CN104940423A - Traditional Chinese medicine preparation for treating gout - Google Patents
Traditional Chinese medicine preparation for treating gout Download PDFInfo
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- CN104940423A CN104940423A CN201510377712.XA CN201510377712A CN104940423A CN 104940423 A CN104940423 A CN 104940423A CN 201510377712 A CN201510377712 A CN 201510377712A CN 104940423 A CN104940423 A CN 104940423A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating gout. The traditional Chinese medicine preparation for treating gout is prepared from the following raw materials: selfheal, hyacinthus orientalis, fructus aurantii, pawpaw, radix clematidis, nutgall, salviae miltiorrhizae, felwort, liquorice, ligusticum wallichii, pericarpium citri reticulatae, wolfberry, asarum, garden balsam stem, semen plantaginis, root of kudzu vine, rhizoma atractylodis, eclipta, notopterygium root and poria cocos. The traditional Chinese medicine preparation provided by the invention has the functions of relieving spasm, dispelling wind, inducing diuresis, relieving pain, expelling wind and reducing acid.
Description
Technical field
The invention belongs to Chinese medicine preparation processing technique field, what be specifically related to is a kind of Chinese medicine preparation for the treatment of gout.
Background technology
Gout is that the excessive production of uric acid or uric acid row are rushed down insufficient uric acid of causing and piled up and cause, and uric acid crystal is deposited in cartilage, soft tissue, kidney and joint. violent pain can be caused in the deposition of joint.Gout is a kind of disease caused due to purine metabolic disturbance, and past China's sickness rate is lower, and along with the raising of people's living standard, gout has become commonly encountered diseases and frequently-occurring disease in recent years.One group of authority's survey data makes us startling, and nearly two 3 Nian Lai China patient with gout double many, and wherein 95% is male, and the trend that clinical discovery China patient with gout has rejuvenation to develop causes highly vigilant of and the concern of medical circle.
At present, the medicine of conventional treatment gout is mainly Western medicine, as colchicine, allopurinol, probenecid and benzbromarone.Colchicine is the required medicines of general gout patients, and its side effect is usually expressed as: gastrointestinal symptom, muscle, peripheral neuropathy, bone marrow depression, teratogenesis and other influences; This medicine of allopurinol can suppress xanthine oxidase, affects uricopoiesis, uric acid in blood is reduced, prevents gout from showing effect.Side effect shows hepatic insufficiency, erythema multiforme exudativu, aplastic anemia, interstitial pneumonia, rhabdomyolysis etc.Probenecid shows effect for preventing gout, and help kidney to get rid of uric acid, this medicine side effect shows as: hemolytic anemia, anaphylactic shock, nephrotic syndrome, aplastic anemia; Benzene smells Ma Longwei benzofuran derivative, is uricosureic agent, and mechanism of action mainly by suppressing renal tubules to the heavily absorption of uric acid, thus reduces uric acid concentration in blood, and this medicine side effect shows as serious hepatic insufficiency.
The advantage that Chinese medicine is good with its safety, toxic and side effects is little, more and more by the favor of people, researches and develops a kind of Chinese medicine preparation of the treatment gout of uric acid, excretion uric acid, reducing swelling and alleviating pain, safe without toxic side effect that can suppress and seems particularly important.
Summary of the invention
The object of the present invention is to provide a kind of good effect, the Chinese medicine preparation of the treatment gout that toxic and side effects is little.
Object of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine preparation for gout, it is made up of following raw materials by weight portion: Spica Prunellae 15-30 part, hyacinth 15-25 part, Fructus Aurantii 8-15 part, Fructus Chaenomelis 15-25 part, Radix Clematidis 10-15 part, Galla Turcica (Galla Helepensis) 10-15 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Gentianae 10-15 part, Radix Glycyrrhizae 5-20 part, Rhizoma Chuanxiong 8-15 part, Pericarpium Citri Reticulatae 10-20 part, Fructus Lycii 5-10 part, Herba Asari 5-15 part, Herba speranskiae tuberculatae 10-20 part, Semen Plantaginis 10-15 part, Radix Puerariae 5-15 part, Rhizoma Atractylodis 8-12 part, Herba Ecliptae 5-10 part, Rhizoma Et Radix Notopterygii 10-18 part and Poria 3-10 part.
