CN113633667A - Traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicine - Google Patents
Traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicine Download PDFInfo
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- CN113633667A CN113633667A CN202111131158.9A CN202111131158A CN113633667A CN 113633667 A CN113633667 A CN 113633667A CN 202111131158 A CN202111131158 A CN 202111131158A CN 113633667 A CN113633667 A CN 113633667A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
Abstract
The invention discloses a traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines, which belongs to the technical field of traditional Chinese medicine processing and comprises the following steps: (1) drying treatment; (2) performing cold plasma treatment; (3) cooking; (4) ultrasonic-magnetic field coupling treatment; (5) spreading. The application provides a traditional Chinese medicine processing method for reducing the toxic and side effects of traditional Chinese medicines, which not only can obviously reduce the toxicity of the traditional Chinese medicines, but also can prevent the inactivation of effective components, and simultaneously can obviously improve the medicinal value of the traditional Chinese medicines and make up for the problem of the loss of the effective components caused by the traditional Chinese medicine processing technology.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines.
Background
The processing of traditional Chinese medicine refers to the technology of processing the medicinal materials into decoction pieces of certain specifications by cleaning, cutting and processing according to the treatment requirements of syndrome differentiation of traditional Chinese medicine under the guidance of the theory of traditional Chinese medicine, and can alleviate the medicine property, enhance the medicine property or change the medicine property. After being processed by different methods, the traditional Chinese medicine has changed appearance, has larger change in aspects of medicine property, chemical components, pharmacological action and the like, can fully exert medicinal value, enhances clinical curative effect, and proves that the processing of the traditional Chinese medicine is a necessary means for ensuring safe medication and improving the medicine effect.
In the actual application process of the traditional Chinese medicine, the requirements of the patient's condition, the traditional Chinese medicine theory and the modern scientific technology are combined, and an appropriate processing method is selected to process the medicine, so that the medicine safety is ensured, and the curative effect of the medicine is fully exerted. However, the traditional Chinese medicine processing has the problems of original processing technology, low production efficiency and loss of effective components, so that the development and research of a traditional Chinese medicine processing method for reducing the toxic and side effects of traditional Chinese medicines on the premise of not damaging the effective components are urgently needed, an effective modern traditional Chinese medicine processing research system is established, and the key for promoting the modernized development of traditional Chinese medicines is provided.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine processing method for reducing the toxic and side effects of traditional Chinese medicines, aiming at the existing problems.
The invention is realized by the following technical scheme:
a traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, and taking out the traditional Chinese medicine for later use after the treatment is finished;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 30-50 mL, boiling, and boiling at 70-80 ℃ for 30-40 min to obtain a mixture for later use;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe in a position 4-6 cm below the liquid level of the mixture obtained in the step (3), and simultaneously connecting a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, and filtering out for later use after completion;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place of the bamboo mat, turning once every 5-6 hours, and continuing for 3-5 days.
Further, the vacuum degree is controlled to be 2-4 Pa during the low-temperature vacuum drying treatment in the step (1), the temperature is controlled to be 30-40 ℃, and the drying is carried out until the water content is 2-3%.
By adopting the technical scheme, the white vinegar is uniformly sprayed on the surface of the traditional Chinese medicine, then low-temperature vacuum drying treatment is carried out, under the actions of vacuum, low temperature and several times of white vinegar, cell channels are opened, the permeability is enhanced, the aim of drying can be realized under the low-temperature condition, and in addition, the stability of the original color and luster and physicochemical property of the traditional Chinese medicine can be effectively ensured.
Further, the power of the cold plasma treatment in the step (2) is 200-400W, and the total treatment time is 20-30 min.
By adopting the technical scheme, the dried traditional Chinese medicine is subjected to cold plasma treatment, and the surface tension and surface wettability of the traditional Chinese medicine are improved by utilizing the properties of the cold plasma, so that the subsequent treatment and the migration of toxic substances and irritants are facilitated.
