CN101264205A - Chinese medicinal composition for treating gout and preparation thereof - Google Patents

Chinese medicinal composition for treating gout and preparation thereof Download PDF

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Publication number
CN101264205A
CN101264205A CN 200810105048 CN200810105048A CN101264205A CN 101264205 A CN101264205 A CN 101264205A CN 200810105048 CN200810105048 CN 200810105048 CN 200810105048 A CN200810105048 A CN 200810105048A CN 101264205 A CN101264205 A CN 101264205A
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Prior art keywords
radix
rhizoma
parts
gout
medicine composition
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何俊保
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BEIJING ZHONGTAI TIANHE SCIENCE AND TECHNOLOGY Co Ltd
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BEIJING ZHONGTAI TIANHE SCIENCE AND TECHNOLOGY Co Ltd
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Priority to CN 200810105048 priority Critical patent/CN101264205A/en
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Abstract

The invention discloses a Chinese herbal medicine composition for curing gout and the preparation method. The active ingredients in the invention are extracted from astragalus, aconite, Chinese rhubarb, pinelliae tuber, notopterygium, plantain seed, root of herbaceous peony, herba epimedii, dioscorea spongiosa, angelica sinensis, Oriental Waterplantain Rhizome, cyathula root, poria cocos, asarum, radix stephaniae tetrandrae, pubescent angelica, cassia bark, baked radix glycyrrhizae and rhizoma ligustici wallichii. The special medical active components in the invention have the functions of wind dispelling, humidity clearing, blood promoting, collaterals dredging, swelling releasing, pain taking and serum uric acid reducing.