As preferably, the Chinese medicine preparation of described treatment gout, it is made up of following raw materials by weight portion: Spica Prunellae 25 parts, hyacinth 20 parts, Fructus Aurantii 11 parts, Fructus Chaenomelis 20 parts, Radix Clematidis 12 parts, Galla Turcica (Galla Helepensis) 12 parts, Radix Salviae Miltiorrhizae 13 parts, Radix Gentianae 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Chuanxiong 11 parts, Pericarpium Citri Reticulatae 15 parts, Fructus Lycii 8 parts, Herba Asari 6 parts, Herba speranskiae tuberculatae 13 parts, Semen Plantaginis 13 parts, Radix Puerariae 10 parts, Rhizoma Atractylodis 10 parts, Herba Ecliptae 8 parts, Rhizoma Et Radix Notopterygii 15 parts and 5 parts, Poria.
Present invention also offers the preparation method of the Chinese medicine preparation of described treatment gout, comprise the following steps:
(1) pulverize: by raw material pulverizing to 24-65 order, obtain mixing coarse powder;
(2) flood: with alcoholic solution as solvent soaking mixing coarse powder 24-36h;
(3) percolation: control percolation speed, constantly add alcoholic solution, collects percolate;
(4) concentrated: to boil off the whole solvent of percolate, obtained extract dry powder;
(5) required gout form of Chinese drug is mixed with by extract dry powder.
As preferably, in alcoholic solution described in step (2) and (3), volume fraction of ethanol is 65-75%.
As preferably, percolation speed described in step (3) is 2-5mL/ (min*kg), and collecting percolate is that 30-40 doubly mixes meal quality.
As preferably, described in step (5), form of Chinese drug is tablet, powder, capsule, granule or pill.
Compared with prior art, the invention has the beneficial effects as follows:
(1) Chinese medicine preparation of the present invention adopts natural Chinese medicine, and raw material sources are extensive, practical and convenient, have no side effect, have the effects such as spasmolytic expelling wind to relieve convulsion dispels the wind, promoting urination and stopping pain, wind dispelling deacidification.
(2) tool synergistic function between each composition of Chinese medicine preparation of the present invention.It is started with from affected area, treat because of disease, and pathogen that entirety is dispelled in patient " wind, wet, cold ", to reach righting, to consolidate training sun, improves patient's body constitution, recover the original function of body, reach the target of inside and outside environmental balance.
Detailed description of the invention
Below in conjunction with specific embodiment, elaboration detailed is further done to the present invention, but embodiments of the present invention are not limited to the scope that embodiment represents.These embodiments only for illustration of the present invention, but not for limiting the scope of the invention.In addition, after reading content of the present invention, those skilled in the art can do various amendment to the present invention, and these equivalent variations fall within appended claims limited range of the present invention equally.
embodiment 1:
Take following raw material by weight:
Spica Prunellae 160g, hyacinth 100g, Fructus Aurantii 80g, Fructus Chaenomelis 180g, Radix Clematidis 100g, Galla Turcica (Galla Helepensis) 100g, Radix Salviae Miltiorrhizae 100g, Radix Gentianae 100g, Radix Glycyrrhizae 80g, Rhizoma Chuanxiong 100g, Pericarpium Citri Reticulatae 110g, Fructus Lycii 50g, Herba Asari 50g, Herba speranskiae tuberculatae 100g, Semen Plantaginis 100g, Radix Puerariae 80g, Rhizoma Atractylodis 90g, Herba Ecliptae 60g, Rhizoma Et Radix Notopterygii 130g and Poria 40g.
Its preparation method is: cross 24 mesh sieve by after above pulverizing medicinal materials, it is the mixing coarse powder of the alcoholic solution moistening gained of 65% by volume fraction, make it abundant expansion, bottom percolator, try to give a false impression the end and place mat filter material, the medicated powder gradation of swells is loaded percolator, answer degree of tightness to be suitable for, even pressing, top filter paper or gauze cover, and add a small amount of weight, in case medicated powder floats during solubilizer.Open the piston of percolate outlet, the alcoholic solution being 65% from medicated powder top interpolation volume fraction flows out to percolate from outlet, makes several centimetres, solution submergence medicated powder surface, closes percolate and exports.Carry stain 24h, make the abundant diffusion of solvent.Open percolate outlet reception to filter liquid, it is constantly should supplement alcohol solvent in 3.82mL/min percolation process that liquid stream of filtering goes out speed controlling, makes solvent submergence medicated powder all the time.Stop when the percolate collected is 57.3kg collecting.Fling to ethanol, concentrate drying, obtained extract dry powder, subpackage can obtain powder.
embodiment 2:
Take following raw material by weight:
Spica Prunellae 250g, hyacinth 200g, Fructus Aurantii 110g, Fructus Chaenomelis 200g, Radix Clematidis 120g, Galla Turcica (Galla Helepensis) 120g, Radix Salviae Miltiorrhizae 130g, Radix Gentianae 120g, Radix Glycyrrhizae 100g, Rhizoma Chuanxiong 110g, Pericarpium Citri Reticulatae 150g, Fructus Lycii 80g, Herba Asari 60g, Herba speranskiae tuberculatae 130g, Semen Plantaginis 130g, Radix Puerariae 100g, Rhizoma Atractylodis 100g, Herba Ecliptae 80g, Rhizoma Et Radix Notopterygii 150g and Poria 50.
