CN100534466C - Preparation for treating arthritis and preparation method thereof - Google Patents
Preparation for treating arthritis and preparation method thereof Download PDFInfo
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- CN100534466C CN100534466C CNB2006101277290A CN200610127729A CN100534466C CN 100534466 C CN100534466 C CN 100534466C CN B2006101277290 A CNB2006101277290 A CN B2006101277290A CN 200610127729 A CN200610127729 A CN 200610127729A CN 100534466 C CN100534466 C CN 100534466C
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Abstract
The invention discloses a preparation for treating arthritis which comprises the following raw material herbs: prepared Sichuan aconite root, prepared wild aconite root, seed of nuxvomica, epimeddium, achyranthes and cyathula root, notopterygium root, basket fern, herba siehesbeckiae, black-tail snake, morinda root, dipsacus root, smoked plum, asaryl, Chinese ephedra, cassia twig, safflower, acanthopanax root, honeysuckle flower, earthworm, Loranthus mulberry mistletoe, licorice root, drynaria, anisetree bark, myrrh and red ginseng. The invention also discloses the process for its preparation.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be used for the treatment of arthritis.
Background technology
Rheumatism, rheumatoid arthritis, osteoarthritis are a worldwide commonly encountered diseases, are difficult for radical cure, easily recurrence.According to the numeral that WTO provides, the patient that rheumatism and GUFENG wet arthritis are suffered from by the world reaches 1.65 hundred million more than, and this type of sick medical expense annual rate of growth is 7%.Arthritic's number of China surpasses 100,000,000, and wherein the osteoarthritis patient is about 6,500 ten thousand, and annual medical expense expenditure is more than 13,500,000,000 yuan.
The medicine of treatment rheumatic, rheumatoid and osteoarthritis is more at present, can be divided into Western medicine and Chinese medicine two big classes basically.
The most effects of Western medicine are fast, but the more characteristics of untoward reaction have limited application clinically.The Chinese medicine majority can be alleviated or remove symptom, and toxic and side effects is little.
In the Chinese medicine of treatment of arthritis, WANTONG JINGU PIAN has unique curative effect aspect treatment of arthritis.The unblocking collaterals to treat arthritis tablet recipe is by Radix Aconiti Preparata 22.5g, Radix Aconiti Kusnezoffii Preparata 22.5g, Semen Strychni (system) 22.5g, Herba Epimedii 30.0g, Radix Achyranthis Bidentatae 22.5g, Rhizoma Et Radix Notopterygii 22.5g, Rhizoma Osmundae 30.0g, Cortex Phellodendri 22.5g, Zaocys 22.5g, Cornu Cervi Pantotrichum 15.0g, Radix Dipsaci 22.5g, Fructus Mume 22.5g, Herba Asari 11.25g, Herba Ephedrae 22.5g, Ramulus Cinnamomi 22.5g, Flos Carthami 22.5g, Radix Et Caulis Acanthopanacis Senticosi 22.5g, Flos Lonicerae 22.5g, Pheretima 22.5g, Herba Taxilli 22.5g, Radix Glycyrrhizae 22.5g, Rhizoma Drynariae (scalding) 22.5g, Cortex Illicii 22.5g, Myrrha (processed) 22.5g, Radix Ginseng Rubra 22.5g totally 25 flavor medicines forms, be mainly used in rheumatism, rheumatoid arthritis, heavy or the swelling of limbs joint cold type of pain that osteoarthritis etc. cause, local fear of cold pain increase in intensity under coldness, pain alleviated while getting warmth, slightly enlargement of light red tongue, the greasy in vain or whiten of tongue, arteries and veins is profound tight.
Yet in above-mentioned prescription, Cortex Phellodendri and Cornu Cervi Pantotrichum are medical materials in imminent danger, are difficult to obtain and cost an arm and a leg, and have caused omnipotent JINGU PIAN cost height, have limited the use of low-income groups.
Summary of the invention
The objective of the invention is to, a kind of new arthritic preparation that is used for the treatment of is provided, the raw material of this preparation is easy to get, and can reduce its production cost, and has curative effect preferably.
The present invention also provides a kind of preparation method of described preparation.