Further, the treating fluid in the step (3) comprises the following components in percentage by weight: 1-2% of fulvic acid, 8-10% of white vinegar, 10-12% of starch and the balance of pure water.
Through adopting above-mentioned technical scheme, this application adopts the treatment fluid of a speciality to boil traditional chinese medicine, and at the in-process of boiling, the treatment fluid can fully contact with traditional chinese medicine, further accelerates the migration of poisonous, irritant, can also kill and get rid of the pathogen or the worm's ovum etc. that probably exist on the traditional chinese medicine surface.
Further, the ultrasonic frequency is controlled to be 40-60 kHz during the ultrasonic-magnetic field coupling treatment in the step (4), the power of the magnetic field is controlled to be 1000-1300W, and the treatment time is 20-30 min.
By adopting the technical scheme, the mixture obtained after boiling is subjected to ultrasonic-magnetic field coupling treatment, the ultrasonic and the magnetic field are mutually synergistic, the tissue refining effect is achieved, the generation of active ingredients can be stimulated, the medicinal quality of the traditional Chinese medicine is improved, and the medicinal value of the traditional Chinese medicine is also improved. And finally, performing collapse under the ventilation condition to remove the water on the surface.
Compared with the prior art, the invention has the following advantages:
the application provides a traditional Chinese medicine processing method for reducing the toxic and side effects of traditional Chinese medicines, which not only can obviously reduce the toxicity of the traditional Chinese medicines, but also can prevent the inactivation of effective components, and simultaneously can obviously improve the medicinal value of the traditional Chinese medicines and make up for the problem of the loss of the effective components caused by the traditional Chinese medicine processing technology.
Detailed Description
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 2-4 Pa, controlling the temperature to be 30-40 ℃, drying until the water content is 2-3%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 200-400W, and taking out the traditional Chinese medicine for later use after 20-30 min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment solution into a pot together according to the weight-volume ratio of 1g: 30-50 mL, boiling, and boiling at 70-80 ℃ for 30-40 min to obtain a mixture for later use, wherein the treatment solution comprises the following components in percentage by weight: 1-2% of fulvic acid, 8-10% of white vinegar, 10-12% of starch and the balance of pure water;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe in a position 4-6 cm below the liquid level of the mixture obtained in the step (3), simultaneously switching on a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 40-60 kHz and the power of the magnetic field to be 1000-1300W, and filtering out for later use after 20-30 min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place of the bamboo mat, turning once every 5-6 hours, and continuing for 3-5 days.
For further explanation of the present invention, reference will now be made to the following specific examples.
Example 1
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 2Pa and the temperature to be 30 ℃, and drying until the water content is 2%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 200W, and taking out the traditional Chinese medicine for later use after 20min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 30mL for boiling, and boiling the mixture at 70 ℃ for 30min for later use, wherein the treatment fluid comprises the following components in percentage by weight: 1% of fulvic acid, 8% of white vinegar, 10% of starch and the balance of pure water;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe in a position 4cm below the liquid level of the mixture obtained in the step (3), simultaneously connecting a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 40kHz and the power of the magnetic field to be 1000W, and filtering out for later use after 20min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5 hours, and continuing for 3 days.
Example 2
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 3Pa and the temperature to be 35 ℃, drying until the water content is 2.5%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 300W, and taking out the traditional Chinese medicine for later use after 25min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 40mL for boiling, and boiling at 75 ℃ for 35min to obtain a mixture for later use, wherein the treatment fluid comprises the following components in percentage by weight: 1.5% of fulvic acid, 9% of white vinegar, 11% of starch and the balance of pure water;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe into a position 5cm below the liquid level of the mixture obtained in the step (3), simultaneously switching on a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 50kHz and the power of the magnetic field to be 1150W, and filtering out for later use after 25min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Example 3
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 4Pa and the temperature to be 40 ℃, drying until the water content is 3%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 400W, and taking out the traditional Chinese medicine for standby after 30min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 50mL for boiling, and boiling at 80 ℃ for 40min to obtain a mixture for later use, wherein the treatment fluid comprises the following components in percentage by weight: 2% of fulvic acid, 10% of white vinegar, 12% of starch and the balance of pure water;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe in a position 6cm below the liquid level of the mixture obtained in the step (3), simultaneously switching on a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 60kHz and the power of the magnetic field to be 1300W, and filtering out for later use after 30min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place on the bamboo mat, and turning the bamboo mat once every 6 hours for 5 days.
