CN107693767A - A kind of external medicine composition, its preparation method and application for preventing and treating diabetes - Google Patents

Abstract

The invention discloses an external Chinese medicine composition for preventing and treating diabetic foot, which comprises the following raw materials: astragalus, achyranthes bidentata, angelica, chuanxiong, safflower, Caulis Spatholobus, atractylodes atractylodes, cassia twig, asarum, dried ginger, aconitum, Ephedra, rhubarb, Phellodendron, Glauber's salt, Zihua Diding, Nuxychnium, Licorice, Earthworm, Frankincense, Myrrh, Angelica dahurica, Saponaria thorn. The invention also discloses a preparation method and application of an external Chinese medicinal composition for preventing and treating diabetic foot. The present invention, through dialectical compatibility of various flavors of traditional Chinese medicines, complements and assists each other, has the effects of invigorating blood and promoting qi, warming meridian and dispelling cold, dispelling blood stasis and relieving pain, clearing away heat and detoxification, removing putrefaction and promoting granulation. The prevention and treatment of diabetic foot has definite curative effect, no toxic and side effects, and patients are not easy to relapse after recovery.

Description

A kind of external Chinese medicine composition for preventing and treating diabetic foot, its preparation method and application

technical field

The invention relates to the technical field of traditional Chinese medicine, in particular to an external Chinese medicine composition for preventing and treating diabetic foot, its preparation method and application.

Background technique

Diabetes mellitus (DM) is a common endocrine and metabolic disease characterized by metabolic disorders of sugar, fat, and protein caused by insufficient insulin secretion or action defect in the body. In recent years, with the improvement of people's living standards and changes in lifestyle and many other factors, the incidence of diabetes worldwide has increased rapidly, and diabetes has become the third common disease that seriously threatens human health and life after tumors and cardiovascular diseases. . Diabetes itself does not necessarily cause serious harm to patients, but long-term high blood sugar, damage to large blood vessels and microvessels and endangering the heart, brain, kidney, peripheral nerves, eyes, feet, etc., will lead to a series of complications of diabetes as the disease progresses. disease.

Diabetic complications mainly include diabetic foot, diabetic eye disease, diabetic nephropathy, diabetic neuropathy, diabetic cardiovascular disease and other diseases. Among them, the concept of diabetic foot was first proposed by Oakley in 1956. In 1972, Catterall defined it as a foot that lost sensation due to neuropathy, lost vitality due to ischemia, and was co-infected. The World Health Organization (WHO) definition is: Foot infection, ulceration and/or deep tissue destruction associated with distal lower extremity neurological abnormalities and varying degrees of peripheral vascular disease. The Wagner classification divides the diabetic foot into the following 5 grades:

Grade 0: No open lesions on the skin. It often manifests as insufficient blood supply to the extremities, weakened dorsalis pedis artery pulse, cool skin, purple-brown color, numbness, tingling, burning pain, dullness or loss of sensation, and high-risk foot manifestations such as toe or foot deformity.

Grade 1: There are open lesions on the skin of the extremities. Superficial skin ulcers caused by blisters, blood blisters, corns or calluses, frostbite or burns, and other skin injuries. But the lesion has not spread to deep tissue.

Grade 2: Infected lesions have invaded deep muscle tissue. There are often cellulitis, multiple pus foci and sinus formation, or the infection expands along the muscle space to cause penetrating ulcers on the plantar and dorsum of the foot, with more purulent secretions, but the tendons and ligaments have not been damaged.

Grade 3: tendon and ligament tissue destruction, cellulitis fusion to form a large abscess cavity, purulent secretions and necrotic tissue increase, but bone destruction is not obvious.

Grade 4: Severe infection has caused bone defect, osteomyelitis and bone and joint destruction or pseudarthrosis has been formed.

Grade 5: Most or all of the foot is infected or ischemic, resulting in severe wet or dry necrosis. The extremities turn black, and the corpse often spreads to the ankle joint and lower leg.

Diabetic gangrene or amputees are 15-40 times more common than the general population. Every 30 seconds in the world, there is a diabetic foot amputation due to diabetes, and the quality of life after amputation is significantly reduced, resulting in physical and mental damage to diabetic foot patients. The mortality rate of diabetic foot patients after surgery is very high, and the mortality rate within 6 months is 20%. , and the mortality rate after 5 years of amputation is even as high as 50%-70%. Therefore, it is of great significance to carry out early prevention and middle and late treatment of foot problems in diabetic patients.

At present, the treatment of diabetic foot in Western medicine mainly includes the application of insulin and/or oral hypoglycemic drugs to control blood sugar, the intravenous application of drugs for promoting blood circulation and removing blood stasis to improve microcirculation, and the application of antibiotics to resist infection, etc., although the corresponding symptoms can be relieved to a certain extent , but it cannot fundamentally eliminate the suffering of patients. If treatment fails to alleviate and control symptoms and complications in the lower extremities, amputation will eventually result.

