CN107693767A - A kind of external medicine composition, its preparation method and application for preventing and treating diabetes - Google Patents
A kind of external medicine composition, its preparation method and application for preventing and treating diabetes Download PDFInfo
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- CN107693767A CN107693767A CN201711205856.2A CN201711205856A CN107693767A CN 107693767 A CN107693767 A CN 107693767A CN 201711205856 A CN201711205856 A CN 201711205856A CN 107693767 A CN107693767 A CN 107693767A
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Abstract
The invention discloses a kind of external medicine composition for preventing and treating diabetes, including following raw materials according：The Radix Astragali, radix cyathulae, Radix Angelicae Sinensis, Ligusticum wallichii, safflower, reticulate millettia, rhizoma atractylodis, cassia twig, asarum, rhizoma zingiberis, monkshood, Chinese ephedra, rheum officinale, golden cypress, saltcake, Chinese violet, vomiting nut, radix glycyrrhizae, earthworm, frankincense, myrrh, the root of Dahurain angelica, spina gleditsiae.The invention also discloses a kind of preparation method and application for the external medicine composition for preventing and treating diabetes.The present invention is by all dialectical compatibilities of taste Chinese medicine, mutually auxiliary help, the effect of playing blood-activating and qi-promoting, warming channel and expelling cold, stasis-dispelling and pain-killing, clearing heat and detoxicating, putrefaction-removing granulation-promoting altogether.It is curative for effect to the prevention and treatment of diabetes, have no toxic side effect, patient's difficulty in relapse after healing.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of external medicine composition for preventing and treating diabetes, its system
Preparation Method and application.
Background technology
Diabetes (Diabetes mellitus, DM) be due to internal hypoinsulinism or effect defect caused by
A kind of common endocrine metabolism disease using the metabolic disorder such as sugar, fat, protein as principal character.In recent years, with people
The factors such as growth in the living standard, living-pattern preservation, the incidence of disease rapid development of global diabetes, diabetes are
Through as the third-largest serious threat human health and the common disease of life after tumour, cardiovascular pathological changes.Diabetes sheet
Body can not necessarily cause to seriously endanger to patient, but long-term blood glucose increases, big blood vessel, capilary are damaged and jeopardize the heart, brain, kidney,
Peripheral nerve, eyes, foot etc., a series of diabetic complication can be caused with patient's course advancement.
Diabetic complication mainly has diabetes, diabetic eye diseases, diabetic nephropathy, diabetic neuropathy, glycosuria
A variety of diseases such as sick cardiovascular pathological changes.Wherein, the concept of diabetes was proposed first in 1956 by Oakley, 1972
Catterall is defined as losing sensibility and losing vigor because of ischemic, the foot of concurrent infection because of DPN.Defend in the world
Raw tissue (WHO) defines：The foot infection related to Lower Distal Extremities dysautonomia and different degrees of peripheral angiopathy, burst
Ulcer and (or) deep tissues destroy.Diabetes are divided into following 5 grades by Wagner stagings：
0 grade：Skin is without open focus.Acra blood supply insufficiency is often shown as, pulsation of foot dorsal artery weakens, and skin is cool, face
Color is purple brown, numb, shouting pain, cusalgia, insensitive or forfeiture, has the high-risk foot performance such as the deformity of toes or foot concurrently.
1 grade：Acra skin has open focus.Blister, blood blister, corn or callosity, frostbite or scald and other skins damage
The caused skin superficial ulcer of wound.But focus not yet involves deep tissue.
2 grades：Infection focus have invaded deep muscle tissue.Often there are cellulitis, multiple purulence stove and tunnel, or sense
Dye expands along spatium intermusculare causes vola, instep connectivity ulcer, and purulent secretion is more, but tendon ligament not yet destroys.
3 grades：Tendon and ligament tissue destroy, and cellulitis merges to form big vomica, and purulent secretion and slough increase
It is more, but destruction of bone still unobvious.
4 grades：Severe infections have resulted in bony defect, osteomyelitis and Bones and joints and destroy or formed pseudarthrosis.
5 grades：The most or all infection of foot or ischemic, cause serious moist or dry necrosis.Acra blackening, corpse are done,
Ordinary wave and ankle-joint and shank.
Diabetic gangrene or amputee are 15-40 times more than common people.The whole world just have within every 30 seconds a diabetic because
Diabetes amputation, and quality of life is decreased obviously after amputation, causes patient with diabetic feet body and mind all to damage, postoperative diabetes
Mortality is very high, and the death rate in 6 months is 20%, and the death rate after amputation 5 years is even as high as 50%-70%.Cause
This, carrying out early prevention and the middle and advanced stage treatment to foot problems in diabetic has important meaning.
At present, treatment of the doctor trained in Western medicine to diabetes is mainly included using insulin and/or OHA control blood glucose, quiet
Arteries and veins improves microcirculation, anti-infective etc. using antibiotic using medicine promoting blood circulation and removing blood stasis, although can alleviate phase to a certain extent
The symptom answered, but can not from be at all it is upper removing sufferer pain.If the symptom that lower limb occur can not still be alleviated and be controlled to treatment
And complication, the result of amputation will eventually occur.