Example 4
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine in an oven for drying treatment, controlling the temperature to be 35 ℃, drying until the water content is 2.5%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 300W, and taking out the traditional Chinese medicine for later use after 25min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 40mL for boiling, and boiling at 75 ℃ for 35min to obtain a mixture for later use, wherein the treatment fluid comprises the following components in percentage by weight: 1.5% of fulvic acid, 9% of white vinegar, 11% of starch and the balance of pure water;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe into a position 5cm below the liquid level of the mixture obtained in the step (3), simultaneously switching on a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 50kHz and the power of the magnetic field to be 1150W, and filtering out for later use after 25min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Example 5
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) cold plasma treatment:
placing the traditional Chinese medicine in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 300W, and taking out the traditional Chinese medicine for later use after 25min of treatment;
(2) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (1) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 40mL for boiling, and boiling at 75 ℃ for 35min to obtain a mixture for later use, wherein the treatment fluid comprises the following components in percentage by weight: 1.5% of fulvic acid, 9% of white vinegar, 11% of starch and the balance of pure water;
(3) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe into a position 5cm below the liquid level of the mixture obtained in the step (2), simultaneously switching on a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 50kHz and the power of the magnetic field to be 1150W, and filtering out for later use after 25min of treatment;
(4) spreading:
and (4) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (3) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Example 6
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 3Pa and the temperature to be 35 ℃, drying until the water content is 2.5%, and taking out the traditional Chinese medicine for later use;
(2) boiling:
putting the dried traditional Chinese medicine and the treatment solution in the step (1) into a pot according to the weight-volume ratio of 1g to 40mL for boiling, and boiling at 75 ℃ for 35min to obtain a mixture for later use, wherein the treatment solution comprises the following components in percentage by weight: 1.5% of fulvic acid, 9% of white vinegar, 11% of starch and the balance of pure water;
(3) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe into a position 5cm below the liquid level of the mixture obtained in the step (2), simultaneously switching on a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 50kHz and the power of the magnetic field to be 1150W, and filtering out for later use after 25min of treatment;
(4) spreading:
and (4) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (3) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Example 7
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 3Pa and the temperature to be 35 ℃, drying until the water content is 2.5%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 300W, and taking out the traditional Chinese medicine for later use after 25min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and pure water together into a pot according to the weight-volume ratio of 1g to 40mL for boiling, and boiling for 35min at 75 ℃ to obtain a mixture for later use;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe into a position 5cm below the liquid level of the mixture obtained in the step (3), simultaneously switching on a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, controlling the frequency of ultrasonic waves to be 50kHz and the power of the magnetic field to be 1150W, and filtering out for later use after 25min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Example 8
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 3Pa and the temperature to be 35 ℃, drying until the water content is 2.5%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 300W, and taking out the traditional Chinese medicine for later use after 25min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 40mL for boiling, and boiling at 75 ℃ for 35min to obtain a mixture for later use, wherein the treatment fluid comprises the following components in percentage by weight: 1.5% of fulvic acid, 9% of white vinegar, 11% of starch and the balance of pure water;
(4) ultrasonic treatment:
immersing an ultrasonic probe into a position 5cm below the liquid level of the mixture obtained in the step (3), controlling the frequency of ultrasonic waves to be 50kHz, and filtering out for later use after 25min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Example 9
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 3Pa and the temperature to be 35 ℃, drying until the water content is 2.5%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 300W, and taking out the traditional Chinese medicine for later use after 25min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 40mL for boiling, and boiling at 75 ℃ for 35min to obtain a mixture for later use, wherein the treatment fluid comprises the following components in percentage by weight: 1.5% of fulvic acid, 9% of white vinegar, 11% of starch and the balance of pure water;
(4) magnetic field treatment:
placing the mixture obtained in the step (3) in a magnetic field, switching on a direct-current magnetic field for magnetic field treatment, controlling the power of the magnetic field to 1150W, and filtering out for later use after 25min of treatment;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place on the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Example 10
A traditional Chinese medicine processing method for reducing toxic and side effects of traditional Chinese medicines comprises the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, controlling the vacuum degree to be 3Pa and the temperature to be 35 ℃, drying until the water content is 2.5%, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, wherein the power of the cold plasma treatment is 300W, and taking out the traditional Chinese medicine for later use after 25min of treatment;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 40mL for boiling, and boiling at 75 ℃ for 35min to obtain a mixture for later use, wherein the treatment fluid comprises the following components in percentage by weight: 1.5% of fulvic acid, 9% of white vinegar, 11% of starch and the balance of pure water;
(4) spreading:
and (4) spreading the mixture obtained in the step (3) on a ventilated place of the bamboo mat, turning the bamboo mat once every 5.5 hours, and continuing for 4 days.
