CN100394950C - Making method for wound external-wash Chinese-medicinal preparation and granules - Google Patents
Making method for wound external-wash Chinese-medicinal preparation and granules Download PDFInfo
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Abstract
A Chinese medicine in the form of particles for treating wound by external washing is prepared from 12 Chinese-medicinal materials including dahurian angelica root, Chinese angelica root, myrrh, dandelion herb, etc. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of wound external-wash Chinese medicine preparation.
Background technology
Swelling is the Orthopeadic Surgery common sympton after the wound, mainly is because tissue is damaged, and blood capillary breaks in a large number, oozing of blood, and tissue permeability increases, tissue edema, due to inflammatory mediator was assembled, body was difficult for carrying out self-regeneration.But in this process, a lot of miseries and sequela have also been brought.By endo-medicine, washout medicine, physical therapy, functional exercise or the like, can obtain good effect.Especially in the most of area of China, external washout with traditional Chinese herbs is subjected to the welcome of extensive patients, also has curative effect very reliably.But a lot of patients are because be unfamiliar with the decocting method of Chinese medicine, feel to use inconvenience, and decocting improperly also can influence therapeutic effect.
Summary of the invention
Purpose of the present invention is exactly to decoct trouble for the external washout with traditional Chinese herbs preparation that solves present treatment wound, in case deal with the problem that can influence drug effect improperly, provide a kind of both convenient, practical, guarantee good efficacy again, the wound external-wash Chinese medicine preparation of the advantages such as use that are easy to carry about with one.
For achieving the above object, the present invention has adopted following technical scheme: a kind of wound external-wash Chinese medicine preparation, and its prescription restrains by weight and consists of, Radix Angelicae Dahuricae 4-8 gram, Radix Saposhnikoviae 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Radix Achyranthis Bidentatae 6-12 gram, Myrrha 6-12 gram, Olibanum 6-12 gram, Radix Rubiae 6-12 gram, Herba Ephedrae 6-12 gram, Herba Spirodelae grass 10-14 gram, Herba Taraxaci 10-14 gram, Herba Violae 10-14 gram, Fructus Chaenomelis 12-18 gram.
Its prescription restrains composition by weight and also can be, the Radix Angelicae Dahuricae 4 grams, Radix Saposhnikoviae 6 grams, Radix Angelicae Sinensis 6 grams, Radix Achyranthis Bidentatae 6 grams, Myrrha 6 grams, Olibanum 6 grams, Radix Rubiae 6 grams, Herba Ephedrae 6 grams, Herba Spirodelae grass 10 grams, Herba Taraxaci 10 grams, Herba Violae 10 grams, Fructus Chaenomelis 12 grams.
Its prescription restrains composition by weight and also can be, the Radix Angelicae Dahuricae 8 grams, Radix Saposhnikoviae 12 grams, Radix Angelicae Sinensis 12 grams, Radix Achyranthis Bidentatae 12 grams, Myrrha 12 grams, Olibanum 12 grams, Radix Rubiae 12 grams, Herba Ephedrae 12 grams, Herba Spirodelae grass 14 grams, Herba Taraxaci 14 grams, Herba Violae 14 grams, Fructus Chaenomelis 18 grams.
Its prescription restrains composition by weight and also can be, the Radix Angelicae Dahuricae 6 grams, Radix Saposhnikoviae 9 grams, Radix Angelicae Sinensis 9 grams, Radix Achyranthis Bidentatae 9 grams, Myrrha 9 grams, Olibanum 9 grams, Radix Rubiae 9 grams, Herba Ephedrae 9 grams, Herba Spirodelae grass 12 grams, Herba Taraxaci 12 grams, Herba Violae 12 grams, Fructus Chaenomelis 15 grams.