Traditional Chinese medicine believes that diabetic foot is mainly due to deficiency of yin in the body, weakness of the five internal organs, complex diet, overeating fat and sweet, emotional disorders, and excessive labor, resulting in deficiency of kidney yin, dryness and heat in the lung and stomach; the pathogenesis focuses on Deficiency of yin is dry and hot, and the deficiency of yin is the root and heat is the standard; the disease is prolonged, the yin is damaged and the yang is affected, and both yin and yang are deficient; the deficiency of yin is dry and hot, and the burning fluid is consumed, making the blood sticky, and the blood flow is astringent and stagnant to form stasis; Yin damages and affects yang, and yang deficiency and cold coagulation can also cause blood stasis and internal yang. This disease is mostly a syndrome of deficiency in origin and excess in superficiality, with the deficiency of qi and blood, yin and yang as the foundation, and network obstruction, blood stasis, damp heat, fire and poison as the standard. Clinical manifestations of diabetic foot are ischemia, peripheral neuropathy, and infection. Especially in the late stage, the remote local soft tissue skin erosion of the feet or limbs, initially blisters or shallow ulcers, and then ulceration penetrates into the tendon and muscle layer, destroying bone, tissue necrosis and decay, forming pus cavities and sinuses, discharging foul-smelling secretions, surrounding Proliferative solid swelling.

Clinical practice in recent years shows that traditional Chinese medicine has great advantages in treating diabetic foot, and has achieved remarkable curative effect and accumulated rich experience. Compared with Western medicine, TCM treatment overcomes the disadvantages of drug resistance that may be caused by topical antibiotics, and TCM topical prescriptions directly act on local lesions of diabetic feet, allowing the drugs to reach the disease directly, with higher safety and fewer side effects, making quite a few patients Freedom from amputation.

Contents of the invention

On the basis of research on dialectical theory of traditional Chinese medicine for diabetic foot, the present inventor has obtained the formula of the present invention through screening and compounding from numerous traditional Chinese medicines through years of clinical trials.

The object of the present invention is to provide a traditional Chinese medicine composition for external use for preventing and treating diabetic foot, which has scientific and reasonable composition, definite curative effect, convenient use, good patient compliance, no toxic and side effects and is not easy to relapse, its preparation method and application.

Specifically, in order to achieve the above object, the first aspect of the present invention provides an external Chinese medicine composition for preventing and treating diabetic foot, the Chinese medicine composition includes the following raw materials in parts by weight: the Chinese medicine composition includes the following parts by weight Raw materials: 30-150 parts of Astragalus, 15-30 parts of Achyranthes chinensis, 5-15 parts of Angelica sinensis, 5-15 parts of Chuanxiong, 5-10 parts of safflower, 15-30 parts of Caulis Spatholobus, 5-15 parts of Atractylodes atractylodes, Guizhi 15-30 parts, Asarum 5-10 parts, dried ginger 10-20 parts, Chuanwu 5-15 parts, ephedra 5-10 parts, rhubarb 15-30 parts, Phellodendron 5-15 parts, Glauber's salt 10-20 parts 5-15 parts of Viola chinensis, 5-10 parts of Nymphony chinensis, 5-10 parts of licorice, 5-15 parts of earthworm, 5-15 parts of frankincense, 5-15 parts of myrrh, 5-20 parts of Angelica dahurica, 15-30 parts of saponins.

Further, the traditional Chinese medicine composition includes the following raw materials in parts by weight: 60-120 parts of astragalus, 18-25 parts of Achyranthes chinensis, 8-12 parts of angelica, 5-12 parts of Chuanxiong, 5-10 parts of safflower, chicken 18-24 parts of Rhododendron, 10-15 parts of Cangzhu, 18-24 parts of Guizhi, 5-10 parts of Asarum, 12-16 parts of dried ginger, 5-12 parts of Aconitum, 5-10 parts of Ephedra, 20-20 parts of Rhubarb 30 parts, 5-15 parts of Cortex Phellodendri, 15-20 parts of Glauber's Salt, 8-15 parts of Viola chinensis, 5-10 parts of Nuxychia, 5-10 parts of Licorice, 10-15 parts of Earthworm, 5-15 parts of Frankincense, 5-12 parts of myrrh, 10-20 parts of Angelica dahurica, 15-25 parts of saponins.

