CN107998315A - A kind of compound Chinese medicinal preparation for treating hyperuricemia - Google Patents
A kind of compound Chinese medicinal preparation for treating hyperuricemia Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to a kind of compound Chinese medicinal preparation for treating hyperuricemia, belong to tcm field.A kind of medicament for treating hyperuricemia and its complication provided by the invention, including following components：Cortex Phellodendri, smilax, caulis trachelospermi, pueraria lobata, coix seed, the root of Chinese clematis and desmodium.The medicament of the present invention has the effect such as anti-trioxypurine, diuresis defaecation, removing damp-heat, anti-inflammatory analgetic, evident in efficacy to the related symptoms such as hyperuricemia and caused gout.The present invention medicament have scientific formula, curative for effect, security is good, it is without side-effects the characteristics of.
Description
Technical field
The present invention relates to Chinese medicine, more particularly to a kind of compound Chinese medicinal preparation for treating hyperuricemia.
Background technology
Gout is a kind of complication of hyperuricemia, long-term to keep blood uric acid male 416 when treating hyperuricemia
μm below ol/L, 357 μm of below ol/L of women, are the methods for preventing gout recurrent exerbation.Gout is due to purine metabolic disturbance,
Excessive uric acid or underexcretion are produced, causes Monosodium urate to crystallize, calmness is in caused by joint and its surrounding connective tissue
A kind of metabolic disease, it is closely related with hyperuricemia.
Gout is a kind of metabolic disease, the uric acid in body fluid, and 98% exists in the form of sodium salt.In 37 DEG C, PH7.4
Under physiological condition, the maxima solubility of uric acid is 380 μm of ol/L (6.4mg/dl).It is generally believed that as the μ of serum uric acid value >=417
Mol/L (7.0mg/dl) is considered as hyperuricemia.
If treatment can cause joint deformity not in time, tophus, kidney stone generation, cause kidney failure, uremia, sepsis
The diseases such as disease.During activity, gout causes arthralgia, and swelling is numb, stiff, lopsided and chronic gout arthritis, gouty
The recurrent exerbations such as calculus, gouty ephritis, gouty heart disease, gouty diabetes, or cureless difficult gout.
Hyperuricemia is at present without specific short, and the routine medication of hyperuricemia is more using probenecid, benzene bromine horse
Grand, Allopurinol.Above-mentioned 3 class is chemicals, can cause gastrointestinal reaction, and the side effect such as liver damage, hepatic and renal function
The crowd such as complete, kidney stone patient should not take, and patient is difficult to long-term use of and tolerance mostly.Therefore it is clinical for good effect,
There are larger demand for the good Chinese medicine preparation of security.Chinese patent application Publication No. disclosed in 29 days April in 2015
Disclosed in the patent application of CN104547354A using mullein nightbrier leaf, Chinese small iris is sub, windproof, hairyvein agrimony, salvia chinensis, reticulate millettia, shield
Wing rattan, rhizoma homalonemae, notopterygium root, sweet wormwood, Mao Xu Cao, radix berberidis, lanceolate jasmine root or stem, the fruit of Cherokee rose, carles indigo root, whiteflower violet herb with root, paniculate swallowwort, phoenix are celestial
Flower, the composition treatment hyperuricemia of Artemisia anomala；Although also there is the Chinese medicine preparation of some treatment hyperuricemias and gout,
Be often have higher formula herbs cost, unsatisfactory curative effect, clinical uric acid level easily repeatedly the defects of.
The content of the invention
The object of the present invention is to provide a kind of compound Chinese medicinal preparation for treating hyperuricemia, to solve current Chinese medicine cost
The problem of high, unsatisfactory curative effect, uric acid level is unstable.
According to an aspect of the present invention, a kind of compound Chinese medicinal preparation for treating hyperuricemia provided by the invention, bag
Include following components：Cortex Phellodendri, smilax, caulis trachelospermi, pueraria lobata, coix seed, the root of Chinese clematis and desmodium.
Further, medicament includes the component of following parts by weight：15-30 parts of Cortex Phellodendri；20-30 parts of smilax；Caulis trachelospermi 15-
25 parts；20-40 parts of pueraria lobata；30-40 parts of coix seed；10-15 parts of the root of Chinese clematis；10-15 parts of desmodium.
Further, medicament includes the component of following parts by weight：18-25 parts of Cortex Phellodendri；22-28 parts of smilax；Caulis trachelospermi 18-
22 parts；25-35 parts of pueraria lobata；32-38 parts of coix seed；11-14 parts of the root of Chinese clematis；Desmodium 11-14.
