CN101874874A - Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof - Google Patents

Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof Download PDF

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CN101874874A
CN101874874A CN 201010216048 CN201010216048A CN101874874A CN 101874874 A CN101874874 A CN 101874874A CN 201010216048 CN201010216048 CN 201010216048 CN 201010216048 A CN201010216048 A CN 201010216048A CN 101874874 A CN101874874 A CN 101874874A
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white
helicobacter pylori
cuttlebone
powder
stomach
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CN101874874B (en )
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夏黎明
孟玲
李凤燕
李文华
杨秀军
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夏黎明
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Abstract

The invention discloses a Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis, which is prepared from jiuxiang bug, rose, notoginseng root powder, astragalus, szechwon tangshen root, large-headed atractylodes rhizome, cassia twig, white paeony root, golden thread, medcinal evodia fruit, calcined ark shell, cuttlebone, fructus citri immaturus exsiccatus, common bletilla pseudobulb, cinnamomvine, mongolian dandelion herb, areca seed and liquorice root serving as raw materials in a certain weight ratio by a certain process according to different properties of each traditional Chinese medicine. The Chinese medicinal preparation has the advantages of scientific formula and reasonable compatibility, has the effects of warming middle-jiao and invigorating the spleen, regulating the flow of qi and harmonizing stomach, removing blood stasis and stopping pain, eliminating helicobacter pylori, promoting tissue regeneration and treating cutaneous pyogenic infection, protecting mucosa and healing stomach, promoting the healing of mucosa and reducing relapse, and particularly has the unique curative effect on symptoms such as epigastric pain, acid regurgitation, hiccough and eructation, anorexia and acratia, sallow complexion and the like which are caused by gastritis.

Description

一种治疗幽门螺旋菌相关性慢性胃炎的中药制剂及其制备 Chinese medicine preparation for the treatment of chronic gastritis associated with Helicobacter pylori and preparation

方法 method

技术领域 FIELD

[0001] 本发明涉及一种治疗幽门螺旋菌相关性慢性胃炎的中药制剂及其制备方法,属于中药技术领域。 [0001] The present invention relates to a traditional Chinese medicine preparation and preparation method of treating chronic Helicobacter pylori associated gastritis, it belongs to the technical field of medicine.

背景技术 Background technique

[0002] 幽门螺旋菌相关性慢性胃炎是一种常见病和多发病,现代医学研究认为50-90% 的胃炎与幽门螺旋菌感染有关,该病发病率高,病史长,常反复发作,不易根治。 [0002] Helicobacter pylori related chronic gastritis is a common and frequently-occurring disease, modern medicine studies suggest that 50-90% of gastritis and Helicobacter pylori infection, the disease incidence, long history, often recurrent and difficult cure. 随着生活水平的提高和现代生活工作节奏的增快,该病发病率有日益上升的趋势。 With the faster pace of work to improve the living and modern living standards, the incidence of the disease has a rising trend. 目前该病多用西药治疗,虽然有一定的疗效,但不易根治,往往还是反复发作,迁延不愈,幽门螺旋菌相关性慢性胃炎久病也容易转变成胃溃疡,也可以出现病变黏膜处出血,导致贫血,使机体免疫力降低,并且可以发生恶变形成胃癌,危及生命。 The disease currently use western medicine, although there is a certain effect, but difficult to cure, often or recurrent, delayed healing, H. pylori related chronic gastritis and chronic illness also easily turned into ulcers, mucosal lesions can also occur at the bleeding, anemia results in the reduced immunity, and malignant transformation of gastric cancer can occur, life-threatening. 本系列疾病属于中医胃脘痛、痞证、吐酸等范围,常由于饮食不节、情志失畅、外感风寒、脾胃虚弱而发病。 This series of disease belongs to Chinese medicine epigastric pain, swelling of the liver certificate, spit acid range, often due to improper diet, emotional loss of smooth, exogenous cold, spleen and stomach disease. 所以治疗本病的关键是温中健脾、理气和胃、化瘀止痛。 Therefore, the key to the treatment of this disease is temperature in the spleen, and stomach qi, blood pain.

发明内容 SUMMARY

[0003] 本发明的目的在于提供一种治疗幽门螺旋菌相关性慢性胃炎的中药制剂,该药物组方科学,配伍合理,能够有效调节胃肠功能,促进胃动力,助消化,促进胃黏膜病变的愈合,使胃肠失调恢复正常。 [0003] The object of the present invention is to provide a method of treating Helicobacter pylori Chinese medicine related chronic gastritis, the pharmaceutical science party, and reasonable compatibility can effectively regulate gastrointestinal function, gastric motility, digestion, promote gastric mucosal lesions healing, gastrointestinal disorders back to normal.

[0004] 本发明的另一目的在于提供治疗幽门螺旋菌相关性慢性胃炎的中药制剂的制备方法。 [0004] Another object of the present invention to provide a method for preparing the traditional Chinese medicine preparation treatment of Helicobacter pylori associated chronic gastritis.

