CN115501289B - Chinese medicinal composition and pad for relieving pain and blood permeation and preparation method thereof - Google Patents
Chinese medicinal composition and pad for relieving pain and blood permeation and preparation method thereof Download PDFInfo
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- CN115501289B CN115501289B CN202211405557.4A CN202211405557A CN115501289B CN 115501289 B CN115501289 B CN 115501289B CN 202211405557 A CN202211405557 A CN 202211405557A CN 115501289 B CN115501289 B CN 115501289B
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Abstract
The invention discloses a traditional Chinese medicine composition for relieving pain and bleeding and a preparation method thereof, relates to the field of medicines, and solves the problems of poor product effect and high cost in the field of traditional analgesic traditional Chinese medicines and analgesic traditional Chinese medicine pads, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 25-45 parts of amur corktree bark, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of viola philippica, 25-45 parts of platycodon grandiflorum, 25-45 parts of szechuan lovage rhizome, 25-45 parts of cassia twig and 22-24 parts of raw liquorice; the invention also relates to a preparation method of the traditional Chinese medicine composition and a preparation method of a traditional Chinese medicine pad based on the traditional Chinese medicine composition, by compatibility of various traditional Chinese medicines, pure traditional Chinese medicines are taken as raw materials, and all the raw materials are synergistic, so that pain is effectively improved, pain is relieved, inflammation is reduced, wound healing is promoted, and a new medicine selection is provided for nursing of clinical anorectal operation wounds.
Description
Technical Field
The invention relates to the field of medicines, in particular to the field of traditional Chinese medicine compositions for relieving pain and bleeding.
Background
Pain and discomfort in patients after anorectal surgery is generally treated with analgesic drugs, including oral drugs and topical drugs, such as: oral ibuprofen capsules and local lidocaine gel can be used for cleaning anus incision by hip bath, and potassium permanganate solution can be used for cleaning anus incision in a hip bath, so that most patients have psychological dependence on analgesic, and most oral medicines and local analgesic have great liver and kidney functions and gastrointestinal irritation.
Therefore, in order to cope with the symptoms of pain and bleeding after anorectal surgery, the traditional Chinese medicine pad is inconvenient to carry, is complex to use and high in cost after the patient leaves home, and has a plurality of inconveniences for the patient because the patient has to exchange medicine in anorectal surgery or wound clinic.
Therefore, the existing traditional Chinese medicine for relieving pain after anorectal operation and the product in the field of the traditional Chinese medicine pad for relieving pain have poor effect and high cost.
Disclosure of Invention
The invention aims at: in order to solve the problems of poor effect and high cost of the traditional Chinese medicine for relieving pain and pain after anorectal operation and the traditional Chinese medicine pad field, the invention provides the traditional Chinese medicine composition for relieving pain and bleeding, the traditional Chinese medicine pad and the preparation method thereof, and the traditional Chinese medicine pad is convenient to use and replace and can effectively improve pain, relieve pain and diminish inflammation and promote wound healing through compatibility of various traditional Chinese medicinal materials.
The invention adopts the following technical scheme for realizing the purposes:
the traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 25-45 parts of amur corktree bark, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of viola philippica, 25-45 parts of platycodon grandiflorum, 25-45 parts of szechuan lovage rhizome, 25-45 parts of cassia twig and 22-24 parts of raw liquorice.
Optionally, the composition comprises the following components in parts by weight: 30 parts of phellodendron, 20 parts of mirabilite, 20 parts of alum, 20 parts of viola yedoensis, 20 parts of platycodon grandiflorum, 20 parts of ligusticum wallichii, 20 parts of cassia twig and 30 parts of raw liquorice.
The invention also provides a preparation method of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps: according to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition is obtained.
The invention also provides a preparation method of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps:
s1, taking a first preset amount of finished traditional Chinese medicine composition, filling the finished traditional Chinese medicine composition into a non-woven fabric bag, and sealing the non-woven fabric bag to prepare a medicine bag;
s2, placing the medicine bag into a medicine bag accommodating bag, and arranging a reinforcing component on the medicine bag accommodating bag to obtain the traditional Chinese medicine pad.
Optionally, the first preset amount is 3-5g.
The invention also provides an application of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps:
s1, opening a reinforcing component of a traditional Chinese medicine pad to fix the traditional Chinese medicine pad on underwear corresponding to a wound;
s2, dripping a second preset amount of physiological saline on the medicine bag.
Optionally, the second preset amount is 2-3ml.
Optionally, the physiological saline is 0.9% physiological saline.
