CN105362798A - Traditional Chinese medicine for treating gouty arthritis and preparation method of traditional Chinese medicine - Google Patents

Traditional Chinese medicine for treating gouty arthritis and preparation method of traditional Chinese medicine Download PDF

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CN105362798A
CN105362798A CN201510985348.5A CN201510985348A CN105362798A CN 105362798 A CN105362798 A CN 105362798A CN 201510985348 A CN201510985348 A CN 201510985348A CN 105362798 A CN105362798 A CN 105362798A
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radix
chinese medicine
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radix angelicae
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葛晓军
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
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    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/22Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)
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    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses traditional Chinese medicine for treating gouty arthritis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following herbs in parts by weight: 5-17 parts of angelica dahurica, 3-12 parts of glutinous rice root, 11-20 parts of eucommia ulmoides, 1-10 parts of Chinese wedelia herb, 5-19 parts of pollen pini, 15-29 parts of Chinese angelica, 8-18 parts of resina liquidamberis, 3-16 parts of fructus trichosanthis, 12-25 parts of fructus choerospondiatis, 9-21 parts of astragalus membranaceus, 5-15 parts of picrasma quassioides, 7-20 parts of radix ranunculi ternati, 10-20 parts of safflower, 16-29 parts of scrophularia, 9-20 parts of cimicifugae foetidae, 12-25 parts of laricifomes officinalis, 5-16 parts of chrysanthemum, 3-8 parts of ampelopsis japonica and 11-20 parts of glabrous sarcandra herb. The traditional Chinese medicine preparation is appropriate in compatibility of the selected herbs, has the efficacies of dispelling wind to eliminate dampness, dredging numbness to stop pain, activating blood to dredge collaterals and dredging arthrosis, is convenient to use, good in the absorption effect, and free of adverse, toxic or side effect, can obviously reduce the blood uric acid value, has excellent prevention and treatment effects on gouty arthritis, and is suitable for prevention and treatment of gouty arthritis; the traditional Chinese medicine is simple to prepare, low in cost and quick in effect, and can treat both symptoms and root causes.

Description

One treats arthritic Chinese medicine of air permeability and preparation method thereof
Technical field
The present invention relates to one and treat the arthritic Chinese medicine of air permeability, belong to medical art.
Background technology
Gouty arthritis belongs to motherland's medical science " arthromyodynia " category, waits phase class with the disease such as " severe and migratory arthralgia ", " severe and migratory arthralgia ".Bright Zhang Jingyue thinks gout " be that YIN-cold water wets, modern damp attacks people's flesh tendon, interior excessive by delicious food usually, the moist chamber part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, coldly ties strongly fragrant and heat-transformation with damp mutually, stops the diseased region redness hectic fever such as skin, for a long time then osteomyelitis " outward in " Jing Yue's complete work beriberi ".Gong Tingxian is pointed out in " ten thousand cause of disease spring " " all gout limb pain person, pain belongs to fire, and swollen genus wets ".Modern medicine thinks that gout is the disease caused because heritability or the acquired cause of disease cause disorders of purine metabolism and blood uric acid to continue to raise.One group of disease that it is long-term purine metabolic disturbance, blood uric acid increases caused tissue injury.It is red, swollen, hot, bitterly that gouty arthritis First-episode mostly is affected joints, as treatment not in time, the course of disease is delayed, and can cause cartilage hypertrophy, deformity, stiff, tophaceous formation, even can cause skin diabrosis, forms fistula.
Clinically usual with alleviate acute arthritis outbreak, prevent arthritis from recur, correct hyperuricemia, prevent because of urate deposition in kidney, joint etc. caused by complication be main purpose.During acute arthritis outbreak, the main inflammation eliminated urate and bring out, adopts colchicine, nonsteroidal anti-inflammatory drug, with alkalized urine, impels uric acid to dissolve.Disease alleviation and prevent in gout recurrence, allopurinol, skin graft immediately, probenecid etc. have certain curative effect.Although western medical treatment can relief of symptoms, toxic and side effects is larger.Because disease condition has gradually ascendant trend in recent years, many scholars are caused more and more to pay attention to the Therapy study of gout.