In order to realize purpose of the present invention, adopt following technical solution: a kind of preparation of treatment of arthritis is characterized in that: made by following raw medicaments in portion by weight:
16～29 parts of Radix Aconiti Preparatas, 16～29 parts of Radix Aconiti Kusnezoffii Preparatas, 16～29 parts of Semen Strychni (processed)s, 21～39 parts of Herba Epimedii, 16～29 parts of Radix Achyranthis Bidentataes, 16～29 parts of Rhizoma Et Radix Notopterygiis, 16～29 parts of 21～39 parts of Herba Siegesbeckiaes of Rhizoma Osmundae, 16～29 parts of Zaocyss, 11～19 parts of Radix Morindae Officinaliss, 16～29 parts of Radix Dipsacis, 16～29 parts of Fructus Mumes, 8～14 parts of Herba Asaris, 16～29 parts in Herba Ephedrae, 16～29 parts of Ramulus Cinnamomi, 16～29 parts on Flos Carthami, 16～29 parts of Radix Et Caulis Acanthopanacis Senticosis, 16～29 parts of Flos Loniceraes, 16～29 parts of Pheretimas, 16～29 parts of Herba Taxillis, 16～29 parts in Radix Glycyrrhizae, 16～29 parts of Rhizoma drynariae preparatas, 16～29 parts of Cortex Illiciis, 16～29 parts of 16～29 parts of Myrrha (processed)s and Radix Ginseng Rubra.
Mode as a kind of the best of the present invention is to be made by the following materials based on weight medicine:
22.5 parts of Radix Aconiti Preparatas, 22.5 parts of Radix Aconiti Kusnezoffii Preparatas, 22.5 parts of Semen Strychni (processed)s, 30.0 parts of Herba Epimedii, 22.5 parts of Radix Achyranthis Bidentataes, 22.5 parts of Rhizoma Et Radix Notopterygiis, 22.5 parts of 30.0 parts of Herba Siegesbeckiaes of Rhizoma Osmundae, 22.5 parts of Zaocyss, 15.0 parts of Radix Morindae Officinaliss, 22.5 parts of Radix Dipsacis, 22.5 parts of Fructus Mumes, 11.25 parts of Herba Asaris, 22.5 parts in Herba Ephedrae, 22.5 parts of Ramulus Cinnamomi, 22.5 parts on Flos Carthami, 22.5 parts of Radix Et Caulis Acanthopanacis Senticosis, 22.5 parts of Flos Loniceraes, 22.5 parts of Pheretimas, 22.5 parts of Herba Taxillis, 22.5 parts in Radix Glycyrrhizae, 22.5 parts of Rhizoma drynariae preparatas, 22.5 parts of Cortex Illiciis, 22.5 parts of 22.5 parts of Myrrha (processed)s and Radix Ginseng Rubra.
The present invention also provides a kind of preparing such formulations, and this method comprises following process:
(1) get Herba Taxilli, Herba Ephedrae, Herba Epimedii, Radix Dipsaci, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Herba Siegesbeckiae, Rhizoma Drynariae, Pheretima, Radix Achyranthis Bidentatae, Cortex Illicii, Rhizoma Osmundae, Fructus Mume 13 flavors and decoct with water, filter, filtrate is concentrated into the clear paste that relative density is 1.25-1.30, and is standby;
(2) all the other 12 flavors are ground into fine powder, with above-mentioned clear paste mixing, drying, add the additives of 0-95%, and being prepared into can be for the preparation of clinical practice.
Decocting in the step of the present invention (1) boils technology, can be with 13 flavors such as Herba Taxilli, Herba Ephedrae, Herba Epimedii, Radix Dipsaci, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Herba Siegesbeckiae, Rhizoma Drynariae, Pheretima, Radix Achyranthis Bidentatae, Cortex Illicii, Rhizoma Osmundae, Fructus Mume, percentage by weight in medical material and water is 1: 6-1: 25 ratio extracting in water is more than 0.5 hour, decoct more than 1 time, extracting solution merges, concentrate, promptly.
Preparation of the present invention comprises various types of pills, tablet, capsule, powder, granule and other suitable clinically dosage forms.