Traditional Chinese medicine thinks, for diabetes mainly due to the ferritic deficiency of Yin, the five internal organs are weak, multiple because of eating and drinking without temperance, overfeeding delicious food,
Disorder of emotion, labor is intended to excessively, and causes deficiency of kidney-YIN, and lung stomach is scorching；Interpretation of the cause, onset and process of an illness emphasis is that the deficiency of Yin is scorching, and using the deficiency of Yin as this, it is dry
Heat is mark；With the passing of time disease is prolonged, yin deficiency affecting yang, deficiency in both YIN and YANG；The deficiency of Yin is scorching, and burn liquid in consumption Tianjin, makes blood viscous, blood is not smooth to be formed
The stasis of blood；Yin deficiency affecting yang, the deficiency of yang is cold solidifying, can also cause positive in hemostasis.This disease is mostly the card of asthenia in origin and asthenia in superficiality, using negative and positive of qi and blood virtual loss as it
This, hindered using network, blood stasis, damp and hot, fiery poison for mark.Diabetes clinically more the performance such as ischemic, peripheral neuropathy, infection.
Especially remotely local skin of soft tissue is rotten to the corn for late period foot or limbs, just be blister or fester, followed by fester go deep into tendon with
Muscle layer, sclerotin is destroyed, necrosis rots, and forms vomica and sinus, discharges dirty smelly secretion, is around swollen in Hypertrophic reality
It is swollen.
Clinical practice in recent years shows that TCM Treatment of Diabetes has larger advantage enough, and obtains significant treatment
Effect, have accumulated rich experience.Compared to doctor trained in Western medicine, Chinese traditional treatment overcome topical antibiotic may caused by resistance drawback, and in
Doctor's external application prescription directly acts on diabetes local lesion, can guide drugs to illness station medicine, and security is higher, side effect compared with
It is few, make considerable part patient from amputation.
The content of the invention
The present inventor, by clinical test for many years, comforms on the basis of to diabetes differential diagnosis in tcm theoretical research
Screened and compounded in more Chinese medicine, obtained the formula of the present invention.
It is an object of the invention to provide a kind of prescription compatibility is scientific and reasonable, curative for effect, easy to use, patient compliance
It is good, have no toxic side effect and the uneasy to recur external medicine composition, its preparation method and application that are used to prevent and treat diabetes.
Specifically, to achieve the above object, the first aspect of the present invention is provided in a kind of external application for preventing and treating diabetes
Drug composition, the Chinese medicine composition include the raw material of following parts by weight：The Chinese medicine composition includes following parts by weight
Raw material：30~150 parts of the Radix Astragali, 15~30 parts of radix cyathulae, 5~15 parts of Radix Angelicae Sinensis, 5~15 parts of Ligusticum wallichii, 5~10 parts of safflower, chicken blood
15~30 parts of rattan, 5~15 parts of rhizoma atractylodis, 15~30 parts of cassia twig, 5~10 parts of asarum, 10~20 parts of rhizoma zingiberis, 5~15 parts of monkshood, Chinese ephedra
5~10 parts, 15~30 parts of rheum officinale, 5~15 parts of golden cypress, 10~20 parts of saltcake, 5~15 parts of Chinese violet, 5~10 parts of vomiting nut,
5~10 parts of radix glycyrrhizae, 5~15 parts of earthworm, 5~15 parts of frankincense, 5~15 parts of myrrh, 5~20 parts of the root of Dahurain angelica, 15~30 parts of spina gleditsiae.
Further, the Chinese medicine composition includes the raw material of following parts by weight：60~120 parts of the Radix Astragali, radix cyathulae 18
~25 parts, 8~12 parts of Radix Angelicae Sinensis, 5~12 parts of Ligusticum wallichii, 5~10 parts of safflower, 18~24 parts of reticulate millettia, 10~15 parts of rhizoma atractylodis, cassia twig 18
~24 parts, 5~10 parts of asarum, 12~16 parts of rhizoma zingiberis, 5~12 parts of monkshood, 5~10 parts of Chinese ephedra, 20~30 parts of rheum officinale, golden cypress 5~
15 parts, 15~20 parts of saltcake, 8~15 parts of Chinese violet, 5~10 parts of vomiting nut, 5~10 parts of radix glycyrrhizae, 10~15 parts of earthworm, frankincense
5~15 parts, 5~12 parts of myrrh, 10~20 parts of the root of Dahurain angelica, 15~25 parts of spina gleditsiae.