Control group 1
The application numbers are: CN201110138815.2 discloses a method for processing rhizoma typhonii.
Control group 2
The application numbers are: CN201410616114.9 discloses a processing method of tripterygium wilfordii.
In order to compare the technical effects of the application, the same batch of rhizoma typhonii samples are selected as test objects, then the selected rhizoma typhonii is randomly divided into 9 groups with equal mass and quantity, then the rhizoma typhonii of each group is processed by the methods of the above examples 2, 4-10 and the comparison group 1, and then after being respectively crushed, water is added to prepare the rhizoma typhonii powder suspension with the concentration of 0.1 g/mL.
54 rabbits with nearly identical physical constitution were selected, and then randomly divided into 10 groups of equal mass and volume, 6 rabbits in each group, raised the upper and lower eyelids during the test, and each sample suspension was dropped into the left and right eyes of the rabbits, each eye being 50. mu.L. After administration, the upper eyelid and the lower eyelid are closed passively for 5-10 seconds to enable the sample suspension to be in full contact with eyes, after 2 minutes, the eyes are immediately washed with 40-50 mL of physiological saline until no foreign matter exists in the rabbit eyes, the rabbit eye condition is observed after 1.5 hours, and the stimulation response of the rabbit eyes is recorded by taking a picture. The blank was made with physiological saline. The evaluation standard of the rabbit eye irritation test is shown in table 1, the rabbit eye irritation test is recorded and counted according to the evaluation standard, the rabbit eye irritation reaction condition is recorded by photographing, and the influence of each group of processed rhizoma typhonii on the rabbit eye irritation score is recorded and counted in table 2.
TABLE 1 Rabbit eye irritation test Scoring Standard
TABLE 2 influence of processed rhizoma Typhonii on eye irritation score of rabbit (n ═ 6)
| Group of | Score of |
| Physiological saline | 0 |
| Example 2 | 0.01 |
| Example 4 | 0.09 |
| Example 5 | 2.35 |
| Example 6 | 4.15 |
| Example 7 | 3.89 |
| Example 8 | 2.35 |
| Example 9 | 1.98 |
| Example 10 | 4.27 |
| Control group | 0.67 |
As can be seen from table 2 above, when the processing method of traditional Chinese medicine provided by the present application is applied to processing rhizoma typhonii, the finally processed rhizoma typhonii has almost no irritation, that is, the purpose of destroying toxic components can be achieved.
In order to further compare the technical effects of the application, the tripterygium wilfordii produced in the same batch is selected as a test object, the selected tripterygium wilfordii is randomly divided into 9 groups with equal quality and quantity, then the processing is carried out by the methods of the embodiment 2, the embodiments 4-10 and the comparison group 2, and the attenuation effect of the processing methods of each group on the tripterygium wilfordii is measured (see table 3) and the influence on the drug effect is measured (see table 4).