Optionally, the application of the traditional Chinese medicine pad for relieving pain and bleeding further comprises the step of arranging an autothermal patch on one side of the underwear far away from the traditional Chinese medicine pad for heating the pad with the clothing interposed therebetween.
The beneficial effects of the invention are as follows:
1. the invention relates to a traditional Chinese medicine composition for relieving pain and bleeding, which has the effects of resisting bacteria and diminishing inflammation of phellodendron, detumescence and hemostasis of mirabilite and alum, improving immunity of a patient and improving wound healing capacity of the patient, and the antibacterial effect of platycodon grandiflorum and phellodendron, wherein the ligusticum wallichii, the cassia twig and the raw licorice are matched for further relieving pain and hemostasis, so that the traditional Chinese medicine composition can perform antibacterial and anti-inflammatory effects, stop bleeding and relieving pain and promote wound healing from multiple dimensions.
According to the invention, pure traditional Chinese medicines are taken as raw materials, the raw materials are synergistic, and cortex phellodendri, herba violae, platycodon grandiflorum, ramulus cinnamomi and raw liquorice added in the raw materials all contain rich amino acids and active enzymes, so that the immunity can be improved, and the wound healing capacity of a patient is improved; the berberine contained in the phellodendron can effectively obtain antifungal, antiviral and antibacterial effects, so that the traditional Chinese medicine composition has good antibacterial and anti-inflammatory effects, and the added alum and phellodendron cooperate to enhance the hemostatic effect of the composition; further, the platycodin rich in platycodon grandiflorum is matched with berberine, so that the antibacterial effect of the berberine is enhanced; the rhizoma ligustici wallichii contains alkaloid ligustrazine and glycyrrhizin in raw liquorice which are matched with cassia twig aldehyde in cassia twig, so that the antibacterial, antiviral and analgesic effects of the cassia twig are enhanced. The traditional Chinese medicine composition is subjected to antibiosis and antiphlogosis through multiple dimensions, and various components are cooperated to form an effective component for antibiosis, antiphlogosis and antalgic, so that pain is effectively improved, pain is relieved, inflammation is relieved, wound healing is promoted, pain and bleeding of a wound after anorectal operation are relieved, operation pain of a patient is relieved, time for wound pain, bleeding and swelling is shortened, and a new medicine selection is provided for nursing of clinical anorectal operation wounds. Solves the problems of poor product effect and high cost in the traditional Chinese medicine field for relieving pain after anorectal operation.
The traditional Chinese medicine composition for relieving pain and bleeding is an external medicine for relieving pain, bleeding and swelling of wounds after anorectal surgery, can replace excessive dependence of patients on oral administration and intramuscular injection of analgesics after surgery, directly relieves pain, bleeding and swelling after surgery on local wounds, reduces toxic and side effects, and provides a safe and reliable new choice for clinical medication.
2. The preparation method of the traditional Chinese medicine pad for relieving pain and bleeding is simple, low in manufacturing cost and high in convenience. The traditional Chinese medicine composition is arranged in the non-woven fabric bag, so that medicines are concentrated and not spilled, the non-woven fabric bag is fixed in the medicine container bag, the medicines are released slowly, the use of the medicine pad is facilitated due to the arrangement of the reinforcing component, and the medicine absorption efficiency is enhanced.
3. The traditional Chinese medicine pad for relieving pain and bleeding has the advantages of simple use mode, extremely high convenience, convenient replacement and enhanced superiority. When the medicine pad is required to be used, the reinforcing component is opened and fixed, the medicine pad is fixed at the position of the corresponding wound of the underwear, the medicine pad can be used by dripping normal saline, and after the normal saline enters the medicine bag, the traditional Chinese medicine composition in the medicine bag is materialized and opened, so that the wound can be conveniently and rapidly absorbed by the wound from the non-woven fabric bag of the medicine bag. After the use, the reinforcing component is discharged, and the traditional Chinese medicine pad is taken down from the underwear, so that the traditional Chinese medicine pad can be replaced and is convenient to replace.
Drawings
FIG. 1 is a block diagram of a traditional Chinese medicine pad for relieving pain and bleeding, which is related to the invention;
fig. 2 is a reference schematic diagram of an application of a traditional Chinese medicine pad for relieving pain and bleeding.
1-medicine bag, 2-medicine bag accommodating bag, 3-reinforcing component, 4-underwear, 5-heating patch or pressurizing patch.
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Detailed Description
The patient can have pain and bleeding of wounds after anorectal surgery, so that the pain of the patient during surgery is relieved, the time for pain, bleeding and swelling of the wounds is shortened, and the medicine pad can be used.