Current gouty arthritis Therapeutic Method comprises takes good care of auxiliary treatment, acupuncture and moxibustion therapy and Drug therapy etc., but also exists that western medicine DeGrain, side effect are large, take effect the problem such as slow.Therefore there is great demand in the Chinese medicine of people to rapid, effective treatment gouty arthritis.
Summary of the invention
Technical problem to be solved by this invention is: provide one to treat the arthritic pure Chinese medicine formula of air permeability, and the preparation of this Chinese medicine composition is convenient, cost is low, evident in efficacy, reliable effect, have no side effect.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
The arthritic Chinese medicine for the treatment of air permeability provided by the invention is made up of the medical material of following portions by weight: Radix Angelicae Dahuricae 5-17 part, Radix Oryzae Glutinosae 3-12 part, Cortex Eucommiae 11-20 part, Chinese Wedelia Herb 1-10 part, Pollen Pini 5-19 part, Radix Angelicae Sinensis 15-29 part, Resina Liquidambaris 8-18 part, Fructus Trichosanthis 3-16 part, Fructus Choerospondiatis 12-25 part, Radix Astragali 9-21 part, Ramulus Et Folium Picrasmae 5-15 part, Radix Ranunculi Ternati 7-20 part, Flos Carthami 10-20 part, Radix Scrophulariae 16-29 part, Rhizoma Cimicifugae 9-20 part, bitter white hoof 12-25 part, Flos Chrysanthemi 5-16 part, Radix Ampelopsis 3-8 part, Herba Sarcandrae 11-20 part.
Preferably, described Chinese medicine is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 11 parts, Radix Oryzae Glutinosae 8 parts, the Cortex Eucommiae 15 parts, Chinese Wedelia Herb 5 parts, Pollen Pini 12 parts, Radix Angelicae Sinensis 22 parts, Resina Liquidambaris 13 parts, Fructus Trichosanthis 10 parts, Fructus Choerospondiatis 20 parts, the Radix Astragali 15 parts, Ramulus Et Folium Picrasmae 10 parts, Radix Ranunculi Ternati 13 parts, 15 parts, Flos Carthami, Radix Scrophulariae 22 parts, Rhizoma Cimicifugae 15 parts, bitter white hoof 20 parts, Flos Chrysanthemi 11 parts, Radix Ampelopsis 3-8 part, Herba Sarcandrae 15 parts.
Further, described Chinese medicine is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 17 parts, Radix Oryzae Glutinosae 12 parts, the Cortex Eucommiae 20 parts, Chinese Wedelia Herb 10 parts, Pollen Pini 19 parts, Radix Angelicae Sinensis 29 parts, Resina Liquidambaris 18 parts, Fructus Trichosanthis 16 parts, Fructus Choerospondiatis 25 parts, the Radix Astragali 21 parts, Ramulus Et Folium Picrasmae 15 parts, Radix Ranunculi Ternati 20 parts, 20 parts, Flos Carthami, Radix Scrophulariae 29 parts, Rhizoma Cimicifugae 20 parts, bitter white hoof 25 parts, Flos Chrysanthemi 16 parts, Radix Ampelopsis 8 parts, Herba Sarcandrae 20 parts.
Further, described Chinese medicine is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 5 parts, Radix Oryzae Glutinosae 3 parts, the Cortex Eucommiae 11 parts, Chinese Wedelia Herb 1 part, Pollen Pini 5 parts, Radix Angelicae Sinensis 15 parts, Resina Liquidambaris 8 parts, Fructus Trichosanthis 3 parts, Fructus Choerospondiatis 12 parts, the Radix Astragali 9 parts, Ramulus Et Folium Picrasmae 5 parts, Radix Ranunculi Ternati 7 parts, 10 parts, Flos Carthami, Radix Scrophulariae 16 parts, Rhizoma Cimicifugae 9 parts, bitter white hoof 12 parts, Flos Chrysanthemi 5 parts, Radix Ampelopsis 3 parts, Herba Sarcandrae 11 parts.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into decoction, tablet or capsule.
