CN104069162B - A kind of Chinese medicine for treating urarthritis and various bone joint pains - Google Patents
A kind of Chinese medicine for treating urarthritis and various bone joint pains Download PDFInfo
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Abstract
The present invention relates to tcm field, more particularly to a kind of Chinese medicine for treating urarthritis and various bone joint pains.It is made up of each component of following parts by weight：Pseudo-ginseng, ganoderma lucidum, ginseng, the Radix Astragali, balloonflower root, the bark of eucommia, the root of kudzu vine, the root of bidentate achyranthes, dandelion, Poria cocos is windproof, rhizoma atractylodis.The present invention has nourishing liver and kidney, tonifying Qi and lifting yang, hemostasis stasis, inducing diuresis for removing edema, the effect of tonifying spleen is calmed the nerves, inducing diaphoresis is stimulated the menstrual flow, has significant curative effect to treatment urarthritis, rheumatic arthritis and various bone joint pains.
Description
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, and in particular to one kind treats urarthritis and various bone joint pains
Chinese medicine.
Background technology
Urarthritis is the arthritis of recurrent exerbation caused by disorders of purine metabolism, blood uric acid increase.Uric Acid
It is the purine decomposition in the nucleic acid and other purine compounds and food decomposed by cell metabolism.The generation of uric acid increases
Many and excretion reduction can all make uric acid accumulate and produce hyperuricemia.Lithate be deposited on joint, periarticular tissue and
Hypodermis, causes arthritic recurrent exerbation, there is acute red, swollen, severe pain, gradually produces B＆J destruction, deformity, joint
Tetanic and dysfunction.
Clinical manifestation：
1st, primary gout is multiple is born in more than 40 years old male, and women is rare, accounts for 5%.Some patients have family history.
2nd, asymptomatic stage, only high blood uric acid.Blood uric acid increased to joint symptoms duration of seizure up to the several years.
3rd, acute attack stage：Often broken out in night, the first Plantar toe joints, severe pain, in a few hours are betided first
Culminate, hence it is evident that swelling is rubescent, tenderness is obvious, dysfunction.Can be with heating, up to 38~39 DEG C.Weak, apocleisis, head
The symptoms such as pain.The remission after 1~2 week, recurs after the interval several months to several years.Other joint toes, thumb, metacarpophalangeal joints, ankle,
Wrist, knee, shoulder etc. can also occur.Drink, gluttony, fatigue, wound or direct stimulation etc. can induce arthritis breaking-out.
4th, the chornic arthritis phase：Arthritis is frequently broken out, the intermittent phase shortens, arthroncus, the destruction of joint epiphysis and hyperplasia
And teratogenesis shape.There is tophus in auricle or joint part.It is located subcutaneously, in faint yellow tubercle.It can be flowed during tophus ulceration
Go out lime shape thing, sinus is difficult to heal, can secondary pyogenic infection.Urate calculi occurs for about 10~20% patients, and can draw
Play blood urine, renal colic symptom.Can occur the complication such as hypertension, coronary heart disease.
Rheumatic arthritis：The typical performance of rheumatic arthritis is slight or moderate heating, migratory polyarthritis, by
Tired joint is generally the large joints such as knee, ankle, shoulder, elbow wrist, common to be transferred to another joint by a joint, and lesion locally presents red
Swollen, scorching hot, severe pain some patients also have several joints to fall ill simultaneously, and atypical patient only has arthralgia and without other inflammation
Performance, acute inflammation typically disappeared in 2~4 weeks does not stay sequelae, but often recurrent exerbation.It can be sent out if active rheumatism influence heart
Raw myocarditis even leaves valve disorder.
Rheumatic arthritis has two features
1st, it is that joint is red, swollen, hot, bitterly obvious, it is impossible to activity, site of pathological change is often the lower limb large joint such as knee, hip, ankle,
Next to that shoulder, elbow, wrist joint, the Minor articulus of brothers are rare.
2nd, it is that pain migration is indefinite, is the breaking-out of this joint for a period of time, is that joint is uncomfortable for a period of time, but pain
Duration is not long, can disappear within several days.Blood chemical examination erythrocyte sedimentation rate is accelerated, and resists the rise of " 0 " titre, rheumatoid factor negative.After healing
Deformity is not stayed in seldom recurrence, joint, and some patients can leave heart disease.
Symptom：
1st, febris acuta.It is irregular fever phenomenon, is not in phenomenon of shivering, it is invalid with antibiotic therapy.
2nd, arthralgia.Pain migration is indefinite.
3rd, morning stiffness.Can alleviate or disappear from patient's morning or after rest long period, activity, but the morning stiffness duration compared with
It is short.
Various bone joint pains：
Clinical manifestation and symptom
1st, cardinal symptom is arthralgia, and pain occurs when activity, disappears or takes a turn for the better after rest.During acute attack, pain
Pain is aggravated, while can have arthroncus, anchylosis, intra-articular crunch etc..
2nd, the patient joint having is in certain position too long, or morning removes ground, just feels arthralgia, i.e., so-called rest
Bitterly.Such patient is gradually after turning joint certain time, and pain disappears, and joint can feel relaxed.