[0005] 本发明的解决方案是基于西医的发病机制与中医的辩证用药相结合原则,辨病辨证互渗,治疗上突出体现生肌敛疮、护膜愈胃之法,促进胃粘膜病变修复和愈合。 [0005] The inventive solution is based on the pathogenesis and treatment dialectic TCM Western medicine combined principle, Syndrome Differentiation mutual infiltration, highlighted myogenic sore treatment, healing method pellicle stomach, gastric mucosal lesion repair promoting and healing. 目前医学界普遍认为胃炎病因与幽门螺杆菌感染密切相关,结合现代药理研究,本方药可起到清除幽门螺杆菌(幽门螺杆菌以下简称HP)、生肌敛疮、护膜愈胃、促进黏膜病变愈合、减少复发等作用。 The medical profession generally believe that the cause of gastritis and Helicobacter pylori infection is closely related, combined with modern pharmacological research, the herbs can play a clear Helicobacter pylori (H. pylori hereinafter referred to as HP), myogenic sores, stomach more cuticle, promote mucosal healing lesions, to reduce the effect of recurrence. 中医理论认为,消化系统功能的正常依赖于脾胃生理功能的相互协调及肝胆疏泄功能的正常发挥,在生理上,脾胃健旺则气血生化有源,肝胆司职,则脾胃升降有序。 TCM theory holds that the normal function of the digestive system depend on the normal functioning of the stomach physiological function of the liver and gallbladder catharsis and coordination functions, physiologically, the blood biochemical active stomach healthy and vigorous, the functional liver and gallbladder, the spleen and stomach movements and orderly. 因此, 当饮食不节伤胃、情志不畅而肝郁、冷暖不调、大病久病、脾胃虚弱,引起肝胃气滞、气滞血瘀,均可造成胃炎的发生。 Therefore, improper diet Shang Wei, poor emotional and liver depression, well-being is not adjusted, serious chronic illness, spleen and stomach, causing liver and stomach qi stagnation, blood stasis, can cause gastritis occur. 本发明创造性的运用虫类药九香虫和花类药玫瑰花、根茎类药物三七粉等中药,起到理气和胃、散瘀止血,消肿定痛等作用,极大地提高了临床疗效。 Creative use of insect drugs present invention Aspongopus drugs roses and flowers, roots drugs thirty-seven powder medicine, play qi and stomach, stasis to stop bleeding, swelling and pain and other effects, which greatly improved the clinical efficacy .

[0006] 本发明中药制剂是由下列组分制成的:(用量为重量份) [0006] The Chinese medicine of the present invention is prepared from the following components in an amount of parts by weight :()

[0007] 九香虫3-12,玫瑰花3-15,三七粉3-10,黄芪10_30,党参6_15,白术6_12,桂枝3-10,白芍6-15,黄连6-10,吴茱萸2-4,煅瓦楞子10-20,海螵蛸6_15,枳壳6_15,白及10-20,山药10-30,蒲公英10-30,槟榔6-15,甘草3-10。 [0007] Aspongopus 3-12, 3-15 roses, seven powder 3-10, 10_30 Astragalus, Codonopsis 6_15, 6_12 Atractylodes, 3-10 Gui, white peony root 6-15, 6-10 berberine, Evodia 2-4, 10-20 calcined corrugated child, cuttlebone 6_15, 6_15 Citrus aurantium, white and 10-20, 10-30 yam, dandelion 10-30, 6-15 betel nut, licorice 3-10.

[0008] 制备本发明中药制剂的配方优选重量(份)配比范围是: [0008] The preferred weight Formulation (parts) prepared according to the present invention, the ratio of Chinese medicine are:

[0009] 九香虫6-10,玫瑰花6-12,三七粉3-6,黄芪10-25,党参10-15,白术9_12,桂枝3-6,白芍10-15,黄连6-10,吴茱萸2-4,煅瓦楞子10-15,海螵蛸6-12,枳壳9-15,白及10-15,山药20-30,蒲公英10-20,槟榔6-10,甘草3-6。 [0009] Aspongopus 6-10, 6-12 roses, 3-6 notoginseng powder, tragacanth 10-25, 10-15 Codonopsis, Atractylodes 9_12, Gui 3-6, 10-15 peony root, Coptis 6 -10, Evodia 2-4, 10-15 calcined corrugated child, cuttlebone 6-12, 9-15 bitter orange, white, and 10-15, 20-30 yam, dandelion 10-20, 6-10 betel nut, licorice 3-6.

[0010] 本发明中药制剂的最佳重量(份)配比是: [0010] The optimum weight of the traditional Chinese medicine preparation of the present invention (parts) is the ratio of:

[0011] 九香虫9,玫瑰花10,三七粉6,黄芪20,党参10,白术10,桂枝6,白芍15,黄连9, [0011] Aspongopus 9, 10 roses, 6 notoginseng powder, tragacanth 20, 10 Codonopsis, Atractylodes 10, Gui 6, peony root 15, berberine 9,

吴茱萸3,煅瓦楞子15,海螵蛸10,枳壳9,白及15,山药25,蒲公英15,槟榔9,甘草6。 Evodia 3, calcined corrugated sub 15, 10 cuttlebone, Citrus aurantium 9, 15 and white, yam 25, 15 dandelion, betel nut 9, licorice 6.

[0012] 将上述各组分制成本发明中药制剂的生产方法是: [0012] The method of producing the above components made of traditional Chinese medicine preparation cost to the invention are:

[0013] a按照上述重量配比分别称取九香虫、玫瑰花、三七粉、黄芪、党参、白术、桂枝、白芍、黄连、吴茱萸、煅瓦楞子、海螵蛸、枳壳、白及、山药、蒲公英、槟榔、甘草18味中药为原料; [0013] a weight proportion according to the above were weighed Aspongopus, rose, seven powder, Astragalus, Codonopsis, Atractylodes, Gui, peony root, Coptis, Evodia, calcined corrugated child, cuttlebone, Citrus aurantium, and white, yam, dandelion, nuts, herbs liquorice as the raw material 18;

[0014] b选取称量后的九香虫、玫瑰花、三七粉、白及、海螵蛸,分别粉碎成120-200目细粉,过筛、混勻,得到备用料一; [0014] After the selected weighing Aspongopus b, roses, notoginseng powder, and White, cuttlebone, 120-200 mesh were crushed into a fine powder, sieved, mixed, to obtain a standby material;

[0015] c将剩余的13味中药,加水煎煮二次,第一次1.5-2小时,第二次1-1. 5小时,合并煎液,滤过,在温度为60°C的条件下、减压浓缩成相对密度为1. 2-1. 3的稠膏,低温干燥,粉碎成120-200目细粉,得到备用料二; [0015] c remaining 13 herbs, add boiling water twice, the first 1.5-2 hours, a second 1-1. 5 hours, the merger decoction, filtration, at a temperature of 60 ° C Condition under reduced pressure and concentrated to a relative density of 1. 2-13 thick paste, low temperature drying, 120-200 mesh crushed into fine powder, to give two alternate materials.;

[0016] d将备用料一与备用料二混合均勻,烘干,消毒,再粉碎成200目细度,装入胶囊(0. 3-0. 5克/粒),即得本发明药剂。 [0016] d with a spare backup material feed two mixing, drying, sterilization, and then pulverized to a fineness of 200 mesh, into the capsule (0. 3-0. 5 g / grain), to obtain the agent of the invention.

