CN107441169A - A kind of concocting method of Chinese medicine vomiting nut - Google Patents
A kind of concocting method of Chinese medicine vomiting nut Download PDFInfo
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- CN107441169A CN107441169A CN201610366521.8A CN201610366521A CN107441169A CN 107441169 A CN107441169 A CN 107441169A CN 201610366521 A CN201610366521 A CN 201610366521A CN 107441169 A CN107441169 A CN 107441169A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/11—Preparation or pretreatment of starting material involving culturing conditions, e.g. cultivation in the dark or under defined water stress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The invention discloses a kind of concocting method of Chinese medicine vomiting nut, this method is that Chinese medicine vomiting nut is placed in water into leaching drift；The Chinese medicine vomiting nut peeling after floating will be soaked plus vinegar boils altogether, dried；Dried Chinese medicine vomiting nut is subjected to sand stir-fry, sand obtains horse spleen ferrtin product after frying.The Preparation process method of the present invention, can be effectively reduced the content of the peace strychnia of taxi in the vomiting nut of processing, the content of the larger strychnia of toxicity can effectively reduce the effective scope of safe handling.The Preparation process method of the vomiting nut of the present invention, method is scalded with vinegar plus sand, scalds method different from traditional sand, the present invention can control toxic component strychnine and strychnia content the scope in safety, the effect of and can reaches clinically promoting blood circulation, dredging meridian and relieving pain, and softening and resolving hard mass is subsided a swelling.Therefore, the inventive method can play a part of being attenuated and surely imitate to Chinese medicine vomiting nut well, there is provided a kind of concocting method of more effectively Chinese medicine vomiting nut.And the inventive method is controllable, stably, reliably.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, it is related to a kind of Preparation process method of vomiting nut, and in particular to a kind of preparation method of vinegar vomiting nut.
Background technology
Vomiting nut is LoganiaceaeLoganiaceaePlant Strychnos nux-vomicaStrychnos nux-vomica LDry mature seed, original name vomiting nut.Tool is removed obstruction in channels to relieve pain, the work(of mass dissipating and swelling eliminating, and warm-natured, bitter is very toxic.Tool is removed obstruction in channels to relieve pain, the effect of mass dissipating and swelling eliminating, for rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain, sequelae of infantile paralysis and rheumatoid arthritis.
Because vomiting nut has violent toxicity, therefore must can be used as medicine after processing.From ancient times to the present, vomiting nut is just like up to more than 20 concocting methods planted such as sand stir-fry, frying, radix glycyrrhizae system, mung bean system, boys' urine system, Chinese ephedra system, milk system, baking, vinegar system, the preparation method of Yangjiang nine.
Main composition is alkaloid in vomiting nut, content 2% ~ 5%, wherein mainly brucine（Strychnine）And strychnia（2,3-dimethoxystrychnidin-10-one）, respectively account for 45% of total alkali or so.Content roughly equal strychnia and strychnine, the former toxicity are the 1/20 of the latter.It can be seen that controlling the safety and stability risk of the product, it is very important to establish reliable and stable concocting method.And how effectively to reduce vomiting nut toxicity and hold its drug effect, it is the problem of current processing vomiting nut is difficult to overcome.
Existing Semen Strychni (processed) technique is that regulation vomiting nut of Chinese Pharmacopoeia 2015 edition scalds method processing using sand, but concocting process controls by experience, is not easy to grasp；And the effect for making vomiting nut attenuation surely imitate is not highly desirable yet.
The content of the invention
In order to solve above-mentioned problem, the present invention is processed by studying the technique being combined using vinegar and sand stir-fry to vomiting nut, safer compared with CP method and effective, can effectively have the function that attenuation is surely imitated.The stable risk of the product safety is effectively controlled, establishes reliable and stable processing procedure.
It is an object of the invention to provide a kind of concocting method of Chinese medicine vomiting nut.
The technical solution used in the present invention is：
A kind of concocting method of Chinese medicine vomiting nut, comprises the following steps:
1）Chinese medicine vomiting nut is placed in water leaching drift；
2）The Chinese medicine vomiting nut peeling after floating will be soaked plus vinegar boils altogether, dried；
3）Dried Chinese medicine vomiting nut is subjected to sand stir-fry, sand obtains horse spleen ferrtin product after frying.
Further, step 1）The time of the leaching drift is 120h~216h.
Further, step 2）Described in the dosage of vinegar be 6~8 times of Strychnos nux-vomica protonatomic mass after peeling.
Further, the concentration of the vinegar is 1.5~5.5%v/v.
Further, step 2）The temperature of middle cooking is 80~120 DEG C, and the time is 1~3h.