Further, the parts by weight of each raw material are: 100 parts of Radix Astragali, 20 parts of Achyranthes Radix, 10 parts of Angelica Sinensis, 9 parts of Rhizoma Chuanxiong, 8 parts of Safflower, 20 parts of Miltonia Spatholobus, 15 parts of Atractylodes Rhizome, 20 parts of Guizhi, 6 parts of pungent, 15 parts of dried ginger, 10 parts of Aconitum, 5 parts of ephedra, 22 parts of rhubarb, 12 parts of Cortex Phellodendri, 15 parts of Glauber's salt, 11 parts of Viola chinensis, 7 parts of Nymphaeum chinensis, 10 parts of licorice, 12 parts of earthworm , 10 parts of frankincense, 8 parts of myrrh, 16 parts of angelica, 20 parts of saponin.

Furthermore, when the traditional Chinese medicine composition is used, one or more traditional Chinese medicines for improving or treating concurrent symptoms can be added.

Further, the traditional Chinese medicine composition is made into powder or ointment.

The second aspect of the present invention provides a kind of preparation method of the above-mentioned external Chinese medicine composition for preventing and treating diabetic foot, described Chinese medicine composition is powder, and its preparation method is:

According to the proportion of the composition, the dried raw materials are weighed in corresponding parts by weight, pulverized by a pulverizer, passed through a 40-60 mesh sieve, and mixed uniformly to obtain the finished drug powder.

Method of use: Weigh the above-mentioned 50-55 grams of finished powder, add appropriate amount of water (according to the amount that the water surface can soak the inner and outer malleolus of the foot after decoction), soak for 10 minutes, boil for 20 minutes, let it cool down, and make the liquid temperature Maintain at 40 degrees, soak your feet in the medicinal solution for 30-45 minutes. Soak your feet twice a day, 30 days as a course of treatment. It is suitable for patients with grade 0 diabetic foot without ulcers on the foot.

Further, the traditional Chinese medicine composition is an ointment, and its preparation method is:

Weigh the dried raw materials according to the proportion of the composition, coarsely pulverize them, add water 6 to 8 times the total weight of the raw materials, decoct for 1 to 2 hours, filter, and add 3 times the total weight of raw materials to the filter residue. ~4 times the amount of water, decoct for 0.5-1h, filter, combine the filtrates from two decoctions, concentrate the filtrate to a clear paste with a relative density of 1.18-1.22 at 70°C, add a pharmaceutically acceptable carrier to the clear paste , stirred and mixed, finely refined, the ointment is collected until the relative density is 1.48-1.55, cooled, and the finished ointment of the drug is obtained.

Wherein, the carrier refers to a conventional drug carrier in the field of pharmacy. Preferred are petrolatum or glycerin.

How to use: Apply the ointment evenly to the lesion, three times a day, 30 days as a course of treatment. It is suitable for diabetic foot patients with grade 1 or above ulcers on the feet.

The third aspect of the present invention provides an application of the above-mentioned traditional Chinese medicine composition for external use in the preparation of a medicament for preventing and treating diabetic foot.

The pharmacological effect of each flavor Chinese medicine selected for use in the present invention is as follows:

Astragalus: sweet, slightly warm. Return lung, gallbladder, spleen, large intestine, small intestine channel. It has the effects of replenishing qi and solidifying the surface, astringing sweat and solidifying, promoting sores and promoting granulation, diuresis and detumescence. It is used to treat qi deficiency and fatigue, depression of middle qi, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, surface deficiency and spontaneous sweating, carbuncle and gangrene, chronic ulceration, blood deficiency and chlorosis, internal heat and thirst, chronic nephritis, proteinuria, diabetes, etc. Sun-roasted Astragalus nourishes qi and invigorates the middle, and is used to strengthen the surface and support sores.

Chuan Achyranthes bidentata: sweet in taste, slightly bitter, flat in nature. Return liver, kidney channel. Dispersing and reducing diarrhea has the effects of promoting blood circulation and promoting menstrual flow, expelling wind and removing dampness, benefiting joints, diuresis and treating stranguria.

Angelica: sweet in the mouth, pungent, warm in nature. Return liver, heart, spleen channel. Functions and indications: Tonify blood and activate blood circulation, regulate menstruation and relieve pain, moisten intestines and relieve constipation. For blood deficiency and yellow complexion, dizziness and palpitations, irregular menstruation, amenorrhea dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to dryness of the intestine, rheumatic arthralgia, injury from falls, carbuncle sores. Wine angelica invigorates blood and stimulates menstrual flow. For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling.

Chuanxiong: pungent in taste, warm in nature. Return liver, gallbladder, heart channel. It is often used for promoting blood circulation and promoting qi, dispelling wind and relieving pain. Ligusticum chuanxiong is pungent, warm, fragrant and dry. It has a wide range of functions of promoting blood circulation and removing blood stasis, suitable for stagnation of various diseases; dispelling wind and relieving pain, has very good effects, and can cure head wind, headache, rheumatic arthralgia and other diseases. The ancients said that Chuanxiong is the qi medicine in the blood, and it is almost said that it has the functions of dispersing pungent, relieving depression, opening up the mind, and relieving pain.

