CN103028002A - Pharmaceutical preparation for treating gout and preparation method thereof - Google Patents
Pharmaceutical preparation for treating gout and preparation method thereof Download PDFInfo
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- CN103028002A CN103028002A CN2011102913665A CN201110291366A CN103028002A CN 103028002 A CN103028002 A CN 103028002A CN 2011102913665 A CN2011102913665 A CN 2011102913665A CN 201110291366 A CN201110291366 A CN 201110291366A CN 103028002 A CN103028002 A CN 103028002A
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Abstract
The invention relates to a pharmaceutical preparation for treating gout and a preparation method thereof. The pharmaceutical preparation is prepared from Clerodendranthus spicatus and other drugs. Compared with the prior art, the pharmaceutical preparation provided in the invention has the advantages of clear functions, convenient administration, good curative effects. Also, the invention provides a reasonable and feasible preparation method.
Description
Technical field: the present invention is a kind of pharmaceutical preparation and method for making thereof for the treatment of gout, belongs to the technical field of medicine.
Technical background: gout is because living standard improves, and long-term purine metabolism obstacle, hyperuricemia cause one group of disease of tissue injury.Because uric acid excessive concentration in blood of human body, in soft tissue such as membrana articulata or tendon, form acicular crystal, cause health immune system overreaction (sensitivity) and the inflammation that causes suffering.General outbreak position is the thumb joint, ankle joint, knee joint etc.Long-term patient with gout has and shows effect in finger-joint, even auricle contains the case of soft tissue portion.That the gouty attack,acute position occurs is red, swollen, hot, have an intense pain, and general manyly show effect the midnight can make the people wake up with a start from sleep.Moreover, the urate crystal of needle point size can also be deposited on the positions such as kidney, heart, causes kidney damage renal calculus, renal failure; Cause heart disease, diabetes, hypertension, hyperlipidemia, obesity.Existing nearly 9,000 ten thousand patient with gout of China, potential patient 1.2 hundred million, 90% concentrates on the male between 25-45 year, and the gout sickness rate also rising year by year with annual 10% speed and being the trend of rejuvenation, has now become second largest threat human life and healthy metabolic system disease.Just because of gout crowd's continuous increase, and gout increases the weight of day by day to the infringement of human health, and researcher has also progressively strengthened the R﹠D intensity to goat.The patient of gout relies on the therapy of doctor trained in Western medicine more at present, and the medicine with colchicine and so on alleviates acute arthritis, also can reduce the uric acid content in the blood simultaneously.Colchicine is on the not impact of metabolism of uric acid, and the outbreak why it can alleviate gout be because it can suppress the crystalline solid that leukocyte is engulfed uric acid, and leukocytic phagocytosis is to cause arthritic main cause.But colchicine has a lot of side effect: oral administration can cause nausea, vomiting, anorexia, diarrhoea and watery diarrhea, and this medicine can also cause performance and the alopecias such as bone marrow depression such as leukopenia, thrombocytopenia in addition.
In view of such circumstances, develop a kind of safe and effective, the thing that the pharmaceutical preparation of the treatment gout that side effect is little has just become people to be badly in need of solving.
Summary of the invention: the object of the invention is to: a kind of pharmaceutical preparation and method for making thereof for the treatment of gout is provided; The present invention is directed to prior art, Chinese medicine is made modern preparation, not only taking convenience, and craft science is reasonable, can better keep effective ingredient, and therapeutical effect is good, extensive market.
