CN103027958A - Pharmaceutical preparation for treating gout and preparation method thereof - Google Patents
Pharmaceutical preparation for treating gout and preparation method thereof Download PDFInfo
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- CN103027958A CN103027958A CN2011102913701A CN201110291370A CN103027958A CN 103027958 A CN103027958 A CN 103027958A CN 2011102913701 A CN2011102913701 A CN 2011102913701A CN 201110291370 A CN201110291370 A CN 201110291370A CN 103027958 A CN103027958 A CN 103027958A
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Abstract
The invention relates to a pharmaceutical preparation for treating gout and a preparation method thereof. Prepared from radix astragali and other drugs, the product has obvious anti-inflammatory, analgesic and anti-gout effects. Compared with the prior art, the pharmaceutical preparation provided in the invention has the advantages of clear functions, convenient administration, good curative effects. Also, a reasonable and feasible preparation method is provided.
Description
Technical field: the present invention is a kind of pharmaceutical preparation and method for making thereof for the treatment of gout, belongs to the technical field of medicine.
Technical background: gout is a kind of chronic metabolic disturbance diseases, has the characteristics of intermittent attack.Its main feature is that urate generates too much or the minimizing of renal excretion uric acid in the body, thereby causes that the uric acid in blood salinity raises, and is called clinically high hematuria acid disease.Blood uric acid is elevated to a certain degree afterwards can be at tissue, especially deposition and cause arthritis in joint and the kidney.Severe patient can cause joint movement disorder, deformity, is called clinically gouty arthritis.Renal failure and uremia can occur in severe patient, are to cause one of gout patients main causes of death.Gout has become a kind of pandemic metabolic disease, can betide country variant and different ethnic population, its prevalence and heredity, sex, age, life style, dietary habit, economic development level, medicine, other diseases, the factors such as diagnostic criteria of taking are relevant.The sickness rate of American-European countries's gout is higher, accounts for 0.13%~0.37% of total number of people, and annual morbidity is about 0.20%~0.35%.Before World War II, gout in the Orient national prevalence is very low.And Japan World War II by the Ji develop rapidly, protein-based food is multiplied, nowadays gout become Japan commonly encountered diseases.China made a definite diagnosis 2 routine gout cases first in 1948, only reported 25 routine gouts before 1958, to existing over thousands of routine gout case report of nineteen ninety, did not wherein still comprise the case of failing to pinpoint a disease in diagnosis in a large number with mistaken diagnosis.Since the reform and opening-up, along with the absorption with high protein diet of developing rapidly of economy, the prevalence of gout and hyperuricemia is also in continuous increase.Owing to do not carry out fairly large generaI investigation, so the sickness rate of present domestic gout rises year by year.
Just because of gout crowd's continuous increase, and gout increases the weight of day by day to the infringement of human health, and researcher has also progressively strengthened the R﹠D intensity to goat.The patient of gout relies on the therapy of doctor trained in Western medicine more at present, and the medicine with colchicine and so on alleviates acute arthritis, also can reduce the uric acid content in the blood simultaneously.Colchicine is on the not impact of metabolism of uric acid, and the outbreak why it can alleviate gout be because it can suppress the crystalline solid that leukocyte is engulfed uric acid, and leukocytic phagocytosis is to cause arthritic main cause.But colchicine has a lot of side effect: oral administration can cause nausea, vomiting, anorexia, diarrhoea and watery diarrhea, and this medicine can also cause performance and the alopecias such as bone marrow depression such as leukopenia, thrombocytopenia in addition.
In view of such circumstances, develop a kind of safe and effective, the thing that the pharmaceutical preparation of the treatment gout that side effect is little has just become people to be badly in need of solving.
Summary of the invention: the object of the invention is to: a kind of pharmaceutical preparation and method for making thereof for the treatment of gout is provided; The present invention is directed to prior art, Chinese medicine is made modern preparation, not only taking convenience, and craft science is reasonable, can better keep effective ingredient, and therapeutical effect is good, extensive market.