Flos Carthami: spicy in taste, warm in nature. GUIXIN, Liver Channel. Functions and indications: promoting blood circulation to stimulate menstrual flow, dissipating blood stasis and relieving pain. For amenorrhea, dysmenorrhea, lochia, mass in the abdomen, injury from falls, sores and swelling.

Spatholobus Spatholobus: bitter in the mouth, sweet, warm in nature. Return liver, kidney channel. Functions and indications: nourishing blood, invigorating blood circulation, dredging collaterals. For irregular menstruation, blood deficiency and chlorosis, numbness and paralysis, rheumatic arthralgia.

Herba Atractylodes: spicy, bitter, warm in nature. Return spleen, stomach, liver channel. Function cures mainly: dry damp and invigorate the spleen, dispel wind and cold, improve eyesight. For abdominal fullness, diarrhea, edema, beriberi flaccidity, rheumatic arthralgia, anemofrigid cold, night blindness.

Cinnamon Twig: spicy, sweet, warm in nature. Guixin, lung, bladder channel. Functions and indications: Sweating and relieving muscles, warming the meridians, helping yang to transform qi, calming and descending qi. For anemofrigid cold, cold pain in the abdomen, amenorrhea due to cold in blood, arthralgia, phlegm retention, edema, palpitation, running ton.

Asarum: spicy in the mouth, warm in nature. Guixin, lung, kidney channel. Functions and indications: expelling wind and cold, clearing the orifice and relieving pain, warming the lung and transforming drink. For anemofrigid cold, headache, toothache, nasal congestion, rheumatic arthralgia, dyspnea and cough due to phlegm retention.

Dried ginger: pungent in taste, hot in nature. Return spleen, stomach, kidney, heart, lung channel. Functions and indications: Dried ginger warms the middle and dispels cold, restores yang and unblocks the veins, dries dampness and eliminates phlegm. For epigastric cold and pain, vomiting and diarrhea, cold extremities and weak pulse, phlegm retention, dyspnea and cough.

Chuanwu: pungent, bitter, hot in nature. GUIXIN, liver, kidney, spleen channel. It has the effects of expelling wind and removing dampness, warming meridian and relieving pain. Indications: For wind-cold-damp arthralgia, joint pain, cold pain in trusted subordinates, cold colic pain and anesthesia for pain relief.

Ephedra: spicy, slightly bitter, warm in nature. Return lung meridian, bladder meridian. Efficacy and function: Sweating and dispelling cold, clearing lung and relieving asthma, diuresis and detumescence. It belongs to Xinwen Jieyiao medicine under the category of anti-outside medicine.

Rhubarb: Bitter in the mouth, cold in nature. Return spleen, stomach, large intestine, liver, pericardium channel. Functions and indications: purging heat and dredging intestines, cooling blood and detoxifying, dispelling blood stasis and dredging menstrual flow. Used for excess heat and constipation, stagnant abdominal pain, dysentery, damp-heat jaundice, vomiting of blood heat, red eyes, swollen throat, abdominal pain in the intestine, carbuncle and furuncle, blood stasis, amenorrhea, bruises, external treatment of water and fire burns ; Upper gastrointestinal bleeding. Liquor rhubarb is good at clearing the heat and poison of the upper burnt blood. For conjunctival congestion and pharynx swelling, gingival swelling and pain. Cooked rhubarb relieves diarrhea, relieves fire and detoxifies. For fire sores. Rhubarb charcoal cools blood, removes blood stasis and stops bleeding. For blood heat with stasis and hemorrhage.

Cortex Phellodendri: bitter in the mouth, cold in nature. Return kidney, urinary bladder channel. Functions and indications: clearing away heat and dampness, purging fire and removing steam, detoxifying and treating sores. For damp-heat diarrhea, jaundice, leukorrhea, stranguria, beriberi, flaccidity {discharge}, bone steam labor fever, night sweats, nocturnal emission, sore swelling, eczema and itching. Salt Phellodendron nourishes yin and reduces fire. For hyperactivity of fire due to yin deficiency, night sweat and bone steam.

Glauber's salt: salty, bitter, cold in nature. Return stomach, large intestine channel. Functions and indications: purging heat and laxative, moistening dryness and softening hardness, clearing fire and reducing swelling. For excess heat constipation, dry stool, stagnant abdominal pain, intestinal abscess swelling and pain; external treatment mastitis, hemorrhoid swelling and pain.

Radix Viola: bitter in the mouth, pungent, cold in nature. GUIXIN, lung meridian. It has the effects of clearing heat and detoxifying, cooling blood and reducing swelling, clearing heat and promoting dampness, and can be used to treat furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhea, red eyes, sore throat, and snake bites.