Its preparation method is: first cross 50 mesh sieve by after above pulverizing medicinal materials, it is the mixing coarse powder of the alcoholic solution moistening gained of 70% by volume fraction, make it abundant expansion, bottom percolator, try to give a false impression the end and place mat filter material, the medicated powder gradation of swells is loaded percolator, answer degree of tightness to be suitable for, even pressing, top filter paper or gauze cover, and add a small amount of weight, in case medicated powder floats during solubilizer.Open the piston of percolate outlet, the alcoholic solution being 70% from medicated powder top interpolation volume fraction flows out to percolate from outlet, makes several centimetres, solution submergence medicated powder surface, closes percolate and exports.Carry stain 30h, make the abundant diffusion of solvent.Open percolate outlet reception to filter liquid, it is constantly should supplement alcohol solvent in 7.47mL/min percolation process that liquid stream of filtering goes out speed controlling, makes solvent submergence medicated powder all the time.Stop when the percolate collected is 87.15kg collecting.Fling to ethanol, concentrate drying, obtained extract dry powder, adds the adjuvant such as starch, dextrin, can obtain Tablet and Capsula agent respectively.
embodiment 3:
Take following raw material by weight:
Spica Prunellae 270g, hyacinth 210g, Fructus Aurantii 130g, Fructus Chaenomelis 250g, Radix Clematidis 200g, Galla Turcica (Galla Helepensis) 150g, Radix Salviae Miltiorrhizae 150g, Radix Gentianae 150g, Radix Glycyrrhizae 100g, Rhizoma Chuanxiong 150g, Pericarpium Citri Reticulatae 170g, Fructus Lycii 100g, Herba Asari 120g, Herba speranskiae tuberculatae 150g, Semen Plantaginis 150g, Radix Puerariae 160g, Rhizoma Atractylodis 120g, Herba Ecliptae 110g, Rhizoma Et Radix Notopterygii 180g and Poria 80g.
Its preparation method is: first cross 65 mesh sieve by after above pulverizing medicinal materials, it is the mixing coarse powder of the alcoholic solution moistening gained of 75% by volume fraction, make it abundant expansion, bottom percolator, try to give a false impression the end and place mat filter material, the medicated powder gradation of swells is loaded percolator, answer degree of tightness to be suitable for, even pressing, top filter paper or gauze cover, and add a small amount of weight, in case medicated powder floats during solubilizer.Open the piston of percolate outlet, the alcoholic solution being 75% from medicated powder top interpolation volume fraction flows out to percolate from outlet, makes several centimetres, solution submergence medicated powder surface, closes percolate and exports.Carry stain 36h, make the abundant diffusion of solvent.Open percolate outlet reception to filter liquid, it is constantly should supplement alcohol solvent in 19.1mL/min percolation process that liquid stream of filtering goes out speed controlling, makes solvent submergence medicated powder all the time.Stop when the percolate collected is 152.8kg collecting.Fling to ethanol, concentrate drying, obtained extract dry powder, carries out pelletize to the extract dry powder of gained, can obtain granule after dry subpackage.
embodiment 4:typical case
Patient poplar, male, 52 years old, there is finger, toes arthralgia in patient before 3 years, and night, pain was the most serious, right finger anchylosis ulceration 2 years.Patient often goes on business dinner party at ordinary times, once wind and cold, feels finger immediately, toes swell and ache, because work is busier, do not go to a doctor.Drink at every turn later or tired, catch cold after, swell and ache inside right hand articulations digitorum manus and left sufficient thumb, sharp ache, took allopurinol after removing hospital admission, the state of an illness took a turn for the better to some extent, but withdraw because having a stomachache discomfort night.But swell and ache unbearably, continue drug administration, do not heal so far.Result of having a medical check-up is: right hand forefinger middle finger swells and ache inside ulceration, left hallux and also swells and ache, and hypnalgia is more serious.Blood uric acid 684 μm of ol/L, bitter tastes, yellow and greasy fur, wiry and frequent pulse, right two have tophus tuberosity.