Description

A kind of Chinese medicine composition that is used for the treatment of gout and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of Chinese medicine composition that is used for the treatment of gout and preparation method thereof.
Technical background
Gout is the chronic metabolic disturbance diseases due to one group of purine metabolic disturbance.Main clinical characters is that uric acid produces too much or the minimizing of renal excretion uric acid in the body, causes that uric acid raises in the blood, forms gouty acute arthritis, tophus deposition, gouty chronic arthritis and the joint deformity etc. of hyperuricemia and outbreak repeatedly.Gout is often involved kidney and is caused chronic interstitial nephritis and uric acid renal calculus.
Along with improving constantly of people's living standard, the dietary structure imbalance causes purine metabolic disturbance, causes that blood uric acid increases, and the urate crystal of needle point size is deposited on positions such as joint, soft tissue, kidney, heart, forms goat.Conservative estimation, existing nearly 9,000 ten thousand patient with gout of China, potential patient 1.2 hundred million.90% concentrates on the male between 25-45 year, and the gout sickness rate also rises year by year in the speed with annual 10%.
Gout is divided into primary gout and secondary gout two in class.Primary gout except that minority because genetic cause causes in the body some enzyme defect, and mostly the cause of disease is not bright, and often with obesity, hyperlipemia, hypertension, coronary heart disease, arteriosclerosis, diabetes and hyperthyroidism etc.Secondary gout is to be secondary to leukemia, lymphoma, multiple myeloma, hemolytic anemia, polycythemia vera, malignant tumor, chronic renal insufficiency, some congenital metabolism disorder disease such as glycogen storage disease I type etc.Some drugs such as furosemide, ethambutol, salicylic acid (aspirin, para-aminosalicylic acid) and nicotinic acid etc. all can cause the broken hair gout.In addition, excessive drinking, lead poisoning, berylliosis and lactic acidosis etc. also can concurrent secondary gouts.Custom is omitted " constitutional " in the clinic diagnosis work, and " gout " that we hear usually generally all refers to primary gout.
Other has " chondrocalcinosis ", due to the articular cartilage calcification, is more common in the old man, gets involved so that knee joint is the easiest.Symptom exactly likes gout during acute attack, clinical very easily mistaken diagnosis.
The present invention is the crystallization of traditional traditional Chinese medical science and modern science and technology.Be on the basis of traditional traditional Chinese medical science to the understanding of gout and treatment, to the pathogenesis of gout and the analysis and the understanding of pathogenesis, and the pharmacological action of the uniqueness that Chinese medicine had is developed in conjunction with modern medicine.Clinical practice shows that the present invention has expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, falls the blood uric acid effect, can obviously suppress uric acid in the inflammatory reaction that the joint tissue localized precipitation causes, alleviates the degeneration of synovial membrane flesh, necrosis.Obviously reduce serum uric acid level.
Summary of the invention:
One of purpose of the present invention provides a kind of Chinese medicine composition that is used for the treatment of gout.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1, prescription:
Radix Astragali 100-300 part Radix Aconiti Lateralis Preparata 100-200 part Radix Et Rhizoma Rhei 100-300 part
Rhizoma Pinelliae Preparata 100-200 part Rhizoma Et Radix Notopterygii 100-200 part Semen Plantaginis 100-200 part
Radix Paeoniae Alba 100-200 part Herba Epimedii 100-200 Fen Rhizoma Dioscoreae Septemlobae 100-200 part
Radix Angelicae Sinensis 100-300 part Rhizoma Alismatis 100-200 part Radix Cyathulae 100-200 part
Poria 100-200 part Herba Asari 100-300 part Radix Stephaniae Tetrandrae 100-300 part
Radix Angelicae Pubescentis 100-200 part Cortex Cinnamomi 100-200 part Radix Glycyrrhizae Preparata 100-200 part
Rhizoma Chuanxiong 100-300 part
The active component that preferred following raw materials according is made, curative effect is better:
200 parts of 100 parts of Radix Et Rhizoma Rhei of 200 parts of Radix Aconiti Lateralis Preparatas of the Radix Astragali
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Pinelliae Preparata
100 parts of 150 parts of Herba Epimedii of the Radix Paeoniae Alba, 150 Fen Rhizoma Dioscoreae Septemlobae
150 parts of 100 portions of Radix Cyathulaes of 200 portions of Rhizoma Alismatis of Radix Angelicae Sinensis
200 parts of 150 parts of Radixs Stephaniae Tetrandrae of 150 parts of Herba Asaris of Poria
200 parts of 150 parts of Radix Glycyrrhizae Preparatas of 100 portions of Cortex Cinnamomis of Radix Angelicae Pubescentis
200 parts of Rhizoma Chuanxiongs