Nuxychia: bitter in taste, warm in nature. Return liver, spleen channel. It has the effects of dredging collaterals and relieving pain, dissipating stagnation and detumescence. Cure mainly: bruises, bone fracture swelling and pain, rheumatism obstinate numbness, numbness and paralysis, carbuncle sore, throat swelling and pain.

Licorice: sweet in nature and flavor, flat in nature. GUIXIN, lung, spleen, stomach warp. Functions and indications: invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and relieving pain, harmonizing various medicines. For weakness of the spleen and stomach, lassitude and weakness, palpitation and shortness of breath, cough with copious phlegm, epigastric abdomen, extremity convulsion acute pain, carbuncle sore tumefacting virus, alleviates drug toxicity, strong.

Earthworm: salty in taste, cold in nature. Return liver, spleen, urinary bladder channel. Function cures mainly: clearing away heat and calming convulsions, dredging collaterals, relieving asthma, inducing diuresis. Used for high fever, coma, convulsions, arthralgia, numbness, hemiplegia, cough due to lung heat, oliguria, edema, and high blood pressure.

Olibanum: pungent in nature and flavor, bitter, warm. GUIXIN, liver, spleen channel. Efficacy: promoting blood circulation, promoting qi and relieving pain, reducing swelling and promoting muscle growth. Indications: used for chest obstruction and heartache, epigastric pain, dysmenorrhea, postpartum stasis, abdominal pain in the abdomen, rheumatic arthralgia, spasm of tendons, bruises, carbuncle sores.

Myrrha: acrid in the mouth, bitter, flat in nature. GUIXIN, liver, spleen channel. Efficacy: dissipating blood stasis and relieving pain, reducing swelling and promoting granulation. Indications: It is used for the treatment of chest obstruction and heartache, epigastric pain, dysmenorrhea, postpartum stasis, abdominal pain, rheumatic arthralgia, bruises, carbuncle, sore and other diseases.

Angelica dahurica: spicy in taste, warm in nature. Return stomach, large intestine, lung meridian. Functions and indications: dehumidification, clearing the orifice and relieving pain, reducing swelling and draining pus. For cold headache, brow bone pain, nasal congestion, nasal sinusitis, toothache, leucorrhea, sore swelling and pain.

Glycyrrhizae thorn: pungent in taste, warm in nature. Return liver, stomach warp. Functions and indications: reducing swelling and detoxification, evacuating pus, killing parasites. For the initial onset of carbuncle or ulceration; external treatment of scabies and leprosy.

The present invention has the following advantages:

1. The present invention complements each other through the dialectical compatibility of various flavors of traditional Chinese medicines. Among them, Astragalus tonifying the middle and nourishing Qi is the monarch drug; Achyranthes bidentata, Angelica, Rhizoma Chuanxiong, Safflower, and Caulis Spatholobus for promoting blood circulation and removing stasis are ministerial drugs; Branches, Asarum, Dried Ginger, Aconitum Aconitum, Ephedra to dispel dampness and dispel cold as adjuvant medicine; Detoxification, dispelling putrefaction and promoting granulation are the main medicines, which have the effects of promoting blood circulation and promoting qi, warming the meridian and dispelling cold, dispelling blood stasis and relieving pain, clearing away heat and detoxification, removing putrefaction and promoting granulation. It has a good curative effect on the prevention and treatment of diabetic foot. For patients with grade 0 diabetic foot without ulcers, the powder of the present invention is used for foot bath treatment, which has the health care effect of enhancing physical fitness and controlling the development of diabetic feet; Diabetic foot patients above grade 1, using the ointment of the present invention for coating treatment, can reduce the pain of the patient, control the infection of the sore surface, improve local microcirculation, enhance the bidirectional transport function of endothelial cells, increase the conduction speed of peripheral nerves, and promote tissue Repair and wound healing.

2. The raw materials of the present invention are easy to obtain and low in cost, and the preparation method is simple and easy to operate. The obtained traditional Chinese medicine composition has definite curative effect on the prevention and treatment of diabetic foot, has no toxic and side effects, and is not easy to relapse after the patient recovers.

detailed description

The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

Example 1

An external Chinese medicine composition for preventing and treating diabetic foot, comprising the following raw materials in parts by weight: 30 parts of astragalus, 15 parts of Achyranthes bidentata, 5 parts of angelica, 5 parts of Chuanxiong, 5 parts of safflower, 15 parts of Caulis Spatholobus, and 5 parts of atractylodes 15 parts of Gui Zhi, 5 parts of Asarum, 10 parts of Dried Ginger, 5 parts of Aconitum, 5 parts of Ephedra, 15 parts of Rhubarb, 5 parts of Phellodendron Phellodendri, 10 parts of Glauber's Salt, 5 parts of Zihua Diding, 5 parts of Nymphaeum, 5 parts of licorice, 5 parts of earthworm, 5 parts of frankincense, 5 parts of myrrh, 5 parts of angelica, 15 parts of saponins.

