of Radixs Astragali of 50 parts of Cortex Magnoliae Officinalis of Radix Glycyrrhizae
50 parts of Endothelium Corneum Gigeriae Galli.
3, according to the described a kind of drug regimen for the treatment of chronic gastritis of claim 1-2, it is characterized in that adopting following method to make:
(1) businesses such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Fructus Amomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Radix Glycyrrhizae, the Radix Astragali, Endothelium Corneum Gigeriae Galli flavor flavor is decocted with water secondary, 3 hours for the first time, 2 hours for the second time, filter merging filtrate;
(2) Cortex Magnoliae Officinalis 70% ethanol, the heating and refluxing extraction secondary, each 1.5 hours, merge extractive liquid, reclaimed ethanol, merged with step (1) gained filtrate, and it is the thick paste of 1.36 (60 ℃) that concentrating under reduced pressure becomes to relative density;
(3) with gained thick paste drying in the step (2), be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of drug regimen for the treatment of chronic gastritis among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen for the treatment of chronic gastritis of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| CNA2008101153418A CN101607074A (en) | 2008-06-20 | 2008-06-20 | A kind of drug regimen for the treatment of chronic gastritis and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874874A (en) * | 2010-07-01 | 2010-11-03 | 夏黎明 | Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof |
| CN102579787A (en) * | 2012-03-19 | 2012-07-18 | 付光春 | Traditional Chinese medicine composition for treating chronic gastritis |
| CN104353036A (en) * | 2014-10-29 | 2015-02-18 | 崔小花 | Traditional Chinese medicine composition for curing epigastric pain caused by cold-heat jumble |
| CN104352965A (en) * | 2014-10-15 | 2015-02-18 | 刘昌海 | Compound consolidant for treating helicobacter pylori and peptic ulcer |
| CN104398726A (en) * | 2014-10-22 | 2015-03-11 | 蔺洪俊 | Traditional Chinese medicine for treating diarrhea and preparing method thereof |
| CN105031587A (en) * | 2015-08-14 | 2015-11-11 | 任德旺 | Chinese herba preparation for curing gastrointestinal diseases |
| CN105435064A (en) * | 2015-12-11 | 2016-03-30 | 赵爱良 | Pill with function of nourishing stomach and preparation method thereof |
| CN106215031A (en) * | 2016-08-22 | 2016-12-14 | 成都威迪视特生物科技有限公司 | A kind of for synthetic drug treating gastroenteritis and preparation method thereof |
-
2008
- 2008-06-20 CN CNA2008101153418A patent/CN101607074A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874874A (en) * | 2010-07-01 | 2010-11-03 | 夏黎明 | Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof |
| CN102579787A (en) * | 2012-03-19 | 2012-07-18 | 付光春 | Traditional Chinese medicine composition for treating chronic gastritis |
| CN102579787B (en) * | 2012-03-19 | 2013-06-19 | 付光春 | Traditional Chinese medicine composition for treating chronic gastritis |
| CN104352965A (en) * | 2014-10-15 | 2015-02-18 | 刘昌海 | Compound consolidant for treating helicobacter pylori and peptic ulcer |
| CN104398726A (en) * | 2014-10-22 | 2015-03-11 | 蔺洪俊 | Traditional Chinese medicine for treating diarrhea and preparing method thereof |
| CN104353036A (en) * | 2014-10-29 | 2015-02-18 | 崔小花 | Traditional Chinese medicine composition for curing epigastric pain caused by cold-heat jumble |
| CN105031587A (en) * | 2015-08-14 | 2015-11-11 | 任德旺 | Chinese herba preparation for curing gastrointestinal diseases |
| CN105435064A (en) * | 2015-12-11 | 2016-03-30 | 赵爱良 | Pill with function of nourishing stomach and preparation method thereof |
| CN106215031A (en) * | 2016-08-22 | 2016-12-14 | 成都威迪视特生物科技有限公司 | A kind of for synthetic drug treating gastroenteritis and preparation method thereof |
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Open date: 20091223 |