Additives of the present invention include but not limited to filler, wetting agent, binding agent, disintegrating agent, lubricant, flavoring agent, coloring agent.Percentage by weight shared in described preparation is respectively: filler 0-95%, lubricant 0-5%, binding agent 0-50%, disintegrating agent 0-50%, and wetting agent, flavoring agent, coloring agent can be according to dosage form, the required flexible interpolation of preparation technology.
This preparation is mainly used in the heavy or swelling of limbs joint cold type of pain that rheumatism, rheumatoid arthritis, osteoarthritis etc. cause, local fear of cold pain increase in intensity under coldness, and pain alleviated while getting warmth, slightly enlargement of light red tongue, the greasy in vain or whiten of tongue, arteries and veins is profound tight.
Of the present inventionly be used for the treatment of arthritic preparation, Radix Aconiti, Radix Aconiti Kusnezoffii, the Semen Strychni of getting Da Xin, big heat, big poison in the prescription close and are monarch.The Radix Aconiti warming the interior cold expelling that dispels the wind, the cold-damp of both heatable flesh table, the kind numbness disease for the treatment of cold-damp resistance network, YIN-cold that again can the logical internal organs of temperature; The slightly same Radix Aconiti of Radix Aconiti Kusnezoffii function, but it is longer than and searches wind and remove cold damp eliminating, and its pain relieving eliminating impediment effect is stronger is closed with Radix Aconiti and use it, the logical the exterior and the interior of temperature, and the direct attack cold-damp hinders network disease machine.Semen Strychni hardship, cold, merit is arrogated to oneself removing obstruction in the collateral to relieve pain, and mass dissipating and swelling eliminating " can be searched the rheumatism that muscles and bones is gone into joint, the expectorant poison that the flesh side film of dispelling condenses outward ", and especially " it opens meridians, reaches thoroughly that the power in joint is real to outclass his medicine also." so black mutually 5 with two, stress muscles and tendons relaxing to alleviate pain, be combined into monarch.5 Herba Epimedii, Radix Morindae Officinalis, Herba Asari, Ramulus Cinnamomi, Herba Taxilli, Rhizoma Drynariae, Radix Et Caulis Acanthopanacis Senticosi, Zaocys, Rhizoma Et Radix Notopterygii, Radix Dipsaci, Radix Ginseng Rubra, Rhizoma Osmundae, the Cortex Illiciis that stimulate the menstrual flow with group's temperature compensation are to strengthen three monarchs drug.Herba Ephedrae, the mutual hot temperature of Ramulus Cinnamomi are walked table, and lung qi dispersing is a minister with removing dampness altogether.The all medicines of monarch drug mostly are hot, fragrant, dry strong product, the flavor in consumption impairment of QI Tianjin promotes the production of body fluid and holds back liquid so get Fructus Mume, resides in opening and closes, to prevent the hot dry blood of product impairment of body fluid that looses, warm strongly fragrant mechanism of qi is easily accompanied hot and suffocating, so extracting honeysuckle, Herba Siegesbeckiae heat clearing and damp drying can prevent the hot temperature of monarch drug fraud too again, is assistant altogether.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making, though our flavour of a drug are many, how and not assorted, the monarch and his subjects are orderly, and assistant makes clearly demarcated, and eliminating evil is main double setting upright, the clear saturating folding of the assistant convergence of residing again during temperature is perfectly straight.So all medicines share plays relaxing muscles and tendons to promote blood circulation altogether, the good effect of the analgesia of dispeling the wind.In the side, Radix Morindae Officinalis is a yang-tonifying drug, its property suffering, sweet, and tepor has reinforcing the kidney and supporting YANG, and the effect of expelling wind and removing dampness also can be strengthened monarch drug together with all medicines, strengthens the effect of the expelling wind and removing dampness of prescription.The existing heat-clearing and toxic substances removing of Herba Siegesbeckiae has wind-damp dispelling again, the effect of the meridian dredging.Both can play the effect of heat clearing and damp drying, can strengthen the wind-damp dispelling of whole prescription again, the effect of the meridian dredging.
In the preparation of the present invention, do not adopt medicine Cortex Phellodendri in imminent danger, Cornu Cervi Pantotrichum, therefore reduced product cost.And it is to arthritic therapeutic effect, and is suitable with WANTONG JINGU PIAN.