Further, step 2）Described in the temperature dried be 40~70 DEG C, the dry time is to make the water content of Chinese medicine vomiting nut be 10~30%.
Further, step 3）Described in sand fry temperature be 180 DEG C ~ 240 DEG C, sand fry the time be 3~6min.
Further, a kind of concocting method of Chinese medicine vomiting nut, comprises the following steps:
1）Chinese medicine vomiting nut is placed in water leaching drift 192h；
2）The Chinese medicine vomiting nut peeling after floating will be soaked plus 3.5%v/v vinegar boils altogether, the temperature of cooking is 120 DEG C, time 1h, and it is 10% then to be dried under the conditions of 50 DEG C to water content；Wherein the dosage of vinegar is 7 times of Strychnos nux-vomica protonatomic mass after peeling；
3）By the progress sand stir-fry of dried Chinese medicine vomiting nut, it is 180 DEG C that sand, which fries temperature, and the sand stir-fry time is 6min, and sand obtains horse spleen ferrtin product after frying.
The beneficial effects of the invention are as follows：
1）The alkaloid processed through the inventive method in the horse spleen ferrtin product (vinegar vomiting nut) of gained substantially reduces (in terms of the total amount of strychnine and strychnia), and the preparation method than scalding vomiting nut using conventional method sand is shown in " Chinese Pharmacopoeia Commission's Chinese Pharmacopoeias (one) [S] Beijing:China Medical Science Press, 2015.) alkaloid of the horse spleen ferrtin product prepared is all low.
2）The Preparation process method of the vomiting nut of the present invention, scalds method with vinegar plus sand, scalds method different from traditional sand.The effect of present invention can control toxic component strychnine and strychnia content the scope in safety, and and can reaches clinically promoting blood circulation, dredging meridian and relieving pain, and softening and resolving hard mass is subsided a swelling.Therefore, the inventive method can play a part of being attenuated and surely imitate to Chinese medicine vomiting nut well, there is provided a kind of concocting method of more effectively Chinese medicine vomiting nut.And the inventive method is controllable, stably, reliably.
3）During the Preparation process of the present invention, control vinegar liquid concentration, heat time, heating-up temperature, soak time, the main noxious material strychnine of vomiting nut and strychnia part is set through thermal transition to be nitrogen oxides, or ehter bond open loop reduces toxicity for different series.The inventive method can control the content of the toxicant of vomiting nut well, and mass-temperature is controllable, suitable industrialized production, and effectively overcoming needs to control by experience in the prior art, is not easy to grasp, it is difficult to the defects of industrialized production.And obtained vomiting nut toxic component strychnia therein and strychnine content drop in rational scope, ensure that security and validity that medicine materical crude slice uses.
4）The Preparation process method of the present invention, can be effectively reduced the content of the peace strychnia of taxi in the vomiting nut of processing, the content of the larger strychnia of toxicity can effectively reduce the effective scope of safe handling, the horse spleen ferrtin product especially prepared in embodiment 3 can make the content of the peace strychnia of taxi in vomiting nut while reach minimum so that the best results that attenuation is surely imitated.Surely imitated it can be seen that the inventive method can play a part of attenuation to Chinese medicine vomiting nut well, there is provided a kind of concocting method of more effectively Chinese medicine vomiting nut.
Embodiment
With reference to specific embodiment, the present invention is further illustrated, but is not limited thereto.
Embodiment
1
A kind of concocting method of Chinese medicine vomiting nut
1）Chinese medicine vomiting nut is placed in water leaching drift 120h；
2）The Chinese medicine vomiting nut peeling after floating will be soaked plus 2.5%v/v vinegar boils altogether, the temperature of cooking is 100 DEG C, time 1h, and it is 20% then to be dried under the conditions of 50 DEG C to water content；Wherein the dosage of vinegar is 6 times of Strychnos nux-vomica protonatomic mass after peeling；
3）By the progress sand stir-fry of dried Chinese medicine vomiting nut, it is 200 DEG C that sand, which fries temperature, and the sand stir-fry time is 5min, and sand obtains horse spleen ferrtin product after frying.
Embodiment
2
A kind of concocting method of Chinese medicine vomiting nut
1）Chinese medicine vomiting nut is placed in water leaching drift 168h；
2）The Chinese medicine vomiting nut peeling after floating will be soaked plus 1.5%v/v vinegar boils altogether, the temperature of cooking is 100 DEG C, time 1h, and it is 20% then to be dried under the conditions of 50 DEG C to water content；Wherein the dosage of vinegar is 6 times of Strychnos nux-vomica protonatomic mass after peeling；
3）By the progress sand stir-fry of dried Chinese medicine vomiting nut, it is 200 DEG C that sand, which fries temperature, and the sand stir-fry time is 5min, and sand obtains horse spleen ferrtin product after frying.