Take powder prepared in the present embodiment 1 after 3 months, finger, toes arthralgia relax, and night, pain number of times reduced.Because this preparation has no adverse reaction to stomach, in drug administration process, there is not the phenomenons such as stomachache discomfort.Continue to take this preparation 5 months, chemical examination of having a medical check-up, Level of Serum Uric Acid is down to 400 μm of ol/L, and after adhering to taking 2 years, chemical examination of having a medical check-up, Level of Serum Uric Acid is 296 μm of ol/L, returns to blood uric acid normal range value.
Patient Lee, male, 26 years old, the left toes of patient, instep repeatability swelled and ache 4 years.Patient is before 3 years after once drinking, and suddenly left instep occurs, thumb swells and ache, and has difficulty in going to sleep, the scorching hot redness in local.After taking anti-inflammation analgesic, pain relief after a week.After drinking whenever or catching a cold, i.e. easily outbreak, takes anti-inflammation analgesic certainly.Take medicine in this year poor effect, pain is fixed on left instep and left thumb.Suffered from cold because being lying when sleeping after drinking again before January and cause this onste, having a medical check-up: flushing, quite row, left instep and thumb is red, swollen, tenderness, function limitation.Red tongue, yellow and greasy fur, stringy and rolling pulse number.Chemical examination: erythrocyte sedimentation rate 80 ㎜/h, blood uric acid 624 μm of ol/L.
After the tablet taken prepared by the embodiment of the present invention 21 first quarter moon, during panic attacks, pain is light, panic attacks number of times is few, panic attacks is long for interval time.Adhere to taking this preparation after four months, the near 376 μm of ol/L of blood test uric acid content of having a medical check-up, blood uric acid is the high level level in normal range value.Continue to take this preparation 1 year, gout is not sent out always, and blood test uric acid of having a medical check-up is 295 μm of ol/L, and blood uric acid is normal level.
Patient Lee, female, 42 years old, because of Polyarthralgia 8 years, increases the weight of to be admitted to hospital for 2 months.Before 8 years, patient happens suddenly right Metatarsophalangeal joint red and swollen heat pain, after involve left Metatarsophalangeal joint, two ankle, two knee joint, two carpal joint gradually, the intermission is without discomfort.Outer court's acid that has urine examined is increased, and erythrocyte sedimentation rate fluctuation is at 94-122mm/h, and the visible gout crystallization of arthrocentesiS liquid, is diagnosed as chalky gout.Before 4 years, patient sends out multi-joint pain again, uses colchicine and nonsteroidal anti-inflammatory (NSAID) poor effect, gives prednisone 20mg/d and treats rear pain relief; Give Allopurinol in Treatment subsequently, stop using because of hypersensitive syndrome, probenecid 500mgbid therapeutic effect is not obvious, stops using because of renal calculus.Before 2 months, patient's multi-joint swells and ache outbreak frequently, takes prednisone 20mg/d, still has outbreak, for further diagnosis and treatment are admitted to hospital.
Take capsule prepared by the embodiment of the present invention 2 after 3 months, each redness and swelling of joints disappears, and joint motion freely, during medication, anaphylaxis does not occur.Continue to take this preparation 6 months, period panic attacks number of times little.After adhering to taking 2 years, chemical examination of having a medical check-up, Level of Serum Uric Acid is 250 μm of ol/L, returns to blood uric acid normal range value, and without recurrence sign.
Patient Wang, female, 36 years old, before 4 years, patient started to occur biped Metatarsophalangeal joint, two carpal joint and multiple joints of hand pain, and often monthly have outbreak, and minimal invasive treatment can not take care of oneself.Before 2 years, patient starts to accept Allopurinol in Treatment, but stops using because of irritated, and accepting benzbromarone 50mgqd fails to respond to any medical treatment, and uric acid long term maintenance is at 500 μm of more than ol/L.Before 1 year, patient starts to occur both hands DIPJ and biped Metatarsophalangeal joint subcutaneous nodule, and matter is hard, renal function exacerbation.
Take granule prepared by the embodiment of the present invention 3 after 2 months, both hands and biped joint can be movable, mild pain, but still have that xerostomia is pained, the yellow problem such as greasy of thick fur.Continue to take this preparation 4 months, both hands biped can normally be taken action, white and thin fur is greasy, the little string of thready pulse, the mental status is good.After adhering to taking 2 years, chemical examination of having a medical check-up, Level of Serum Uric Acid is 200 μm of ol/L, returns to blood uric acid normal range value.