The specific embodiment
Below in conjunction with specific embodiment the arthritic preparation and preparation method thereof that is used for the treatment of of the present invention is described further.
Embodiment 1:
Get 13 flavors such as Herba Taxilli 22.5g, Herba Ephedrae 22.5g, Herba Epimedii 30.0g, Radix Dipsaci 22.5g, Radix Glycyrrhizae 22.5g, Radix Et Caulis Acanthopanacis Senticosi 22.5g, Herba Siegesbeckiae 22.5g, Rhizoma Drynariae 22.5g, Pheretima 22.5g, Radix Achyranthis Bidentatae 22.5g, Cortex Illicii 22.5g, Rhizoma Osmundae 30.0g, Fructus Mume 22.5g, amount to 296.25g, add 3 liters in water, decoct with water 2 hours, extracting solution is condensed into the clear paste that relative density is 1.25-1.30 (50 ℃).All the other 12 flavor medicines amount to 251.25g by Radix Aconiti Preparata 22.5g, Radix Aconiti Kusnezoffii Preparata 22.5g, Semen Strychni (processed) 22.5g, Rhizoma Et Radix Notopterygii 22.5g, Radix Morindae Officinalis 15.0g, Zaocys 22.5, Herba Asari 11.25g, Ramulus Cinnamomi 22.5g, Flos Carthami 22.5g, Flos Lonicerae 22.5g, Myrrha 22.5g and Radix Ginseng Rubra 22.5g, be ground into fine powder, with above-mentioned clear paste mixing, dry, be ground into 40-200 purpose powder with pulverizer, it is an amount of and stick together to add starch and wetting agent, pill makes the concentrated pill of the heavily about 0.45g of ball.
Instructions of taking is: every day 2-3 time, each 2-3 ball.
Embodiment 2:
Get 13 flavors such as Herba Taxilli 22.5g, Herba Ephedrae 22.5g, Herba Epimedii 30.0g, Radix Dipsaci 22.5g, Radix Glycyrrhizae 22.5g, Radix Et Caulis Acanthopanacis Senticosi 22.5g, Herba Siegesbeckiae 11.25g, Rhizoma Drynariae 22.5g, Pheretima 22.5g, Radix Achyranthis Bidentatae 22.5g, Cortex Illicii 22.5g, Rhizoma Osmundae 30.0g, Fructus Mume 22.5g, add 3 liters in water, decoct with water 2 hours, it is the clear paste of 1.25-1.30 (50 ℃) that extracting solution is condensed into density.All the other 12 flavor medicines amount to 262.5g by Radix Aconiti Preparata 22.5g, Radix Aconiti Kusnezoffii Preparata 22.5g, Semen Strychni (processed) 22.5g, Rhizoma Et Radix Notopterygii 22.5g, Radix Morindae Officinalis 26.25g, Zaocys 22.5, Herba Asari 11.25g, Ramulus Cinnamomi 22.5g, Flos Carthami 22.5g, Flos Lonicerae 22.5g, Myrrha 22.5g and Radix Ginseng Rubra 22.5g, be ground into fine powder, with above-mentioned clear paste mixing, dry, be ground into 40-200 purpose powder with pulverizer, it is an amount of to add starch, mixing, encapsulated, the content of every capsules is 0.35g.
Its instructions of taking is: every day 2-3 time, each 2-3 grain.
Embodiment 3:
Get 13 flavors such as Herba Taxilli 22.5g, Herba Ephedrae 22.5g, Herba Epimedii 30.0g, Radix Dipsaci 22.5g, Radix Glycyrrhizae 22.5g, Radix Et Caulis Acanthopanacis Senticosi 22.5g, Herba Siegesbeckiae 30.0g, Rhizoma Drynariae 22.5g, Pheretima 22.5g, Radix Achyranthis Bidentatae 22.5g, Cortex Illicii 22.5g, Rhizoma Osmundae 30.0g, Fructus Mume 22.5g, amount to 315g, add 3 liters in water, decoct with water 2 hours, it is the clear paste of 1.25-1.30 (50 ℃) that extracting solution is condensed into density.All the other 12 flavor medicines amount to 243.75g by Radix Aconiti Preparata 22.5g, Radix Aconiti Kusnezoffii Preparata 22.5g, Semen Strychni (processed) 22.5g, Rhizoma Et Radix Notopterygii 22.5g, Radix Morindae Officinalis 7.5g, Zaocys 22.5, Herba Asari 11.25g, Ramulus Cinnamomi 22.5g, Flos Carthami 22.5g, Flos Lonicerae 22.5g, Myrrha 22.5g and Radix Ginseng Rubra 22.5g, be ground into fine powder, with above-mentioned clear paste mixing, drying is ground into 40-200 purpose powder with pulverizer, adds the appropriate amount of starch slurry and granulates, 65 ℃ of dryings, granulate, tabletting, bag film-coat or sugar-coat.The every heavy 0.28g of substrate.