TABLE 3 attenuation of Tripterygium wilfordii by different processing methods
TABLE 4 influence of different processing methods on the efficacy of radix Tripterygii Wilfordii
As can be seen from the above tables 3 and 4, the processing method of the application is used for processing the tripterygium wilfordii, which not only reduces the toxicity of the tripterygium wilfordii, but also improves the drug effect, and can obviously improve the anti-inflammatory and neuroprotective effects of the tripterygium wilfordii.
Claims (5)
1. A traditional Chinese medicine processing method for reducing the toxic and side effects of traditional Chinese medicines is characterized by comprising the following steps:
(1) and (3) drying treatment:
uniformly spraying white vinegar on the surface of the traditional Chinese medicine to be treated, then placing the traditional Chinese medicine into a vacuum drying oven for low-temperature vacuum drying treatment, and taking out the traditional Chinese medicine for later use;
(2) cold plasma treatment:
placing the dried traditional Chinese medicine in the step (1) in low-temperature plasma equipment for low-temperature cold plasma treatment, and taking out the traditional Chinese medicine for later use after the treatment is finished;
(3) boiling:
putting the traditional Chinese medicine treated by the cold plasma in the step (2) and the treatment fluid into a pot together according to the weight-volume ratio of 1g to 30-50 mL, boiling, and boiling at 70-80 ℃ for 30-40 min to obtain a mixture for later use;
(4) ultrasonic-magnetic field coupling treatment:
immersing an ultrasonic probe in a position 4-6 cm below the liquid level of the mixture obtained in the step (3), and simultaneously connecting a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, and filtering out for later use after completion;
(5) spreading:
and (5) spreading the traditional Chinese medicine subjected to ultrasonic-magnetic field coupling treatment in the step (4) on a ventilated place of the bamboo mat, turning once every 5-6 hours, and continuing for 3-5 days.
2. The method for processing traditional Chinese medicines for reducing the toxic and side effects of traditional Chinese medicines according to claim 1, wherein the vacuum degree of the low-temperature vacuum drying treatment in the step (1) is controlled to be 2-4 Pa, the temperature is 30-40 ℃, and the drying is carried out until the water content is 2-3%.
3. The method for processing traditional Chinese medicines for reducing the toxic and side effects of traditional Chinese medicines according to claim 1, wherein the power of the cold plasma treatment in the step (2) is 200-400W, and the total treatment time is 20-30 min.
4. The traditional Chinese medicine processing method for reducing the toxic and side effects of traditional Chinese medicines according to claim 1, wherein the treatment liquid in the step (3) comprises the following components in percentage by weight: 1-2% of fulvic acid, 8-10% of white vinegar, 10-12% of starch and the balance of pure water.
5. The traditional Chinese medicine processing method for reducing the toxic and side effects of traditional Chinese medicines as claimed in claim 1,
and (4) controlling the frequency of the ultrasonic wave to be 40-60 kHz, the power of the magnetic field to be 1000-1300W and the processing time to be 20-30 min during the ultrasonic wave-magnetic field coupling processing.
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| CN103040907A (en) * | 2012-12-27 | 2013-04-17 | 浙江中医药大学 | Vinegar-processed tripterygium processing method |
| CN104800257A (en) * | 2014-01-24 | 2015-07-29 | 成都雪瑞安健康管理有限公司 | Vinegar processed pseudo-ginseng and processing technology and application thereof |
| CN107441169A (en) * | 2016-05-30 | 2017-12-08 | 广州市药材公司中药饮片厂 | A kind of concocting method of Chinese medicine vomiting nut |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040907A (en) * | 2012-12-27 | 2013-04-17 | 浙江中医药大学 | Vinegar-processed tripterygium processing method |
| CN104800257A (en) * | 2014-01-24 | 2015-07-29 | 成都雪瑞安健康管理有限公司 | Vinegar processed pseudo-ginseng and processing technology and application thereof |
| CN107441169A (en) * | 2016-05-30 | 2017-12-08 | 广州市药材公司中药饮片厂 | A kind of concocting method of Chinese medicine vomiting nut |
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