The present invention consists of like this: it is by Herba clerodendranthi spicati 100-300g, Ampelopsis grossedentata 100-250g, Caulis Aspidopterydis obcordatae 100-250g, Radix Angelicae Sinensis 100-200g, Rhizoma Corydalis 100-200g, Herba Epimedii 100-200g, is made.Specifically: it is to be made by Herba clerodendranthi spicati 250g, Ampelopsis grossedentata 200g, Caulis Aspidopterydis obcordatae 200g, Radix Angelicae Sinensis 150g, Rhizoma Corydalis 150g, Herba Epimedii 150g.The method for making of the pharmaceutical preparation of described treatment gout: the thing of getting it filled, pulverize or extract, then make respectively multiple peroral dosage form, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.Furthermore: get Herba clerodendranthi spicati, Ampelopsis grossedentata, Caulis Aspidopterydis obcordatae, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 1-3 time, add 5-12 times of water gaging decocted 1-3 hour at every turn, collecting decoction, filter, filtrate is concentrated, adds ethanol and makes and contain the alcohol amount and reach 50-85%, leave standstill, get the supernatant Recycled ethanol, concentrated, make again corresponding preparations.Specifically: get Herba clerodendranthi spicati, Ampelopsis grossedentata, Caulis Aspidopterydis obcordatae, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 2 times, adding for the first time 8 times of water gagings decocted 2 hours, add for the second time 6 times of water gagings and decocted 1.5 hours, collecting decoction filters, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, add ethanol and make and contain alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, make again corresponding preparations.Selection process: get Herba clerodendranthi spicati, Ampelopsis grossedentata, Caulis Aspidopterydis obcordatae, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 2 times, adding for the first time 8 times of water gagings decocted 2 hours, adding for the second time 6 times of water gagings decocted 1.5 hours, collecting decoction, filter, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, adding ethanol makes and contains alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, 1 part of qinghuo reagent, with 3 parts of sucrose, 1 part of granulation of dextrin, drying namely gets granule.
Our take Herba clerodendranthi spicati as monarch drug, heat-clearing and toxic substances removing, the damp eliminating diuresis and expelling stone, kidney is protected in the kidney invigorating, giving consideration to both the incidental and fundamental.According to modern pharmacological research, kidney tea can increase the permeability of glomerule, recovers kidney homergy and kidney circulation volume, promotes toxicity secretions to drain, and can significantly reduce blood uric acid.Take Ampelopsis grossedentata, Caulis Aspidopterydis obcordatae as ministerial drug, the existing clearing away heat-damp and promoting diuresis of Ampelopsis grossedentata, the detumescence merit of eliminating the phlegm, but promoting blood circulation to remove obstruction in the collateral again, wind-damp dispelling, bone and muscle strengthening, hepatoprotective; Caulis Aspidopterydis obcordatae function clearing away heat and promoting diuresis, dispelling wind and removing obstruction in the collateral, and can promote the nephrotoxin to drain, reduce blood uric acid.Rhizoma Gastrodiae energy wind-damp dispelling, the meridian dredging, stopping numbness pain, invigorating the liver and kidney.This group medicine both can increase kidney strengthening tea clearing heat and expelling damp effect, but removing obstruction in the collateral to relieve pain again.Make as helping take Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii.With the promoting flow of QI and blood pain relieving of enrich blood promoting blood circulation and stopping pain and the Rhizoma Corydalis of Radix Angelicae Sinensis, be retarded by silt and stopping numbness pain to disappear.Use the Cortex Cinnamomi promoting the flow of QI-blood by warming the meridian, with the sharp joint of promoting blood circulation, and warm activating the spleen kidney.Wherein Radix Angelicae Sinensis can dissolve uric acid crystal again, and Cortex Cinnamomi also can reduce uric acid in the blood.This three flavor, or return through the liver spleen, or return through the spleen kidney, not only can strengthen the therapeutical effect of all medicines but also play the effect that all medicines reach disease institute of drawing.In a word, all medicines share has removing damp-heat, and loose silt is invigorated blood circulation, promoting the circulation of QI to relieve pain, the merit of the kidney invigorating hepatoprotective spleen invigorating.Can significantly reduce uric acid level in the blood, and the pain when gout shown effect there is good analgesic effect.