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 25-45 parts of amur corktree bark, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of viola philippica, 25-45 parts of platycodon grandiflorum, 25-45 parts of szechuan lovage rhizome, 25-45 parts of cassia twig and 22-24 parts of raw liquorice.
It can be understood that the phellodendron added in the invention has bitter taste and cold property; the Chinese medicinal composition has the effects of clearing heat, drying dampness, purging pathogenic fire and removing toxin after entering kidney, bladder and large intestine meridians and being bitter and cold in nature; furthermore, more importantly, the phellodendron bark has an antibacterial effect, the antibacterial active ingredient of the phellodendron bark is berberine, and the pharmacological effect of the phellodendron bark is similar to that of coptis chinensis; has strong inhibiting effect on mold, red mold, staphylococcus aureus, pneumococcus, diphtheria bacillus, streptococcus viridae, dysentery bacillus (except Sonnella), hemolytic streptococcus, meningococcus, vibrio cholerae, bacillus anthracis and the like, and also has inhibiting effect on bacillus subtilis, pertussis bacillus, tetanus bacillus and the like; therefore, the added phellodendron bark has antifungal, antiviral and antibacterial effects, so that the traditional Chinese medicine composition has obvious antibacterial and anti-inflammatory effects.
It is understood that the mirabilite added by the invention is salty, bitter and cold. Enter stomach and large intestine meridians. Clear heat and remove dampness, break blood and remove meridian obstruction, reduce swelling and treat sore. Can treat excessive heat accumulation, abdominal distention and constipation, phlegm accumulation, conjunctival congestion and nebula, erysipelas and carbuncle swelling, so that the addition of mirabilite in the composition can reduce swelling and relieve pain, so that the traditional Chinese medicine composition has the effect of relieving pain.
It can be understood that the alum added in the invention is prepared by processing and refining sulfate mineral alunite, mainly contains hydrous aluminum potassium sulfate, has the effects of detoxifying, disinsection, drying dampness and relieving itching after entering lung, spleen, liver and large intestine channels, and is used for treating eczema, mange, rectocele, hemorrhoids and purulent ear; it has effects of stopping bleeding, relieving diarrhea, and dispelling wind phlegm. The traditional Chinese medicine composition has the function of stopping bleeding, has a synergistic effect when being combined with the added mirabilite, and enhances the effects of easing pain and stopping bleeding.
It can be understood that the viola yedoensis makino added by the invention is rich in active enzyme, so that the synthesis of human immunoglobulin can be promoted, the immunity of human body can be enhanced, and the disease resistance of human body can be obviously improved, thereby enhancing the wound healing speed of patients and further enhancing the healing promoting effect of the traditional Chinese medicine composition.
It is understood that the platycodon grandiflorum added by the invention is the root of platycodon grandiflorum of the platycodon family. Bitter and pungent. Enter lung meridian. Radix Platycodi is rich in various saponins, mainly platycodin. Radix Platycodi has effects of dispersing lung qi, eliminating phlegm, relieving sore throat, expelling pus, and removing lung qi, and can be used for treating laryngopharynx swelling and pain, aphonia, cough, purulent phlegm, etc. The platycodon root has the effects of dispersing lung qi, eliminating phlegm, relieving sore throat and expelling pus, and can open lung qi to promote the thoracic diaphragm and throat, and has better phlegm eliminating effect, so the platycodon root is a main medicine for treating lung meridian qi components, can treat cough with excessive phlegm, and can take the effects of dispersing lung qi, eliminating phlegm, relieving cough and relieving sore throat no matter cold or heat. Jie Geng can release lung to relieve sore throat, so it can be used for sore throat and aphonia, and can be combined with symptoms regardless of deficiency and excess. Jie Geng can promote lung qi to expel purulent phlegm, so it can treat cough, chest pain, cough with phlegm and fishy smell, and pulmonary abscess. Because the lung and the large intestine are both exterior-interior, the platycodon root also has the function of opening and extracting lung qi, so the platycodon root can indirectly dredge the function of intestines and stomach and is used for treating diarrhea and tenesmus.
It is understood that the added Ligusticum wallichii is rhizome of Ligusticum wallichii of Umbelliferae, which is pungent and warm, and enters liver, gall bladder and pericardium meridian. The rhizoma Ligustici Chuanxiong contains alkaloid ligustrazine, volatile oil ligustilide, and stewed alkene. Ligusticum wallichii has the effects of promoting blood circulation, activating qi-flowing, dispelling wind and relieving pain. Rhizoma Ligustici Chuanxiong and Carthami flos: chuan Xiong has the effects of promoting blood circulation, promoting qi circulation and relieving pain, and can ascend to top and descend to the blood sea; hong Hua has the actions of activating blood and inducing menstruation, removing stasis and relieving pain. When the two herbs are combined, it is indicated for pain due to qi stagnation and blood stasis with cold manifested as strong actions of activating blood, promoting qi circulation and alleviating pain.