Present invention also offers a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: the Radix Angelicae Dahuricae of described weight, Radix Oryzae Glutinosae, the Cortex Eucommiae, Chinese Wedelia Herb, Pollen Pini, Radix Angelicae Sinensis, Resina Liquidambaris, Fructus Trichosanthis, Fructus Choerospondiatis, the Radix Astragali, Ramulus Et Folium Picrasmae, Radix Ranunculi Ternati, Flos Carthami, Radix Scrophulariae, Rhizoma Cimicifugae, bitter white hoof, Flos Chrysanthemi, Radix Ampelopsis, Herba Sarcandrae medicine are added water and first do not have water soaking 1 hour, rear decoction twice, add water 8 times amount for the first time, intense fire decocts boiling, use slow fire boiling again 45 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.Medicinal residues after filtration add water 6 times amount, decoct boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor.Merge twice decoction liquor stir and get final product, decoction liquor be divided into 6 doses to take.
Chinese medicine of the present invention is oral, instructions of taking: every day twice, each 1 dose, decoction being taken warmly after 1 hour after meal.It within 15 days, is 1 course for the treatment of.
Beneficial effect: selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, there is effect of expelling wind and removing dampness, numbness relieving and pain relieving, promoting blood circulation to remove obstruction in the collateral, clearance profit joint, easy to use, good absorbing effect, without bad and toxic and side effects, obviously can reduce Level of Serum Uric Acid, have fabulous prevention and therapeutic effect to gouty arthritis, be suitable for prevention and the treatment of gouty arthritis; Chinese drug preparation of the present invention is simple, and cost is low, and take effect fruit, can treating both the principal and secondary aspects of a disease.
Detailed description of the invention
embodiment 1
The Chinese medicine of the present embodiment is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 11 parts, Radix Oryzae Glutinosae 8 parts, the Cortex Eucommiae 15 parts, Chinese Wedelia Herb 5 parts, Pollen Pini 12 parts, Radix Angelicae Sinensis 22 parts, Resina Liquidambaris 13 parts, Fructus Trichosanthis 10 parts, Fructus Choerospondiatis 20 parts, the Radix Astragali 15 parts, Ramulus Et Folium Picrasmae 10 parts, Radix Ranunculi Ternati 13 parts, 15 parts, Flos Carthami, Radix Scrophulariae 22 parts, Rhizoma Cimicifugae 15 parts, bitter white hoof 20 parts, Flos Chrysanthemi 11 parts, Radix Ampelopsis 3-8 part, Herba Sarcandrae 15 parts.
Preparation method and using method: the Radix Angelicae Dahuricae of described weight, Radix Oryzae Glutinosae, the Cortex Eucommiae, Chinese Wedelia Herb, Pollen Pini, Radix Angelicae Sinensis, Resina Liquidambaris, Fructus Trichosanthis, Fructus Choerospondiatis, the Radix Astragali, Ramulus Et Folium Picrasmae, Radix Ranunculi Ternati, Flos Carthami, Radix Scrophulariae, Rhizoma Cimicifugae, bitter white hoof, Flos Chrysanthemi, Radix Ampelopsis, Herba Sarcandrae medicine are added water and first do not have water soaking 1 hour, rear decoction twice, add water 8 times amount for the first time, intense fire decocts boiling, use slow fire boiling again 45 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.Medicinal residues after filtration add water 6 times amount, decoct boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor.Merge twice decoction liquor stir and get final product, decoction liquor be divided into 6 doses to take.
Instructions of taking: every day twice, each 1 dose, decoction being taken warmly after 1 hour after meal.It within 15 days, is 1 course for the treatment of.
embodiment 2
The Chinese medicine of the present embodiment is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 17 parts, Radix Oryzae Glutinosae 12 parts, the Cortex Eucommiae 20 parts, Chinese Wedelia Herb 10 parts, Pollen Pini 19 parts, Radix Angelicae Sinensis 29 parts, Resina Liquidambaris 18 parts, Fructus Trichosanthis 16 parts, Fructus Choerospondiatis 25 parts, the Radix Astragali 21 parts, Ramulus Et Folium Picrasmae 15 parts, Radix Ranunculi Ternati 20 parts, 20 parts, Flos Carthami, Radix Scrophulariae 29 parts, Rhizoma Cimicifugae 20 parts, bitter white hoof 25 parts, Flos Chrysanthemi 16 parts, Radix Ampelopsis 8 parts, Herba Sarcandrae 20 parts.