[0017] 本发明的有益技术效果是: [0017] Advantageous effects of the invention are:

[0018] 本发明具有温中健脾、理气和胃、化瘀止痛之功效,特别对HP相关性慢性胃炎导致的胃脘疼痛、泛酸,呃逆嗳气、纳呆乏力、面黄等症状具有独特的疗效。 [0018] The present invention has a temperature in the spleen, and stomach qi, circulation analgesic effect, especially for HP epigastric pain caused by chronic gastritis correlation, pantothenic acid, hiccups belching, anorexia, fatigue, and other symptoms yellow face has a unique effect. 通过近几年的临床和药理研究,本品可清除幽门螺杆菌、生肌敛疮、促进病变黏膜愈合,具有易吸收、起效快、 止痛疗效好、治愈率高、复发率低、价格低廉、无毒副作用等优点,而且配方合理,服用方便, 在纯中药治疗HP相关性慢性胃炎中开辟了一条新途径。 Through years of clinical and pharmacological research, the product can remove H. pylori, myogenic sores and promote healing of mucosal lesions, with easy absorption, rapid onset of analgesic effect is good, high cure rate, low recurrence rate, low prices , non-toxic side effects, etc., and reasonable formula, easy to take, has opened up a new route in pure Chinese medicine treatment HP related chronic gastritis.

[0019] 本发明选取九香虫,玫瑰花,三七粉,黄芪,党参,白术,桂枝,白芍,黄连,吴茱萸, 煅瓦楞子,海螵蛸,枳壳,白及,山药,蒲公英,槟榔,甘草多味中药制成中药胶囊,其中,九香虫:味咸、温。 [0019] The present invention is selected Aspongopus, rose, seven powder, Astragalus, Codonopsis, Atractylodes, Gui, peony root, Coptis, Evodia, calcined corrugated child, cuttlebone, Citrus aurantium, and white, yam, dandelion , made of betel nut, licorice and more herbs medicine capsules, which Aspongopus: taste salty, warm. 归肝、脾、肾经。 In the liver, spleen and kidney. 具有理气止痛,温中助阳功效。 With qi pain, temperature and yang efficacy. 用于胃寒胀痛,肝胃气痛等, 《本草纲目》称其主治肠脘滞气。 For stomach pain, liver and stomach gas pain, "Compendium of Materia Medica" called Indications intestinal gas, abdominal stagnation. 玫瑰花:味甘、微苦,温。 Rose: sweet, bitter, warm. 归肝、脾经。 The liver and spleen. 具有行气解郁,和血, 止痛功效。 A line of gas stagnation, and blood, analgesic efficacy. 用于肝胃气痛,食少呕恶,胸膈满闷,胃脘、胁肋疼痛等。 Stomach pain for gas, food less Oue, mediastinoscopy nausea, epigastric pain flank. 现代药理研究认为可改善胃部血液循环。 Modern pharmacological studies suggest that the stomach can improve blood circulation. 三七粉:味甘、微苦,温。 Seven powder: sweet, bitter, warm. 归肝、胃经。 Liver and stomach. 具有散瘀止血、消肿定痛之功效。 It has stasis to stop bleeding, swelling and pain of the effect. 用于呕血、便血等各种出血止血及胸腹胃脘部刺痛等病症。 For vomiting, bloody diarrhea and other bleeding bleeding and epigastric abdominal irritation and other disorders. 黄芪:味甘,温。 Astragalus: sweet, warm. 归肺、脾经。 In the lungs, spleen. 具有补气固表,敛疮生肌功能,用于气虚乏力,食少便溏,中气下陷,久泄便血,气虚血虚等症。 With qi solid form, sore myogenic function, for deficiency fatigue, eat less loose stools, gas settlement, long time to vent blood in the stool, Qi deficiency embolism. 党参:味甘,平。 Dangshen: sweet, flat. 归脾、肺经。 Spleen and lung. 补中益气,健脾益肺功能。 Deficiency of spleen Yifei function. 用于脾肺虚弱,食少便溏,胃病久虚。 For Insufficiency of weakness, eat less, loose stools, stomach long illness. 白术:味苦、甘,温。 Baizhu: bitter, sweet, warm. 归脾、胃经。 The spleen and stomach. 具有健脾益气,和胃燥湿等功效。 With spleen qi, dampness and stomach and other effects. 用于脾虚食少,胃痛腹胀等。 Spleen eat less, stomach pain, bloating and the like. 桂枝:味辛、甘,温。 Gui: spicy, sweet, warm. 归心、肺、膀胱经。 Heart, lung, bladder through. 具有发汗解肌,温通经脉,助阳化气,平冲降气功效,可用于胃脘及腹部冷痛。 Jieji with sweating, warm meridians, air-yang, the balancing effect reducing gas, can be used and epigastric abdominal Lengtong. 白芍:味苦、酸,微寒。 TGP: bitter, sour, slightly cold. 归肝、脾经。 The liver and spleen. 平肝止痛,养血调经,敛阴止汗,用于头痛眩晕,胁痛,胃痛,腹痛,血虚萎黄。 Liver pain, nourishing menstruation, yin convergence antiperspirant for headache, dizziness, hypochondriac pain, stomach pain, abdominal pain, blood deficiency chlorosis. 黄连:味苦,寒。 Berberine: bitter, cold. 归心、脾、胃、肝、胆、大肠经。 Heart, spleen, stomach, liver, gall bladder, large intestine. 具有清热燥湿,泻火解毒功能,和胃止呕之功效。 With heat and dampness, purging fire detoxification function, and stomach antiemetic efficacy. 用于寒热互结,湿热中阻,痞满呕吐, 肝胃不和,呕吐吞酸。 Each node for cold and heat, the heat resistance, vomiting, fullness, liver and stomach, vomiting Tunsuan. 常用于各种胃病,并有健胃助消化之功效。 Commonly used in various stomach problems and a stomach to aid digestion effect. 吴茱萸:味辛、苦,热;有小毒。 Evodia: spicy, bitter, hot; a small drug. 归肝、脾、胃、肾经。 The liver, spleen, stomach, kidney. 可散寒止痛,降逆止呕,助阳止泻。 It can be cold pain, Jiangni vomiting, diarrhea yang. 用于寒疝腹痛,脘腹账痛,呕吐吞酸,五更泄泻等病症。 For Han Shan abdominal pain, abdominal pain accounts, Tunsuan vomiting, Diarrhea and other diseases. 黄连吴茱萸合用,名左金丸,作用辛开苦降,和胃降逆。 Berberine Evodia combination, name Zuojinwan role Acrid bitter drop, Heweijiangni. 现代药理 Modern pharmacology

