CN101317958A - Medicament for treating uarthritis, that is Tongfengning capsule and preparation method thereof - Google Patents

Abstract

The present invention discloses a medicine for curing gout---Tongfengning Capsule and a preparation method thereof. The present invention takes small-dose thunder god vine extract as the main material and combines other raw materials of pleione rhizome, prepared corktree, prepared rhizoma atractylodis, prepared szechuan aconite, prepared wild aconite, radix stephaniae tetrandrae, salvia miltiorrhiza, trumpetweed and achyranthes root. The raw materials are respectively broiled, extracted by water and concentrated by decoction according to different features of Chinese medicines, then mixed with the fine powder of the Chinese medicinal herbs of prepared nux vomica, scorpions, ground beetles and notoginseng and proportionally processed into capsules. The medicine of the present invention has the effects of clearing toxic heat, promoting blood circulation for removing blood stasis, benefiting qi and promoting granulation, dissolving the stagnant and alleviating pain, and is mainly used for treating gout and hyperuricemia.

Description

Medicine---capsule for treating gout and preparation method thereof of treatment gout

Technical field

The present invention relates to a kind of medicine for the treatment of gout, the invention still further relates to the preparation method of this medicine capsule for treating gout.

Background technology

Gouty arthritis is that its clinical characters is hyperuricemia and repeated relapsing arthralgia and joint deformity because of a kind of disease due to the purine metabolic disturbance in the body.The symptom that " the just clear gout of red small stream " describes gout is " it is also that extremity hundred joints are walked pain "." Lei Zheng Zhi Cai gout " thinks that gout is " a cold-damp Yu Biyin branch, then pain is attacked in heat-transformation for a long time "." Elementary Medicine gout " thinks that " the not nutrition of vim and vigour asthenia joint close space between skin and muscles " describe the gout later stage characteristics of " pain penetrates even into the marrow does not move Qi Chu ", " Medical Treasures of the Golden Chamber apoplexy severe and migratory arthralgia " piece of writing: " addiction for sour flavor harming tendons, harmed tendons becoming loose, addiction for salty flavor damaging bone, harmed bones becoming flaccid simultaneously." because of experiencing pathogen damp and hot, wind and cold, outbreak and development repeatedly gradually, the gout deposition finally can cause joint deformity or dysfunction.

The base therapy method is a Drug therapy both at home and abroad at present, colchicine commonly used is classics and choice drug, using colchicine after 24 hours, NSAID (non-steroidal anti-inflammatory drug) such as naproxen, ibuprofen, piroxicam etc. become a line medication of treatment gout, when the patient is invalid with above-mentioned two kinds of medicines, select for use adrenocortical hormone such as prednisone, dexamethasone to treat as the two wires medication, these medicines all can only relief of symptoms, only cures the symptoms, not the disease, do not have basic therapeutical effect, and untoward reaction is many.The untoward reaction of colchicine and NSAID (non-steroidal anti-inflammatory drug) is bigger, and safety range is narrower, and digestive system, blood system and the heart, liver, renal function are all had injury.Adrenocortical hormone cooperates colchicine to use, and takes effect rapidly, but is easy to " knock-on " after the drug withdrawal, and life-time service easily causes complication such as diabetes, hypertension.Also fundamentally do not treat gout good medicine at present in the world.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation capsule for treating gout, be used for the treatment of gout, hyperuricemia.

Another object of the present invention provides the preparation method of the medicine capsule for treating gout of this treatment gout.

Solution of the present invention combines based on motherland's medical science and modern medicine, and all medicine synergism in the prescription both can impel urate excretion fast, can impel inflammation to eliminate fast again, the economic benefits and social benefits unification, treating both the principal and secondary aspects of a disease is a kind of treatment gout, hyperuricemia safe and effective medicine.

Medicine of the present invention comprises following raw materials by weight proportions:

(1), extracts part

Pseudobulbus Cremastrae Seu Pleiones 50～70 manufacture-yellow cypresses 20～50 system Rhizoma Atractylodis 25～50 Radix Aconiti Preparatas 10～30

Radix Aconiti Kusnezoffii Preparata 10～30 Radix Stephaniae Tetrandrae 50～80 Radix Salviae Miltiorrhizaes 50～70 Herba Lycopi 20～30

Radix Achyranthis Bidentatae 25～50

(2), fines part

Semen Strychni (processed) 50～100 Scorpios 10～20 ground beetles 10～20 Radix Notoginseng 10～20

Radix Tripterygii Wilfordii extractum 5～10

The preferred weight proportioning for preparing each crude drug of this medicine is:

(1), extracts part

Pseudobulbus Cremastrae Seu Pleiones 50 manufacture-yellow cypresses 25 system Rhizoma Atractylodis 25 Radix Aconiti Preparatas 15 Radix Aconiti Kusnezoffii Preparatas 15

Radix Stephaniae Tetrandrae 50 Radix Salviae Miltiorrhizaes 50 Herba Lycopi 30 Radix Achyranthis Bidentataes 25

(2), fines part

Semen Strychni (processed) 50 Scorpios 15 ground beetles 15 Radix Notoginseng 10 Radix Tripterygii Wilfordii extractum 6

Medicine of the present invention is powder or granule, can make capsule.