Preparation method and using method: the Radix Angelicae Dahuricae of described weight, Radix Oryzae Glutinosae, the Cortex Eucommiae, Chinese Wedelia Herb, Pollen Pini, Radix Angelicae Sinensis, Resina Liquidambaris, Fructus Trichosanthis, Fructus Choerospondiatis, the Radix Astragali, Ramulus Et Folium Picrasmae, Radix Ranunculi Ternati, Flos Carthami, Radix Scrophulariae, Rhizoma Cimicifugae, bitter white hoof, Flos Chrysanthemi, Radix Ampelopsis, Herba Sarcandrae medicine are added water and first do not have water soaking 1 hour, rear decoction twice, add water 8 times amount for the first time, intense fire decocts boiling, use slow fire boiling again 45 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.Medicinal residues after filtration add water 6 times amount, decoct boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor.Merge twice decoction liquor stir and get final product, decoction liquor be divided into 6 doses to take.
Instructions of taking: every day twice, each 1 dose, decoction being taken warmly after 1 hour after meal.It within 15 days, is 1 course for the treatment of.
embodiment 3
The Chinese medicine of the present embodiment is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 5 parts, Radix Oryzae Glutinosae 3 parts, the Cortex Eucommiae 11 parts, Chinese Wedelia Herb 1 part, Pollen Pini 5 parts, Radix Angelicae Sinensis 15 parts, Resina Liquidambaris 8 parts, Fructus Trichosanthis 3 parts, Fructus Choerospondiatis 12 parts, the Radix Astragali 9 parts, Ramulus Et Folium Picrasmae 5 parts, Radix Ranunculi Ternati 7 parts, 10 parts, Flos Carthami, Radix Scrophulariae 16 parts, Rhizoma Cimicifugae 9 parts, bitter white hoof 12 parts, Flos Chrysanthemi 5 parts, Radix Ampelopsis 3 parts, Herba Sarcandrae 11 parts.
Preparation method and using method: the Radix Angelicae Dahuricae of described weight, Radix Oryzae Glutinosae, the Cortex Eucommiae, Chinese Wedelia Herb, Pollen Pini, Radix Angelicae Sinensis, Resina Liquidambaris, Fructus Trichosanthis, Fructus Choerospondiatis, the Radix Astragali, Ramulus Et Folium Picrasmae, Radix Ranunculi Ternati, Flos Carthami, Radix Scrophulariae, Rhizoma Cimicifugae, bitter white hoof, Flos Chrysanthemi, Radix Ampelopsis, Herba Sarcandrae medicine are added water and first do not have water soaking 1 hour, rear decoction twice, add water 8 times amount for the first time, intense fire decocts boiling, use slow fire boiling again 45 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.Medicinal residues after filtration add water 6 times amount, decoct boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor.Merge twice decoction liquor stir and get final product, decoction liquor be divided into 6 doses to take.
Instructions of taking: every day twice, each 1 dose, decoction being taken warmly after 1 hour after meal.It within 15 days, is 1 course for the treatment of.
zoopery
Adopt the pharmaceutical formulation in embodiment 1 to make experimental drug, carry out zoopery:
1, select healthy white rat 30 only with healthy guinea pig 30, by 5g/kg gavage, every day twice, continue 30 days, there is not toxicity in two groups of experimental mouse.