Further, the parts by weight of each raw material are：It is 100 parts of the Radix Astragali, 20 parts of radix cyathulae, 10 parts of Radix Angelicae Sinensis, 9 parts of Ligusticum wallichii, red
Spend 8 parts, 20 parts of reticulate millettia, 15 parts of rhizoma atractylodis, 20 parts of cassia twig, 6 parts of asarum, 15 parts of rhizoma zingiberis, 10 parts of monkshood, 5 parts of Chinese ephedra, rheum officinale 22
Part, 12 parts of golden cypress, 15 parts of saltcake, 11 parts of Chinese violet, 7 parts of vomiting nut, 10 parts of radix glycyrrhizae, 12 parts of earthworm, 10 parts of frankincense, myrrh 8
Part, 16 parts of the root of Dahurain angelica, 20 parts of spina gleditsiae.
Further, the Chinese medicine composition when in use, can add one or more for improving or treating accompanying symptoms
Chinese medicine.
Further, powder agent or paste is made in the Chinese medicine composition.
The second aspect of the present invention provides a kind of preparation method of the external medicine composition of above-mentioned preventing and treating diabetes,
The Chinese medicine composition is powder agent, and its preparation method is：
The raw material of the corresponding parts by weight after drying is weighed according to composition proportioning, pulverizer crosses 40~60 mesh after crushing
Sieve, it is well mixed, produces the powder agent finished product of the medicine.
Application method：Above-mentioned 50~55 grams of powder agent finished product is weighed, adds appropriate amount of water (can be dipped into the water surface after decoction in foot
The amount of external malleolus is defined), soak 10 minutes, boil 20 minutes, place cooling, fluid temperature is maintained 40 degree, both feet are put into
Soaked 30~45 minutes in decoction.Bubble pin 2 times daily, 30 days are a course for the treatment of.Suitable for 0 grade diabetes of the foot without ulcer surface
Sufficient patient.
Further, the Chinese medicine composition is paste, and its preparation method is：
Weigh the raw materials of the corresponding parts by weight after drying according to composition proportioning, coarse crushing, add raw material gross weight 6~
The water of 8 times of amounts, 1~2h of decoction, filtrations, the water of 3~4 times of amounts of raw material gross weight are added in filter residue, decoct 0.5~1h, are filtered,
Merging decocts filtrate twice, and relative density is 1.18~1.22 clear cream when filtrate is concentrated into 70 DEG C, and pharmacy is added in clear cream
Upper acceptable carrier, is stirred and evenly mixed, micro- refining, and it is 1.48~1.55 to receive cream to relative density, cooling, produces the paste of the medicine
Finished product.
Wherein, carrier refers to the conventional pharmaceutical carrier of pharmaceutical field.It is preferred that vaseline or glycerine.
Application method：Paste is uniformly applied into affected area, three times a day, 30 days are a course for the treatment of.Go out suitable for foot
More than 1 grade patient with diabetic feet of existing ulcer surface.
The third aspect of the present invention provides a kind of above-mentioned external medicine composition and is preparing the medicine of preventing and treating diabetes
In application.
The pharmacological effect of each taste Chinese medicine is as follows selected by the present invention：
The Radix Astragali：It is sweet, tepor.Return lung, courage, spleen, large intestine, small intestinl channel.With invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic,
The effect of inducing diuresis for removing edema.For treating treatment deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst,
Burst for a long time and does not holds back, blood deficiency chlorosis, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..Astragalus root invigorating middle warmer and replenishing QI, raw solid table support
Sore.
Radix cyathulae：Sweet, slight bitter, it is mild-natured.Return liver and kidney channel.Surname dissipate drop is let out, and has invigorate blood circulation, dispelling wind and eliminating dampness, and tonneau closes
Section, the effect of inducing diuresis for treating strangurtia.
Radix Angelicae Sinensis：It is sweet, pungent, it is warm-natured.Return liver, the heart, the spleen channel.Major function：Replenishing and activating blood, menstruction regulating and pain relieving, relax bowel.With
In blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, carbuncle
Subcutaneous ulcer sore.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.
Ligusticum wallichii：Acrid flavour, it is warm-natured.Return liver, courage, the heart channel of Hang-Shaoyin.Be usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, Ligusticum wallichii pungent-warm perfume (or spice) is dry, walk and
Do not keep, can go scattered, up reachable mountain peak top；Enter blood system, the descending reachable sea of blood again.Promoting blood circulation effect is extensive, suitable hemostasis resistance
Stagnant various illnesss；Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as head wind headache, arthralgia pain due to rheumatism.It is the gas in blood that former times people, which calls Ligusticum wallichii,
Medicine, nearly say its function such as pungent scattered, Xie Yu, sensible, analgesic of residing.
Safflower：Acrid flavour, it is warm-natured.The thoughts of returning home, Liver Channel.Major function：Invigorate blood circulation, blood stasis removing analgesic.For Amenorrhea, dysmenorrhoea, dislike
Reveal not all right, abdominal mass lump in the abdomen, injury from falling down, sore swell and ache curative.
Reticulate millettia：It is bitter, sweet, it is warm-natured.Return liver and kidney channel.Major function：Enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, blood
Empty sallow, paralysis and numbness, arthralgia pain due to rheumatism.