4学研究认为黄连具有杀灭幽门螺杆菌的作用,吴茱萸具有抗胃炎胃溃疡、止吐止泻的作用。 4 studies that berberine has the effect of killing Helicobacter pylori, gastritis with anti-ulcer Evodia, antiemetic antidiarrheal effect. 煅瓦楞子:味咸,平。 Duan corrugated sub: taste salty, flat. 归肺、胃、肝经。 In the lungs, stomach, liver. 可消痰化瘀,制酸止痛。 Can Xiaotan circulation, acid pain. 用于胃痛泛酸等。 For stomach pantothenic acid. 海螵蛸: 味咸、涩,温。 Cuttlebone: taste salty, astringent, warm. 归脾、肾经。 Spleen and kidney. 具有收敛止血,制酸之作用。 Having convergence of bleeding, the effect of acid. 用于胃痛吞酸,吐血,溃疡类病等。 Tunsuan for stomach, vomiting, ulcer disease category. 枳壳:味苦、辛、酸,温。 Citrus aurantium: bitter, acrid, acid, temperature. 归脾、胃经。 The spleen and stomach. 理气宽中,行滞消肿等功效。 Width of qi, stagnation line swelling and other effects. 用于胸胁气滞,胃胀疼痛, 食积不化,痰饮内停;胃下垂等。 For stagnation chest, pain, bloating, of the food product is not, stopping the phlegm; gastroptosis. 白及:味苦、甘、涩,微寒。 And White: bitter, sweet, astringent, slightly cold. 归肺、肝、胃经。 In the lungs, liver and stomach. 具有收敛止血, 消肿生肌功效。 Convergence bleeding, swelling and tissue regeneration effect. 用于咯血呕血,胃炎溃疡病出血等。 For hematemesis hemoptysis, gastritis ulcer bleeding. 山药:味甘、平。 Yam: sweet, flat. 归脾、肺、肾经。 Spleen, lung, kidney. 具有补脾养胃作用。 With spleen and stomach action. 用于脾虚食少,久泻不止等,并有保护胃粘膜的功效。 For Spleen eat less, chronic diarrhea, etc., and have the effect of protecting the gastric mucosa. 蒲公英:味苦、甘,寒。 Dandelion: bitter, sweet, cold. 归肝、胃经。 Liver and stomach. 清热解毒,消肿散结,并有健胃作用。 Detoxification, and reducing swelling, and the role of a stomach. 近年来常用于胃部疾患的治疗。 In recent years, commonly used in the treatment of stomach disorders. 槟榔:味苦、辛,温。 Betel nut: bitter, acrid, warm. 归胃、大肠经。 Owned by the stomach, large intestine. 有杀虫消积,降气,行水等功效。 Insecticidal consumer product, reducing gas, water lines and other effects. 常用于胃脘疼痛、气滞食积。 Commonly used in epigastric pain, stagnation food product. 甘草:味甘,平。 Licorice: sweet, flat. 归心、肺、脾、胃经。 Heart, lung, spleen and stomach. 具有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。 Having Spleen Qi, detoxification, expectorant cough, urgency and pain relief, to reconcile various drugs. 用于脾胃虚弱,胃脘疼痛、缓解药物毒性等。 For spleen and stomach, epigastric pain, alleviate drug toxicity and the like.

[0020] 下面通过几组病例的治疗情况对本中药制剂的治疗效果进行详细说明: [0020] The following detailed description of the treatment of this traditional Chinese medicine preparation treatment by several groups of patients:

[0021] 一、王某某,男,67岁,退休干部,患胃病三十余年,经常胃脘隐痛,饭后胃脘胀满、 嗳气泛酸。 [0021] First, the surname Wang, male, 67 years old, retired cadres, suffering from stomach problems more than thirty years, often epigastric pain, epigastric fullness after meals, belching pantothenic acid. 舌苔白、脉弦。 White fur, pulse string. 胃镜检查诊断为慢性浅表性胃炎,HP检测阳性。 Endoscopy diagnosis of chronic superficial gastritis, HP testing positive. 服用本发明中药制剂胶囊,日服三次,每次三粒(0.4克/粒),一周后症状逐渐减轻,60日后原有症状已基本消失,胃镜复查胃粘膜病变恢复正常,HP检测阴性,随访数年未见复发。 Taking Chinese medicine capsules, three times a day to the present invention, each three (0.4 g / tablets), a week after symptoms gradually reduced, after 60 days of the original symptoms have disappeared, endoscopy review gastric mucosal lesions returned to normal, HP tested negative, follow-up no recurrence several years.