2, select healthy drug study with dog 30, by 5g/kg gavage, every day twice, continue experimental dog after 30 days and do not occur toxicity.
the inhibitory action of Chinese medicine composition of the present invention on the swelling of Gout Model rat articular and the impact of blood uric acid
1, animal model and administration
Get the male wista rat 120 that body weight is 200 ~ 220g, weigh after adapting to laboratory 5d, number, be divided into 6 groups at random, often organize 20, i.e. Normal group, model group, positive drug group (allopurinol group), Chinese medicine composition high dose group of the present invention, middle dosage group, low dose group.Chinese medicine composition senior middle school of the present invention low dose group group rat presses 2.5g/kg, 1.0g/kg, 0.5g/kg gastric infusion, the distilled water of the capacity such as Normal group and model group gavage, administration every day 1 time, continuous gavage 5d respectively.
Prepare Monosodium urate crystallization: 194ml distilled water adds 6mlNaOH simultaneously, boil and add 1g uric acid, adjust pH7.2 with dilute hydrochloric acid, stir cooling, 4 DEG C of Refrigerator store 24h, remove supernatant, with filter paper, precipitate moisture is blotted, put into 70 DEG C, drying baker and dry 2h, take out, scrape powder, put into mortar pulverization, with the wire-mesh screen of aperture 250mm, sieve, bottle for subsequent use.Used time gets the crystallization of 250mg Monosodium urate and adds 45ml0.9% chloride injection solution, then adds 5ml Tween 80, heated and stirred, is made into 50ml Monosodium urate solution.
Except normal group, every experimental mouse all selects right Ankle lateral rear to be point of puncture, and pin mouth inclined-plane penetrates ankle joint chamber in angle of 45 degrees towards front upper place and tibia, injects 0.2ml Monosodium urate solution with No. 4 syringe needles to articular cavity, heave for injection standard with joint capsule offside, induction Gout Model.Each group of rat 3h before modeling, after modeling, and after medication 5d (i.e. 120h after modeling) respectively in tested ankle joint same area, with its diameter of vernier caliper measurement, observe before and after modeling and each group tested joint diameter change after medication treatment, after last administration, 2h puts to death rat, abdominal aortic blood, 2500r/min, centrifugal 5min, gets determination of serum uric acid level, carries out group difference and compares.
2, experimental result
Result proved invention Chinese medicine composition is respectively organized and is compared with model group with positive controls, all obviously can suppress the ankle swelling (P<0.01) of rat caused by Monosodium urate, wherein in Chinese medicine composition of the present invention, high dose 5h and joint diameter of 80h after modeling after modeling has the difference of pole significance compared with model group.Chinese medicine composition of the present invention obviously reduces the serum uric acid level (P<0.01) of hyperuricemia rat compared with model group, and wherein in Chinese medicine composition of the present invention, high dose group has the difference of pole significance compared with model group.
clinical data
1, physical data
Accept out-patient 150 example for medical treatment.
2, diagnostic criteria
(1) primary gout is multiple is born in more than 40 years old male, and women is rare, accounts for 5%.Some patients has family history.
(2) asymptomatic stage, only has hyperuricemia.Blood uric acid increases to joint symptoms duration of seizure can reach the several years.
(3) acute attack stage: often break out night, first betide a Plantar toe joint, severe pain, culminates within a few hours, and obvious tumefaction is rubescent, and tenderness is obvious, dysfunction.Can with heating, up to 38-39 DEG C.The symptoms such as weak, anorexia, headache.Remission after 1-2 week, recurred after the interval several months to several years.Other joint toe, thumb, metacarpophalangeal joints, ankle, wrist, knee joint, shoulders etc. also can occur.Drink, gluttony, fatigue, wound or direct stimulation etc. all can bring out arthritis outbreak.
(4) the chronic arthritis phase: arthritis is frequently shown effect, the intermission shortens, arthroncus, joint epiphysis destroy and hypertrophy and teratogenesis shape.Tophus is there is in auricle or joint part.Be positioned at subcutaneous, in faint yellow tuberosity.Can flow out Calx shape thing during tophus ulceration, sinus tract is difficult to healing, can secondary pyogenic infection.About there is urate calculi in patient 10-20%, and can cause hematuria, renal colic symptom.The complication such as hypertension, coronary heart disease can be there is.
3, Therapeutic Method
Take Chinese medicine prepared by the embodiment of the present invention, each serving with 1 dose, every day early, evening respectively takes 1 time, within 15 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.Period in a medicine, avoids tobacco and wine, pluck, seafood, beans, the contour purine food of high protein.