Rhizoma atractylodis：Acrid flavour, hardship, it is warm-natured.Returns spleen, stomach, Liver Channel.Major function：It is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For gastral cavity
Distention and fullness in the abdomen, diarrhea, oedema, tinea pedis Wei lame, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia.
Cassia twig：It is acrid flavour, sweet, it is warm-natured.The thoughts of returning home, lung, bladder warp.Major function：Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi,
Flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.
Asarum：Acrid flavour, it is warm-natured.The thoughts of returning home, lung, kidney channel.Major function：Expelling wind and clearing away cold, sensible analgesic, Wenfei of drink.For
Anemofrigid cold, have a headache, toothache, nasosinusitis of having a stuffy nose, arthralgia pain due to rheumatism, sputum cough.
Rhizoma zingiberis：Acrid flavour, property heat.Returns spleen, stomach, kidney, the heart, lung channel.Major function：Rhizoma zingiberis warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness
Dissolving phlegm.For coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb, sputum cough.
Monkshood：Acrid flavour, hardship, property heat.The thoughts of returning home, liver,kidney,spleen warp.With dispelling wind and eliminating dampness, the effect of antalgic.Cure mainly：With
In wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain and narcotic analgesic.
Chinese ephedra：Acrid flavour, slight bitter, it is warm-natured.Return lung warp, bladder warp.Effect and effect：Sweating cold dispelling, freeing lung and relieving asthma, Li Shui disappears
It is swollen.Belong to the warm-pungent diaphoretic drug of diaphoretic medicine subordinate classification.
Rheum officinale：Bitter, it is cold in nature.Returns spleen, stomach, large intestine, liver, pericardium channel.Major function：Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, by the stasis of blood
Stimulate the menstrual flow.For real heat constipation, stagnate stomachache, and rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells
Furunculosis, blood stasis closed, traumatic injury, scald is controlled outside；UGB.Prepared RADIX ET RHIZOMA RHEI with wine is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For
Hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, exerts oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.With
There is stasis of blood haemorrhage in blood-head.
Golden cypress：Bitter, it is cold in nature.Return kidney, bladder warp.Major function：Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For wet
Hot rush down dysentery, jaundice, under band, heat gonorrhea, tinea pedis, impotence { wards off }, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution
Nourishing Yin and falling fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
Saltcake：Taste is salty, bitter, cold in nature.Return stomach, large intestine channel.Major function：Purgating heat and bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.With
In real heat constipation, dry feces, stagnate stomachache, acute appendicitis swelling and pain；Control acute mastitis, hemorrhoid gall outside.
Chinese violet：It is bitter, pungent, it is cold in nature.The thoughts of returning home, lung channel.With clearing heat and detoxicating, cool blood detumescence, the effect of clearing heat and promoting diuresis,
Cure mainly furunculosis, carbuncle swells, scrofula, jaundice, dysentery, diarrhoea, hot eyes, larynx numbness, venomous snake bite.
Vomiting nut：Bitter, it is warm-natured.Return liver, the spleen channel.With removing obstruction in channels to relieve pain, the effect of mass dissipating and swelling eliminating.Cure mainly：Traumatic injury,
Fracture swelling and pain, rheumatoid arthritis stubborn, paralysis and numbness, skin sore, abscess of throat.
Radix glycyrrhizae：Nature and flavor are sweet, mild-natured.The thoughts of returning home, lung, spleen, stomach.Major function：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing,
Relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction,
Carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
Earthworm：Taste is salty, cold in nature.Return liver, spleen, bladder warp.Major function：Heat-clearing is calmed the frightened, and dredging collateral, is relievingd asthma, diuresis.For height
Hot coma, twitch, joint pain, extremity numbness, hemiplegia, dyspnea and cough due to lung-heat, oliguria oedema, hypertension.
Frankincense：Nature and flavor are pungent, bitter, temperature.The thoughts of returning home, liver, the spleen channel.Effect：Blood-activating and qi-promoting relieves pain, detumescence and promoting granulation.Cure mainly：For chest
Numbness is pained, gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis, abdominal mass stomachache, arthralgia pain due to rheumatism, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore
Ulcer.
Myrrh：Acrid flavour, hardship, it is mild-natured.The thoughts of returning home, liver, the spleen channel.Effect：Scattered stasis pain, detumescence and promoting granulation.Cure mainly：For the obstruction of qi in the chest heart
Bitterly, the illnesss such as gastral cavity pain, dysmenorrhoea Amenorrhea postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore are controlled
Treat.
The root of Dahurain angelica：Acrid flavour, it is warm-natured.Return stomach, large intestine, lung channel.Major function：Dehumidifying, sensible analgesic, detumescence and apocenosis.For feeling
Emit headache, pain in the supra-orbital bone, nasal obstruction, nasosinusitis, toothache, leukorrhea, sore swell and ache curative.
Spina gleditsiae：Acrid flavour, it is warm-natured.Return liver, stomach.Major function：Detumescence eliminating toxic, apocenosis, desinsection.For ulcer from the beginning of or
Purulence is not into bursting；Control mange leprosy outside.