A kind of process for producing granula of aforementioned wound external-wash Chinese medicine preparation, it is with Radix Angelicae Dahuricae 4-8 gram, and Radix Saposhnikoviae 6-12 restrains, Radix Angelicae Sinensis 6-12 gram, Radix Achyranthis Bidentatae 6-12 gram, Myrrha 6-12 gram, Olibanum 6-12 gram, Radix Rubiae 6-12 gram, Herba Ephedrae 6-12 gram, Herba Spirodelae grass 10-14 gram, Herba Taraxaci 10-14 gram, Herba Violae 10-14 gram, Fructus Chaenomelis 12-18 gram, add suitable quantity of water and decoct secondary, each 1.5 hours, collecting decoction staticly settled 24 hours, filter, under 50 ℃～60 ℃, filtrate is concentrated into the thick paste of relative density 1.4, gets thick paste 40g, add starch 100g, medicinal dextrin 20g, an amount of in 2: 5: 1 ratios and ethanol, 12 mesh sieves are granulated, after 70 ℃ of dryings, and granulate, get granule 150g, be distributed into every bag 50g and get final product.
The present invention adopts the multiple Chinese medicine ingredients with treatment wound of knowing clearly, and its prescription analysis is as follows:
(1) Radix Angelicae Dahuricae
Radix Angelicae Dahuricae acrid in the mouth is warm in nature, attaches to the lung and stomach meridians, and the diffusing wind that can induce sweat is sensible, pain relieving, dampness leukorrhagia stopping, detumescence and apocenosis.Be used for affection of exogenous wind-cold, headache, nasal obstruction.Be used for YANG MING headache, toothache, nasal sinusitis, rheumatic arthralgia.Anemofrigid-damp arthralgia, lumbar and back pain, normal and Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Clematidis are used together.This product energy detumescence and apocenosis, pain relieving.In addition, still available skin rheumatism pruritus and the venom controlled of this product.
Radix Angelicae Dahuricae water decoction is to escherichia coli, dysentery bacterium, typhoid fever bar Cao, and bacillus pyocyaneus, Bacillus proteus have certain inhibitory action, and the water logging agent has certain inhibitory action to pathomycetes such as Austria Du big belly microspore tinea bacterium.
(2) Radix Saposhnikoviae
Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature is returned bladder, liver, spleen channel.Can deliver all removing dampness to relieve pains that looses, relieving convulsion, antidiarrheal.Be used for headache due to common cold, the rubella pruritus.The hot temperature of this product is dispersed, and abnormal smells from the patient all rises, with Xin Weiyong, and the kind wind for the treatment of of merit: the flesh table ailment said due to cold or exposure of both loosing, to remove meridians again and stay wetly, the pain relieving merit is good, and tepor is not dry.Be used for rheumatic arthralgia.This product expelling wind and cold, removing dampness to relieve pain is applicable to anemofrigid-damp arthralgia, arthrodynia of extremities, muscle arteries and veins contraction urgency person, but medicine for rheumatisms such as compatibility Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, Rhizoma Curcumae Longae are as JUANBI TANG.
" herbal classic ": " the ailment said due to cold or exposure blindness does not have finding, is in fashion the whole body, arthralgia numbness for main big dizziness due to wind pain, aversion to wind.”
" book on Chinese herbal medicine converges and says ": " main all wind whole body is unsuccessful, and joint is ached, and the extremity contraction is anxious, diseases such as flaccidity syndrome and arthralgia syndrome epilepsy convulsion.”
This product contains volatile oil, mannitol, bitterness glycoside, phenols, polysaccharide and organic acid etc.That this product has is analgesic, antiinflammatory, analgesia, anticonvulsant action, and the fresh juice of Radix Saposhnikoviae has certain antibacterial action to bacillus pyocyaneus and staphylococcus aureus, and decoct is to dysentery bacterium, and Hemolytic streptococcus etc. have inhibitory action in various degree.
(3) Radix Angelicae Sinensis
Radix Angelicae Sinensis sweet in the mouth, suffering, warm in nature.Return liver, the heart, spleen channel.Can enrich blood, invigorate blood circulation, regulating menstruation, pain relieving, intestine moistening.Be used for blood deficiency, stasis and have cold coagulation concurrently, and traumatic injury, the pain card of wind-damp numbness.Chinese angelica blood supplementing is invigorated blood circulation, and the energy dispersing cold for relieving pain of holding concurrently again is so can use with the card compatibility.As control traumatic injury, often join Olibanum, Myrrha etc.The general usefulness of giving birth to, then wine stir-fry is used in order to strengthen invigorating blood circulation.