[0022] 二、刘某某,男,53岁,出租车司机,患胃病已有10多年,近年来由于工作劳累且饮食不规律,病情逐渐加重,进食后胃脘刺痛,胀闷不适,近日出现黑便,查舌紫脉涩,胃镜检查提示:糜烂性胃炎伴出血,HP检测阳性。 [0022] Second, Liu XX, male, 53-year-old taxi driver suffering from stomach problems for over 10 years, in recent years because of work fatigue and eating disorders, the condition gradually worsened after eating epigastric irritation, swelling, nausea discomfort, recently, there have black, purple tongue, pulse astringent investigation, endoscopy Tip: erosive gastritis with hemorrhage, HP testing positive. 服用本发明中药制剂胶囊,日服三次,每次三粒(0. 5克/粒),10天后症状明显减轻,50日活动性胃炎症状消失,胃镜检查黏膜病变明显好转,幽门螺旋菌检测阴性,治疗3个月后恢复正常,随访数年未复发。 Chinese medicine preparation of the present invention taking the capsules, three times a day, every three (0.5 g / grain), significantly reduced the symptoms after 10 days, 50 days active gastritis symptoms, gastroscopy mucosal lesions improved significantly, Helicobacter pylori test negative after 3 months of treatment returned to normal, follow-up several years without recurrence.

[0023] 三、张某某,女,49岁,患者自20岁时候因生活没有规律,患上了慢性胃炎,近几年病情逐渐加重,胃脘疼痛喜暖喜按,泛酸灼热,并且经常出现黑便,贫血,肢冷乏力,舌淡脉弱。 [0023] Third, Moumou, female, 49 years old, 20-year-old patient from the time because life is not the law, suffering from chronic gastritis, in recent years, the condition gradually worsened, epigastric pain hi hi by warm, pantothenic acid burning, and often melena, anemia, fatigue, cold extremities, pale tongue, weak pulse. 胃镜检查提示:慢性萎缩性胃炎伴胃溃疡,HP检测阳性。 Gastroscopy Tip: chronic atrophic gastritis with gastric ulcer, HP testing positive. 服用本发明中药制剂胶囊,日服三次,每次三粒(0. 45克/粒),60日症状逐渐减轻,食欲增加,大便规律,大便潜血阴性, 精神状态好转。 Taking the medicine into capsules, three times a day according to the present invention, each three (0.45 g / grain), 60 days symptoms gradually reduced, increased appetite, stool law, negative stool occult blood, mental state improved. 胃镜复查,胃黏膜炎症病变基本恢复,胃溃疡面明显好转,胃炎症状消失,HP 检查阴性。 Gastroscopy, gastric mucosal inflammatory lesions recovered, ulcer face significant improvement, gastritis symptoms, HP negative.

[0024] 为了进一步表明本发明中药制剂的治疗效果,申请人对152例幽门螺旋菌相关性慢性胃炎患者进行了系统的临床研究。 [0024] In order to further demonstrate the therapeutic effect of the Chinese medicine preparation of the present invention, applicants in 152 Helicobacter pylori gastritis patients Associated Chronic clinical study system was.

[0025] 本组病例共152例均来源青岛市黄岛中医院消化内科,诊断标准:中医诊断依据《中医病症诊断疗效标准》,西医诊断依据《常见疾病诊断依据与疗效判断标准》。 [0025] The patients were 152 cases of all sources of Huangdao of Qingdao City Hospital of Gastroenterology, Diagnostic criteria: traditional Chinese medicine diagnosis is based on "Chinese disease diagnostic efficacy standards", Western medicine diagnosis is based on "common disease diagnosis is based on the efficacy criteria." 具体为: (1)具有胃脘部胀痛、烧灼感或刺痛,泛酸、呃逆等上消化道症状者。 Specifically: (1) having epigastric pain, burning or tingling, pantothenic acid, hiccups and other upper gastrointestinal symptoms. (2)胃镜检查发现胃黏膜充血水肿、出血点、糜烂点。 (2) found in gastric endoscopy edema, bleeding, erosions point. ⑶胃及粘膜及胃液尿素酶快速诊断试纸测试为阳性(即HP 检测阳性)。 ⑶ gastric mucosa and gastric urease positive rapid diagnostic test strips (i.e. HP test positive).

[0026] 将上述152例诊断为幽门螺旋菌相关性慢性胃炎病例,随机分为治疗组83例和对照组69例。 [0026] The above 152 cases diagnosed as chronic gastritis associated with Helicobacter pylori patients, 69 cases were randomized into treatment group and 83 cases in the control group.

[0027] 治疗组83例:其中男54例,女29例,年龄17_64岁,病程1_3年31例,3年以上52例。 [0027] treatment group, 83 cases: 54 cases were male and 29 females, aged 17_64 years, duration of 1 _ 3 years 31 cases, 52 cases more than 3 years. 治疗方法:停用所有治疗药物,服用本发明药物,每日3次,每次三粒(0.3-0. 5克/ 粒),治疗30天为一个疗程,每一个疗程后复查一次胃镜及HP试纸测试试验。 Treatment: disable all therapeutic drugs, drugs of the present invention, 3 times a day, every three (0.3-0 5 g / grain.), 30 days a course of treatment, after a course review once every endoscopy and HP dipstick test trials. [0028] 对照组69例:其中男47例,女22例,年龄19_66岁,病程1_3年21例,3年以上48例。 [0028] 69 cases in the control group: wherein 47 males and 22 females, aged 19_66 years, 3 years duration 1 _ 21 cases, 48 ​​cases more than 3 years. 治疗方法:停用所有治疗药物,服用下列药物治疗:氨苄青霉素胶囊,每次0.5g,每日3次;硫酸庆大霉素片每次16万单位,每日3次;硫糖铝片每次lg,每日3次;雷尼替丁片每次0. 15g,每日2次。 Treatment: disable all drugs, taking the following medications: ampicillin capsules, 3 times per 0.5g, per day; gentamicin sulfate tablets per 160,000 units, 3 times a day; each of sucralfate tablets Ci lg, 3 times a day; each sheet ranitidine 0. 15g, 2 times a day. 30天为一个疗程,每一个疗程后复查一次胃镜及HP试纸测试试验。 30 days for a course of treatment, after each course to review the first endoscopy and HP dipstick test trials.