3rd, the spur of hyperplasia is stimulated or adjacent to nerve radiated pain occurs for compressing, and such as cervical vertebra hyperplasia causes upper limbs to ache,
Hyperosteogeny causes inner side pain etc. before stock caused by melosalgia, hip joint hyperplasia.The serious hyperplasia of vertebra can oppress spinal cord and nerve
Root, appearance sensation, motion, stool and urine obstacle, nerve stimulation are levied, or even paraplegia.
4th, early stage joint profile and activity are without exception, and bone can be seen in the less joint of the surrounding soft tissue such as late period knee, finger
Property thickening, there is tenderness in arthroncus, muscular atrophy and dysarthrasis, joint, limitation of activity, has friction to feel when movable.
Bone and joint diseases are classified as after right outside cardiovascular and cerebrovascular disease, cancer, diabetes " three big killers " by the World Health Organization
Human body endangers widest problem.At present, treatment bone and joint diseases are clinical uses western medicine more, and Western medicine is rapid-action, but western
Produce toxic side effect more medicine, while producing serious drug resistance, furthermore due to medicament residue, patient is injured in itself greatly.
The content of the invention
In order to overcome deficiency of the prior art, the present invention provides one kind and treats urarthritis and various Bones and joints pain
The Chinese medicine of pain, especially has significant curative effect to urarthritis.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is as follows：One kind treat urarthritis and
The Chinese medicine of various bone joint pains, it is characterised in that：It is made up of each component of following parts by weight：
1~20 part of pseudo-ginseng, 1~30 part of ganoderma lucidum, 1~30 part of ginseng, 1~25 part of the Radix Astragali, 1~35 part of balloonflower root part, the bark of eucommia 1~
40 parts, 1~100 part of the root of kudzu vine, 1~30 part of the root of bidentate achyranthes, 1~30 part of dandelion, 1~50 part of Poria cocos, windproof 1~50 part, rhizoma atractylodis 1~50
Part.
A kind of Chinese medicine for treating urarthritis and various bone joint pains, can be grouped by each group of following parts by weight
Into：
5~20 parts of pseudo-ginseng, 10~30 parts of ganoderma lucidum, 10~30 parts of ginseng, 5~25 parts of the Radix Astragali, 10~35 parts of balloonflower root, the bark of eucommia 15
~40 parts, 10~100 parts of the root of kudzu vine, 10~30 parts of the root of bidentate achyranthes, 5~30 parts of dandelion, 10~50 parts of Poria cocos is windproof 10~50 parts, grey
10~50 parts of art.
A kind of urarthritis and the Chinese medicine of various bone joint pains for the treatment of can prepare piece agent, capsule, electuary.
The tablet comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, and it is standby to be then cut into thin slice, by institute
State medicinal material component to mix in proportion, be placed in micronizer and crush 20 minutes~60 minutes, by the Chinese medicine after crushing
The drug powder of 100 mesh sieves is crossed, it is standby；
Second step, the herb powder that the first step is obtained and the additive of tablet are put into mixer and are well mixed, plus
Enter adhesive and softwood is made in wetting agent, dried softwood using baking oven, whole grain；
3rd step, the drug particles that second step whole grain is obtained are poured into mixer, add lubricant and disintegrant mixing
, ozone sterilization 3 hours, last tabletting obtains finished product.
The tablet can be as needed, carries out sweet tablet or film coating.
Prepared by the capsule comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, is then cut into thin slice standby.By institute
State medicinal material component to mix in proportion, be placed in micronizer and crush 10 minutes~30 minutes, by the Chinese medicine after crushing
The drug particles of 80 mesh sieves are crossed, it is standby；
Second step, the drug particles that the first step is obtained and capsule auxiliary material, weigh, stir and evenly mix in proportion, 80 DEG C
Drying 1 hour, then ozone sterilization is after 60 minutes, and finally mixed powder is loaded capsule by use conventional capsule machine.
The capsule is hard capsule, cylindrical, can be selected according to the size of drug dose.
Prepared by the electuary comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, and it is standby to be then cut into thin slice, by institute
State medicinal material component to mix in proportion, be placed in micronizer and crush 10 minutes~30 minutes, by the Chinese medicine after crushing
The drug particles of 80 mesh sieves are crossed, it is standby；
Second step, the drug particles obtained by the first step are added water to cook, and are decocted three times, merging filtrate, and excessive internal heat is concentrated into leaching
Cream, using negative pressure of vacuum by extract dry into dry cream body；
3rd step, the dry cream body obtained by second step is crushed with micronizer, is added electuary auxiliary material and is well mixed, then adds
Enter adhesive starch slurry, pelletized, oven drying, temperature is 60 degree~80 degree, the time is 1~3 hour, disinfection by ultraviolet light 3
Hour, it is fitted into bag, the finished product of packaging
The alternative tealeaves of medicine, is made alternative tea and takes, and prepared by alternative tea comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, is then cut into thin slice standby.By institute
State medicinal material component to mix in proportion, be placed in micronizer and crush 10 minutes~30 minutes, by the Chinese medicine after crushing
The drug particles of 80 mesh sieves are crossed, it is standby；
Second step, the drug particles obtained by the first step are dried, and drying temperature is 60 degree~90 degree, and the time is 0.5
~2 hours；
Drug particles described in second step are carried out ultraviolet and irradiated 2 hours, sterilization is degerming, finally by medicine by the 3rd step
Particle packing enters bag and obtains finished product.