Adopt inflammation, pain and Gout Model to carry out the pharmacodynamic study of this product.The result shows that this product has obvious inhibitory action to Ovum Gallus domesticus album and the foot swelling of carrageenin induced mice, can obviously resist rat gouty arthritis due to the uric acid sodium, and hot plate is caused that the mice pain in foot has antagonism.Conclusion: this product has obvious antiinflammatory, analgesia and gout effect.
Concrete embodiment:
Embodiments of the invention 1: Herba clerodendranthi spicati 250g, Ampelopsis grossedentata 200g, Caulis Aspidopterydis obcordatae 200g, Radix Angelicae Sinensis 150g, Rhizoma Corydalis 150g, Herba Epimedii 150g
Get above medicine, decoct with water 2 times, add 8 times of water gagings for the first time and decocted 2 hours, add 6 times of water gagings for the second time and decocted 1.5 hours, collecting decoction filters, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, add ethanol and make and contain alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, 1 part of qinghuo reagent is with 3 parts of sucrose, 1 part of granulation of dextrin, drying is made 1000g, namely gets granule, boiled water is taken after mixing it with water, every day 2 times, each 6g.
Embodiments of the invention 2: Herba clerodendranthi spicati 100g, Ampelopsis grossedentata 100g, Caulis Aspidopterydis obcordatae 100g, Radix Angelicae Sinensis 200g, Rhizoma Corydalis 200g, Herba Epimedii 200g
Get above medicine, decoct with water 2 times, add 8 times of water gagings for the first time and decocted 2 hours, add for the second time 6 times of water gagings and decocted 1.5 hours, collecting decoction filters, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, add ethanol and make and contain alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, drying is pulverized tabletting, namely gets tablet.
Embodiments of the invention 3: Herba clerodendranthi spicati 300g, Ampelopsis grossedentata 250g, Caulis Aspidopterydis obcordatae 250g, Radix Angelicae Sinensis 200g, Rhizoma Corydalis 200g, Herba Epimedii 200g
Get above medicine, add 5 times of water gagings and decocted 1 hour, filter, filtrate is concentrated, adds ethanol and makes and contain the alcohol amount and reach 50%, leaves standstill, and gets the supernatant Recycled ethanol, and concentrated, drying is granulated, and is encapsulated, namely gets capsule.
Embodiments of the invention 4: Herba clerodendranthi spicati 120g, Ampelopsis grossedentata 150g, Caulis Aspidopterydis obcordatae 120g, Radix Angelicae Sinensis 110g, Rhizoma Corydalis 160g, Herba Epimedii 130g
Get above medicine, decoct with water 3 times, add 12 times of water gagings at every turn and decocted 3 hours, collecting decoction filters, and filtrate is concentrated, adds ethanol and makes and contain the alcohol amount and reach 85%, leaves standstill, and gets the supernatant Recycled ethanol, and concentrated, drying is pulverized, and pill namely gets pill.
Claims (6)
1. pharmaceutical preparation for the treatment of gout is characterized in that: it is to be made by Herba clerodendranthi spicati 100-300g, Ampelopsis grossedentata 100-250g, Caulis Aspidopterydis obcordatae 100-250g, Radix Angelicae Sinensis 100-200g, Rhizoma Corydalis 100-200g, Herba Epimedii 100-200g.
2. according to the pharmaceutical preparation for the treatment of gout claimed in claim 1, it is characterized in that: it is to be made by Herba clerodendranthi spicati 250g, Ampelopsis grossedentata 200g, Caulis Aspidopterydis obcordatae 200g, Radix Angelicae Sinensis 150g, Rhizoma Corydalis 150g, Herba Epimedii 150g.
3. according to the method for making of the pharmaceutical preparation of claim 1 or 2 described treatment gouts, it is characterized in that: the thing of getting it filled, pulverize or extract, then make respectively multiple peroral dosage form, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.