The invention has the advantages that：
1st, the present invention is by all dialectical compatibilities of taste Chinese medicine, mutually auxiliary help, wherein, Radix Astragali tonifying middle-Jiao and Qi is monarch drug in a prescription；Radix cyathulae,
Radix Angelicae Sinensis, Ligusticum wallichii, safflower, reticulate millettia activate blood circulation and disperse blood clots as ministerial drug；Rhizoma atractylodis, cassia twig, asarum, rhizoma zingiberis, monkshood, Chinese ephedra clearing damp cold dispelling are assistant
Medicine；Rheum officinale, golden cypress, saltcake, Chinese violet, vomiting nut, radix glycyrrhizae, earthworm, frankincense, myrrh, the root of Dahurain angelica, spina gleditsiae are clearing heat and detoxicating, dispel
Necrotic tissue and promoting muscle growing is makes medicine, the effect of playing blood-activating and qi-promoting, warming channel and expelling cold, stasis-dispelling and pain-killing, clearing heat and detoxicating, putrefaction-removing granulation-promoting altogether.To diabetes
The prevention and treatment of foot has good efficacy, for 0 grade of patient with diabetic feet without ulcer surface, is carried out using the powder agent of the present invention
Lavipeditum is treated, and has the health-care effect built up health, control diabetes to develop；For more than 1 grade glycosuria of existing ulcer surface
Foot disease patient, treatment is coated using the paste of the present invention, patient pain's sense, the infection of control sore face, improvement office can be mitigated
Portion's microcirculation, strengthen the two-way transhipment function of endothelial cell, improve perineural conduction of velocity, promotion organization reparation and the surface of a wound
Healing.
2nd, raw material of the invention is easy to get and cost is low, and preparation method is simple and easy to operate, and obtained Chinese medicine composition is to glycosuria
The prevention and treatment of foot disease is curative for effect, has no toxic side effect, patient's difficulty in relapse after healing.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
A kind of external medicine composition for preventing and treating diabetes, include the raw material of following parts by weight：30 parts of the Radix Astragali, river ox
15 parts of knee, 5 parts of Radix Angelicae Sinensis, 5 parts of Ligusticum wallichii, 5 parts of safflower, 15 parts of reticulate millettia, 5 parts of rhizoma atractylodis, 15 parts of cassia twig, 5 parts of asarum, 10 parts of rhizoma zingiberis,
5 parts of monkshood, 5 parts of Chinese ephedra, 15 parts of rheum officinale, 5 parts of golden cypress, 10 parts of saltcake, 5 parts of Chinese violet, 5 parts of vomiting nut, 5 parts of radix glycyrrhizae, earthworm 5
Part, 5 parts of frankincense, 5 parts of myrrh, 5 parts of the root of Dahurain angelica, 15 parts of spina gleditsiae.
The preparation method and application method of the Chinese medicine composition powder agent of the present embodiment are as follows：
Each raw material after drying is weighed according to above-mentioned parts by weight, pulverizer is crossed 40~60 mesh sieves after crushing, is well mixed,
Produce the powder agent finished product of the medicine；Above-mentioned 50~55 grams of powder agent is weighed, adds appropriate amount of water that (foot can be dipped into the water surface after decoction
The amount of medial and lateral malleolus is defined), soak 10 minutes, boil 20 minutes, place cooling, fluid temperature is maintained 40 degree, both feet are put
Into the liquid immersion 30~45 minutes.Bubble pin 2 times daily, 30 days are a course for the treatment of.
The preparation method and application method of the Traditional Chinese medicine composition paste of the present embodiment are as follows：
Each raw material after drying is weighed according to above-mentioned parts by weight, coarse crushing, the water of 7 times of amounts of raw material gross weight is added, decocts
1.5h is boiled, is filtered, the water of 3 times of amounts of raw material gross weight is added in filter residue, 0.5h is decocted, filtration, merges decoction liquor twice, filtrate
Relative density is 1.20 clear cream when being concentrated into 70 DEG C, and vaseline is added in clear cream, is stirred and evenly mixed, micro- refining, receives cream to relative
Density is 1.50, cooling, produces the paste finished product of the medicine.Above-mentioned paste is uniformly coated on affected area, thickness is 0.2 li
Rice or so, three times a day, 30 days are a course for the treatment of.
Embodiment 2
A kind of external medicine composition for preventing and treating diabetes, include the raw material of following parts by weight：60 parts of the Radix Astragali, river ox
18 parts of knee, 6 parts of Radix Angelicae Sinensis, 8 parts of Ligusticum wallichii, 5 parts of safflower, 15 parts of reticulate millettia, 5 parts of rhizoma atractylodis, 18 parts of cassia twig, 5 parts of asarum, 12 parts of rhizoma zingiberis,
5 parts of monkshood, 8 parts of Chinese ephedra, 18 parts of rheum officinale, 8 parts of golden cypress, 12 parts of saltcake, 8 parts of Chinese violet, 5 parts of vomiting nut, 5 parts of radix glycyrrhizae, earthworm 5
Part, the preparation method of Chinese medicine composition of 10 parts of frankincense, 5 parts of myrrh, 5 parts of the root of Dahurain angelica, 15 parts of spina gleditsiae, the present embodiment, user
Method is the same as embodiment 1.