Further, medicament includes the component of following parts by weight：20 parts of Cortex Phellodendri；25 parts of smilax；20 parts of caulis trachelospermi；Pueraria lobata
30 parts；35 parts of coix seed；13 parts of the root of Chinese clematis；12 parts of desmodium.
According to another aspect of the present invention, a kind of compound Chinese medicinal preparation for treating hyperuricemia provided by the invention
Preparation method, including step：Cortex Phellodendri, smilax, caulis trachelospermi, pueraria lobata, coix seed, the root of Chinese clematis are mixed with desmodium, add decocting
Boil, mixed liquor is obtained after filtering；Extracting solution is obtained after mixed liquor is concentrated；Ethanol, stirring, standing, two are added in extracting solution
Secondary filtering；Filtrate after secondary filter is dried to fine powder, obtains medicament.
Further, it is 1.15-1.25g/mL extracting solution to be concentrated into density.
Further, it is mixed into auxiliary material in fine powder after the drying.
Further, the auxiliary material is any in cyclodextrin, mannitol, starch, lactose, sodium carboxymethylcellulose.
Further, the medicament is made any in tablet, pill, granule, capsule, oral liquid.
Compared with prior art, the present invention has the following advantages：
1. the medicament of the present invention has the effect such as anti-trioxypurine, diuresis defaecation, removing damp-heat, anti-inflammatory analgetic, to antihyperuricemic
The related symptoms such as disease and caused gout are evident in efficacy.
2. the present invention medicament have scientific formula, curative for effect, security is good, it is without side-effects the characteristics of.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of specification, and in order to allow above and other objects of the present invention, feature and advantage can
Become apparent, below especially exemplified by the embodiment of the present invention.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, it is clear that described reality
It is part of the embodiment of the present invention to apply example, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this area
Art personnel all other embodiments obtained without making creative work, belong to the model that the present invention protects
Enclose.
The treatment hyperuricemia of the present invention and its medicament of complication, including following components：Cortex Phellodendri, smilax, trachelospermum jasminoide
Rattan, pueraria lobata, coix seed, the root of Chinese clematis and desmodium.
The following detailed description of various raw materials used in the present invention once.
Cortex Phellodendri, bitter are cold in nature.There is the effect of heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice urine
Red, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution enriching yin
Fall fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
Smilax, it is sweet in flavor, light, it is mild-natured.Have removing toxic substances, dehumidify, it is easing joint movement the effect of, be mainly used for syphilis and mercury poisoning institute
The limbs contraction of cause, arthralgia and myalgia；Damp and hot stranguria with turbid discharge, with, carbuncle swells, scrofula, mange.
Caulis trachelospermi, cold nature, bitter.Dispelling wind and removing obstruction in the meridians, cool blood detumescence.For beriberoid pyretic arthralgia, muscle arteries and veins contraction, soreness of waist and knee joint,
Larynx numbness, carbuncle swells, injury from falling down.
Pueraria lobata, it is sweet in flavor, pungent, it is cool in nature；There is expelling pathogenic factors from muscles and skin to bring down a fever, the effect of promoting eruption, promotes the production of body fluid to quench thirst, Shengyang Zhixie.It is usually used in exterior syndrome
Fever, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.Experimental studies have found that pueraria lobata carries
Take thing can to alleviate acute gouty arthritis in rats arthroncus, and reduce serum uric acid level；
Coix seed, sweet in flavor, light, cold nature；There are invigorating spleen to remove dampness, clearing away heat and eliminating pus, remove numbness antidiarrheal function.For splenasthenic diarrhea water
The diseases such as swollen tinea pedis, leukorrhea, wet, arthralgia, acute appendicitis, consumptive lung disease.Still it is used for the cancers such as stomach cancer, cervix cancer, chorioepithelioma
And multiple wart；Document shows that Semen Coicis extract can significantly reduce hyperuricemia mice serum uric acid level；
The root of Chinese clematis, Xin Xian, temperature are poisonous；The effect of its root and stem are used as medicine with wind-damp dispelling, degrading the channel, the bone that disappears stalk.In the modern times
The new purposes of its in clinical practice is constantly found, and such as treats gall stone, calcaneal spur, talagia, the cancer of the esophagus etc..
Desmodium, sweet in flavor, salty, cold nature.Removing dampness through diuresis and removing jaundice, inducing diuresis for treating strangurtia, removing toxicity for detumescence.For jaundice with damp-heat pathogen, courage the is swollen side of body
Bitterly, urolithiasis, heat gonorrhea, difficulty and pain in micturition, carbuncle swells furunculosis, snakebite and bugbite.