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Et Rhizoma Rhei, Radix Stephaniae Tetrandrae, add 80% alcohol dipping three times, flooded 48 hours for the first time, second and third time flooded respectively 24 hours, filtered, decompression filtrate recycling ethanol is condensed into the thick paste shape, vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radixs Astragali, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae Preparata, Rhizoma Et Radix Notopterygii, Semen Plantaginis, the Radix Paeoniae Alba, Herba Epimedii, Rhizoma Dioscoreae Septemlobae, Radix Angelicae Sinensis, Rhizoma Alismatis, Radix Cyathulae, Poria, Herba Asari, Radix Angelicae Pubescentis, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08~1.14 (50~60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, falls the effect of blood uric acid.Be used for ankylosis, numbness, red and swollen heat pain, joint stuffiness such as gout, rheumatism, rheumatoid; The blood uric acid that gout is caused increases unusually tangible reduction effect; The joint that other arthritis are caused is weighing, numbness, pain etc.Multiple rheumatalgia there is good analgesia detumescence effect.
By the following examples technical scheme of the present invention is described further.
The specific embodiment
Embodiment 1: the preparation method of granule
1, prescription:
200 parts of 100 parts of Radix Et Rhizoma Rhei of 200 parts of Radix Aconiti Lateralis Preparatas of the Radix Astragali
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Pinelliae Preparata
100 parts of 150 parts of Herba Epimedii of the Radix Paeoniae Alba, 150 Fen Rhizoma Dioscoreae Septemlobae
150 parts of 100 portions of Radix Cyathulaes of 200 portions of Rhizoma Alismatis of Radix Angelicae Sinensis
200 parts of 150 parts of Radixs Stephaniae Tetrandrae of 150 parts of Herba Asaris of Poria
200 parts of 150 parts of Radix Glycyrrhizae Preparatas of 100 portions of Cortex Cinnamomis of Radix Angelicae Pubescentis
200 parts of Rhizoma Chuanxiongs
2. preparation technology
(1) Radix Et Rhizoma Rhei, Radix Stephaniae Tetrandrae, add 80% alcohol dipping three times, flooded 48 hours for the first time, second and third time flooded respectively 24 hours, filtered, decompression filtrate recycling ethanol is condensed into the thick paste shape, vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radixs Astragali, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae Preparata, Rhizoma Et Radix Notopterygii, Semen Plantaginis, the Radix Paeoniae Alba, Herba Epimedii, Rhizoma Dioscoreae Septemlobae, Radix Angelicae Sinensis, Rhizoma Alismatis, Radix Cyathulae, Poria, Herba Asari, Radix Angelicae Pubescentis, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08~1.14 (50~60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1, prescription:
200 parts of 100 parts of Radix Et Rhizoma Rhei of 200 parts of Radix Aconiti Lateralis Preparatas of the Radix Astragali
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Pinelliae Preparata
100 parts of 150 parts of Herba Epimedii of the Radix Paeoniae Alba, 150 Fen Rhizoma Dioscoreae Septemlobae
150 parts of 100 portions of Radix Cyathulaes of 200 portions of Rhizoma Alismatis of Radix Angelicae Sinensis
200 parts of 150 parts of Radixs Stephaniae Tetrandrae of 150 parts of Herba Asaris of Poria
200 parts of 150 parts of Radix Glycyrrhizae Preparatas of 100 portions of Cortex Cinnamomis of Radix Angelicae Pubescentis
200 parts of Rhizoma Chuanxiongs
2. preparation technology
(1) Radix Et Rhizoma Rhei, Radix Stephaniae Tetrandrae, add 80% alcohol dipping three times, flooded 48 hours for the first time, second and third time flooded respectively 24 hours, filtered, decompression filtrate recycling ethanol is condensed into the thick paste shape, vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radixs Astragali, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae Preparata, Rhizoma Et Radix Notopterygii, Semen Plantaginis, the Radix Paeoniae Alba, Herba Epimedii, Rhizoma Dioscoreae Septemlobae, Radix Angelicae Sinensis, Rhizoma Alismatis, Radix Cyathulae, Poria, Herba Asari, Radix Angelicae Pubescentis, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08~1.14 (50~60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1, prescription:
200 parts of 100 parts of Radix Et Rhizoma Rhei of 200 parts of Radix Aconiti Lateralis Preparatas of the Radix Astragali
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Pinelliae Preparata
100 parts of 150 parts of Herba Epimedii of the Radix Paeoniae Alba, 150 Fen Rhizoma Dioscoreae Septemlobae
150 parts of 100 portions of Radix Cyathulaes of 200 portions of Rhizoma Alismatis of Radix Angelicae Sinensis
200 parts of 150 parts of Radixs Stephaniae Tetrandrae of 150 parts of Herba Asaris of Poria
200 parts of 150 parts of Radix Glycyrrhizae Preparatas of 100 portions of Cortex Cinnamomis of Radix Angelicae Pubescentis
200 parts of Rhizoma Chuanxiongs
2. preparation technology
(1) Radix Et Rhizoma Rhei, Radix Stephaniae Tetrandrae, add 80% alcohol dipping three times, flooded 48 hours for the first time, second and third time flooded respectively 24 hours, filtered, decompression filtrate recycling ethanol is condensed into the thick paste shape, vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radixs Astragali, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae Preparata, Rhizoma Et Radix Notopterygii, Semen Plantaginis, the Radix Paeoniae Alba, Herba Epimedii, Rhizoma Dioscoreae Septemlobae, Radix Angelicae Sinensis, Rhizoma Alismatis, Radix Cyathulae, Poria, Herba Asari, Radix Angelicae Pubescentis, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08~1.14 (50~60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.