The theoretical foundation of the present invention：Ganoderma lucidum：Sweet mild-natured, the thoughts of returning home, liver, spleen, lung, the kidney Five Classics support essence, nourishing with calming the nerves
Strong, relieving cough and asthma the effect of.《Sheng Nong's herbal classic》Described in：" the sweet temperature of purple sesame, main deafness, sharp joint, protect refreshing strengthening the essence, hard
Muscles and bones, good color, long term usage is made light of one's life by commiting suicide not old macrobiosis." main treatment consumptive disease, the careful clothes of real example.
Pseudo-ginseng：Come from《Compendium of Materia Medica》, also known as it is pseudo-ginseng, invaluable.Sweet, slight bitter, warm-natured, Return liver, stomach, the heart, lung and big
Intestines are passed through.Have hemostasis stasis, detumescence ding-tong, the effect for the row stasis of blood of promoting blood circulation.Cure mainly to fall and flutter the swollen stasis of blood, obstruction of qi in the chest angina, abdominal mass, blood stasis amenorrhoea, production
The cloudy stomachache of the stasis of blood, sore, carbuncle and painful swelling etc. afterwards.《Jade seizes medicine solution》Say：" all postpartum, menstrual period, bruise, carbuncle swells, all hemostasis are all broken；It is all to tell
Nosebleed, uterine bleeding, knife wound, arrow are penetrated, and all new blood all stop." taboo：Dysmenorrhoea caused by deficiency of qi and blood, irregular menstruation etc..
Red ginseng：Sweet, slight bitter, returns spleen, lung, the heart channel of Hang-Shaoyin.Tool reinforce vital energy, veins takes off admittedly, nourishing qi to stop the effect of.Cure mainly body
Void is intended to take off, cold weak pulse of limb, Qi dysfunction in blood control, metrostaxis, and modern study is still applied to heart failure, cardiogenic shock etc..Instead
Black false hellebore, can not be with use.《Compendium of Materia Medica》Say：" all asthenic symptoms of male woman are controlled, generate heat spontaneous perspiration, dizziness and headache, regurgitation and emesis, lingering diarrhea is long
Dysentery, frequent urination drenches drip, and overstrain internal injury, apoplexy, heatstroke, Impotence numbness is spitted blood, lower blood, blood strangury, metrorrhagia, postpartum all diseases before tire.”
The Radix Astragali：It is sweet, slightly warm in nature, returns spleen, lung channel.Belong to Qi-tonifying drug.Solid table, promoting pus discharge and tissue regeneration, profit are defended with tonifying Qi and lifting yang, benefit
The effects such as water is subsided a swelling.Cure mainly treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, spontaneous sweating, the unrestrained swollen, deficiency of vital energy water of cloudy subcutaneous ulcer
Swollen, Heat Diabetes etc..Modern study finds there are the effects such as decompression, liver protection, regulation blood glucose.
Balloonflower root：Bitter, pungent, slightly warm in nature, return lung warp.With freeinging lung and relieving asthma, relieving sore-throat eliminating the phlegm, fill blood, mend the exhaustion or lesion of the five internal organs, relieving the five internal organs
Work(.Cure mainly coughing with a lot of sputum, abscess of throat, lung carbuncle spit, fullness in the chest and hypochondriac pain, dysentery stomachache, aphthae, red eye, swell pain, urine
The diseases such as the retention of urine.《Japan hanako materia medica》Described in：" all lower gas, only choleraic myospasm, trusted subordinate's distending pain, mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility, evil removing is warded off
Abdominal mass is broken in temperature, qi-restoratives dissolving phlegm, and interior leakage and larynx numbness are mended in blood-nourishing apocenosis." yin chronic cough, the circulation of vital energy in the wrong direction and hemoptysis person avoid clothes.
The bark of eucommia：Sweet, micro-pungent, it is warm-natured, return liver and kidney channel.Can filling liver kidney, strengthening the bones and muscles.Cure mainly spinal column ache, foot and knee flaccidity,
Dribbling urination, uncontrolled urination, threatened abortion are intended to fall, fetal irritability etc..Modern study confirms that the bark of eucommia has stronger antitumor and decompression to make
With caused by hypertension dizziness headache symptom can be obviously improved.The careful clothes of fire excess from yin deficiency person.《Bencao Jingshu》：" kidney deficiency heated person is not
Preferably use, i.e., be entered together with when with golden cypress, the wind-weed.”
The root of kudzu vine：It is sweet, pungent, it is cool in nature, attach to the lung and stomach meridians.Main relieving muscles diaphoresis, promoting eruption, Shengyang Zhixie, promote the production of body fluid to quench thirst, be used for
Fever caused by exogenous pathogens, stiff nape and back, measles without adequate eruption, damp-heat dysentery, splenasthenic diarrhea, pyreticosis polydipsia, diabete etc..《Compendium of Materia Medica》Carry：
The root of kudzu vine, cool in nature, gas is flat, sweet, tool heat-clearing, fall fire, all effects of toxin expelling.Modern medicine study shows：Osajin in the root of kudzu vine
Compound Puerarin has certain curative effect to hypertension, high fat of blood, hyperglycaemia and cardiovascular and cerebrovascular disease.
The root of bidentate achyranthes：Bitter, acid, it is mild-natured, return liver and kidney channel.Tool filling liver kidney, strengthening the bones and muscles, invigorate blood circulation, descending, diuresis of igniting are led to
Drench etc. effect, cure mainly soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhoea, postpartum abdominal pain due to blood stasis, abdominal mass, placenta retension, heat gonorrhea,
Blood strangury, traumatic injury, too fat to move malignant sore, abscess of throat etc..