The method for preparing this medicine is:

(1) Semen Strychni (processed) powder: after getting qualified Semen Strychni and soaking 10 days with urine of baby boys, the gunnysack of packing into was put in the flowing water flushing 8 hours, took out, and stir-baking with sand to color is sepia, pulverizes, and sieves, and is standby.

(2) preparation of Radix Tripterygii Wilfordii extractum: with Radix Tripterygii Wilfordii concoct qualified after, place decoction pot, add water and cross powder, decoct secondary, collecting decoction filters, and is condensed into cream, it is that 1.30,80 ℃ of crushed after being dried are sieved that heat is surveyed density (d), standby.

(3) preparation fines part medicated powder: will concoct qualified fines medical material partly, pulverize, sieve, standby.

(4) medicated powder is partly extracted in preparation: will extract medical material partly, concocts qualified after, place decoction pot, add water and cross powder, decoct secondary, collecting decoction filters, and is condensed into cream, hot survey density (d) is that 1.30,80 ℃ of crushed after being dried are sieved, and is standby.

(5) mix: will extract the medicated powder of part, abundant mixing, the method that increases progressively by equivalent adds fines medicated powder partly, after sieving, incapsulates promptly.

The present invention stops to becoming silted up according to motherland's medical science blood, and wet coagulating is expectorant, phlegm accumulating with stagnant blood, and the impatency meridians stagnate in the muscle joint, and cause the understanding of arthralgia red heat, subcutaneous nodule formation, and its method of treatment should be let out turbid blood stasis dispelling, and removing obstruction in the collateral to relieve pain is dissolved turbid poison, the hot and suffocating elimination.Radix Tripterygii Wilfordii extractum has the blood uric acid of falling and significant antiinflammatory, function of promoting blood circulation to disperse blood clots in the side, the dosage that uses in the side is 1/6 of usual amounts, alleviated its side effect, why selecting Radix Tripterygii Wilfordii extractum is principal agent, be because we find that in research process Radix Tripterygii Wilfordii extractum has the effect of corticosteroid hormone, do not have simultaneously the advantage of the corresponding side effect of corticosteroid hormone again, also have significant uric acid resisting effect.Contain the colchicine composition in the Chinese medicine Pseudobulbus Cremastrae Seu Pleiones, outbreak has good action to gout, because content is few, can not cause all has injury to digestive system, blood system and the heart, liver, renal function.Expelling wind and removing dampness such as Cortex Phellodendri, Rhizoma Atractylodis, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Stephaniae Tetrandrae, Radix Salviae Miltiorrhizae, Herba Lycopi, Radix Achyranthis Bidentatae, removing obstruction in the collateral to relieve pain.Semen Strychni, Scorpio, ground beetle, Radix Notoginseng etc. are then searched and pick the meridians expectorant stasis of blood, and the priming sick institute that goes directly reaches the purpose of eliminating stasis to stop pain, promoting blood circulation and detumescence.All medicines share, play heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation, eliminating stasis to stop pain altogether, microcirculation improvement, promote the blood supply of joint and surrounding tissue thereof, improve nutritional status, quicken the regeneration capacity and the cell viability of tissue, promote joint and inflammation absorption on every side thereof, algogenic substance is piled up reduced, impel urate excretion.Thereby remove stiff pain symptom, promote functional rehabilitation.Be mainly used in the treatment of gout, hyperuricemia.

The inventor uses Drug therapy gout of the present invention and hyperuricemia 128 examples, Therapeutic Method: take this capsule every day 3 times, one time 2, logotype 1 month was 1 course of treatment, general three courses of treatment, and advise diet based on light, be equipped with an amount of Fish, eggs or poultry food, do not eat the high food of purine content, as pluck etc.Finish back check blood uric acid each course of treatment.The treatment standard: (it is normal that blood uric acid recovers, and urinates no crystal salt or (±) only arranged, and person's tuberosity disappears the subcutaneous nodule, and person's calculus is discharged the urinary stone, and drug withdrawal does not have recurrence more than 1 year in recovery from illness.) take a turn for the better 2. that (blood uric acid is basic normal or obviously descend, and crystallization reduces or basic the disappearance in the urine, and person's tuberosity disappears substantially the subcutaneous nodule, has calculus person's calculus to discharge or move down, and drug withdrawal does not have recurrence half a year.) 3. invalid (uric acid does not have decline or rising on the contrary in the blood, and subcutaneous nodule does not change, and crystallization does not reduce in the urine, has calculus person's calculus to move.) therapeutic outcome: 78 examples of fully recovering, effective 46 examples, invalid 4 examples, total effective rate is 96.9%.