4, efficacy assessment standard
Effective: gouty arthritis is eliminated, physical recovery is normal, without recurring after observing half a year;
Take a turn for the better: gouty arthritis symptom is clearly better, and body constitution obviously recovers;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
By Drug therapy gouty arthritis patient 150 example of the present invention, effective 120 examples of result, take a turn for the better 25 examples, and invalid 5 examples, total effective rate is 96.7%.
model case
Case 1: grandson, man, 59 years old, left toe joint swelled and ache 2 months repeatedly.Clinical observation: left toe joint is red, swollen, pain and burning sensation, the aggravation of pressing, and night increases the weight of, difficulty in walking, with agitation, bitter taste, constipation, red tongue yellow and greasy fur, rolling pulse, Level of Serum Uric Acid 610 μm of ol/L.Take 2 courses for the treatment of of treatment by Chinese herbs prepared by the embodiment of the present invention 1, symptom alleviates, and can walk, and continues to take 3 courses for the treatment of, all transference cures, Level of Serum Uric Acid 320 μm of ol/L, and exhorts that patient avoids and drink and high purine food, follows up a case by regular visits to without recurrence after half a year.
Case 2: still certain, man, 47 years old, patient caused disease damage and inflammatory reaction due to urate deposition in joint capsule, synovial bursa, cartilage, sclerotin and its hetero-organization, is diagnosed as gouty arthritis.After taking 3 courses for the treatment of of Chinese medicine of the present invention, symptom is obviously alleviated, and continues to take 2 courses for the treatment of, and clinical symptoms all disappears.Follow up a case by regular visits to and do not recur so far.
Case 3: poplar, female, 49 years old, patient suffered from gouty arthritis, and Relapse rate shows effect, and interval, short, stadium extended, and pathological changes joint is increased gradually, very painful, general weakness, heating, headache.Take 3 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is obviously alleviated, and after continuing to take 2 courses for the treatment of, transference cure, follows up a case by regular visits to not recurrence.
Case 4: beam, man, 55 years old, patient because of drinking, gluttony causes gouty arthritis, joint severe pain, involves big toe joint, ankle, knee joint etc., and joint is red, swollen, hot and tenderness, general weakness, heating, headache etc.After taking 3 courses for the treatment of of Chinese medicine of the present invention, symptom takes a turn for the better, and after then taking 3 courses for the treatment of, physical recovery is normal.Follow up a case by regular visits to and do not recur so far.
The explanation of above embodiment just understands method of the present invention and core concept thereof for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.

Claims (5)

1. treat the arthritic Chinese medicine of air permeability, it is characterized in that, described Chinese medicine is made up of the medical material of following portions by weight: Radix Angelicae Dahuricae 5-17 part, Radix Oryzae Glutinosae 3-12 part, Cortex Eucommiae 11-20 part, Chinese Wedelia Herb 1-10 part, Pollen Pini 5-19 part, Radix Angelicae Sinensis 15-29 part, Resina Liquidambaris 8-18 part, Fructus Trichosanthis 3-16 part, Fructus Choerospondiatis 12-25 part, Radix Astragali 9-21 part, Ramulus Et Folium Picrasmae 5-15 part, Radix Ranunculi Ternati 7-20 part, Flos Carthami 10-20 part, Radix Scrophulariae 16-29 part, Rhizoma Cimicifugae 9-20 part, bitter white hoof 12-25 part, Flos Chrysanthemi 5-16 part, Radix Ampelopsis 3-8 part, Herba Sarcandrae 11-20 part.
2. Chinese medicine according to claim 1, is characterized in that, described Chinese medicine is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 11 parts, Radix Oryzae Glutinosae 8 parts, the Cortex Eucommiae 15 parts, Chinese Wedelia Herb 5 parts, Pollen Pini 12 parts, Radix Angelicae Sinensis 22 parts, Resina Liquidambaris 13 parts, Fructus Trichosanthis 10 parts, Fructus Choerospondiatis 20 parts, the Radix Astragali 15 parts, Ramulus Et Folium Picrasmae 10 parts, Radix Ranunculi Ternati 13 parts, 15 parts, Flos Carthami, Radix Scrophulariae 22 parts, Rhizoma Cimicifugae 15 parts, bitter white hoof 20 parts, Flos Chrysanthemi 11 parts, Radix Ampelopsis 3-8 part, Herba Sarcandrae 15 parts.