4. according to the method for making of the pharmaceutical preparation for the treatment of gout claimed in claim 3, it is characterized in that: get Herba clerodendranthi spicati, Ampelopsis grossedentata, Caulis Aspidopterydis obcordatae, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 1-3 time, add 5-12 times of water gaging at every turn and decocted 1-3 hour, collecting decoction filters, filtrate is concentrated, add ethanol and make and contain alcohol amount and reach 50-85%, leave standstill, get the supernatant Recycled ethanol, concentrated, make again corresponding preparations.
5. according to the method for making of the pharmaceutical preparation for the treatment of gout claimed in claim 4, it is characterized in that: get Herba clerodendranthi spicati, Ampelopsis grossedentata, Caulis Aspidopterydis obcordatae, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 2 times, adding for the first time 8 times of water gagings decocted 2 hours, adding for the second time 6 times of water gagings decocted 1.5 hours, collecting decoction, filter, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, adding ethanol makes and contains alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, corresponding preparations made again.
6. according to the method for making of the pharmaceutical preparation for the treatment of gout claimed in claim 5, it is characterized in that: get Herba clerodendranthi spicati, Ampelopsis grossedentata, Caulis Aspidopterydis obcordatae, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii decocts with water 2 times, adding for the first time 8 times of water gagings decocted 2 hours, adding for the second time 6 times of water gagings decocted 1.5 hours, collecting decoction, filter, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃ adds ethanol and makes and contain the alcohol amount and reach 65%, leaves standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, 1 part of qinghuo reagent is with 3 parts of sucrose, 1 part of granulation of dextrin, drying namely gets granule.
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| CN2011102913665A CN103028002A (en) | 2011-09-29 | 2011-09-29 | Pharmaceutical preparation for treating gout and preparation method thereof |
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| CN2011102913665A CN103028002A (en) | 2011-09-29 | 2011-09-29 | Pharmaceutical preparation for treating gout and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735697A (en) * | 2013-12-31 | 2014-04-23 | 广西中医药大学 | Chinese medicinal preparation having gout-resisting effect and preparation method thereof |
| CN104161912A (en) * | 2013-05-16 | 2014-11-26 | 康普药业股份有限公司 | Tongfengshu capsule and preparation method thereof |
| CN104825874A (en) * | 2015-05-07 | 2015-08-12 | 林艳芳 | Dai food capable of promoting uric acid metabolism and preparation method thereof |
| CN106177297A (en) * | 2016-08-30 | 2016-12-07 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating gout |
| CN106616968A (en) * | 2016-09-21 | 2017-05-10 | 中国科学院西北高原生物研究所 | Healthcare food capable of relieving gout symptoms |
-
2011
- 2011-09-29 CN CN2011102913665A patent/CN103028002A/en active Pending
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| 卢祥之，缪正来主编: "《中华药茶谱》", 31 August 1998, 科学出版社 * |
| 周晨骥主编: "《内科临床手册》", 28 February 1985, 广西人民出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104161912A (en) * | 2013-05-16 | 2014-11-26 | 康普药业股份有限公司 | Tongfengshu capsule and preparation method thereof |
| CN103735697A (en) * | 2013-12-31 | 2014-04-23 | 广西中医药大学 | Chinese medicinal preparation having gout-resisting effect and preparation method thereof |
| CN103735697B (en) * | 2013-12-31 | 2015-12-30 | 广西中医药大学 | There is Chinese medicine preparation of gout effect and preparation method thereof |
| CN104825874A (en) * | 2015-05-07 | 2015-08-12 | 林艳芳 | Dai food capable of promoting uric acid metabolism and preparation method thereof |
| CN106177297A (en) * | 2016-08-30 | 2016-12-07 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating gout |
| CN106616968A (en) * | 2016-09-21 | 2017-05-10 | 中国科学院西北高原生物研究所 | Healthcare food capable of relieving gout symptoms |
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Application publication date: 20130410 |