The specific embodiment

With the capsule formulation is example, takes by weighing raw material by following proportioning: (gram)

1, extracts part

Pseudobulbus Cremastrae Seu Pleiones 50g manufacture-yellow cypress 25g system Rhizoma Atractylodis 25g Radix Aconiti Preparata 15g

Radix Aconiti Kusnezoffii Preparata 15g Radix Stephaniae Tetrandrae 50g Radix Salviae Miltiorrhizae 50g Herba Lycopi 30g

Radix Achyranthis Bidentatae 25g

2, fines part

Semen Strychni (processed) 50g Scorpio 15g ground beetle 15g Radix Notoginseng 10g

Radix Tripterygii Wilfordii extractum 6g

2, the preparation method of gout capsule:

(1) Semen Strychni (processed) powder: after getting qualified Semen Strychni and soaking 10 days with urine of baby boys, the gunnysack of packing into was put in the flowing water flushing 8 hours, took out, and stir-baking with sand to color is sepia, pulverizes, and sieves, and is standby.

(2) preparation of Radix Tripterygii Wilfordii extractum: with Radix Tripterygii Wilfordii concoct qualified after, place decoction pot, add water and cross powder, decoct secondary, collecting decoction filters, and is condensed into cream, it is that 1.30,80 ℃ of crushed after being dried are sieved that heat is surveyed density (d), standby.

(3) preparation fines part medicated powder: will concoct qualified fines medical material partly, pulverize, sieve, standby.

(4) medicated powder is partly extracted in preparation: will extract medical material partly, concocts qualified after, place decoction pot, add water and cross powder, decoct secondary, collecting decoction filters, and is condensed into cream, hot survey density (d) is that 1.30,80 ℃ of crushed after being dried are sieved, and is standby.

(5) mix: will extract the medicated powder of part, abundant mixing, the medicated powder of fines part adds by the method that equivalent increases progressively, and after sieving, incapsulates promptly.

Produce capsule by the present invention, the heavy 0.3g of every capsules medicine ± 5% by the gout capsule that above amount is made, can be obeyed three months, and one month is a course of treatment.Usage and dosage is one day three times, each 2～3, and taking medicine after meal.Tangible curative effect was promptly arranged in ten days.

Claims (5)

1. a medicine for the treatment of gout is characterized in that it comprises following raw materials by weight proportions, and is the medicament made from this:

(1), extracts part

Pseudobulbus Cremastrae Seu Pleiones 50～70 manufacture-yellow cypresses 20～50 system Rhizoma Atractylodis 25～50 Radix Aconiti Preparatas 10～30

Radix Aconiti Kusnezoffii Preparata 10～30 Radix Stephaniae Tetrandrae 50～80 Radix Salviae Miltiorrhizaes 50～70 Herba Lycopi 20～30

Radix Achyranthis Bidentatae 25～50

(2), fines part

Semen Strychni (processed) 50～100 Scorpios 10～20 ground beetles 10～20 Radix Notoginseng 10～20

Radix Tripterygii Wilfordii extractum 5～10.

2. the medicine of treatment gout according to claim 1 is characterized in that wherein the weight proportion of each raw material is:

(1), extracts part

Pseudobulbus Cremastrae Seu Pleiones 50 manufacture-yellow cypresses 25 system Rhizoma Atractylodis 25 Radix Aconiti Preparatas 15 Radix Aconiti Kusnezoffii Preparatas 15

Radix Stephaniae Tetrandrae 50 Radix Salviae Miltiorrhizaes 50 Herba Lycopi 30 Radix Achyranthis Bidentataes 25

(2), fines part

Semen Strychni (processed) 50 Scorpios 15 ground beetles 15 Radix Notoginseng 10 Radix Tripterygii Wilfordii extractum 6.

3. the medicine of treatment gout according to claim 1 and 2 is characterized in that described medicament is powder or granule.

4. the medicine of treatment gout according to claim 3 is characterized in that described powder or granule make capsule.

5. the preparation method of the medicine of treatment gout according to claim 1 is characterized in that:

(1) Semen Strychni (processed) powder: after getting qualified Semen Strychni and soaking 10 days with urine of baby boys, the gunnysack of packing into was put in the flowing water flushing 8 hours, took out, and stir-baking with sand to color is sepia, pulverizes, and sieves, and is standby.

(2) preparation of Radix Tripterygii Wilfordii extractum: with Radix Tripterygii Wilfordii concoct qualified after, place decoction pot, add water and cross powder, decoct secondary, collecting decoction filters, and is condensed into cream, it is that 1.30,80 ℃ of crushed after being dried are sieved that heat is surveyed density (d), standby.

(3) preparation fines part medicated powder: will concoct qualified fines medical material partly, pulverize, sieve, standby.

(4) medicated powder is partly extracted in preparation: will extract medical material partly, concocts qualified after, place decoction pot, add water and cross powder, decoct secondary, collecting decoction filters, and is condensed into cream, hot survey density (d) is that 1.30,80 ℃ of crushed after being dried are sieved, and is standby.

(5) mix: will extract the medicated powder of part, abundant mixing, the method that increases progressively by equivalent adds the medicated powder of fines part again, after sieving, incapsulates promptly.