" herbal classic ": " main cough with dyspnea ... the married woman is leaked down; Sterilization, all malignant boil infectionss, incised wound.
" the Jing Yue's complete work book on Chinese herbal medicine just ": " so specially can enrich blood, its gas is light and hot, so again can promoting the circulation of blood for Radix Angelicae Sinensis, its sweet in the mouth and weighing.Invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, and also the panacea in the blood is also.”
Radix Angelicae Sinensis contains volatile oil, and main component is ligustilide etc., angelicone, carvacrol etc. in the oil.Other contains water soluble ingredient ferulic acid, succinic acid, Yan acid, uracil, adenine, stigmasterol-D-glycoside, vanillic acid, Herba Gelsemii Elegantis luciferin etc.In addition, still contain Radix Angelicae Sinensis polysaccharide, several amino acids, disorderly A, B support one's family
12, E and multiple be the multiple element etc. of needed by human.And proving that ferulic acid can improve peripheral circulation, Radix Angelicae Sinensis has the blood fat reducing effect to experimental hyperlipidemia.Non-specific and specific immune function are all seen potentiation.In addition, also have calmness, analgesia, antiinflammatory, anti-hypoxia, Antiradiation injury and suppress that some tumor line is grown and vitro antibacterial activity etc.
Modern pharmacology research: 1. vasodilative effect: Radix Angelicae Sinensis has dilating effect to blood vessel.The intravenous injection of Radix Angelicae Sinensis water extract can make anesthetized dog arteria coronaria, vasodilation blood flow increase, and Radix Angelicae Sinensis volatile oil and composition ligustilide etc. thereof can resist platelet T XA
2The vasoconstriction that causes.Sodium ferulate then has inhibition TXA
2The effect that generates, these all are the effective ingredient of Radix Angelicae Sinensis vasodilative effect.2. to microcirculatory influence: Radix Angelicae Sinensis speeds blood flow rate to the acute microcirculation of rabbit pia mater encephali due to the intravenous injection high molecular dextran, the hemocyte depolymerization, and fluidised form is improved.The equal little degree that can raise of sodium ferulate abdominal cavity or subcutaneous injection, showing has the periphery of improvement microcirculation and blood vessel dilating effect.Ferulic acid is the important component of Radix Angelicae Sinensis " the Wen Huahan stasis of blood ".
(4) Radix Achyranthis Bidentatae
Radix Achyranthis Bidentatae bitter in the mouth, sweet, sour, property is flat.Return liver, kidney channel.The energy promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, ignite (blood) is descending.The amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pain etc. and the traumatic pain that are used for stagnation of blood stasis.This moral character is kind descending, and promoting blood circulation to restore menstrual flow is controlled all diseases of gynecological's multiparity, traumatic injury, and waist knee joint stasis of blood pain person joins Radix Dipsaci, Radix Angelicae Sinensis, Olibanum, Myrrha and is equal to usefulness.
" herbal classic ": " main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, the gonalgia unable to flex and stretch the extremities, by vim and vigour, the fire of getting mildewed in warm conditions is mashed, induced abortion.
(5) Olibanum
Olibanum acrid in the mouth, hardship, warm in nature.Return liver, the heart, spleen channel.The pain relieving of energy blood-activating and qi-promoting, detumescence and promoting granulation.Be used for the external wounds traumatic injury, the skin infection carbuncle.This product can promoting blood circulation, removing blood stasis and relieving pain, the eliminating carbuncle of invigorating blood circulation again, and removing the necrotic tissue and promoting granulation is the external wounds key medicine.Control the traumatic injury stasis of blood and stagnate and to swell and ache, normal and Myrrha, compatibilities such as Sanguis Draxonis are as Anisodus carniolicoides C.Y.Wu et C.Chen.Be used for all pain cards of stagnation of blood stasis.As trusted subordinate's stasis of blood pain, lump in the abdomen and rheumatic arthralgia etc.The hot temperature of loosing of this product is logical, can blood-activating and qi-promoting.Pain relieving again can blood stasis dispelling be stretched muscle and is exempted from numbness, so control above-mentioned all cards.Control trusted subordinate's stasis of blood pain, lump in the abdomen is often joined Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, the same usefulness of Myrrha, as Huoluo Xiaoling Dan.Control anemofrigid-damp arthralgia, the limbs pain numbness is often joined Qiang's Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae is equal to usefulness, as " Medicine Comprehended " JUANBI TANG.