Dandelion：Sweet, slight bitter, cold in nature, Return liver, stomach.The effect of tool is clearing heat and detoxicating, inducing diuresis and reducing edema.Cure mainly heat toxin sore
Ulcer, jaundice, heat gonorrhea and red eye, swell pain etc., it is outstanding to be apt to control acute mastitis.It is mainly used in treating the infection of the upper respiratory tract, eye conjunctivitis are popular
Parotitis, hyperglycaemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary infection, pelvic infecton, carbuncle
Furuncle furunculosis, pharyngitis controls acute mastitis, adenolymphitis, scrofula (espespecially methylene is scorching), and acute conjunctivitis, cold, fever is acute flat
Peach body is scorching, acute bronchitis, urinary tract infections.Modern study shows that regulating immunological function, antitumor, gastric ulcer etc. are acted on.
Poria cocos：It is sweet, light, it is mild-natured, enter the heart, spleen, kidney channel.The effect of having clearing damp and promoting diuresis, spleen-benefiting mind-tranquilizing.Cure mainly oedema swollen
Full, diarrhea, difficult urination, phlegm and retained fluid coughs inverse, palpitaition, has a sleepless night, seminal emission, forgetful to wait disease.Modern study is confirmed with gastric acid inhibitory point
Secrete, the effects such as suppressing necrosis of liver cells and antibacterial.
It is windproof：Pungent, sweet, slightly warm in nature returns bladder warp, lung, spleen, Liver Channel.With expelling pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, spasmolysis are stopped
The effects such as itching, cure mainly catch cold, bodily pain of having a headache, arthralgia pain due to rheumatism, skeletal pain, stomachache diarrhea, discharging fresh blood stool, lockjaw, wind
Rash itch, sore from the beginning of etc. disease.Belong to diaphoretic medicine, dispel-wind drug.It is windproof that there is good two-way work with different clinical compatibility applications
With, i.e., can sweating again can hidroschesis, can antidiarrheal again can defaecation, and effect that can stop blooding and can stimulate the menstrual flow.Modern study is confirmed
There are stronger analgesia, sedation.
Rhizoma atractylodis：Pungent, hardship, warm-natured, returns spleen, lung, Liver Channel.Effect with drying damp and strengthening spleen, expelling wind and clearing away cold and improving eyesight, it is main to use
Withered the diseases such as numbness, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia in treatment abdominal fullness and distention, diarrhea oedema, tinea pedis, main the spleen and stomach being stranded by dampness, burnout are thermophilic
The wet swollen, exterior syndrome of sleeping, born of the same parents' ruffian abdominal distension, poor appetite, phlegm and retained fluid is pressed from both sides wet, nose heave bodily pain, podomere and ached.Yin asthenia generating intrinsic heat, deficiency of vital energy hidrosis
Person avoids clothes, and the deficiency of blood is timid and weak-willed and the unhappy person of seven feelings uses with caution.
The present invention is using the root of kudzu vine as monarch drug in a prescription, to solve the heresy of diseases caused by external factors, and relieving muscles diaphoresis takes into account insufficiency of the spleen card of ferritic, and yang invigorating is mended
Spleen antidiarrheal；
Using windproof, Poria cocos, rhizoma atractylodis, the Radix Astragali as ministerial drug, to strengthen monarch drug in a prescription expelling wind and clearing away cold, inducing diaphoresis analgesic, drying damp and strengthening spleen work(
Effect, while nourishing liver and kidney, to help the healthy tendency of plain void, the heresy of tonifying middle-Jiao and Qi then diseases caused by external factors can take advantage of a situation and solve；
Help with the bark of eucommia, ganoderma lucidum, red ginseng to turn round and look at the accompanying symptoms of its consumptive disease usually, filling liver kidney, strengthening the bones and muscles, nourishing qi to stop are calmed the nerves foster
Essence, to control its overstrain internal injury, the card such as emission due to the kidney deficiency or Qi dysfunction in blood control, metrostaxis；
Pseudo-ginseng is also adjutant, there is the effect for the row stasis of blood of stimulating the menstrual flow, and meaning removes its hemostasis with raw new blood, should though deficiency of qi and blood card is disabled
Side cures mainly the card that should have the deficiency of blood to press from both sides the stasis of blood, and its stasis of blood is not dissipated, and then metrostaxis is more than；
Balloonflower root, dandelion are corrigent, with monarch drug in a prescription and most of ministerial drug nature and flavor on the contrary, party major part monarch, ministerial drug are intended to
Solve the wind-cold damp pathogen of diseases caused by external factors, but patient's healthy tendency element is empty, spleen, liver, kidney are not enough, change heat in wind-cold damp pathogen easy entry, with element it is empty just
Gas phase fight easily cause it is physically weak to be taken off, cold weak pulse of limb, thus using corrigent with heat-clearing and detoxifying drug；
It is the root of bidentate achyranthes to make medicine, and coordinating the drug actions of a prescription strengthens the effect of the efficacy of a drug, the root of bidentate achyranthes is apt to kidney tonifying, ensuringd proper downward flow of the blood, so that kidney-nourishing is smart, ease constipation
Road, the root of bidentate achyranthes is also apt to ignite descending, internal heat and kidney aqueous phase is helped, auxiliary Poria cocos more Li Shui is (if the party is used for gynaecology and should use river
The root of bidentate achyranthes, consumption cuts down according to the circumstance).