Embodiment 3
A kind of external medicine composition for preventing and treating diabetes, include the raw material of following parts by weight：90 parts of the Radix Astragali, river ox
22 parts of knee, 10 parts of Radix Angelicae Sinensis, 12 parts of Ligusticum wallichii, 5 parts of safflower, 18 parts of reticulate millettia, 10 parts of rhizoma atractylodis, 20 parts of cassia twig, 8 parts of asarum, rhizoma zingiberis 15
Part, 9 parts of monkshood, 8 parts of Chinese ephedra, 23 parts of rheum officinale, 12 parts of golden cypress, 16 parts of saltcake, 10 parts of Chinese violet, 8 parts of vomiting nut, 6 parts of radix glycyrrhizae,
10 parts of earthworm, 12 parts of frankincense, 10 parts of myrrh, 10 parts of the root of Dahurain angelica, 20 parts of spina gleditsiae.
The preparation method of the Chinese medicine composition of the present embodiment, application method are the same as embodiment 1.
Embodiment 4
A kind of external medicine composition for preventing and treating diabetes, include the raw material of following parts by weight：100 parts of the Radix Astragali, river
20 parts of the root of bidentate achyranthes, 10 parts of Radix Angelicae Sinensis, 9 parts of Ligusticum wallichii, 8 parts of safflower, 20 parts of reticulate millettia, 15 parts of rhizoma atractylodis, 20 parts of cassia twig, 6 parts of asarum, rhizoma zingiberis 15
Part, 10 parts of monkshood, 5 parts of Chinese ephedra, 22 parts of rheum officinale, 12 parts of golden cypress, 15 parts of saltcake, 11 parts of Chinese violet, 7 parts of vomiting nut, radix glycyrrhizae 10
Part, 12 parts of earthworm, 10 parts of frankincense, 8 parts of myrrh, 16 parts of the root of Dahurain angelica, 20 parts of spina gleditsiae.
The preparation method of the Chinese medicine composition of the present embodiment, application method are the same as embodiment 1.
Embodiment 5
A kind of external medicine composition for preventing and treating diabetes, include the raw material of following parts by weight：120 parts of the Radix Astragali, river
It is 25 parts of the root of bidentate achyranthes, 10 parts of Radix Angelicae Sinensis, 12 parts of Ligusticum wallichii, 10 parts of safflower, 25 parts of reticulate millettia, 12 parts of rhizoma atractylodis, 25 parts of cassia twig, 10 parts of asarum, dry
It is 18 parts of ginger, 13 parts of monkshood, 10 parts of Chinese ephedra, 28 parts of rheum officinale, 15 parts of golden cypress, 18 parts of saltcake, 12 parts of Chinese violet, 8 parts of vomiting nut, sweet
9 parts of grass, 15 parts of earthworm, 12 parts of frankincense, 10 parts of myrrh, 15 parts of the root of Dahurain angelica, 25 parts of spina gleditsiae.
The preparation method of the Chinese medicine composition of the present embodiment, application method are the same as embodiment 1.
Embodiment 6
A kind of external medicine composition for preventing and treating diabetes, include the raw material of following parts by weight：150 parts of the Radix Astragali, river
It is 30 parts of the root of bidentate achyranthes, 15 parts of Radix Angelicae Sinensis, 15 parts of Ligusticum wallichii, 10 parts of safflower, 30 parts of reticulate millettia, 15 parts of rhizoma atractylodis, 30 parts of cassia twig, 10 parts of asarum, dry
20 parts of ginger, 15 parts of monkshood, 10 parts of Chinese ephedra, 30 parts of rheum officinale, 15 parts of golden cypress, 20 parts of saltcake, 15 parts of Chinese violet, 10 parts of vomiting nut,
10 parts of radix glycyrrhizae, 15 parts of earthworm, 15 parts of frankincense, 15 parts of myrrh, 20 parts of the root of Dahurain angelica, 30 parts of spina gleditsiae,
The preparation method of the Chinese medicine composition of the present embodiment, application method are the same as embodiment 1.
Test example
In order to show therapeutic effect of the Chinese medicine composition of the present invention to the patient with diabetic feet of different stage, the present invention enters
Following clinical trial is gone.
1st, patient data：In August, 2015 is chosen to the patient with diabetic feet 100 of hospitalization during in October, 2016.
Wherein, man 68, female 32 is age 49-85 year, average 61.2 years old, diabetic duration：6-15, the diabetes course of disease：4 weeks-
5 years, sufferer was without other serious diseases.Meet the diagnostic criteria of diabetes, according to clinical rating scales (Wagner classifications),
26,1 grade of wherein 0 grade (no ulcer) (superficial ulcer) 38,2 grades (deep ulcer but formed without abscess and bone involvement) 18,3
Level (deep ulcer such as cellulitis or abscess are involved formed with bone) 12,4 grades (local necrosis) 6.