It is understood that the cinnamon twig added in the invention is the dried twig of cinnamon, a lauraceae plant. Pungent, sweet and warm. It enters heart, lung and bladder meridians. The main effective component in ramulus Cinnamomi is volatile oil, and its main component is cinnamaldehyde, etc. Ramulus Cinnamomi has effects of inducing sweat, relieving muscle, warming and activating meridian, supporting yang, activating qi-flowing, and calming the pulse. It is effective in warming, expelling cold, and entering lung and bladder meridians, and is effective in dispersing yang qi, nourishing blood, promoting the function of consolidating superficial resistance, inducing sweat and relieving muscle, and can be used for treating wind-cold exterior syndrome. It also has effects of warming channel and dispelling cold, and can be used for treating abdominal crymodynia, blood cold amenorrhea, arthralgia, etc. In addition, it has the effects of warming spleen yang and promoting water transport, warming kidney yang and promoting bladder qi, and can be used for treating phlegm retention and edema, etc., and it has the effects of pungent and warm nature and also can be used for promoting heart yang, dredging blood vessels, relieving palpitation and flushing adverse qi, and can be used for treating palpitation and running dolphin. Modern pharmacological researches have shown that it has effects of relieving fever and lowering temperature, and also has rich effects of tranquilizing, invigorating stomach, promoting urination, strengthening heart, inhibiting bacteria and virus, relieving pain, etc., and can well improve wound state of patients after use, and relieve pain.
It is understood that the added raw licorice has the functions of invigorating spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain and harmonizing various medicines.
The traditional Chinese medicine composition for relieving pain and bleeding takes pure traditional Chinese medicines as raw materials, and has the effects of resisting bacteria and diminishing inflammation of phellodendron, detumescence and hemostasis of mirabilite and alum, improving immunity of patients and improving wound healing capacity of the patients, and the antibacterial effect of platycodon grandiflorum and phellodendron, the ligusticum chuanxiong, cassia twig and raw licorice are matched to further relieve pain and hemostasis, so that the traditional Chinese medicine composition can perform antibacterial and anti-inflammatory effects, stop bleeding and relieving pain and promote wound healing from multiple dimensions.
According to the traditional Chinese medicine composition for relieving pain and bleeding, the raw materials are synergistic, and cortex phellodendri, herba violae, platycodon grandiflorum, ramulus cinnamomi and raw liquorice added in the raw materials contain rich amino acids and active enzymes, so that immunity can be improved, and the wound healing capacity of a patient is improved; the berberine contained in the phellodendron can effectively obtain antifungal, antiviral and antibacterial effects, so that the traditional Chinese medicine composition has good antibacterial and anti-inflammatory effects, and the added alum and phellodendron cooperate to increase the hemostatic effect of the composition; further, the platycodin rich in platycodon grandiflorum is matched with berberine, so that the antibacterial effect of the berberine is enhanced; the ligusticum chuanxiong hort contains alkaloid ligustrazine, and glycyrrhizin in raw liquorice and cassia twig aldehyde in cassia twig are matched, so that the antibacterial, antiviral and analgesic effects of the cassia twig are enhanced. The traditional Chinese medicine composition performs antibiosis, antiphlogosis, hemostasis and analgesia through multiple dimensions, and various components are cooperated to form an effective component for antibiosis, antiphlogosis and analgesia, so that pain is effectively improved, analgesia, antiphlogosis and wound healing are promoted. Solves the problems of poor effect and high cost of the traditional Chinese medicine for relieving pain after anorectal operation.
It can be understood that after reasonable compatibility, the pharmaceutical composition plays a synergistic effect, can effectively relieve pain and bleeding of wounds after anorectal operation, relieve pain of patients in operation, shorten time of pain, bleeding and swelling of wounds, and provides a new medication option for nursing wounds in clinical anorectal operation.
It can be understood that the traditional Chinese medicine composition for relieving pain and bleeding is an external medicine for relieving pain, bleeding and swelling of wounds after anorectal surgery, can replace excessive dependence of patients on oral administration and intramuscular injection of analgesics after surgery, directly relieves pain, bleeding and swelling after surgery on local wounds, reduces toxic and side effects, and provides a safe and reliable new choice for clinical medication.