Embodiment
3
A kind of concocting method of Chinese medicine vomiting nut
1）Chinese medicine vomiting nut is placed in water leaching drift 192h；
2）The Chinese medicine vomiting nut peeling after floating will be soaked plus 3.5%v/v vinegar boils altogether, the temperature of cooking is 120 DEG C, time 1h, and it is 10% then to be dried under the conditions of 50 DEG C to water content；Wherein the dosage of vinegar is 7 times of Strychnos nux-vomica protonatomic mass after peeling；
3）By the progress sand stir-fry of dried Chinese medicine vomiting nut, it is 180 DEG C that sand, which fries temperature, and the sand stir-fry time is 6min, and sand obtains horse spleen ferrtin product after frying.
Embodiment
4
A kind of concocting method of Chinese medicine vomiting nut
1）Chinese medicine vomiting nut is placed in water leaching drift 216h；
2）The Chinese medicine vomiting nut peeling after floating will be soaked plus 2.5%v/v vinegar boils altogether, the temperature of cooking is 120 DEG C, time 2h, and it is 30% then to be dried under the conditions of 40 DEG C to water content；Wherein the dosage of vinegar is 8 times of Strychnos nux-vomica protonatomic mass after peeling；
3）By the progress sand stir-fry of dried Chinese medicine vomiting nut, it is 220 DEG C that sand, which fries temperature, and the sand stir-fry time is 6min, and sand obtains horse spleen ferrtin product after frying.
Embodiment
5
A kind of concocting method of Chinese medicine vomiting nut
1）Chinese medicine vomiting nut is placed in water leaching drift 120h；
2）The Chinese medicine vomiting nut peeling after floating will be soaked plus 5.5%v/v vinegar boils altogether, the temperature of cooking is 120 DEG C, time 3h, and it is 10% then to be dried under the conditions of 70 DEG C to water content；Wherein the dosage of vinegar is 6 times of Strychnos nux-vomica protonatomic mass after peeling；
3）By the progress sand stir-fry of dried Chinese medicine vomiting nut, it is 240 DEG C that sand, which fries temperature, and the sand stir-fry time is 3min, and sand obtains horse spleen ferrtin product after frying.
The horse spleen ferrtin product prepared below to above-described embodiment make further effect detection.
The horse spleen ferrtin product obtained to embodiment 1~4, strychnine and strychnia assay are carried out, show that the present invention reaches the purpose that attenuation is surely imitated.Each 100g of vomiting nut that the Preparation process method of Semen Strychni and embodiment 1~4 obtains is taken, five cloth bags is respectively put into, is broken into pieces with hammer, by No. 3 sieves (50 mesh), obtains powder.By each group powder about 0.6g, it is accurately weighed, put in conical flask with cover, add sodium hydroxide test solution 3ml, mix, place 30 minutes, precision adds chloroform 20ml, close plug, weighed weight, put refluxing extraction 2 hours in water-bath, let cool, weighed weight again, the weight of less loss is supplied with chloroform, shake up, divide and take chloroform liquid, filtered with the filter paper for being covered with a small amount of anhydrous sodium sulfate, discard primary filtrate, precision measures subsequent filtrate 3ml, put in 10ml measuring bottles, add methanol to scale, shake up, need testing solution 10ml injection high performance liquid chromatographs are drawn respectively to be measured by above-mentioned condition, the strychnine and the measurement result of strychnia content for the vomiting nut that the Preparation process method of Semen Strychni and embodiment 1~4 obtains are as shown in table 1:
The toxicity detection of the horse spleen ferrtin product of the present invention of table 1
Note：RSD represents relative standard deviation.
As can be known from Table 1, compared with Semen Strychni, the Preparation process method of the present invention, can be effectively reduced the content of the peace strychnia of taxi in the vomiting nut of processing, the content of the larger strychnia of toxicity can effectively reduce the effective scope of safe handling, the horse spleen ferrtin product especially prepared in embodiment 3 can make the content of the peace strychnia of taxi in vomiting nut while reach minimum so that the best results that attenuation is surely imitated.Surely imitated it can be seen that the inventive method can play a part of attenuation to Chinese medicine vomiting nut well, there is provided a kind of concocting method of more effectively Chinese medicine vomiting nut.
During the Preparation process of the present invention, control vinegar liquid concentration, heat time, heating-up temperature, soak time, the main noxious material strychnine of vomiting nut and strychnia part is set through thermal transition to be nitrogen oxides, or ehter bond open loop reduces toxicity for different series.The inventive method can control the content of the toxicant of vomiting nut well, and mass-temperature is controllable, suitable industrialized production, and effectively overcoming needs to control by experience in the prior art, is not easy to grasp, it is difficult to the defects of industrialized production.And obtained vomiting nut toxic component strychnia therein and strychnine content drop in the range of States Pharmacopoeia specifications, ensure that security and validity that medicine materical crude slice uses.