Its instructions of taking is: every day 2-3 time, each 2-3 grain.
Embodiment 4
Get 13 flavors such as Herba Taxilli 16g, Herba Ephedrae 29g, Herba Epimedii 21g, Radix Dipsaci 29g, Radix Glycyrrhizae 29g, Radix Et Caulis Acanthopanacis Senticosi 16g, Herba Siegesbeckiae 29g, Rhizoma Drynariae 16g, Pheretima 16g, Radix Achyranthis Bidentatae 29g, Cortex Illicii 16g, Rhizoma Osmundae 39g, Fructus Mume 16g, amount to 301g, add 2 liters in water, decoct with water 2 hours, it is the clear paste of 1.25-1.30 (50 ℃) that extracting solution is condensed into density.All the other 12 flavor medicines amount to 245g by Radix Aconiti Preparata 16g, Radix Aconiti Kusnezoffii Preparata 29g, Semen Strychni (processed) 16g, Rhizoma Et Radix Notopterygii 29g, Radix Morindae Officinalis 19g, Zaocys 16, Herba Asari 14g, Ramulus Cinnamomi 16g, Flos Carthami 16g, Flos Lonicerae 29g, Myrrha 29g and Radix Ginseng Rubra 16g, be ground into fine powder, with above-mentioned clear paste mixing, drying is ground into 40-200 purpose powder with pulverizer, adds the appropriate amount of starch slurry and granulates, 65 ℃ of dryings, granulate, tabletting, bag film-coat or sugar-coat.The every heavy 0.28g of substrate.
Its instructions of taking is: every day 2-3 time, each 2-3 grain.
Embodiment 5
Get 13 flavors such as Herba Taxilli 29g, Herba Ephedrae 16g, Herba Epimedii 38g, Radix Dipsaci 17g, Radix Glycyrrhizae 18g, Radix Et Caulis Acanthopanacis Senticosi 29g, Herba Siegesbeckiae 16g, Rhizoma Drynariae 29g, Pheretima 29g, Radix Achyranthis Bidentatae 20g, Cortex Illicii 29g, Rhizoma Osmundae 32g, Fructus Mume 28g, amount to 330g, add 20 liters in water, decoct with water 2 hours, extracting solution is condensed into the clear paste that relative density is 1.25-1.30 (50 ℃).All the other 12 flavor medicines amount to 258g by Radix Aconiti Preparata 29g, Radix Aconiti Kusnezoffii Preparata 16g, Semen Strychni (processed) 29g, Rhizoma Et Radix Notopterygii 17g, Radix Morindae Officinalis 12g, Zaocys 28g, Herba Asari 8g, Ramulus Cinnamomi 28g, Flos Carthami 29g, Flos Lonicerae 17g, Myrrha 16g and Radix Ginseng Rubra 29g, be ground into fine powder, with above-mentioned clear paste mixing, dry, be ground into 40-200 purpose powder with pulverizer, it is an amount of and stick together to add starch and wetting agent, pill makes the concentrated pill of the heavily about 0.45g of ball.
Instructions of taking is: every day 2-3 time, each 2-3 ball.
But any collocation combination in any among the above embodiment.