[0029] 两组患者的性别、年龄、病程分布进行比较,经统计学处理差异无显著性(P > 0. 05),具有可比性。 [0029] Both groups were sex, age, duration distribution are compared, no statistical significant difference (P> 0. 05), comparable. 治疗结果用统计学方法分析:采用两样本均数t检验和配对t检验、 Ridit检验、X2检验及直线相关分析。 Treatment results analyzed by statistical methods: using two-sample t test and the paired t-test, Ridit test, X2 test and linear correlation analysis. 治疗效果以下表说明: The following table shows the effect of treatment:

[0030] 表1 [0030] TABLE 1

[0031] [0031]

[0032] 表1为服用本发明药物治疗2个疗程后临床主要症状及疗效比较,表中治疗组与对照组比较总有效率有显著性差异(P < 0.05),疗效比较两组均有较高疗效,治疗组明显高于对比组。 [0032] Table 1 Comparison of the clinical symptoms and the main effect of the present invention after taking medication two courses of treatment, the treatment table group and control group with a total efficiency significantly different (P <0.05), the efficacy of the two groups were compared high efficacy, the treatment was significantly higher than the control group.

[0033] 表2 [0033] TABLE 2

[0034] [0034]

[0035] 表2为服用本发明药物治疗2个疗程后胃镜检查变化比较,治疗组与对比组比较有效率、治愈率均有显著性差异(P< 0.05),两组均有较高疗效,治疗组明显高于对比组。 [0035] Table 2 of the present invention is a medication after 2 courses of therapy endoscopy change the treatment group and the control group more efficient, cure rates were significantly different (P <0.05), the two groups have a higher curative effect, treatment group was significantly higher than the control group.

[0036] 表3 [0036] TABLE 3

[0037] [0037]

[0038] 表3为服用本发明药物治疗3个疗程后HP清除情况比较,治疗组与对比组比较1、 2、3个月HP清除率有显著性差异(P < 0. 05),疗效比较两组均有较高疗效,治疗组明显高于对比组。 [0038] Table 3 HP clearance of the comparison, treatment group 1 and control group comparison, there was a significant difference (P <0. 05) after taking medication for the treatment of the present invention is 3 courses 23 months HP clearance, Comparison of efficacy groups have a higher efficacy in the treatment group was significantly higher than the control group.

[0039] 综上所述,以上应用本发明药物对83例胃炎患者做治疗观察,取得显著疗效,而且治疗前后肝肾心功能及血液生化、大小便检查,均未发现明显毒副作用,说明本发明药物服用安全,对人体无毒害作用。 [0039] In summary, the present invention is the above medicament for the treatment of 83 cases of gastritis patients do observation, achieved a significant effect, kidney and heart function before and after treatment and blood biochemistry, urine examination, no obvious side effects, the present description drug discovery taking security, the human body without toxic effects. 具体实施方式 Detailed ways

[0040] 实施例1 [0040] Example 1

[0041] 按下述配比称取原料: [0041] The raw materials weighed according to the following ratio:

[0042] 九香虫10克、玫瑰花10克、三七粉6克,黄芪20克、党参15克,白术12克,桂枝3克,白芍15克,黄连10克,吴茱萸3克,煅瓦楞子15克,海螵蛸9克,枳壳15克,白及15 克,山药25克,蒲公英15克,槟榔6克,甘草6克。 [0042] Aspongopus 10 grams, 10 grams of roses, seven powder 6 grams, 20 grams of astragalus, Codonopsis 15 grams, 12 grams Atractylodes, Gui 3 g, white peony root 15 grams, 10 grams berberine, Evodia 3 g, 15 grams calcined corrugated, cuttlebone 9 g, 15 g of Citrus aurantium, and 15 g of white, 25 g of yam, 15 grams of dandelion, betel nut 6 g, 6 g of licorice.

[0043] 生产方法如下: [0043] The production methods as follows:

[0044] 先将称取后的九香虫、玫瑰花、三七粉、白及、海螵蛸分别粉碎成细粉,然后均过120目筛,混勻,得到备用料一。 [0044] said first taken after Aspongopus, roses, notoginseng powder, and white, respectively, cuttlebone crushed into powder, and then homogenized through a 120 mesh sieve, mixed, to give a backup material. 然后将剩余的13味中药,加水煎煮二次,第一次1.5小时, 第二次1小时,合并煎液,滤过,收集滤液并将其在60°C条件下、减压浓缩成相对密度为1. 3 的稠膏,在5°C下干燥1小时,然后粉碎成120目细粉,得到备用料二。 The remaining 13 herbs, add boiling water twice, the first 1.5 hours, the second time 1 hour, combined decoction, filtration, and the filtrate was collected at 60 ° C under conditions of relatively concentrated under reduced pressure to a density of 1.3 of a thick paste, dried for 1 hour at 5 ° C, and then pulverized into 120 mesh powder, to give two alternate materials. 将上述备用料一与备用料二混合均勻,烘干,消毒,再粉碎成200目细度,装入胶囊(0.5克/粒),即得本发明药剂。 A backup material with the above-described two materials alternate mixing, drying, sterilization, and then pulverized to a fineness of 200 mesh, into capsules (0.5 g / grain), to obtain the agent of the invention.

[0045] 实施例2 [0045] Example 2

[0046] 按下述配比称取原料: [0046] The raw materials weighed according to the following ratio:

[0047] 九香虫6克、玫瑰花10克、三七粉9克,黄芪20、党参10克,白术10克,桂枝3克, 白芍12克,黄连9克,吴茱萸3克,煅瓦楞子15克,海螵蛸10克,枳壳12克,白及15克,山药20克,蒲公英10克,槟榔6克,甘草6克。 [0047] Aspongopus 6 g, 10 g Rose, seven powder 9 g, 20 astragalus, Codonopsis 10 grams, 10 grams Atractylodes, Gui 3 g, 12 g white peony root, Coptis 9 g, 3 g Evodia, fumed corrugated 15 grams, 10 grams cuttlebone, Citrus aurantium 12 g, and 15 g of white, 20 g of yam, 10 g of dandelion, betel nut 6 g, 6 g of licorice.