The present invention is illustrated below by specific embodiment, it will be apparent to a skilled person that this should not be by
It is interpreted as the limitation to scope of the invention as claimed.The number of following embodiment is parts by weight.
Embodiment 1
A kind of medicament for treating hyperuricemia and its complication, is prepared by following quality proportioning：
300 grams of smilax, 200 grams of caulis trachelospermi, 200 grams of pueraria lobata, 400 grams of coix seed, 150 grams of the root of Chinese clematis, 150 grams of desmodium
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.15；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Cyclodextrin is added in fine powder to be uniformly mixed, and tablet is made.
Embodiment 2
15 parts of Cortex Phellodendri, 30 parts of smilax, 15 parts of caulis trachelospermi, 40 parts of pueraria lobata, 30 parts of coix seed, 15 parts of the root of Chinese clematis, desmodium
10 parts.
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.16；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Mannitol is added in fine powder to be uniformly mixed, and pill is made.
Embodiment 3
30 parts of Cortex Phellodendri, 20 parts of smilax, 25 parts of caulis trachelospermi, 20 parts of pueraria lobata, 40 parts of coix seed, 10 parts of the root of Chinese clematis, desmodium
15 parts.
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.17；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Starch is added in fine powder to be uniformly mixed, and capsule is made.
Embodiment 4
18 parts of Cortex Phellodendri, 28 parts of smilax, 18 parts of caulis trachelospermi, 35 parts of pueraria lobata, 32 parts of coix seed, 14 parts of the root of Chinese clematis, desmodium
11 parts.
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.18；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Lactose is added in fine powder to be uniformly mixed, and capsule is made.
Embodiment 5
25 parts of Cortex Phellodendri, 22 parts of smilax, 22 parts of caulis trachelospermi, 25 parts of pueraria lobata, 38 parts of coix seed, 11 parts of the root of Chinese clematis, desmodium
14 parts.
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.19；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Sodium carboxymethylcellulose is added in fine powder to be uniformly mixed, and oral liquid is made.
Embodiment 6
20 parts of Cortex Phellodendri, 25 parts of smilax, 20 parts of caulis trachelospermi, 30 parts of pueraria lobata, 35 parts of coix seed, 13 parts of the root of Chinese clematis, desmodium
12 parts.
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.20；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Cyclodextrin is added in fine powder to be uniformly mixed, and capsule is made.
Embodiment 7
17 parts of Cortex Phellodendri, 29 parts of smilax, 16 parts of caulis trachelospermi, 37 parts of pueraria lobata, 31 parts of coix seed, 10.5 parts of the root of Chinese clematis, money
14.5 parts of grass.
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.22；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Lactose is added in fine powder to be uniformly mixed, and granule is made.
Embodiment 8
28 parts of Cortex Phellodendri, 21 parts of smilax, 23 parts of caulis trachelospermi, 22 parts of pueraria lobata, 39 parts of coix seed, 14.5 parts of the root of Chinese clematis, money
10.5 parts of grass.
Above-mentioned each Chinese herbal medicine is mixed, the water of addition is 10 times of Chinese herbal medicine total amount, is decocted twice, each 2h；Decoct
After filtered, merge extracting solution；At 65 DEG C, extracting solution is concentrated into the medicinal extract that relative density is 1.25；Add afterwards
95% ethanol, ethanol content is 65% after mixing, is stirred, and is stood, filtering；Filtrate is spray-dried into fine powder.Will be dry
Starch is added in fine powder to be uniformly mixed, and tablet is made.
Treat hyperuricemia and its complication to illustrate the Chinese medicine of the present invention, the medicine made from above-described embodiment into
Following experiment is gone：
Zoopery
1 test material
(1) medicine and reagent：
Medicine of the present invention is extract made of the bulk pharmaceutical chemicals weight proportion according to embodiment 2 and method.
Colchicin, is Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product；
Aspirin, Hubei Xin Kang medication chemistries Co., Ltd.
(2) animal：SD rats.
2 test methods and result
Influence to hyperuricemia mouse serum uric acid level
Kunming mouse 60 is taken, male and female are all used, 18~22g of weight, and it is low to be randomly divided into physiological saline group, medicament of the present invention
Dosage group (6g/kg), medicine middle dose group of the present invention (10g/kg), medicine high dose group (18g/kg) of the present invention, positive control
Group, negative control group, gavage physiological saline, medicine of the present invention, colchicin and aspirin, one time a day, continuous 4d respectively.
After last dose 1h, in addition to physiological saline group, remaining each group animal Intraperitoneal injection of hypoxanthine 1mg/kg causes the high blood urine of mouse
The capacity blank control liquid such as acid, physiological saline group injection.0.5h after injection, each group animal pluck eyeball and take blood, 3000r/min centrifugations
15min, takes serum to survey blood uric acid value.