The preparation method and the use method of the Chinese medicine composition powder of the present embodiment are as follows:

Weigh the dried raw materials according to the above-mentioned parts by weight, pass through a 40-60 mesh sieve after being pulverized by a pulverizer, and mix evenly to obtain the finished powder of the drug; weigh the above-mentioned 50-55 grams of powder, add an appropriate amount of water (Based on the amount that the water surface can soak the inner and outer malleolus of the foot after boiling), soak for 10 minutes, boil for 20 minutes, let it cool down, keep the temperature of the liquid medicine at 40 degrees, put your feet in the liquid medicine for 30-45 minute. Soak your feet twice a day, 30 days as a course of treatment.

The preparation method and the use method of the Chinese medicine composition ointment of the present embodiment are as follows:

Weigh the dried raw materials according to the above parts by weight, coarsely crush them, add water 7 times the total weight of the raw materials, decoct for 1.5 hours, filter, add water 3 times the total weight of the raw materials to the filter residue, decoct 0.5h, filter, combine the two decoctions, concentrate the filtrate to a clear paste with a relative density of 1.20 at 70°C, add vaseline to the clear paste, stir and mix well, finely refine, collect the paste until the relative density is 1.50, and cool , to obtain the finished product of the medicine. The above-mentioned ointment is evenly applied to the lesion, with a thickness of about 0.2 cm, three times a day, and 30 days is a course of treatment.

Example 2

An external traditional Chinese medicine composition for preventing and treating diabetic foot, comprising the following raw materials in parts by weight: 60 parts of astragalus, 18 parts of Achyranthes bidentata, 6 parts of angelica, 8 parts of Chuanxiong, 5 parts of safflower, 15 parts of Caulis Spatholobus, and 5 parts of atractylodes 18 parts of Guizhi, 5 parts of Asarum, 12 parts of Dried Ginger, 5 parts of Aconitum, 8 parts of Ephedra, 18 parts of Rhubarb, 8 parts of Phellodendron Phellodendri, 12 parts of Glauber's Salt, 8 parts of Viola chinensis, 5 parts of Nymphaeum, 5 parts of licorice, 5 parts of earthworm, 10 parts of frankincense, 5 parts of myrrh, 5 parts of angelica, 15 parts of saponins.

Example 3

An external Chinese medicine composition for preventing and treating diabetic foot, comprising the following raw materials in parts by weight: 90 parts of astragalus, 22 parts of Achyranthes bidentata, 10 parts of angelica, 12 parts of Chuanxiong, 5 parts of safflower, 18 parts of Caulis Spatholobus, and 10 parts of Atractylodes atractylodes 20 parts of Guizhi, 8 parts of Asarum, 15 parts of Dried Ginger, 9 parts of Aconitum, 8 parts of Ephedra, 23 parts of Rhubarb, 12 parts of Phellodendron Phellodendri, 16 parts of Glauber's Salt, 10 parts of Viola chinensis, 8 parts of Nymphaeum, 6 parts of licorice, 10 parts of earthworm, 12 parts of frankincense, 10 parts of myrrh, 10 parts of angelica, 20 parts of saponins.

The preparation method and usage method of the traditional Chinese medicine composition of this embodiment are the same as that of Embodiment 1.

Example 4

An external traditional Chinese medicine composition for preventing and treating diabetic foot, comprising the following raw materials in parts by weight: 100 parts of astragalus, 20 parts of Achyranthes bidentata, 10 parts of angelica, 9 parts of Chuanxiong, 8 parts of safflower, 20 parts of Millet Spatholobus, and 15 parts of Atractylodes atractylodes 20 parts of Guizhi, 6 parts of Asarum, 15 parts of Dried Ginger, 10 parts of Aconitum, 5 parts of Ephedra, 22 parts of Rhubarb, 12 parts of Phellodendron Phellodendri, 15 parts of Glauber's Salt, 11 parts of Viola chinensis, 7 parts of Nymphaeum, 10 parts of licorice, 12 parts of earthworm, 10 parts of frankincense, 8 parts of myrrh, 16 parts of angelica, 20 parts of saponins.

The preparation method and usage method of the traditional Chinese medicine composition of this embodiment are the same as that of Embodiment 1.