[0048] 生产方法如下: [0048] The production methods as follows:

[0049] 先将称取后的九香虫、玫瑰花、三七粉、白及、海螵蛸分别粉碎成细粉,然后均过160目筛,混勻,得到备用料一。 [0049] said first taken after Aspongopus, roses, notoginseng powder, and white, respectively, cuttlebone crushed into powder, 160 mesh sieve and then homogenized, mixed, to give a backup material. 然后将剩余的13味中药,加水煎煮二次,第一次1.7小时, 第二次1. 2小时,合并煎液,滤过,收集滤液并将其在60°C条件下、减压浓缩成相对密度为1.3的稠膏,在10°C下干燥2小时,然后粉碎成120目细粉,得到备用料二。 The remaining 13 herbs, add boiling water twice, the first 1.7 hours, the second time 1.2 hours, the merger decoction, filtration, and the filtrate was collected at 60 ° C under conditions, concentrated under reduced pressure relative density of 1.3 to a thick paste, dried at 10 ° C 2 hours and then pulverized into 120 mesh powder, to give two alternate materials. 将上述备用料一与备用料二混合均勻,烘干,消毒,再粉碎成200目细度,装入胶囊(0. 45克/粒),即得本发明药剂。 A backup material with the above-described two materials alternate mixing, drying, sterilization, and then pulverized to a fineness of 200 mesh, into the capsule (0.45 g / grain), to obtain the agent of the invention.

[0050] 实施例3 [0050] Example 3

[0051] 按下述配比称取原料: [0051] The raw materials weighed according to the following ratio:

[0052] 九香虫9克、玫瑰花6克、三七粉9克,黄芪20克、党参12克,白术10克,桂枝9 克,白芍12克,黄连6克,吴茱萸3克,煅瓦楞子15克,海螵蛸6克,枳壳6克,白及10克, 山药20克,蒲公英10克,槟榔6克,甘草6克。 [0052] Aspongopus 9 grams, 6 grams of roses, seven powder 9 grams, 20 grams of astragalus, Codonopsis 12 grams, 10 grams Atractylodes, Gui 9 grams, peony 12 grams, 6 grams of berberine, Evodia 3 g, 15 grams calcined corrugated, cuttlebone 6 grams, Citrus aurantium 6 grams, and 10 grams of white, 20 g of yam, 10 g of dandelion, betel nut 6 g, 6 g of licorice.

[0053] 生产方法如下: [0053] The production methods as follows:

[0054] 先将称取后的九香虫、玫瑰花、三七粉、白及、海螵蛸分别粉碎成细粉,然后均过200目筛,混勻,得到备用料一。 [0054] said first taken after Aspongopus, roses, notoginseng powder, and white, respectively, cuttlebone crushed into powder, and then through a 200 mesh sieve are, mixing, to obtain a backup material. 然后将剩余的13味中药,加水煎煮二次,第一次2小时,第二次1. 5小时,合并煎液,滤过,收集滤液并将其在60°C条件下、减压浓缩成相对密度为1. 2 的稠膏,在15°C下干燥1小时,然后粉碎成200目细粉,得到备用料二。 The remaining 13 herbs, add boiling water twice, the first time 2 hours, the second time 1.5 hours, the merger decoction, filtration, and the filtrate was collected at 60 ° C under conditions, concentrated under reduced pressure relative density of 1.2 to a thick paste, dried for 1 hour at 15 ° C, and then pulverized into 200 mesh powder, to give two alternate materials. 将上述备用料一与备用料二混合均勻,烘干,再粉碎成200目细度,装入胶囊(0.4克/粒),即得本发明药剂。 The above-described backup material and a backup material two mixed, dried, pulverized to a fineness of 200 mesh, into capsules (0.4 g / grain), to obtain the agent of the invention.

Claims (4)