2nd, criterion of therapeutical effect
Cure：Patient is after treatment, clinical symptom disappearance, and 0 grade of patient skin coloration recovers normal, more than 1 grade patient
Ulcer heals completely.
It is effective：Patient is after treatment, clinical symptom disappearance, and 0 grade of patient skin recovers normal, more than 1 grade patient's ulcer
Face is largely restored.
Effectively：Patient is after treatment, and clinical symptoms take a turn for the better, 0 grade of patient skin coloration's gradual change to pale red, more than 1 grade
Patient's ulcer surface fraction is restored, and has new granulation tissue to grow.
It is invalid：After treatment, skin color does not change patient, and ulcer surface is not restored.
3rd, treatment method
For 0 grade of patient with diabetic feet without ulcer, lavipeditum treatment, daily bubble are carried out using the powder agent of the present embodiment 4
Pin 2 times, 30 days are a course for the treatment of.Entered for more than 1 grade patient with diabetic feet of existing ulcer surface using the paste of the present embodiment 4
Row applies applying treatment, and three times a day, 30 days are a course for the treatment of.Coordinate following treatment method while above-mentioned treatment by Chinese herbs：1) pancreas islet
Extract for treating, make glycemic control between 7~9mmol/L；2) concurrent infection person, anti-inflammatory and symptomatic treatment are given；3) for suffering from foot
The surface of a wound does corresponding processing.
4th, treatment results
Using Chinese medicine composition of the present invention, original symptom substantially mitigates.According to statistics, 0 grade and the lighter diabetes of other symptoms
Sufficient patient, a course for the treatment of can cure, and after using two courses for the treatment of, cure 72, account for 72%；Effective 17, account for 17%；Effectively
11, account for 11%；Without invalid situation.
In above-mentioned clinical test, inspection has been done to the blood urine routine before and after patient medication, hepatic and renal function, electrocardiogram etc. simultaneously
Details are recorded, contrast is no abnormal, it is seen that the Chinese medicine composition has no toxic side effect.Above-mentioned case is paid a return visit after 1 year,
Without patients with recurrent.
Although above with general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (9)
1. a kind of external medicine composition for preventing and treating diabetes, it is characterised in that the Chinese medicine composition includes following weight
The raw material of number：30~150 parts of the Radix Astragali, 15~30 parts of radix cyathulae, 5~15 parts of Radix Angelicae Sinensis, 5~15 parts of Ligusticum wallichii, 5~10 parts of safflower,
15~30 parts of reticulate millettia, 5~15 parts of rhizoma atractylodis, 15~30 parts of cassia twig, 5~10 parts of asarum, 10~20 parts of rhizoma zingiberis, 5~15 parts of monkshood,
5~10 parts of Chinese ephedra, 15~30 parts of rheum officinale, 5~15 parts of golden cypress, 10~20 parts of saltcake, 5~15 parts of Chinese violet, vomiting nut 5~10
Part, 5~10 parts of radix glycyrrhizae, 5~15 parts of earthworm, 5~15 parts of frankincense, 5~15 parts of myrrh, 5~20 parts of the root of Dahurain angelica, spina gleditsiae 15~30
Part.
2. the external medicine composition of preventing and treating diabetes according to claim 1, it is characterised in that the Chinese traditional medicine composition
Thing includes the raw material of following parts by weight：60~120 parts of the Radix Astragali, 18~25 parts of radix cyathulae, 8~12 parts of Radix Angelicae Sinensis, Ligusticum wallichii 5~12
Part, 5~10 parts of safflower, 18~24 parts of reticulate millettia, 10~15 parts of rhizoma atractylodis, 18~24 parts of cassia twig, 5~10 parts of asarum, rhizoma zingiberis 12~
16 parts, 5~12 parts of monkshood, 5~10 parts of Chinese ephedra, 20~30 parts of rheum officinale, 5~15 parts of golden cypress, 15~20 parts of saltcake, Chinese violet 8
~15 parts, 5~10 parts of vomiting nut, 5~10 parts of radix glycyrrhizae, 10~15 parts of earthworm, 5~15 parts of frankincense, 5~12 parts of myrrh, the root of Dahurain angelica 10
~20 parts, 15~25 parts of spina gleditsiae.
3. the external medicine composition of preventing and treating diabetes according to claim 1, it is characterised in that the weight of each raw material
Number is：100 parts of the Radix Astragali, 20 parts of radix cyathulae, 10 parts of Radix Angelicae Sinensis, 9 parts of Ligusticum wallichii, 8 parts of safflower, 20 parts of reticulate millettia, 15 parts of rhizoma atractylodis, cassia twig
20 parts, 6 parts of asarum, 15 parts of rhizoma zingiberis, 10 parts of monkshood, 5 parts of Chinese ephedra, 22 parts of rheum officinale, 12 parts of golden cypress, 15 parts of saltcake, Chinese violet 11
Part, 7 parts of vomiting nut, 10 parts of radix glycyrrhizae, 12 parts of earthworm, 10 parts of frankincense, 8 parts of myrrh, 16 parts of the root of Dahurain angelica, 20 parts of spina gleditsiae.