In some embodiments of the present invention, the composition comprises the following components in parts by weight: 30 parts of phellodendron, 20 parts of mirabilite, 20 parts of alum, 20 parts of viola yedoensis, 20 parts of platycodon grandiflorum, 20 parts of ligusticum wallichii, 20 parts of cassia twig and 30 parts of raw liquorice.
The invention also provides a preparation method of the traditional Chinese medicine composition for relieving pain and bleeding, which comprises the following steps:
according to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition is obtained.
It can be appreciated that the preparation method of the traditional Chinese medicine pad is simple, the manufacturing cost is low, and the convenience is high.
The invention also provides a preparation method of the traditional Chinese medicine pad for relieving pain and bleeding, which is shown in fig. 1 and comprises the following steps:
s1, taking a first preset amount of finished traditional Chinese medicine composition, filling the finished traditional Chinese medicine composition into a non-woven fabric bag, and sealing to prepare a medicine bag 1;
s2, placing the medicine bag 1 into a medicine bag accommodating bag 2, and arranging a reinforcing component 3 on the medicine bag accommodating bag 2 to prepare the traditional Chinese medicine pad.
It can be understood that the preparation method of the traditional Chinese medicine pad is simple, low in manufacturing cost and high in convenience. The traditional Chinese medicine composition is arranged in the non-woven fabric bag, so that medicines are concentrated and not spilled, the non-woven fabric bag is fixed in the medicine container bag, the medicines are released slowly, the use of the medicine pad is facilitated due to the arrangement of the reinforcing component, and the medicine absorption efficiency is enhanced.
In actual production, before adding the Chinese medicinal composition into the nonwoven bag, the nonwoven bag and the medicated bag should be sterilized to avoid bacteria and infection of patients.
In some embodiments of the present invention, the medicine container bag is made of soft skin-adhering materials such as non-woven fabrics, cotton, etc., so as to avoid further injury to the wound of the patient during the use process and promote healing.
It should be noted that the reinforcement assembly may be provided in a variety of ways. Optionally, set up the double faced adhesive tape on the side that the medicine bag holding bag kept away from the contact wound, when using traditional chinese medicine pad, tear the double faced adhesive tape, paste medicine bag holding bag and underwear fixed, the medicine bag holding bag does not set up one side and wound contact of double faced adhesive tape, traditional chinese medicine in the medicine bag holding bag can be through the contact with the wound, analgesic anti-inflammatory to the wound, has effectively alleviateed patient postoperative pain discomfort.
Furthermore, the setting mode of the reinforcing component can also be modes such as a binding belt, a pull rope, a magic tape and the like, so that one side of the traditional Chinese medicine pad is fixed on underwear, and the other side is contacted with a wound to relieve pain and diminish inflammation.
In some embodiments of the invention, the first predetermined amount is 3-5g. Specifically, the first preset amount is preferably 5g.
The invention also provides an application of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps:
s1, opening a reinforcing component of a traditional Chinese medicine pad to fix the traditional Chinese medicine pad on underwear corresponding to a wound;
s2, dripping a second preset amount of physiological saline on the medicine bag.
It can be understood that the application of the traditional Chinese medicine pad provided by the invention is simple in use mode, extremely high in convenience, convenient to replace and has enhanced superiority. When the medicine pad is required to be used, the reinforcing component is opened and fixed, the medicine pad is fixed at the position of the corresponding wound of the underwear, the medicine pad can be used by dripping normal saline, and after the normal saline enters the medicine bag, the traditional Chinese medicine composition in the medicine bag is materialized and opened, so that the wound can be conveniently and rapidly absorbed by the wound from the non-woven fabric bag of the medicine bag. After the use, the reinforcing component is discharged, and the traditional Chinese medicine pad is taken down from the underwear, so that the traditional Chinese medicine pad can be replaced and is convenient to replace.
Similarly, there are various arrangements of the reinforcement assembly herein, such as double sided tape, tie, pull cord, velcro, etc. In particular embodiments, the desired reinforcement members may be selected according to actual needs.
Further, in some embodiments of the present invention, the reinforcement assembly may also compress the wound in addition to the effect of securing the medicated pad to the undergarment, so that the drug on the pad can be in sufficient contact with the wound to provide a more pronounced analgesic and anti-inflammatory effect.
In some embodiments of the invention, the second predetermined amount is 2-3ml. Specifically, the second preset amount is preferably 2ml.
In some embodiments of the invention, the physiological saline is 0.9% physiological saline.
In some embodiments of the present invention, the application of a medicated pad for pain relief and bleeding may further comprise the step of providing a heating or pressurizing patch 5 on the side of the undergarment 5 facing away from the pouch 2 for heating the pad across the garment.