The aforementioned description to concrete exemplary of the present invention is to illustrate and the object of illustration.These descriptions not want the present invention to be defined as disclosed precise forms, and obviously, according to above-mentioned instruction, can much change and change.The object selected exemplary embodiment and describe is to explain certain principles of the present invention and practical application thereof, thus those skilled in the art can be realized and utilize various different exemplary of the present invention and various different selection and change.Scope of the present invention is intended to limited by claims and equivalents thereof.
Claims (6)
1. treat a Chinese medicine preparation for gout, it is characterized in that: it is made up of following raw materials by weight portion: Spica Prunellae 15-30 part, hyacinth 15-25 part, Fructus Aurantii 8-15 part, Fructus Chaenomelis 15-25 part, Radix Clematidis 10-15 part, Galla Turcica (Galla Helepensis) 10-15 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Gentianae 10-15 part, Radix Glycyrrhizae 5-20 part, Rhizoma Chuanxiong 8-15 part, Pericarpium Citri Reticulatae 10-20 part, Fructus Lycii 5-10 part, Herba Asari 5-15 part, Herba speranskiae tuberculatae 10-20 part, Semen Plantaginis 10-15 part, Radix Puerariae 5-15 part, Rhizoma Atractylodis 8-12 part, Herba Ecliptae 5-10 part, Rhizoma Et Radix Notopterygii 10-18 part and Poria 3-10 part.
2. the Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that: described Chinese medicine preparation is made up of following raw materials by weight portion: Spica Prunellae 25 parts, hyacinth 20 parts, Fructus Aurantii 11 parts, Fructus Chaenomelis 20 parts, Radix Clematidis 12 parts, Galla Turcica (Galla Helepensis) 12 parts, Radix Salviae Miltiorrhizae 13 parts, Radix Gentianae 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Chuanxiong 11 parts, Pericarpium Citri Reticulatae 15 parts, Fructus Lycii 8 parts, Herba Asari 6 parts, Herba speranskiae tuberculatae 13 parts, Semen Plantaginis 13 parts, Radix Puerariae 10 parts, Rhizoma Atractylodis 10 parts, Herba Ecliptae 8 parts, Rhizoma Et Radix Notopterygii 15 parts and 5 parts, Poria.
3. treat a preparation method for the Chinese medicine preparation of gout as claimed in claim 1 or 2, it is characterized in that, described preparation method comprises the following steps:
(1) pulverize: by raw material pulverizing to 30-60 order, obtain mixing coarse powder;
(2) flood: with alcoholic solution as solvent soaking mixing coarse powder 24-36h;
(3) percolation: control percolation speed, constantly add alcoholic solution, collects percolate;
(4) concentrated: to boil off the whole solvent of percolate, obtained extract dry powder;
(5) required gout form of Chinese drug is mixed with by extract dry powder.
4. the preparation method of the Chinese medicine preparation for the treatment of gout according to claim 3, is characterized in that: in alcoholic solution described in step (2) and (3), volume fraction of ethanol is 65-75%.
5. the Chinese medicine preparation preparation method for the treatment of gout according to claim 3, is characterized in that: percolation speed described in step (3) is 2-5mL/ (min*kg), and the percolate of collection is that 30-40 doubly mixes meal quality.
6. the preparation method of the Chinese medicine preparation for the treatment of gout according to claim 3, is characterized in that: described in step (5), form of Chinese drug is tablet, powder, capsule, granule or pill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535194A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating gout and preparation method and application thereof |
| CN106668607A (en) * | 2017-02-14 | 2017-05-17 | 江西金土惠康药业有限公司 | Traditional Chinese medicine for treating gout |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536761A (en) * | 2013-10-08 | 2014-01-29 | 丁华声 | Traditional Chinese medicine preparation for treating gout and preparation method of traditional Chinese medicine preparation |
| CN104352991A (en) * | 2014-11-26 | 2015-02-18 | 路晓芹 | Traditional Chinese medicine preparation for treating gout and preparation method thereof |
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- 2015-06-30 CN CN201510377712.XA patent/CN104940423A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536761A (en) * | 2013-10-08 | 2014-01-29 | 丁华声 | Traditional Chinese medicine preparation for treating gout and preparation method of traditional Chinese medicine preparation |
| CN104352991A (en) * | 2014-11-26 | 2015-02-18 | 路晓芹 | Traditional Chinese medicine preparation for treating gout and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535194A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating gout and preparation method and application thereof |
| CN106668607A (en) * | 2017-02-14 | 2017-05-17 | 江西金土惠康药业有限公司 | Traditional Chinese medicine for treating gout |
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