The present invention consists of like this: it is to be made by following active drug raw material: Radix Astragali 200-600g, Pheretima 50-200g, Radix Angelicae Sinensis 50-200g, Rhizoma Corydalis 50-200g, Herba Epimedii 50-200g.Be preferably: Radix Astragali 300g, Pheretima 100g, Radix Angelicae Sinensis 100g, Rhizoma Corydalis 100g, Herba Epimedii 100g are made.The method for making of the pharmaceutical preparation for the treatment of gout: the thing of getting it filled, pulverize or extract, then make respectively multiple peroral dosage form, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.Furthermore: get the Radix Astragali, Pheretima, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii decocting and boil 1-3 time, add 5-12 times of water gaging at every turn and decocted 1-3 hour, collecting decoction filters, filtrate is concentrated, adds ethanol and makes and contain the alcohol amount and reach 50-85%, leaves standstill, get the supernatant Recycled ethanol, concentrated, make again corresponding preparations.Specifically: get the Radix Astragali, Pheretima, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 2 times, adding for the first time 10 times of water gagings decocted 1.5 hours, add for the second time 8 times of water gagings and decocted 1 hour, collecting decoction filters, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, add ethanol and make and contain alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, make again corresponding preparations.Be preferably: get the Radix Astragali, Pheretima, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 2 times, add 10 times of water gagings for the first time and decocted 1.5 hours, add 8 times of water gagings for the second time and decocted 1 hour, collecting decoction filters, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, adding ethanol makes and contains alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, 1 part of qinghuo reagent, with 2 parts of sucrose, 1 part of granulation of dextrin, drying namely gets granule.
The treatment key of gout is exactly to allow keep purine normally to decompose uric acid, perhaps allows normal renal function drain uric acid.It is monarch drug that we reuse the Radix Astragali, inducing diuresis to remove edema; The promoting blood circulation and stopping pain of enriching blood of Pheretima clearing away heat and promoting diuresis, Radix Angelicae Sinensis is ministerial drug altogether; Make as helping take Rhizoma Corydalis, Herba Epimedii; With the promoting flow of QI and blood pain relieving of Rhizoma Corydalis, stopping numbness pain is used the Herba Epimedii kidney-replenishing, bone and muscle strengthening, wind-damp dispelling to disappear stasis.All medicines share the drainage that can accelerate uric acid, eliminate or the interior inflammation of ameliorate body and reducing swelling and alleviating pain.
Adopt inflammation, pain and Gout Model to carry out the pharmacodynamic study of this product.The result shows that this product has obvious inhibitory action to Ovum Gallus domesticus album and the foot swelling of carrageenin induced mice, can obviously resist rat gouty arthritis due to the uric acid sodium, and hot plate is caused that the mice pain in foot has antagonism.Conclusion: this product has obvious antiinflammatory, analgesia and gout effect.
Set up hyperuricemia rat model, the SD rat is set up the hyperuricemia animal model take adenine, ethambutol as the modeling agent.Experimental result shows that this pharmaceutical composition can significantly reduce hyperuricemia rat blood serum uric acid level; Can obviously suppress hyperuricemia rat serum blood urea nitrogen, creatinine rising, have the effect of certain renal function protecting.
Concrete embodiment:
Embodiments of the invention 1: Radix Astragali 300g, Pheretima 100g, Radix Angelicae Sinensis 100g, Rhizoma Corydalis 100g, Herba Epimedii 100g
Getting the Radix Astragali, Pheretima, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii decocts with water 2 times, adding for the first time 10 times of water gagings decocted 1.5 hours, adding for the second time 8 times of water gagings decocted 1 hour, collecting decoction, filter, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃ adds ethanol and makes and contain the alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, 1 part of qinghuo reagent, with 2 parts of sucrose, 1 part of granulation of dextrin, drying namely gets granule, and boiled water is taken after mixing it with water, every day 2 times, each 6g.
Embodiments of the invention 2: Radix Astragali 200g, Pheretima 50, Radix Angelicae Sinensis 50g, Rhizoma Corydalis 50g, Herba Epimedii 50g
Get above medicine, decoct with water 2 times, add 8 times of water gagings for the first time and decocted 2 hours, add for the second time 6 times of water gagings and decocted 1.5 hours, collecting decoction filters, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, add ethanol and make and contain alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, drying is pulverized tabletting, namely gets tablet.
Embodiments of the invention 3: Radix Astragali 600g, Pheretima 200g, Radix Angelicae Sinensis 200g, Rhizoma Corydalis 200g, Herba Epimedii 200g
Get above medicine, add 5 times of water gagings and decocted 1 hour, filter, filtrate is concentrated, adds ethanol and makes and contain the alcohol amount and reach 50%, leaves standstill, and gets the supernatant Recycled ethanol, and concentrated, drying is granulated, and is encapsulated, namely gets capsule.