It can be appreciated that by arranging the heating patch 5 on the side of the underwear far away from the traditional Chinese medicine pad, the wound can be warmed by mild heating, so that the pain and discomfort of the patient can be relieved, and the postoperative experience of the patient can be improved. The pressurization patch 5 is arranged to pressurize the wound, so that the medicine on the medicine pad can be fully contacted with the wound, the effects of relieving pain and diminishing inflammation are more obvious, and the healing speed of the wound is increased.
Example 1
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 25 parts of phellodendron, 23 parts of mirabilite, 22 parts of alum, 25 parts of viola yedoensis, 25 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 25 parts of cassia twig and 24 parts of raw liquorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 1 is obtained.
Example 2
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 27 parts of phellodendron, 28 parts of mirabilite, 23 parts of alum, 27 parts of viola philippica, 27 parts of platycodon grandiflorum, 27 parts of ligusticum wallichii, 27 parts of cassia twig and 23 parts of raw liquorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 2 is obtained.
Example 3
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 40 parts of phellodendron, 24 parts of mirabilite, 24 parts of alum, 45 parts of viola philippica, 45 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 45 parts of cassia twig and 24 parts of raw liquorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 3 is obtained.
Example 4
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 29 parts of phellodendron, 24 parts of mirabilite, 23 parts of alum, 40 parts of viola yedoensis, 42 parts of platycodon grandiflorum, 42 parts of ligusticum wallichii, 45 parts of cassia twig and 23 parts of raw liquorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 4 is obtained.
Example 5
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 43 parts of phellodendron, 23 parts of mirabilite, 23 parts of alum, 43 parts of viola yedoensis, 43 parts of platycodon grandiflorum, 43 parts of ligusticum wallichii, 43 parts of cassia twig and 23 parts of raw liquorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 5 is obtained.
Example 6
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 44 parts of phellodendron, 23 parts of mirabilite, 23 parts of alum, 45 parts of viola yedoensis, 45 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 45 parts of cassia twig and 24 parts of raw liquorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 6 is obtained.
Example 7
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 38 parts of phellodendron, 24 parts of mirabilite, 23 parts of alum, 36 parts of viola philippica, 37 parts of platycodon grandiflorum, 38 parts of ligusticum wallichii, 39 parts of cassia twig and 23 parts of raw licorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 7 is obtained.
Example 8
The traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 41 parts of phellodendron, 23 parts of mirabilite, 23 parts of alum, 42 parts of viola yedoensis, 45 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 45 parts of cassia twig and 24 parts of raw liquorice. According to the parts by weight, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition 7 is obtained.
Test example 1 test person tested the efficacy of the present composition
1. Test design
Test settings (1), (2), (3), (4), (5), (6), 6 treatment groups respectively:
the Chinese medicinal compositions of examples 1-5 were prepared into Chinese medicinal pads 1-5, respectively.
Treatment group 1: the traditional Chinese medicine composition 1 prepared in the embodiment 1 is used for preparing a traditional Chinese medicine pad 1.
Treatment group 2: the traditional Chinese medicine composition 2 prepared in the example 2 is used for preparing a traditional Chinese medicine pad 2.
Treatment group 3: the traditional Chinese medicine composition 3 prepared in the embodiment 3 is used for preparing a traditional Chinese medicine pad 3.
Treatment group 4: the traditional Chinese medicine composition 4 prepared in the example 4 is used for preparing a traditional Chinese medicine pad 4.
Treatment group 5: the traditional Chinese medicine composition 5 prepared in the example 5 is used for preparing a traditional Chinese medicine pad 5.
Treatment group 6: commercial analgesic pads were used.
The treatment groups 1-6 of the herbal pads were each assigned to 6 groups of testers (1 patient per group) for use, and the experience of the testers after use was recorded. The testers are all patients who finish anorectal operation in anorectal department, and the test period is 7 days.
It should be noted that each test person used two pads per day, and the methods of use were according to the standard methods of use.
2. Test results and analysis
Each tester self-records and scores the pain sensation of the wound and the self condition, the score standard is that the total score is 10, the unconscious pain and state are best 1, the very pain and the mental state are very poor 10, and the lower the score is, the lower the pain sensation is. The score results are shown in the following table.