Claims (5)

1, a kind of Chinese medicine composition that is used for the treatment of gout is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Astragali 100-300 part Radix Aconiti Lateralis Preparata 100-200 part Radix Et Rhizoma Rhei 100-300 part
Rhizoma Pinelliae Preparata 100-200 part Rhizoma Et Radix Notopterygii 100-200 part Semen Plantaginis 100-200 part
Radix Paeoniae Alba 100-200 part Herba Epimedii 100-200 Fen Rhizoma Dioscoreae Septemlobae 100-200 part
Radix Angelicae Sinensis 100-300 part Rhizoma Alismatis 100-200 part Radix Cyathulae 100-200 part
Poria 100-200 part Herba Asari 100-300 part Radix Stephaniae Tetrandrae 100-300 part
Radix Angelicae Pubescentis 100-200 part Cortex Cinnamomi 100-200 part Radix Glycyrrhizae Preparata 100-200 part
Rhizoma Chuanxiong 100-300 part.
2, a kind of Chinese medicine composition that is used for the treatment of gout according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
200 parts of 100 parts of Radix Et Rhizoma Rhei of 200 parts of Radix Aconiti Lateralis Preparatas of the Radix Astragali
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Pinelliae Preparata
100 parts of 150 parts of Herba Epimedii of the Radix Paeoniae Alba, 150 Fen Rhizoma Dioscoreae Septemlobae
150 parts of 100 portions of Radix Cyathulaes of 200 portions of Rhizoma Alismatis of Radix Angelicae Sinensis
200 parts of 150 parts of Radixs Stephaniae Tetrandrae of 150 parts of Herba Asaris of Poria
200 parts of 150 parts of Radix Glycyrrhizae Preparatas of 100 portions of Cortex Cinnamomis of Radix Angelicae Pubescentis
200 parts of Rhizoma Chuanxiongs.
3, according to the described a kind of Chinese medicine composition that is used for the treatment of gout of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Et Rhizoma Rhei, Radix Stephaniae Tetrandrae, add 80% alcohol dipping three times, flooded 48 hours for the first time, second and third time flooded respectively 24 hours, filtered, decompression filtrate recycling ethanol is condensed into the thick paste shape, vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radixs Astragali, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae Preparata, Rhizoma Et Radix Notopterygii, Semen Plantaginis, the Radix Paeoniae Alba, Herba Epimedii, Rhizoma Dioscoreae Septemlobae, Radix Angelicae Sinensis, Rhizoma Alismatis, Radix Cyathulae, Poria, Herba Asari, Radix Angelicae Pubescentis, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08~1.14 (50~60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of Chinese medicine composition that is used for the treatment of gout among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of Chinese medicine composition that is used for the treatment of gout of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
CN 200810105048 2008-04-25 2008-04-25 Chinese medicinal composition for treating gout and preparation thereof Pending CN101264205A (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461911B (en) * 2008-12-01 2011-11-02 马献山 Chinese medicine oral capsule for treating gout
CN101474271B (en) * 2008-12-26 2012-05-30 耿顺安 Medicament for treating uarthritis
CN102716389A (en) * 2011-06-20 2012-10-10 王长锋 Externally dressed drug for treating gout
CN103432418A (en) * 2013-09-06 2013-12-11 大连民族学院 Traditional Chinese medicine composition for stopping pain of podagra as well as preparation method and application thereof
CN103735999A (en) * 2014-01-23 2014-04-23 吴占凤 Traditional Chinese medicinal preparation for treating gout and preparation method thereof
CN104096130A (en) * 2014-07-15 2014-10-15 上海中医药大学附属岳阳中西医结合医院 Traditional Chinese medicine composition for treating rheumatoid arthritis
CN104161912A (en) * 2013-05-16 2014-11-26 康普药业股份有限公司 Tongfengshu capsule and preparation method thereof
CN104815066A (en) * 2015-05-14 2015-08-05 广西梧州茂圣茶业有限公司 Preparation process of liupao tea paste with function of auxiliary control for uric-acid value
CN107669991A (en) * 2017-11-24 2018-02-09 成都中医药大学附属医院 A kind of pharmaceutical composition for reducing serum uric acid level and preparation method thereof
CN111388543A (en) * 2020-04-16 2020-07-10 重庆涪陵李志沧中医骨伤医院有限公司 Traditional Chinese medicine composition for treating gout and preparation and application thereof

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461911B (en) * 2008-12-01 2011-11-02 马献山 Chinese medicine oral capsule for treating gout
CN101474271B (en) * 2008-12-26 2012-05-30 耿顺安 Medicament for treating uarthritis
CN102716389B (en) * 2011-06-20 2014-04-30 王长锋 Externally dressed drug for treating gout
CN102716389A (en) * 2011-06-20 2012-10-10 王长锋 Externally dressed drug for treating gout
CN104161912A (en) * 2013-05-16 2014-11-26 康普药业股份有限公司 Tongfengshu capsule and preparation method thereof
CN103432418A (en) * 2013-09-06 2013-12-11 大连民族学院 Traditional Chinese medicine composition for stopping pain of podagra as well as preparation method and application thereof
CN103432418B (en) * 2013-09-06 2015-10-28 大连民族学院 Chinese medicine composition of a kind of gout pain relieving and its production and use
CN103735999A (en) * 2014-01-23 2014-04-23 吴占凤 Traditional Chinese medicinal preparation for treating gout and preparation method thereof
CN103735999B (en) * 2014-01-23 2015-12-09 吴占凤 A kind of Chinese medicine preparation and preparation method for the treatment of gout
CN104096130A (en) * 2014-07-15 2014-10-15 上海中医药大学附属岳阳中西医结合医院 Traditional Chinese medicine composition for treating rheumatoid arthritis
CN104815066A (en) * 2015-05-14 2015-08-05 广西梧州茂圣茶业有限公司 Preparation process of liupao tea paste with function of auxiliary control for uric-acid value
CN107669991A (en) * 2017-11-24 2018-02-09 成都中医药大学附属医院 A kind of pharmaceutical composition for reducing serum uric acid level and preparation method thereof
CN107669991B (en) * 2017-11-24 2020-11-06 成都中医药大学附属医院 Pharmaceutical composition for reducing blood uric acid level and preparation method thereof
CN111388543A (en) * 2020-04-16 2020-07-10 重庆涪陵李志沧中医骨伤医院有限公司 Traditional Chinese medicine composition for treating gout and preparation and application thereof

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