Example 5

An external Chinese medicine composition for preventing and treating diabetic foot, comprising the following raw materials in parts by weight: 120 parts of astragalus, 25 parts of Achyranthes bidentata, 10 parts of angelica sinensis, 12 parts of Chuanxiong, 10 parts of safflower, 25 parts of Caulis Spatholobus, and 12 parts of Atractylodes atractylodes 25 parts of Guizhi, 10 parts of Asarum, 18 parts of Dried Ginger, 13 parts of Aconitum Aconitum, 10 parts of Ephedra, 28 parts of Rhubarb, 15 parts of Phellodendron Phellodendri, 18 parts of Glauber's Salt, 12 parts of Zihua Diding, 8 parts of Nymphaeum, 9 parts of licorice, 15 parts of earthworm, 12 parts of frankincense, 10 parts of myrrh, 15 parts of angelica, 25 parts of saponins.

The preparation method and usage method of the traditional Chinese medicine composition of this embodiment are the same as that of Embodiment 1.

Example 6

An external traditional Chinese medicine composition for preventing and treating diabetic foot, comprising the following raw materials in parts by weight: 150 parts of astragalus, 30 parts of Achyranthes bidentata, 15 parts of angelica, 15 parts of Chuanxiong, 10 parts of safflower, 30 parts of Millet Spatholobus, and 15 parts of Atractylodes atractylodes 30 parts of Guizhi, 10 parts of Asarum, 20 parts of Dried Ginger, 15 parts of Aconitum Aconitum, 10 parts of Ephedra, 30 parts of Rhubarb, 15 parts of Cortex Phellodendri, 20 parts of Glauber's Salt, 15 parts of Viola chinensis, 10 parts of Nymphaeum, 10 parts of licorice, 15 parts of earthworm, 15 parts of frankincense, 15 parts of myrrh, 20 parts of angelica, 30 parts of saponins,

The preparation method and usage method of the traditional Chinese medicine composition of this embodiment are the same as that of Embodiment 1.

Test case

In order to show the therapeutic effect of the Chinese medicine composition of the present invention on different grades of diabetic foot patients, the present invention has carried out the following curative effect tests.

1. Patient data: 100 diabetic foot patients who were hospitalized from August 2015 to October 2016 were selected. Among them, there were 68 males and 32 females, aged 49-85 years, with an average age of 61.2 years, the duration of diabetes: 6-15 years, the duration of diabetic foot disease: 4 weeks-5 years, and the patients had no other serious diseases. All met the diagnostic criteria for diabetic foot, according to the clinical grading standard (Wagner grading), including 26 cases of grade 0 (no ulcer), 38 cases of grade 1 (superficial ulcer), and grade 2 (deep ulcer without abscess formation and bone involvement) 18 cases, grade 3 (deep ulcer such as cellulitis or abscess formation with bone involvement) in 12 cases, grade 4 (local gangrene) in 6 cases.

2. Curative effect standard

Cure: After treatment, the patient's clinical symptoms disappeared, the skin color of patients with grade 0 returned to normal, and the ulcers of patients with grade 1 and above were completely healed.

Significantly effective: After treatment, the clinical symptoms of patients disappeared, the skin of patients with grade 0 returned to normal, and most of the ulcers of patients with grade 1 and above recovered.

Effective: After treatment, the patient's clinical symptoms improved, the skin color of patients with grade 0 gradually changed to light red, and a small part of the ulcer surface of patients with grade 1 and above recovered, and new granulation tissue grew.

Ineffective: After treatment, the patient's skin color did not change, and the ulcer surface did not recover.

3. Treatment method

For patients with grade 0 diabetic foot without ulcers, the powder of this embodiment 4 is used for foot bath treatment, and the feet are soaked twice a day, and 30 days is a course of treatment. The ointment of this embodiment 4 is used for the treatment of diabetic foot patients above grade 1 with existing ulcers, three times a day, and 30 days is a course of treatment. The above-mentioned traditional Chinese medicine treatment is combined with the following treatment methods: 1) Insulin therapy to control blood sugar between 7-9mmol/L; 2) For co-infected patients, anti-inflammatory and symptomatic treatment; 3) Treat the affected foot wound accordingly .

4. Treatment results

Using the traditional Chinese medicine composition of the present invention, the original symptoms are obviously alleviated. According to statistics, diabetic foot patients with grade 0 and other mild symptoms can be cured in one course of treatment. After two courses of treatment, 72 cases were cured, accounting for 72%; 17 cases were markedly effective, accounting for 17%; 11 cases were effective, accounting for 11%. ;No invalid conditions.

In the above-mentioned clinical trial, hematuria routine, liver and kidney function, electrocardiogram, etc. were checked and recorded in detail before and after the patient took the medicine, and no abnormalities were found in the comparison, which shows that the traditional Chinese medicine composition has no toxic and side effects. A follow-up visit was carried out to the above-mentioned cases after one year, and there was no recurrence patient.

Although the present invention has been described in detail with general descriptions and specific examples above, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, the modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the protection scope of the present invention.