TABLE 1 record of wound pain and conditions of the testee
| Date of day | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 |
| ① | 10 | 8 | 3 | 5 | 7 | 8 | 1 |
| ② | 10 | 7 | 6 | 5 | 5 | 3 | 1 |
| ③ | 10 | 8 | 7 | 5 | 4 | 3 | 3 |
| ④ | 9 | 8 | 6 | 4 | 3 | 3 | 2 |
| ⑤ | 10 | 9 | 6 | 5 | 4 | 4 | 4 |
| ⑥ | 9 | 8 | 7 | 8 | 6 | 5 | 5 |
Referring to Table 1, it can be seen that the test persons used the traditional Chinese medicine pads prepared in examples 1 to 5 of the present invention, the wound pain sensation was significantly reduced, and the conditions of the test persons were significantly improved, while the test persons in treatment group 6 used the commercially available traditional Chinese medicine pads, and the improvement effect on the wound pain sensation and the mental state was poor.
Test example 2 pharmacodynamic experiments of the foot bath drug on promoting wound healing in animals
2.1 design of wound model
The mice were ICR mice, purchased from Chengdu laboratory animal technologies Inc., were male, had body weights of 25-30g, and were tested after 5 days of free feeding, with body weights ranging from about 30-35 g.
After the mice were anesthetized with 10% chloral hydrate at a dose of 0.003mL/g, the body hair of 2cm x 4cm on the back was removed, the body was cleaned with physiological saline, and then sterilized with 75% alcohol, and then round full-thickness skin with a diameter of 1cm was excised at the side of the back spine of the mice at a position of 2cm, and the depth was reached to the subcutaneous (skin to muscular layer) without damaging fat and fascia on the side of the spine or on the abdominal muscle, and one wound was left and right on each side of the spinal column of the mice. The wound after operation is sterilized with 75% alcohol and covered with sterile gauze.
2.2 grouping of animals and wound treatment
Mice were randomly divided into 6 groups of 6 mice each after molding.
The left wounds of the mice in the experimental groups 1-4 and the four groups are respectively dripped with 0.2ml of solvent (0.01M PH7.2 tris hydrochloride buffer solution) as a control, the right wounds are respectively given with the traditional Chinese medicine composition solution prepared in the examples 1-4, after a few minutes, the liquid dripped into the wounds is absorbed, dried, wrapped by sterile gauze, placed in a clean cage for cage feeding, and fed with clean drinking water, taken freely, and changed for each day.
The left wound and the right wound of the mice in the control group 5 are dripped with 0.2ml of solvent (0.01M PH7.2 tris hydrochloride buffer solution), after a few minutes, the dripped liquid in the wounds is absorbed, dried and wrapped by sterile gauze, and the mice are placed in a clean cage for cage feeding, drinking water and free feeding, and changing medicine every day.
The left side wounds of the mice in the control group 6 are respectively dripped with 0.2ml of solvent (0.01M PH7.2 tris hydrochloride buffer solution) as a control, the right side wounds are respectively dripped with 0.2ml of a commercially available traditional Chinese medicine composition, an aqueous solution of the Makino hemorrhoids ointment is selected, after a few minutes, liquid dripped into the wounds is absorbed, dried and wrapped by sterile gauze, and the mixture is placed in a clean cage for cage feeding, and is free to take food for daily dressing.
(1) The healing time of the left and right wounds of experimental groups 1 to 4 and the healing time of the left and right wounds of control group 5 and control group 6 were recorded, and the average value of each group was recorded and calculated, and the results are shown in table 2.
(2) Wound healing rates of mice in each group were recorded separately: and (3) comparing and observing the wound healing conditions of the left side and the right side of the mice after 1,3,5,7, 10 and 15 days after the administration, measuring the area of the wound surface, and calculating the healing rate. Healing rate = { (primary wound area-current wound area)/(primary wound area } ×100%). The average value of each group was calculated and the results are shown in Table 3.
2.3 test results and analysis
TABLE 2 average wound healing time for groups of wounded mice
TABLE 3 average wound healing Rate of various groups of wounded mice at different times
Referring to Table 2, it can be seen that the mice of the control group 5 had neither left wound nor right wound applied the Chinese medicinal composition of the present invention, and the healing time was 14 to 15 days. The traditional Chinese medicine composition prepared in the embodiment 1-5 of the invention is applied to mice in the experimental group 1-4, so that the traditional Chinese medicine composition has obvious effect on promoting wound healing of the mice, specifically, the traditional Chinese medicine composition of the invention is not applied to left wounds of the mice in the experimental group 1-4, the healing time is 13-15 days, and the healing time of right wounds to which the traditional Chinese medicine composition of the invention is applied is 9-11 days, so that the traditional Chinese medicine composition can promote wound healing, increase wound repair speed and effectively shorten the healing time of wound surfaces. The traditional Chinese medicine composition has obvious effects of easing pain, diminishing inflammation and promoting wound healing.