In summary, the present invention there is nourishing liver and kidney, tonifying Qi and lifting yang, hemostasis stasis, inducing diuresis for removing edema, tonifying spleen to calm the nerves, inducing diaphoresis
The effect of stimulating the menstrual flow, we's card is consumptive disease card, and men and women all can use, i.e. the empty damp evil of catching cold again of healthy tendency element, have emission due to the kidney deficiency, waist
Knee ache, insufficiency of the spleen insomnia, diarrhea, or metrorrhagia due to deficiency of vital energy and hemostasis are not gone, new blood is not given birth to, i.e., the deficiency of blood presss from both sides the card of the stasis of blood, are had concurrently recently outer
Sense wind-cold damp pathogen, generates heat, stiff nape and back, Lung Qi obstraction, the symptom such as discomfort in the throat, even the heresy of diseases caused by external factors has entered innerization heat, demonstrate,proves simultaneous
Red eye, swell pain, dribbling urination, pathopyretic ulcer etc..
The present invention uses pure Chinese medicinal preparation, and safety non-pollution has no toxic side effect, and formula is reasonable, evident in efficacy, without bad anti-
Answer and toxic side effect.
Embodiment
The present invention is further elaborated with reference to specific embodiment.
Embodiment 1
The raw material of active ingredient of the present invention is constituted and parts by weight are：5 parts of pseudo-ginseng, 10 parts of ganoderma lucidum, 10 parts of ginseng, the Radix Astragali 5
Part, 10 parts of balloonflower root, 15 parts of the bark of eucommia, 10 parts of the root of kudzu vine, 10 parts of the root of bidentate achyranthes, 5 parts of dandelion, 10 parts of Poria cocos, windproof 10 parts, 10 parts of rhizoma atractylodis.
Said medicine tablet preparation process of the present invention is：The tablet comprises the following steps：
First, the raw medicinal material is put into water and rinsed, drying parches collections, and it is standby to be then cut into thin slice, will described in
Medicinal material component is mixed in proportion, is placed in micronizer and is crushed 20 minutes~60 minutes, by the Chinese medicine mistake after crushing
The drug powder of 100 mesh sieves, it is standby；
Secondly, the herb powder and the additive of tablet that the first step is obtained are put into mixer and are well mixed, and add
Softwood is made in adhesive and wetting agent, is dried softwood using baking oven, whole grain；
Finally, drug particles second step whole grain obtained are poured into mixer, add lubricant and disintegrant mixing is equal
, ozone sterilization 3 hours, last tabletting obtains finished product.
In addition, tablet can be carried out into sweet tablet or film coating according to customer demand.
Said medicine capsule preparation process of the present invention is：
First, the raw medicinal material is put into water and rinsed, drying parches collections, and it is standby to be then cut into thin slice, will described in
Medicinal material component is mixed in proportion, is placed in micronizer and is crushed 10 minutes~30 minutes, by the Chinese medicine mistake after crushing
The drug particles of 80 mesh sieves, it is standby；
Then, the drug particles and capsule auxiliary material first step obtained, weigh, stir and evenly mix in proportion, 80 DEG C of bakings
Dry 1 hour, then mixed powder is finally loaded capsule by ozone sterilization after 60 minutes using conventional capsule machine.
Capsule of the present invention is hard capsule, cylindrical, can be selected according to the size of drug dose.
Prepared by electuary of the present invention comprises the following steps：
First, the raw medicinal material is put into water and rinsed, drying parches collections, and it is standby to be then cut into thin slice, will described in
Medicinal material component is mixed in proportion, is placed in micronizer and is crushed 10 minutes~30 minutes, by the Chinese medicine mistake after crushing
The drug particles of 80 mesh sieves, it is standby；
Secondly, the drug particles obtained by the first step are added water to cook, decocted three times, merging filtrate, excessive internal heat is concentrated into medicinal extract,
Using negative pressure of vacuum by extract dry into dry cream body；
Finally, the dry cream body obtained by second step is crushed with micronizer, adds electuary auxiliary material and be well mixed, add
Adhesive starch slurry, is pelletized, oven drying, and temperature is 60 degree~80 degree, and the time is 1~3 hour, and disinfection by ultraviolet light 3 is small
When, it is fitted into bag, the finished product of packaging.
The alternative tealeaves of medicine of the present invention, is made alternative tea and takes, and prepared by the alternative tea comprises the following steps：
First, the raw medicinal material is put into water and rinsed, drying parches collections, and it is standby to be then cut into thin slice, will described in
Medicinal material component is mixed in proportion, is placed in micronizer and is crushed 10 minutes~30 minutes, by the Chinese medicine mistake after crushing
The drug particles of 80 mesh sieves, it is standby；
Secondly, the drug particles obtained by the first step are dried, drying temperature is 60 degree~90 degree, the time is 0.5~2
Hour；
Finally, drug particles described in second step are carried out into ultraviolet to irradiate 2 hours, sterilization is degerming, finally by drug particles
It is packaged into the finished product of bag.