Experimental example
Be further checking medical material reasonability and curative effect, we have carried out the drug effect comparative study with preparation of the present invention and WANTONG JINGU PIAN under the constant situation of prescription crude drug total amount, and Bing Dui Herba Siegesbeckiae, Radix Morindae Officinalis carry out ratio research, try to achieve best relatively proportioning.Particular content is as follows:
1 test material
1.1 medicine and reagent
Medicine A: former prescription WANTONG JINGU PIAN
Medicine B: press the prescription among the embodiment 1
Medicine C: press the prescription among the embodiment 2
Medicine D: press the prescription among the embodiment 3
Above medicine provides by the TCM Preparation Room of China Pharmaceutical Research ﹠ Development Center Co., Ltd.
Glacial acetic acid: Beijing chemical reagents corporation, lot number: 20020528
1.2 animal
The ICR mice, body weight 18～22g; A cleaning level SD rat is provided by dimension tonneau China laboratory animal technology company limited in half and half, 8～10 ages in week of male and female, on-test body weight be 180～200g.Credit number: SCDK (capital) 2002-0003.Feedstuff is available from Beijing section Australia company that pulls together, and every day, feeding was 1 time.
2. test method
Each prescription of this experiment adopts high and low 2 dosage, and rat is respectively 1.2g crude drug/kg, 0.6g crude drug/kg, and mice is respectively 1.7g crude drug/kg, 0.85g crude drug/kg.Rat and mice dosage are 10ml/kg.
2.1 the antiinflammatory action test of pesticide effectiveness
2.1.1 to Ovum Gallus domesticus album cause rat paw edema influence
Select 90 SD rats for use, body weight 180-220g, male and female half and half are divided into 9 groups at random, 10 every group.Be respectively blank group (giving solvent); Medicine A height (1.2g crude drug/kg), low (0.6 crude drug g/kg); Medicine B height (1.2g crude drug/kg), low (0.6 crude drug g/kg); Medicine C height (1.2 crude drug g/kg), low (0.6 crude drug g/kg); Medicine D height (1.2 crude drug g/kg), low (0.6 crude drug g/kg).Gastric infusion 10ml/kg, successive administration 7 days, caused sufficient volume before scorching with the drainage measurement on the 6th day at every day 1 time.After the last administration 30 minutes, the sterile working was respectively at every right back sufficient plantar subcutaneous injection fresh egg white of rat (sterile saline is mixed with 10% proinflammatory agent) 0.1ml.Cause scorching back 0.5h, 1h, 2h, 3h, the right back sufficient volume of 5h rat with the drainage measurement, cause sufficient volume difference before and after scorching as paw swelling with it.The average of the average of each administration group and blank group relatively carries out statistical test.The results are shown in Table 1.
Table 1 pair Ovum Gallus domesticus album causes the influence of the right foot swelling of rat
Compare * P＜0.05, * * P＜0.01, * * * P＜0.001 with matched group.
2.2 the analgesic activity test of pesticide effectiveness
2.2.1 Dichlorodiphenyl Acetate causes the influence of mouse writhing
Select 130 of ICR mices for use, 18-22g, male and female half and half are divided into 13 groups at random, 10 every group.Be respectively blank group (giving solvent); Medicine A height (1.7g crude drug/kg), low (0.85g crude drug/kg); Medicine B height (1.7g crude drug/kg), low (0.85g crude drug/kg); Medicine C height (1.7g crude drug/kg), low (0.85g crude drug/kg); Medicine D height (1.7g crude drug/kg), low (0.85g crude drug/kg).By the administration of grouping situation, gastric infusion 10ml/kg, successive administration 7 days, every day 1 time, 1h after the last administration, lumbar injection 0.7% acetic acid 10ml/kg causes writhing response (abdominal part indent, trunk and back leg stretching, extension, hips up, crawling).Observe and respectively organize the number of times that mice produces writhing response in 20 minutes, record carries out the t check.The results are shown in Table 2.
Table 2 acetic acid causes the influence of mouse writhing
Compare * P＜0.05, * * P＜0.01, * * * P＜0.001 with matched group.