4. the external medicine composition of preventing and treating diabetes according to claim 1, it is characterised in that the Chinese medicine composition
When in use, one or more Chinese medicines for being used to improving or treating accompanying symptoms can be added.
5. the external medicine composition of the preventing and treating diabetes according to any one of Claims 1 to 4 claim, its feature
It is, powder agent or paste is made in the Chinese medicine composition.
A kind of 6. preparation method of the external medicine composition of the preventing and treating diabetes described in claim 5, it is characterised in that institute
It is powder agent to state Chinese medicine composition, and its preparation method is：
The raw material of the corresponding parts by weight after drying is weighed according to composition proportioning, pulverizer is crossed 40~60 mesh sieves after crushing, mixed
Close the powder agent finished product for uniformly, producing the medicine.
7. the preparation method of the external medicine composition of preventing and treating diabetes according to claim 6, it is characterised in that institute
It is paste to state Chinese medicine composition, and its preparation method is：
The raw material of the corresponding parts by weight after drying is weighed according to composition proportioning, coarse crushing, adds 6~8 times of raw material gross weight
The water of amount, 1~2h is decocted, filtration, the water of 3~4 times of amounts of raw material gross weight is added in filter residue, decocts 0.5~1h, is filtered, is closed
And decoction liquor twice, relative density is 1.18~1.22 clear cream when decoction liquor is concentrated into 70 DEG C, is added pharmaceutically in clear cream
Acceptable carrier, is stirred and evenly mixed, micro- refining, and it is 1.48~1.55 to receive cream to relative density, cooling, produce the paste of the medicine into
Product.
8. the preparation method of the external medicine composition of preventing and treating diabetes according to claim 7, it is characterised in that institute
It is vaseline or glycerine to state carrier.
9. application of the external medicine composition in the medicine for preparing preventing and treating diabetes described in claim 1.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210693A (en) * | 2018-03-22 | 2018-06-29 | 吴蓓莉 | For the Chinese medicine composition of diabetes |
| CN109316596A (en) * | 2018-11-30 | 2019-02-12 | 中商国能孵化器集团有限公司 | A kind of pharmaceutical composition and the preparation method and application thereof for treating diabetic complication |
| CN109908319A (en) * | 2019-04-09 | 2019-06-21 | 彭松云 | The Chinese medicinal lotion for treating hand, sufficient dermal chronic ulcer |
| CN112076246A (en) * | 2020-09-28 | 2020-12-15 | 广东工商职业技术大学 | Traditional Chinese medicine composition for treating early diabetic foot external treatment |
| CN115501289A (en) * | 2022-11-10 | 2022-12-23 | 四川龙马药业有限公司 | Traditional Chinese medicine composition and traditional Chinese medicine pad for relieving pain and bleeding and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682617B2 (en) * | 2005-11-10 | 2010-03-23 | Jose Angel Olalde Rangel | Synergistic phytoceutical compositions |
-
2017
- 2017-11-27 CN CN201711205856.2A patent/CN107693767B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682617B2 (en) * | 2005-11-10 | 2010-03-23 | Jose Angel Olalde Rangel | Synergistic phytoceutical compositions |
Non-Patent Citations (2)
| Title |
|---|
| 张新霞等: "自拟中药浴足方治疗早期糖尿病足患者42例", 《中国老年学杂志》 * |
| 王宇: "从痰瘀论治2型糖尿病的临床体会", 《四川中医》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210693A (en) * | 2018-03-22 | 2018-06-29 | 吴蓓莉 | For the Chinese medicine composition of diabetes |
| CN109316596A (en) * | 2018-11-30 | 2019-02-12 | 中商国能孵化器集团有限公司 | A kind of pharmaceutical composition and the preparation method and application thereof for treating diabetic complication |
| CN109908319A (en) * | 2019-04-09 | 2019-06-21 | 彭松云 | The Chinese medicinal lotion for treating hand, sufficient dermal chronic ulcer |
| CN112076246A (en) * | 2020-09-28 | 2020-12-15 | 广东工商职业技术大学 | Traditional Chinese medicine composition for treating early diabetic foot external treatment |
| CN115501289A (en) * | 2022-11-10 | 2022-12-23 | 四川龙马药业有限公司 | Traditional Chinese medicine composition and traditional Chinese medicine pad for relieving pain and bleeding and preparation method thereof |
| CN115501289B (en) * | 2022-11-10 | 2023-12-12 | 鄢静 | Chinese medicinal composition and pad for relieving pain and blood permeation and preparation method thereof |
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| CN107693767B (en) | 2020-10-27 |
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