  1. 一种治疗幽门螺旋菌相关性慢性胃炎的中药制剂,其特征在于它是由下述重量配比的原料制成:九香虫3-12,玫瑰花3-15,三七粉3-10,黄芪10-30,党参6-15,白术6-12,桂枝3-10,白芍6-15,黄连6-10,吴茱萸2-4,煅瓦楞子10-20,海螵蛸6-15,枳壳6-15,白及10-20,山药10-30,蒲公英10-30,槟榔6-15,甘草3-10。 A method of treating Helicobacter pylori Chinese medicine related chronic gastritis, characterized in that it is made of the following weight proportions of raw materials: Aspongopus 3-12, roses 3-15, 3-10 notoginseng powder, Astragalus 10-30, 6-15 Codonopsis, Atractylodes 6-12, 3-10 Gui, peony 6-15, 6-10 berberine, Evodia 2-4, 10-20 calcined corrugated child, cuttlebone 6-15 , 6-15 Citrus aurantium, white and 10-20, 10-30 yam, dandelion 10-30, 6-15 betel nut, licorice 3-10.
  2. 2.根据权利要求1所述的治疗幽门螺旋菌相关性慢性胃炎的中药制剂,其中各原料的重量配比是:九香虫6-10,玫瑰花6-12,三七粉3-6,黄芪10-25,党参10-15,白术9_12,桂枝3-6,白芍10-15,黄连6-10,吴茱萸2-4,煅瓦楞子10-15,海螵蛸6-12,枳壳9-15,白及10-15,山药20-30,蒲公英10-20,槟榔6-10,甘草36。 The traditional Chinese medicine preparation for treating Helicobacter pylori according to a related chronic gastritis claim, wherein the weight ratio of the raw materials are: Aspongopus 6-10, 6-12 roses, 3-6 notoginseng powder, Astragalus 10-25, 10-15 Codonopsis, Atractylodes 9_12, Gui 3-6, 10-15 peony root, Coptis 6-10, 2-4 Evodia, calcined corrugated sub-10-15, 6-12 cuttlebone, orange shell 9-15, 10-15 and white, yam 20-30 dandelion 10-20, 6-10 betel nut, licorice 36.
  3. 3.根据权利要求2所述的治疗幽门螺旋菌相关性慢性胃炎的中药制剂,其中各原料的重量配比是:九香虫9,玫瑰花10,三七粉6,黄芪20,党参10,白术10,桂枝6,白芍15,黄连9,吴茱萸3,煅瓦楞子15,海螵蛸10,枳壳9,白及15,山药25,蒲公英15,槟榔9,甘草6。 The Chinese medicine preparation for the treatment of Helicobacter pylori related chronic gastritis claim 2, wherein the weight ratio of each raw material is as claimed in claim: Aspongopus 9, 10 roses, 6 notoginseng powder, tragacanth 20, Codonopsis 10, Atractylodes 10, Gui 6, peony root 15, 9 berberine, Evodia 3, calcined corrugated sub 15, 10 cuttlebone, Citrus aurantium 9, 15 and white, yam 25, 15 dandelion, betel nut 9, licorice 6.
  4. 4.治疗幽门螺旋菌相关性慢性胃炎的中药制剂的制备方法,其特征在于包括以下步骤:a按照上述重量配比分别称取九香虫、玫瑰花、三七粉、黄芪、党参、白术、桂枝、白芍、黄连、吴茱萸、煅瓦楞子、海螵蛸、枳壳、白及、山药、蒲公英、槟榔、甘草18味中药为原料;b选取称量后的九香虫、玫瑰花、三七粉、白及、海螵蛸,分别粉碎成120-200目细粉,过筛、混勻,得到备用料一;c将剩余的13味中药,加水煎煮二次,第一次1. 5-2小时,第二次1-1. 5小时,合并煎液,滤过,在温度为60°C的条件下、减压浓缩成相对密度为1. 2-1. 3的稠膏,低温干燥,粉碎成120-200目细粉,得到备用料二;d将备用料一与备用料二混合均勻,烘干,消毒,再粉碎成200目细度,装入胶囊(0. 3-0. 5克/粒),即得本发明药剂。 4. The Chinese medicine preparation of the treatment of H. pylori related chronic gastritis, comprising the steps of: a weight ratio as described above were weighed Aspongopus, rose, seven powder, Astragalus, Codonopsis, Atractylodes, Gui, white peony root, berberine, Evodia, calcined corrugated child, cuttlebone, Citrus aurantium, white, and, yam, dandelion, betel nut, licorice 18 herbs as raw material; b select Aspongopus after weighing, roses, notoginseng powder, and white, cuttlebone, 120-200 mesh were crushed into a fine powder, sieved, mixed, to give a feed standby; C the remaining 13 herbs, add boiling water twice, first 1 5-2 hours, the second 1-1. 5 hours, the merger decoction, filtration, at a temperature condition of 60 ° C, concentrated under reduced pressure to a relative density of 1. 2-1. 3 thick paste low temperature drying, 120-200 mesh crushed into fine powder, to give two alternate materials; D standby spare material with a mixed two materials, drying, sterilization, and then pulverized to a fineness of 200 mesh, into capsules (0.3 -0. 5 g / grain), to give the agents of the invention.
CN 201010216048 2010-07-01 2010-07-01 Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof CN101874874B (en)

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CN103330839A (en) * 2013-05-28 2013-10-02 吴艾潼 Traditional Chinese medicine for treating chronic gastritis
CN103330877A (en) * 2013-05-27 2013-10-02 陈松 Traditional Chinese medicine for treating atrophic gastritis
CN103599367A (en) * 2013-11-15 2014-02-26 刘桂沅 Capsule for gastrointestinal ulcer and preparation technology thereof
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CN101607074A (en) * 2008-06-20 2009-12-23 天科仁祥技术(北京)有限责任公司 Medicinal composition for treating chronic gastritis and preparation method thereof

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CN103211949A (en) * 2013-04-26 2013-07-24 吴起清 Traditional Chinese medicine composition for treating gastric diseases of human body as well as preparation method and application thereof
CN103211949B (en) * 2013-04-26 2017-02-22 吴起清 The composition of traditional Chinese medicine and its preparation method of treating a disease associated with the use of human stomach
CN103330877A (en) * 2013-05-27 2013-10-02 陈松 Traditional Chinese medicine for treating atrophic gastritis
CN103330877B (en) * 2013-05-27 2015-03-25 陈松 Traditional Chinese medicine for treating atrophic gastritis
CN103330839A (en) * 2013-05-28 2013-10-02 吴艾潼 Traditional Chinese medicine for treating chronic gastritis
CN103330839B (en) * 2013-05-28 2015-03-04 吴艾潼 Traditional Chinese medicine for treating chronic gastritis
CN103749802A (en) * 2013-10-25 2014-04-30 南通瑞普埃尔生物工程有限公司 Dendrobium stomach-nourishing tea
CN103599367A (en) * 2013-11-15 2014-02-26 刘桂沅 Capsule for gastrointestinal ulcer and preparation technology thereof
CN103599367B (en) * 2013-11-15 2016-02-17 刘桂沅 Gastrointestinal ulcers capsule and preparation process
CN103845677A (en) * 2014-02-13 2014-06-11 河南中医学院 Traditional Chinese medicine for treating peptic ulcer
CN105343806A (en) * 2015-12-17 2016-02-24 都炳霞 Traditional Chinese medicine preparation for treating gastritis and gastric ulcer
CN105535676A (en) * 2015-12-28 2016-05-04 天长市中医院 Scutellaria baicalensis and rheum officinale fragrant traditional Chinese medicine composition and application thereof
CN105395982A (en) * 2016-01-07 2016-03-16 周传波 Traditional Chinese medicine composition for curing chronic gastritis

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