3 results
3.1 antiinflammatory action
Table 1 is the result show, high and low 0.5h, 1h, 2h, the right paw swelling of 5h rat and the relatively significance reduction (P＜0.05, P＜0.05) of matched group after giving Ovum Gallus domesticus album of A, right paw swelling of medicine A height 3h rat after giving Ovum Gallus domesticus album and matched group relatively significance reduce (P＜0.05), show that A has significant antiinflammatory action, dose relationship is not obvious;
High and low 0.5h, 1h, 2h, the right paw swelling of 3h rat and the relatively significance reduction (P＜0.05, P＜0.01) of matched group after giving Ovum Gallus domesticus album of medicine B shows that B has significant antiinflammatory action, and dose relationship is not obvious;
High and low 1h, the right paw swelling of 2h rat and the relatively significance reduction (P＜0.01, P＜0.01) of matched group after giving Ovum Gallus domesticus album of medicine C shows that C also has certain antiinflammatory action, and dose relationship is not obvious;
Medicine D is 1h, 2h, 3h, the right paw swelling of 5h rat and relatively significance reduction (P＜0.01, P＜0.01, P＜0.01, P＜0.05) of matched group after height is given Ovum Gallus domesticus album, shows that C also has certain antiinflammatory action, and the high dose effect is remarkable.
Above result as can be seen, medicine A, B, C, D all have the obvious suppression effect to acute inflammation, dose relationship is all not fairly obvious, comparatively speaking A, B the group the drug effect basically identical, change not remarkable; C, D effect basically identical.
3.2 analgesic activity
Table 2 is the result show, causes in the mouse writhing test high and low mouse writhing number and the relatively significance reduction (P＜0.05, P＜0.01) of matched group after giving acetic acid of medicine A at acetic acid; High and low mouse writhing number and the relatively significance reduction (P＜0.05, P＜0.05) of matched group after giving acetic acid of medicine B; High and low mouse writhing number and the relatively significance reduction (P＜0.05, P＜0.05) of matched group after giving acetic acid of medicine C; Medicine D height is mouse writhing number and relatively significance reduction (P＜0.05) of matched group after giving acetic acid.
Above result as can be seen, each medicine all has remarkable analgesic activity, the drug effect basically identical of medicine A, B, C also is better than medicine D.
By same test, the preparation among the embodiment 4,5 has analgesic and anti-inflammatory effects equally.
4, conclusion
The preparation of treatment of arthritis of the present invention all has the effect of tangible anti-inflammatory and antalgic.Under same dosage, the drug effect basically identical of the WANTONG JINGU PIAN of the drug effect of preparation of the present invention and employing Cortex Phellodendri and Cornu Cervi Pantotrichum.
Claims (5)
1, a kind of preparation of treatment of arthritis is characterized in that, is made by following raw medicaments in portion by weight:
16～29 parts of Radix Aconiti Preparatas, 16～29 parts of Radix Aconiti Kusnezoffii Preparatas, 16～29 parts of Semen Strychni (processed)s, 21～39 parts of Herba Epimedii, 19～29 parts of Radix Achyranthis Bidentataes, 16～29 parts of Rhizoma Et Radix Notopterygiis, 16～29 parts of 21～39 parts of Herba Siegesbeckiaes of Rhizoma Osmundae, 16～29 parts of Zaocyss, 11～19 parts of Radix Morindae Officinaliss, 16～29 parts of Radix Dipsacis, 16～29 parts of Fructus Mumes, 8～14 parts of Herba Asaris, 16～29 parts in Herba Ephedrae, 16～29 parts of Ramulus Cinnamomi, 16～29 parts on Flos Carthami, 16～29 parts of Radix Et Caulis Acanthopanacis Senticosis, 16～29 parts of Flos Loniceraes, 16～29 parts of Pheretimas, 16～29 parts of Herba Taxillis, 16～29 parts in Radix Glycyrrhizae, 16～29 parts of Rhizoma drynariae preparatas, 16～29 parts of Cortex Illiciis, 16～29 parts of 16～29 parts of Myrrha (processed)s and Radix Ginseng Rubra.