3. Chinese medicine according to claim 1, is characterized in that, described Chinese medicine is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 17 parts, Radix Oryzae Glutinosae 12 parts, the Cortex Eucommiae 20 parts, Chinese Wedelia Herb 10 parts, Pollen Pini 19 parts, Radix Angelicae Sinensis 29 parts, Resina Liquidambaris 18 parts, Fructus Trichosanthis 16 parts, Fructus Choerospondiatis 25 parts, the Radix Astragali 21 parts, Ramulus Et Folium Picrasmae 15 parts, Radix Ranunculi Ternati 20 parts, 20 parts, Flos Carthami, Radix Scrophulariae 29 parts, Rhizoma Cimicifugae 20 parts, bitter white hoof 25 parts, Flos Chrysanthemi 16 parts, Radix Ampelopsis 8 parts, Herba Sarcandrae 20 parts.
4. Chinese medicine according to claim 1, is characterized in that, described Chinese medicine is made up of the medical material of following portions by weight: the Radix Angelicae Dahuricae 5 parts, Radix Oryzae Glutinosae 3 parts, the Cortex Eucommiae 11 parts, Chinese Wedelia Herb 1 part, Pollen Pini 5 parts, Radix Angelicae Sinensis 15 parts, Resina Liquidambaris 8 parts, Fructus Trichosanthis 3 parts, Fructus Choerospondiatis 12 parts, the Radix Astragali 9 parts, Ramulus Et Folium Picrasmae 5 parts, Radix Ranunculi Ternati 7 parts, 10 parts, Flos Carthami, Radix Scrophulariae 16 parts, Rhizoma Cimicifugae 9 parts, bitter white hoof 12 parts, Flos Chrysanthemi 5 parts, Radix Ampelopsis 3 parts, Herba Sarcandrae 11 parts.
5. the method for the Chinese medicine of preparation described in above-mentioned any one claim, it is characterized in that, the Radix Angelicae Dahuricae of described weight, Radix Oryzae Glutinosae, the Cortex Eucommiae, Chinese Wedelia Herb, Pollen Pini, Radix Angelicae Sinensis, Resina Liquidambaris, Fructus Trichosanthis, Fructus Choerospondiatis, the Radix Astragali, Ramulus Et Folium Picrasmae, Radix Ranunculi Ternati, Flos Carthami, Radix Scrophulariae, Rhizoma Cimicifugae, bitter white hoof, Flos Chrysanthemi, Radix Ampelopsis, Herba Sarcandrae medicine are added water and first do not have water soaking 1 hour, rear decoction twice, add water 8 times amount for the first time, intense fire decocts boiling, use slow fire boiling again 45 minutes, filter first time decoction liquor, first time decoction liquor is poured in container; Medicinal residues after filtration add water 6 times amount, decoct boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor, must take medicinal liquid.
CN201510985348.5A 2015-12-25 2015-12-25 Traditional Chinese medicine for treating gouty arthritis and preparation method of traditional Chinese medicine Withdrawn CN105362798A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998991A (en) * 2016-06-24 2016-10-12 何颖 Drug for treating arthritis and preparing method thereof

Citations (1)

* Cited by examiner, † Cited by third party
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CN104069162A (en) * 2014-07-09 2014-10-01 青岛澳普瑞资讯科技有限公司 Traditional Chinese medicine for treating gouty arthritis and various bone and arthrosis pains

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104069162A (en) * 2014-07-09 2014-10-01 青岛澳普瑞资讯科技有限公司 Traditional Chinese medicine for treating gouty arthritis and various bone and arthrosis pains

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998991A (en) * 2016-06-24 2016-10-12 何颖 Drug for treating arthritis and preparing method thereof

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Application publication date: 20160302