Influence of the table 1 to hyperuricemia mouse serum uric acid level
Note：Compared with model group：**P<0.01；
Conclusion：Chinese medicine of the present invention can significantly reduce hyperuricemia mouse serum uric acid level.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe is described in detail the present invention with reference to foregoing embodiments, it will be understood by those of ordinary skill in the art that：Its according to
Can so modify to the technical solution described in foregoing embodiments, either to which part or all technical characteristic into
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (9)
1. a kind of compound Chinese medicinal preparation for treating hyperuricemia, it is characterised in that including following components：Cortex Phellodendri, smilax, network
Shi Teng, pueraria lobata, coix seed, the root of Chinese clematis and desmodium.
2. the compound Chinese medicinal preparation for the treatment of hyperuricemia according to claim 1, it is characterised in that including following weight
The component of part：15-30 parts of Cortex Phellodendri；20-30 parts of smilax；15-25 parts of caulis trachelospermi；20-40 parts of pueraria lobata；30-40 parts of coix seed；Prestige
10-15 parts of medicine xiaolingxian；10-15 parts of desmodium.
3. the compound Chinese medicinal preparation for the treatment of hyperuricemia according to claim 2, it is characterised in that including following weight
The component of part：18-25 parts of Cortex Phellodendri；22-28 parts of smilax；18-22 parts of caulis trachelospermi；25-35 parts of pueraria lobata；32-38 parts of coix seed；Prestige
11-14 parts of medicine xiaolingxian；Desmodium 11-14.
4. the compound Chinese medicinal preparation for the treatment of hyperuricemia according to claim 3, it is characterised in that including following weight
The component of part：20 parts of Cortex Phellodendri；25 parts of smilax；20 parts of caulis trachelospermi；30 parts of pueraria lobata；35 parts of coix seed；13 parts of the root of Chinese clematis；Desmodium
12 parts.
5. a kind of preparation method for the compound Chinese medicinal preparation that hyperuricemia is treated according to any one of claim 1-4,
It is characterised in that it includes step：
Cortex Phellodendri, smilax, caulis trachelospermi, pueraria lobata, coix seed, the root of Chinese clematis are mixed with desmodium, added water to cook, is mixed after filtering
Close liquid；
Extracting solution is obtained after mixed liquor is concentrated；Ethanol is added in extracting solution, stirring, stand, secondary filter；
Filtrate after secondary filter is dried to fine powder, obtains medicament.
6. the preparation method of the compound Chinese medicinal preparation for the treatment of hyperuricemia according to claim 5, it is characterised in that will
It is 1.15-1.25g/mL that extracting solution, which is concentrated into density,.
7. the preparation method of the compound Chinese medicinal preparation for the treatment of hyperuricemia according to claim 5, it is characterised in that
Auxiliary material is mixed into dried fine powder.
8. the preparation method of the compound Chinese medicinal preparation for the treatment of hyperuricemia according to claim 7, it is characterised in that institute
It is any in cyclodextrin, mannitol, starch, lactose, sodium carboxymethylcellulose to state auxiliary material.
9. the preparation method of the compound Chinese medicinal preparation for the treatment of hyperuricemia according to claim 5, it is characterised in that will
The medicament is made any in tablet, pill, granule, capsule, oral liquid.
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| CN201711286282.6A CN107998315A (en) | 2017-12-07 | 2017-12-07 | A kind of compound Chinese medicinal preparation for treating hyperuricemia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946956A (en) * | 2019-12-28 | 2020-04-03 | 成都立泰沐成生物科技有限责任公司 | Tea bag for treating and preventing gout and preparation method thereof |
| CN115671219A (en) * | 2022-11-10 | 2023-02-03 | 山东省科学院新材料研究所 | Traditional Chinese medicine composition for treating gout and preparation method and application thereof |
-
2017
- 2017-12-07 CN CN201711286282.6A patent/CN107998315A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946956A (en) * | 2019-12-28 | 2020-04-03 | 成都立泰沐成生物科技有限责任公司 | Tea bag for treating and preventing gout and preparation method thereof |
| CN115671219A (en) * | 2022-11-10 | 2023-02-03 | 山东省科学院新材料研究所 | Traditional Chinese medicine composition for treating gout and preparation method and application thereof |
| CN115671219B (en) * | 2022-11-10 | 2024-03-22 | 山东省科学院新材料研究所 | Traditional Chinese medicine composition for treating gout and preparation method and application thereof |
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