Above-described embodiment is the preferable embodiment of the present invention; but embodiments of the present invention are simultaneously not restricted to the described embodiments; other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification; equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (8)
- A kind of 1. concocting method of Chinese medicine vomiting nut, it is characterised in that:Comprise the following steps:1）Chinese medicine vomiting nut is placed in water leaching drift；2）The Chinese medicine vomiting nut peeling after floating will be soaked plus vinegar boils altogether, dried；3）Dried Chinese medicine vomiting nut is subjected to sand stir-fry, sand obtains horse spleen ferrtin product after frying.
- 2. according to the method for claim 1, it is characterised in that：Step 1）The time of the leaching drift is 120h~216h.
- 3. according to the method for claim 1, it is characterised in that：Step 2）Described in the dosage of vinegar be 6~8 times of Strychnos nux-vomica protonatomic mass after peeling.
- 4. the method according to claim 1 or 3, it is characterised in that：The concentration of the vinegar is 1.5~5.5%v/v.
- 5. according to the method for claim 1, it is characterised in that：Step 2）The temperature of middle cooking is 80~120 DEG C, and the time is 1~3h.
- 6. according to the method for claim 1, it is characterised in that：Step 2）Described in the temperature dried be 40~70 DEG C, the dry time is to make the water content of Chinese medicine vomiting nut be 10~30%.
- 7. according to the method for claim 1, it is characterised in that：Step 3）Described in sand fry temperature be 180 DEG C ~ 240 DEG C, sand fry the time be 3~6min.
- 8. according to the method for claim 1, it is characterised in that：Including following operating procedure：1）Chinese medicine vomiting nut is placed in water leaching drift 192h；2）The Chinese medicine vomiting nut peeling after floating will be soaked plus 3.5%v/v vinegar boils altogether, the temperature of cooking is 120 DEG C, time 1h, and it is 10% then to be dried under the conditions of 50 DEG C to water content；Wherein the dosage of vinegar is 7 times of Strychnos nux-vomica protonatomic mass after peeling；3）By the progress sand stir-fry of dried Chinese medicine vomiting nut, it is 180 DEG C that sand, which fries temperature, and the sand stir-fry time is 6min, and sand obtains horse spleen ferrtin product after frying.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010436A (en) * | 2018-09-18 | 2018-12-18 | 江西致和堂中药饮片有限公司 | A kind of prepared slices of Chinese crude drugs vomiting nut Processing methods technique |
| CN111494464A (en) * | 2020-05-21 | 2020-08-07 | 北京紫云腾中药饮片有限公司 | Processed nux vomica and processing technology and application thereof |
| CN113633667A (en) * | 2021-09-26 | 2021-11-12 | 许昌学院 | Traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicine |
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| CN101317958A (en) * | 2007-06-06 | 2008-12-10 | 李毅 | Medicament for treating uarthritis, that is Tongfengning capsule and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010436A (en) * | 2018-09-18 | 2018-12-18 | 江西致和堂中药饮片有限公司 | A kind of prepared slices of Chinese crude drugs vomiting nut Processing methods technique |
| CN111494464A (en) * | 2020-05-21 | 2020-08-07 | 北京紫云腾中药饮片有限公司 | Processed nux vomica and processing technology and application thereof |
| CN111494464B (en) * | 2020-05-21 | 2021-11-26 | 北京紫云腾中药饮片有限公司 | Processed nux vomica and processing technology and application thereof |
| CN113633667A (en) * | 2021-09-26 | 2021-11-12 | 许昌学院 | Traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicine |
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Inventor after: Huang Yumei Inventor after: Luo Wenying Inventor after: Wu Zhijian Inventor after: Kong Jian Inventor after: Chen Junxi Inventor after: Zhu Jiahui Inventor after: Ma Enyao Inventor after: Jiang Liyun Inventor before: Huang Yumei Inventor before: Wu Zhijian Inventor before: Jiang Liyun |
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Effective date of registration: 20180411 Address after: No. 12, Liwan District SLA Road, Liwan District, Guangzhou, Guangdong Applicant after: Guangzhou Medicinal Material Co.,Ltd. Traditional Chinese Medicinal Tablet Factory Applicant after: Guangzhou Caizhilin Pharmaceutical Co., Ltd. Address before: No. 12, Liwan District SLA Road, Liwan District, Guangzhou, Guangdong Applicant before: Guangzhou Medicinal Material Co.,Ltd. Traditional Chinese Medicinal Tablet Factory |
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Application publication date: 20171208 |