2, the preparation of treatment of arthritis as claimed in claim 1 is characterized in that, is made by the following materials based on weight medicine:
22.5 parts of Radix Aconiti Preparatas, 22.5 parts of Radix Aconiti Kusnezoffii Preparatas, 22.5 parts of Semen Strychni (processed)s, 30.0 parts of Herba Epimedii, 22.5 parts of Radix Achyranthis Bidentataes, 22.5 parts of Rhizoma Et Radix Notopterygiis, 22.5 parts of 30.0 parts of Herba Siegesbeckiaes of Rhizoma Osmundae, 22.5 parts of Zaocyss, 15.0 parts of Radix Morindae Officinaliss, 22.5 parts of Radix Dipsacis, 22.5 parts of Fructus Mumes, 11.25 parts of Herba Asaris, 22.5 parts in Herba Ephedrae, 22.5 parts of Ramulus Cinnamomi, 22.5 parts on Flos Carthami, 22.5 parts of Radix Et Caulis Acanthopanacis Senticosis, 22.5 parts of Flos Loniceraes, 22.5 parts of Pheretimas, 22.5 parts of Herba Taxillis, 22.5 parts in Radix Glycyrrhizae, 22.5 parts of Rhizoma drynariae preparatas, 22.5 parts of Cortex Illiciis, 22.5 parts of 22.5 parts of Myrrha (processed)s and Radix Ginseng Rubra.
3, the preparation of treatment of arthritis as claimed in claim 1 or 2 is characterized in that: described preparation comprises various types of pills, tablet, capsule, powder, granule.
4, the preparation method of the preparation of described treatment of arthritis one of in a kind of claim 1 to 3, this method comprises following process:
(1) getting Herba Taxilli, Herba Ephedrae, Herba Epimedii, Radix Dipsaci, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Herba Siegesbeckiae, Rhizoma Drynariae, Pheretima, Radix Achyranthis Bidentatae, Cortex Illicii, Rhizoma Osmundae, Fructus Mume 13 flavors by prescription decocts with water, filter, filtrate is concentrated into the clear paste that relative density is 1.25-1.30, and is standby;
(2) all the other 12 flavors are ground into fine powder, with above-mentioned clear paste mixing, drying, add the additives of 0-95%, and being prepared into can be for the preparation of clinical practice.
5, the preparation method of the preparation of treatment of arthritis as claimed in claim 4, it is characterized in that: the decocting in the described step (1) boils process, be with Herba Taxilli, Herba Ephedrae, Herba Epimedii, Radix Dipsaci, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Herba Siegesbeckiae, Rhizoma Drynariae, Pheretima, Radix Achyranthis Bidentatae, Cortex Illicii, Rhizoma Osmundae, Fructus Mume 13 flavors, percentage by weight in medical material and water is 1: 6-1: 25 ratio extracting in water decocted more than 1 time more than 0.5 hour.
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| CNB2006101277290A CN100534466C (en) | 2006-09-01 | 2006-09-01 | Preparation for treating arthritis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006101277290A CN100534466C (en) | 2006-09-01 | 2006-09-01 | Preparation for treating arthritis and preparation method thereof |
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| CN100534466C true CN100534466C (en) | 2009-09-02 |
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| CN101428079B (en) * | 2007-11-05 | 2010-12-22 | 解明泉 | Chinese-medicinal wine for treating cervical vertebra disease |
| CN104666653A (en) * | 2015-03-04 | 2015-06-03 | 济南骄泰信息技术有限公司 | Traditional Chinese medicine ointment for treating arthritis of knee cap and preparation method of traditional Chinese medicine ointment |
| CN104873019B (en) * | 2015-06-09 | 2018-01-30 | 刘中孝 | A kind of preparation method of health care straw plaited futon cushion |
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Assignee: Tonghua Wantong Pharmaceutical Co., Ltd. Assignor: Pan Shoude Contract fulfillment period: 2009.12.29 to 2026.8.30 contract change Contract record no.: 2010220000001 Denomination of invention: Preparation for treating arthritis and preparation method thereof Granted publication date: 20090902 License type: Exclusive license Record date: 2010.1.7 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.12.29 TO 2026.8.30; CHANGE OF CONTRACT Name of requester: TONGHUA WANTONG PHARMACY CO., LTD. Effective date: 20100107 |
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Effective date of registration: 20150616 Address after: Tonghua City, Jilin Province Wan Tong 134001 Dongchang District No. 66 Patentee after: Tonghua Wantong Pharmaceutical Co., Ltd. Address before: 134001 Tonghua City, Jilin Province Wan Road, No. 66 Patentee before: Pan Shoude |