Embodiment 2
The raw material of active ingredient of the present invention is constituted and parts by weight are：The raw material composition and parts by weight of active ingredient of the present invention
Number is：10 parts of pseudo-ginseng, 20 parts of ganoderma lucidum, 20 parts of ginseng, 5 parts of the Radix Astragali, 20 parts of balloonflower root, 30 parts of the bark of eucommia, 40 parts of the root of kudzu vine, 20 parts of the root of bidentate achyranthes,
20 parts of dandelion, 20 parts of Poria cocos, windproof 20 parts, 30 parts of rhizoma atractylodis.
Method for preparing tablet thereof such as embodiment 1
Capsule preparation method thereof such as embodiment 1
Electuary preparation method such as embodiment 1
Alternative tea preparation method such as embodiment 1
Embodiment 3
The raw material of active ingredient of the present invention is constituted and parts by weight are：20 parts of pseudo-ginseng, 30 parts of ganoderma lucidum, 30 parts of ginseng, the Radix Astragali
25 parts, 35 parts of balloonflower root, 40 parts of the bark of eucommia, 80 parts of the root of kudzu vine, 30 parts of the root of bidentate achyranthes, 30 parts of dandelion, 50 parts of Poria cocos, windproof 50 parts, rhizoma atractylodis 50
Part.
Method for preparing tablet thereof such as embodiment 1
Capsule preparation method thereof such as embodiment 1
Electuary preparation method such as embodiment 1
Alternative tea preparation method such as embodiment 1
Toxicity test：
Experimental animal
SD rats are provided by Qingdao City experimental animal and animal experimental center.
Acute toxicity testing is administered in rat oral gavage
40 100g~200g SD rats are chosen, are randomly assigned, every group 20, male and female half and half, gavage is carried out to SD rats
Administration, is three times per day administered, and maximum dose group dosage is 1000mg (crude drug) kg~1, other group of dosage is by 1:0.5 successively decreases, and gives
SD rat response situations are observed after medicine at once, Continuous Observation 7 days, SD rats all survive, put to death SD rats, it is dirty to SD rats
Device, the major organs tissue such as the heart, liver, spleen, lung, kidney carries out pathologic inspection, as a result shows without obvious diseased region.
Long term toxicity test is administered in rat oral gavage
Toxicity test：
SD rats 80 are chosen, are divided into control group, experimental group every group 40, male and female half and half.Control group uses physiological saline
Gavage, experimental group is dispersed in water using the electuary of the present embodiment 1, gavage, and dosage is 200mg (crude drug) kg~1, three times per day
Gavage, successive administration 15 weeks observes the index such as animal ordinary circumstance and body weight.After stopping three days, the hair, OK of SD rats is observed
For indexs such as, stool and urine, body weight, as a result show to have no significant effect, internal organs naked eyes do not find peculiar change.Put to death great Bai
Its internal organ is carried out showing without any lesion and exception under histotomy, Electronic Speculum by mouse.
Table 1 is that SD rat bloods check tables of data
The data display present invention is without any side effects for SD rats.Illustrate medicine of the present invention to SD rat long-term prescriptions
Small toxicity, does not have abnormal reaction, using safety yet afterwards after drug withdrawal.
Clinical test：
Therapeutic scheme：Administration is taken the circumstances into consideration according to the state of an illness.
The standard of curative effect evaluation：Evaluation criteria is treated, is formulated according to State Administration of Traditional Chinese Medicine《Chinese medical disease diagnoses curative effect
Standard》Judge
Cure：The symptoms such as red, swollen, hot, pain are wholly absent, and recovery is bent and stretched normally in joint, no any discomfort symptom；
Effectively：The symptoms such as red, swollen, hot, pain substantially mitigate, and joint, which is bent and stretched, to be returned to normal, and needs continual cure；
It is invalid：Symptom does not have any improvement, even there is the trend of exacerbation；
Treatment results：The medicine of present invention treatment urarthritis, rheumatic arthritis and various bone joint pains faces
Bed applies the several years, and totally 186 people take, patient's max age 80 years old, 11 years old of patient's minimal ages.Wherein women accounts for 44%, man
Property account for 56%, after one course for the treatment of of medication, symptom has taken a turn for the better, after five courses for the treatment of of medication, 70 people recovery from illness, 110 people effectively, 6 people
It is invalid, effective percentage 96.7%, curative effect of medication of the present invention is notable.
Case 1：Manage so-and-so
Medical history：Left foot Metatarsophalangeal joint and left foot back are repeatedly red, swell, heat, and pain 5 years is aggravated 3 days.Patient's nothing before 5 years
It is red that left foot Metatarsophalangeal joint occurs in obvious inducement, swells, heat, night more so, has a strong impact on daily life in working as hospital admission, really
Examine as gout, (specifically unknown) is taken a turn for the better after drug therapy.Recurrent exerbation over 5 years, involves left foot back, occurs again before 3 days left
Sufficient Metatarsophalangeal joint is red, swells, heat, pain, to ask further diagnosis and treatment to our hospital.The patient previously has kidney stone, but nothing
Goat family history.
Clinical symptoms：Left foot Metatarsophalangeal joint is red, swells, Pi Wengao, tenderness is obvious.
Chemically examine monitoring result：Have a blood test uric acid：560.0 μm of ol/L, PE:BP：120/90mmHg, WBC：6.94*10/L.
Therapeutic process：Alternative tea is taken, daily 2 bag starts to take pain disappearance in second day afternoon, redness subtracts within the 3rd day
Gently, the 5th day symptom is wholly absent.