Embodiments of the invention 4: Herba clerodendranthi spicati 120g, Ampelopsis grossedentata 150g, Caulis Aspidopterydis obcordatae 120g, Radix Angelicae Sinensis 110g, Rhizoma Corydalis 160g, Herba Epimedii 130g
Get above medicine, decoct with water 3 times, add 12 times of water gagings at every turn and decocted 3 hours, collecting decoction filters, and filtrate is concentrated, adds ethanol and makes and contain the alcohol amount and reach 85%, leaves standstill, and gets the supernatant Recycled ethanol, and concentrated, drying is pulverized, and pill namely gets pill.
Claims (6)
1. pharmaceutical preparation for the treatment of gout is characterized in that it is to be made by following active drug raw material: Radix Astragali 200-600g, Pheretima 50-200g, Radix Angelicae Sinensis 50-200g, Rhizoma Corydalis 50-200g, Herba Epimedii 50-200g.
2. according to the pharmaceutical preparation for the treatment of gout claimed in claim 1, it is characterized in that it is to be made by following active drug raw material: Radix Astragali 300g, Pheretima 100g, Radix Angelicae Sinensis 100g, Rhizoma Corydalis 100g, Herba Epimedii 100g are made.
3. according to the method for making of the pharmaceutical preparation of claim 1 or 2 described treatment gouts, it is characterized in that: the thing of getting it filled, pulverize or extract, then make respectively multiple peroral dosage form, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.
4. according to the method for making of the pharmaceutical preparation for the treatment of gout claimed in claim 3, it is characterized in that: get the Radix Astragali, Pheretima, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii decocting and boil 1-3 time, add 5-12 times of water gaging at every turn and decocted 1-3 hour, collecting decoction filters, filtrate is concentrated, add ethanol and make and contain alcohol amount and reach 50-85%, leave standstill, get the supernatant Recycled ethanol, concentrated, make again corresponding preparations.
5. according to the method for making of the pharmaceutical preparation for the treatment of gout claimed in claim 4, it is characterized in that: get the Radix Astragali, Pheretima, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii and decoct with water 2 times, adding for the first time 10 times of water gagings decocted 1.5 hours, adding for the second time 8 times of water gagings decocted 1 hour, collecting decoction, filter, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃, adding ethanol makes and contains alcohol amount and reach 65%, leave standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, corresponding preparations made again.
6. according to the method for making of the pharmaceutical preparation for the treatment of gout claimed in claim 5, it is characterized in that: get the Radix Astragali, Pheretima, Radix Angelicae Sinensis, Rhizoma Corydalis, Herba Epimedii decocts with water 2 times, adding for the first time 10 times of water gagings decocted 1.5 hours, adding for the second time 8 times of water gagings decocted 1 hour, collecting decoction, filter, 1.10-1.15 when filtrate is concentrated into relative density and is 80 ℃ adds ethanol and makes and contain the alcohol amount and reach 65%, leaves standstill, get the supernatant Recycled ethanol, and the clear paste of 1.25-1.30 when being concentrated into relative density and being 80 ℃, 1 part of qinghuo reagent is with 2 parts of sucrose, 1 part of granulation of dextrin, drying namely gets granule.
Priority Applications (1)
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CN201110291370.1A CN103027958B (en) | 2011-09-29 | A kind of pharmaceutical preparation treating gout and preparation method thereof |
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CN201110291370.1A CN103027958B (en) | 2011-09-29 | A kind of pharmaceutical preparation treating gout and preparation method thereof |
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CN103027958A true CN103027958A (en) | 2013-04-10 |
CN103027958B CN103027958B (en) | 2016-12-14 |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1178689A (en) * | 1997-11-07 | 1998-04-15 | 李尔明 | Medicinal wine for curing gout |
KR100989112B1 (en) * | 2009-12-31 | 2010-10-26 | 권태선 | Composition for medical treatment and gout prevention |
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1178689A (en) * | 1997-11-07 | 1998-04-15 | 李尔明 | Medicinal wine for curing gout |
KR100989112B1 (en) * | 2009-12-31 | 2010-10-26 | 권태선 | Composition for medical treatment and gout prevention |
Non-Patent Citations (2)
Title |
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张春等: "陈德济教授治疗痛风经验", 《现代中西医结合杂志》 * |
朱步先等: "《朱良春用药经验集》", 31 January 2009 * |
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