The commercial Chinese medicinal composition of the control group 6 has a healing time of 12 days, which is shorter than that of the control group 5, but is inferior to the experimental groups 1-4 related to the invention, so that the Chinese medicinal composition related to the invention has better effect.
Referring to Table 4, it can be seen that the mice of test group 1-4 had a significantly slower healing rate of the left wound than the right wound, for example, on day 7, the mice of test group 3 had a healing rate of 36.8% of the left wound, and the right wound had reached 71.8%, and it was seen that the right wound to which the Chinese medicinal composition of the present invention was applied had a faster healing rate.
In contrast, when the experimental group is compared with the control group, for example, the data of the control group 4 and the control group 5 show that the healing rate of the left wound and the right wound of the mice in the control group is only 67.1% at 15 days, the healing rate of the left wound of the mice in the experimental group 4 is 65.7% at 15 days, and the healing rate of the right wound of the mice in the experimental group reaches 99.6% which is higher than that of the mice in the control group 5.
Comparing the data of the control group 6 with the experimental group 3 and the control group 5, the traditional Chinese medicine composition of the control group 6 has a certain effect of promoting wound healing, for example, the wound healing rate of the right side of the control group 6 reaches 84.9% on the 15 th day, which is higher than the wound healing rate of the control group 5 by 67.1%; at this time, the healing rate of the right side of the experimental group 3 reaches 99.6%, which is higher than that of the control group 6, and therefore, the traditional Chinese medicine composition has better effect.
In summary, the traditional Chinese medicine composition for relieving pain and bleeding takes pure traditional Chinese medicines as raw materials, the raw materials are synergistically enhanced, and cortex phellodendri, herba violae, platycodon grandiflorum, cassia twig and raw liquorice added in the raw materials contain rich amino acids and active enzymes, so that the immunity can be improved, and the wound healing capacity of a patient is improved; the berberine contained in the phellodendron can effectively obtain antifungal, antiviral and antibacterial effects, so that the traditional Chinese medicine composition has good antibacterial and anti-inflammatory effects, and the added alum and phellodendron cooperate to enhance the hemostatic effect of the composition; further, the platycodin rich in platycodon grandiflorum is matched with berberine, so that the antibacterial effect of the berberine is enhanced; the ligusticum chuanxiong hort contains alkaloid ligustrazine, and glycyrrhizin in raw liquorice and cassia twig aldehyde in cassia twig are matched, so that the antibacterial, antiviral and analgesic effects of the cassia twig are enhanced. The traditional Chinese medicine composition performs antibiosis and antiphlogosis through multiple dimensions, and various components are cooperated to form an effective component for antibiosis, antiphlogosis and analgesia, so that pain is effectively improved, analgesia and antiphlogosis are promoted to heal wounds. Solves the problems of poor product effect and high cost in the traditional Chinese medicine field for relieving pain after anorectal operation.
Claims (4)
1. The traditional Chinese medicine composition for relieving pain and bleeding is characterized by comprising the following components in parts by weight: 25-45 parts of amur corktree bark, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of viola philippica, 25-45 parts of platycodon grandiflorum, 25-45 parts of szechuan lovage rhizome, 25-45 parts of cassia twig and 22-24 parts of raw liquorice.
2. The traditional Chinese medicine composition for relieving pain and bleeding according to claim 1, which is characterized by comprising the following components in parts by weight: 30 parts of phellodendron, 20 parts of mirabilite, 20 parts of alum, 20 parts of viola yedoensis, 20 parts of platycodon grandiflorum, 20 parts of ligusticum wallichii, 20 parts of cassia twig and 30 parts of raw liquorice.
3. A method for preparing a traditional Chinese medicine composition for relieving pain and bleeding according to claim 1 or 2, which is characterized by comprising the following steps: according to the weight portions, the phellodendron, mirabilite, alum, viola yedoensis, platycodon grandiflorum, ligusticum wallichii, cassia twig and raw liquorice are weighed, mixed and ground into fine powder, and the finished traditional Chinese medicine composition is obtained.
4. The preparation method of the traditional Chinese medicine pad for relieving pain and bleeding is characterized by comprising the following steps:
s1, loading a first preset amount of the traditional Chinese medicine composition according to claim 1 or 2 into a non-woven bag, and sealing to prepare a medicine bag, wherein the first preset amount is 3-5g;
s2, placing the medicine bag into a medicine bag accommodating bag, and arranging a reinforcing component on the medicine bag accommodating bag to obtain the traditional Chinese medicine pad.
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