Case 2：It is cold so-and-so
Medical history：Left ankle-joint gout recurrent exerbation 3 years, is aggravated 2 days.There is left foot in 3 years after cause drink lot of beer in patient
Ankle-joint is red, swells, heat, and pain has a strong impact on daily life, gout recurrent exerbation over 3 years, and left foot occurs again in cause fatigue in 2 days
Ankle-joint is red, swells, heat, pain, to our hospital to ask further diagnosis and treatment, no gout family's medical history.
Clinical symptoms：Left ankle-joint is red, swells, Pi Wengao, tenderness is obvious.
Chemically examine monitoring result：Have a blood test uric acid 596.0 μm of ol/L, PE:BP：150/90mmHg, WBC：6.91*10/L.
Therapeutic process：Alternative tea is taken, daily 2 bag starts to take pain disappearance in second day afternoon, redness subtracts within the 3rd day
Gently, the 7th day symptom is wholly absent.
Case 3：Zhang
Medical history：5 days causes of patient feed a large amount of seafood, and beer, the outer ankle-joint of the right foot of appearance is red, swells, heat, pain, night is outstanding
Very, daily life is influenceed, it is not alleviated, to ask further diagnosis and treatment to our hospital.
Clinical symptoms：Right foresight ankle-joint is red and swollen, pain 5 days, and it is red to look into the outer ankle-joint of right foot, swells, Pi Wengao, tenderness substantially,
Without deformity, four limbs and auricle are without tophus.
Chemically examine monitoring result：Have a blood test uric acid：460 μm of ol/L, PE:BP：125/80mmHg, WBC：11.0*10/L.
Therapeutic process：Alternative tea is taken, daily 2 bag starts to take pain disappearance in second day afternoon, redness subtracts within the 3rd day
Gently, the 6th day symptom is wholly absent.
Case 4：Mr. Wang
Medical history：Right sufficient Metatarsophalangeal joint occur red in being fed before 8 years after a large amount of seafood by patient, swells, heat has a strong impact on row
Walk and sleep, medical in local hospital, oral drugs are after 2 days, and symptom is alleviated earlier above, (specifically unknown).Gout is sent out repeatedly over 8 years
Make, it is red without obvious inducement to occur biped Metatarsophalangeal joint again before 2 days, swells, pain, to ask further diagnosis and treatment to our hospital.
Clinical symptoms：Biped Metatarsophalangeal joint recurrent exerbation is red, swells, heat, and pain 8 years is aggravated 2 days.
Chemically examine monitoring result：Have a blood test uric acid：460 μm of ol/L, PE:BP：140/90mmHg, WBC：9.6*10/L.
Therapeutic process：Alternative tea is taken, daily 2 bag starts to take pain disappearance in second day afternoon, redness subtracts within the 3rd day
Gently, the 5th day symptom is wholly absent.
Case 5：Zhang
Case history：Left foot the 3rd, four articulationes metatarsophalangeaes and right knee joint recurrent exerbation gout more than 5 years, are aggravated 2 days.Before patient 5 years
There is left foot the 3rd without obvious inducement, four articulationes metatarsophalangeaes and right knee joint are red, swell, heat, pain, night more so, influences daily life.
Taken a turn for the better (specific medicine, dose is unknown) in symptom after the medical treatment of local hospital, gout recurrent exerbation over 5 years went out again before 2 days
Existing left foot the 3rd, four articulationes metatarsophalangeaes are red, swell, heat, pain, to ask further diagnosis and treatment to our hospital.
Clinical symptoms：Left foot the 3rd, four articulationes metatarsophalangeae swelling, slightly red, Pi Wengao, tenderness (+), no deformity.
Chemically examine monitoring result：Have a blood test uric acid：431 μm of ol/L, PE:BP：130/85mmHg, WBC：7.70*10/L.
Therapeutic process：Alternative tea is taken, daily 2 bag starts to take pain disappearance in second day afternoon, redness subtracts within the 3rd day
Gently, the 5th day symptom is wholly absent.
It is described above, only it is highly preferred embodiment of the present invention, any formal limitation not is made to the present invention, appoints
What those skilled in the art, without departing from the scope of the technical proposal of the invention, using in the method for the disclosure above
Appearance makes many possible variations and modification to technical solution of the present invention, belongs to the scope of claims protection.
Claims (8)
1. a kind of Chinese medicine for treating urarthritis and various bone joint pains, it is characterised in that：By following parts by weight
Each component is constituted：
10 parts of pseudo-ginseng, 20 parts of ganoderma lucidum, 20 parts of ginseng, 5 parts of the Radix Astragali, 20 parts of balloonflower root, 30 parts of the bark of eucommia, 40 parts of the root of kudzu vine, 20 parts of the root of bidentate achyranthes, Pu
Public 20 parts of English, 20 parts of Poria cocos, windproof 20 parts, 30 parts of rhizoma atractylodis.
2. a kind of Chinese medicine for treating urarthritis and various bone joint pains according to claim 1, its feature exists
In：The Chinese medicine prepares piece agent, capsule, electuary.