Claims (9)

1. a kind of external medicine composition for preventing and treating diabetes, it is characterised in that the Chinese medicine composition includes following weight The raw material of number：30~150 parts of the Radix Astragali, 15~30 parts of radix cyathulae, 5~15 parts of Radix Angelicae Sinensis, 5~15 parts of Ligusticum wallichii, 5~10 parts of safflower, 15~30 parts of reticulate millettia, 5~15 parts of rhizoma atractylodis, 15~30 parts of cassia twig, 5~10 parts of asarum, 10~20 parts of rhizoma zingiberis, 5~15 parts of monkshood, 5~10 parts of Chinese ephedra, 15~30 parts of rheum officinale, 5~15 parts of golden cypress, 10~20 parts of saltcake, 5~15 parts of Chinese violet, vomiting nut 5~10 Part, 5~10 parts of radix glycyrrhizae, 5~15 parts of earthworm, 5~15 parts of frankincense, 5~15 parts of myrrh, 5~20 parts of the root of Dahurain angelica, spina gleditsiae 15~30 Part.

2. the external medicine composition of preventing and treating diabetes according to claim 1, it is characterised in that the Chinese traditional medicine composition Thing includes the raw material of following parts by weight：60~120 parts of the Radix Astragali, 18~25 parts of radix cyathulae, 8~12 parts of Radix Angelicae Sinensis, Ligusticum wallichii 5~12 Part, 5~10 parts of safflower, 18~24 parts of reticulate millettia, 10~15 parts of rhizoma atractylodis, 18~24 parts of cassia twig, 5~10 parts of asarum, rhizoma zingiberis 12~ 16 parts, 5~12 parts of monkshood, 5~10 parts of Chinese ephedra, 20~30 parts of rheum officinale, 5~15 parts of golden cypress, 15~20 parts of saltcake, Chinese violet 8 ~15 parts, 5~10 parts of vomiting nut, 5~10 parts of radix glycyrrhizae, 10~15 parts of earthworm, 5~15 parts of frankincense, 5~12 parts of myrrh, the root of Dahurain angelica 10 ~20 parts, 15~25 parts of spina gleditsiae.

3. the external medicine composition of preventing and treating diabetes according to claim 1, it is characterised in that the weight of each raw material Number is：100 parts of the Radix Astragali, 20 parts of radix cyathulae, 10 parts of Radix Angelicae Sinensis, 9 parts of Ligusticum wallichii, 8 parts of safflower, 20 parts of reticulate millettia, 15 parts of rhizoma atractylodis, cassia twig 20 parts, 6 parts of asarum, 15 parts of rhizoma zingiberis, 10 parts of monkshood, 5 parts of Chinese ephedra, 22 parts of rheum officinale, 12 parts of golden cypress, 15 parts of saltcake, Chinese violet 11 Part, 7 parts of vomiting nut, 10 parts of radix glycyrrhizae, 12 parts of earthworm, 10 parts of frankincense, 8 parts of myrrh, 16 parts of the root of Dahurain angelica, 20 parts of spina gleditsiae.

4. the external medicine composition of preventing and treating diabetes according to claim 1, it is characterised in that the Chinese medicine composition When in use, one or more Chinese medicines for being used to improving or treating accompanying symptoms can be added.

5. the external medicine composition of the preventing and treating diabetes according to any one of Claims 1 to 4 claim, its feature It is, powder agent or paste is made in the Chinese medicine composition.

A kind of 6. preparation method of the external medicine composition of the preventing and treating diabetes described in claim 5, it is characterised in that institute It is powder agent to state Chinese medicine composition, and its preparation method is：

The raw material of the corresponding parts by weight after drying is weighed according to composition proportioning, pulverizer is crossed 40~60 mesh sieves after crushing, mixed Close the powder agent finished product for uniformly, producing the medicine.

7. the preparation method of the external medicine composition of preventing and treating diabetes according to claim 6, it is characterised in that institute It is paste to state Chinese medicine composition, and its preparation method is：

The raw material of the corresponding parts by weight after drying is weighed according to composition proportioning, coarse crushing, adds 6~8 times of raw material gross weight The water of amount, 1~2h is decocted, filtration, the water of 3~4 times of amounts of raw material gross weight is added in filter residue, decocts 0.5~1h, is filtered, is closed And decoction liquor twice, relative density is 1.18~1.22 clear cream when decoction liquor is concentrated into 70 DEG C, is added pharmaceutically in clear cream Acceptable carrier, is stirred and evenly mixed, micro- refining, and it is 1.48~1.55 to receive cream to relative density, cooling, produce the paste of the medicine into Product.

8. the preparation method of the external medicine composition of preventing and treating diabetes according to claim 7, it is characterised in that institute It is vaseline or glycerine to state carrier.

9. application of the external medicine composition in the medicine for preparing preventing and treating diabetes described in claim 1.