3. a kind of preparation side of Chinese medicine for treating urarthritis and various bone joint pains according to claim 2
Method, it is characterised in that：The preparation of the tablet comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, and it is standby to be then cut into thin slice, by the medicine
Material component is mixed in proportion, is positioned in micronizer and is crushed 20 minutes~60 minutes, the Chinese medicine after crushing is crossed into 100
Mesh sieve obtains drug powder；
Second step, the herb powder and additive of tablet that the first step is obtained is put into mixer and is well mixed, and adds adhesive
And softwood is made in wetting agent, softwood is dried using baking oven, whole grain；
3rd step, the drug particles that second step whole grain is obtained are poured into mixer, add lubricant and disintegrant mixing is equal,
Ozone sterilization 3 hours, last tabletting obtains finished product.
4. a kind of preparation side of Chinese medicine for treating urarthritis and various bone joint pains according to claim 3
Method, it is characterised in that：The tablet as needed, carries out sweet tablet or film coating.
5. a kind of preparation side of Chinese medicine for treating urarthritis and various bone joint pains according to claim 2
Method, it is characterised in that：Prepared by the capsule comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, and it is standby to be then cut into thin slice, by the medicine
Material component is mixed in proportion, is placed in micronizer and is crushed 10 minutes~30 minutes, the Chinese medicine after crushing is crossed into 80
Mesh sieve obtains drug particles, standby；
Second step, the drug particles that the first step is obtained and capsule auxiliary material, weigh, stir and evenly mix in proportion, 80 DEG C of drying 1
Hour, then mixed powder is finally loaded capsule by ozone sterilization after 60 minutes using conventional capsule machine.
6. a kind of Chinese medicinal preparation method for treating urarthritis and various bone joint pains according to claim 5,
It is characterized in that：The capsule is hard capsule, cylindrical, can be selected according to drug dose size.
7. a kind of preparation side of Chinese medicine for treating urarthritis and various bone joint pains according to claim 2
Method, it is characterised in that：Prepared by the electuary comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, and it is standby to be then cut into thin slice, by the medicine
Material component is mixed in proportion, is placed in micronizer and is crushed 10 minutes~30 minutes, the Chinese medicine after crushing is crossed into 80
Mesh sieve obtains drug particles, standby；
Second step, the drug particles obtained by the first step are added water to cook, and are decocted three times, merging filtrate, and excessive internal heat is concentrated into medicinal extract, adopts
With negative pressure of vacuum by extract dry into dry cream body；
3rd step, the dry cream body obtained by second step is crushed with micronizer, is added electuary auxiliary material and is well mixed, adds viscous
Mixture starch slurry, is pelletized, oven drying, and temperature is 60 degree~80 degree, and the time is 1~3 hour, disinfection by ultraviolet light 3 hours,
Finally it is fitted into bag, is packaged to be finished product.
8. a kind of Chinese medicine for treating urarthritis and various bone joint pains according to claim 2, its feature exists
In：The alternative tealeaves of Chinese medicine, is made alternative tea and takes, and prepared by the alternative tea comprises the following steps：
The first step, the raw medicinal material is put into water and rinsed, and drying parches collection, and it is standby to be then cut into thin slice, by the medicine
Material component is mixed in proportion, is placed in micronizer and is crushed 10 minutes~30 minutes, the Chinese medicine after crushing is crossed into 80
Mesh sieve obtains drug particles, standby；
Second step, the drug particles obtained by the first step are dried, and drying temperature is 60 degree~90 degree, and the time is 0.5~2 small
When；
Drug particles described in second step are carried out ultraviolet and irradiated 2 hours, sterilization is degerming, finally by drug particles bag by the 3rd step
Load bag and obtain finished product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105362798A (en) * | 2015-12-25 | 2016-03-02 | 葛晓军 | Traditional Chinese medicine for treating gouty arthritis and preparation method of traditional Chinese medicine |
| CN106138709A (en) * | 2016-08-05 | 2016-11-23 | 武夷山元生泰生物科技有限公司 | A kind of glossy ganoderma composition with treatment gout effect |
| CN106511634A (en) * | 2016-12-30 | 2017-03-22 | 吉林大学 | Traditional Chinese medicine composition for treating uarthritis and preparation method thereof |
| CN107951942A (en) * | 2017-12-05 | 2018-04-24 | 张淑梅 | A kind of Chinese medicine for alleviating gout symptom and plant composition and preparation method thereof |
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| EP0702957A1 (en) * | 1994-09-24 | 1996-03-27 | Krewel-Werke Gmbh | Extracts of St.John's wort |
| CN101850065A (en) * | 2006-10-13 | 2010-10-06 | 吴洵邦 | Chinese medicinal composition for treating gout |
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2014
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0702957A1 (en) * | 1994-09-24 | 1996-03-27 | Krewel-Werke Gmbh | Extracts of St.John's wort |
| CN101850065A (en) * | 2006-10-13 | 2010-10-06 | 吴洵邦 | Chinese medicinal composition for treating gout |
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| 三痹汤治疗类风湿性关节炎30例;李方等;《陕西中医》;20081230;第29卷(第8期);第996-997页，尤其是第996页左栏治疗方法项下 * |
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Effective date of registration: 20151021 Address after: 1, building 266000, building 4, blue pharmaceutical bio Industrial Park, 368 Hedong Road, Hedong District, Qingdao, Shandong Applicant after: Qingdao Liu Xu Kampo Biological Technology Co. Ltd. Address before: 266000 Shandong province Qingdao City, Liaoning Road No. 153 Silver Street Yee's first 1003 Applicant before: QINGDAO AOPURUI INFORMATION SCIENCE & TECHNOLOGY CO., LTD. |
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