" not Lu ": " it be swollen to treat the edema due to wind pathogen poison, removes bad odor.One treats the urticaria poison of itching.”
Compendium of Material Medica: " all poison of eliminating carbuncle cellulitis, the heart is protected in the Tuoli, and muscle is stretched in the analgesic therapy of invigorating blood circulation, and controls married woman's difficult labour, and folding is hindered.”
Modern pharmacological research proves, this product resinous (be mainly free α, β-boswellic acid, in conjunction with boswellic acid, olibanoresene), natural gum (being mainly the calcium salt and the magnesium salt of arabitic acid, bassorin), volatile oil, and a small amount of amaroid.Analgesic activity is arranged.
(6) Myrrha
Myrrha bitter in the mouth, suffering, property is flat.GUIXIN, liver, spleen channel.The energy promoting blood circulation and stopping pain, detumescence and promoting granulation.This product effect cures mainly similar to Olibanum.Control the traumatic injury stasis of blood and stagnate and to swell and ache, the surgery ulcer sore pain does not close up after skin infection is burst and all stasis of bloods all pains of trusted subordinate that stagnate for a long time, often is usefulness with the Olibanum mutual reinforcement between.The difference of the two is that Olibanum is partial to circulation of qi promoting, stretches muscle, the Myrrha blood blood stasis dispelling of relatively loosing.
" property of medicine opinion ": " the leading damage of knocking, trusted subordinate's blood stasis is traumaticd fracture Japan and is fallen, muscles and bones stasis of blood pain, golden sword decreases, and is unbearably painful." Compendium of Material Medica: the blood detumescence of loosing, analgesic therapy granulation promoting." Olibanum invigorates blood circulation, the Myrrha blood that looses all can the alleviating pain and detumescence granulation promoting, so two medicines are often held concurrently mutually and used." " Records of Tradition Chinese and Western Medicine in Combination ": " for declaring logical internal organs, the key medicine of circulation meridians is so all pain of all heart stomach flank limbs joints all can be controlled it for Olibanum, Myrrha, two medicines and usefulness.The power that its ventilation is invigorated blood circulation, the kind again anemofrigid-damp arthralgia of controlling, the whole body is numb, and extremity are unsuccessful and all skin infection are swollen painful, or its skin ulcer is not painful firmly.External is a powder applying skin infection, can removing toxic substances and promoting subsidence of swelling, and granulation promoting relieves the pain.Though be the product of opening, unlikely wasting QI-blood, really good medicine is also.”
This product resinous (α and β heerabomyrrholic acid, α, β and γ myrrholic acid, commiphorinic acid, α and β heerabomyrrhol), natural gum (hydrolysis gets arabinose, galactose and xylose), volatilization wet goods.Multiple pathomycete is had in various degree inhibitory action, and resin has effect for reducing blood fat to male rabbit hypercholesterolemia and can prevent that speckle from forming.
(7) Radix Rubiae
The Radix Rubiae bitter in the mouth is cold in nature, returns Liver Channel.Can stop blooding by cooling blood and removing stasis, stimulate the menstrual flow.Be used for heat in blood and hold the blood disorder that of the stasis of blood under the arm, as haematemesis, epistaxis, metrorrhagia, hematuria, have blood in stool etc.This product purging with bitter and cold drugs is specially gone into the Liver Channel blood system, and the energy cooling blood for hemostasis again can promoting blood circulation to remove blood stasis.Be used for blood stasis amenorrhea and traumatic injury, rheumatic arthralgia etc.This product can stagnate promoting blood circulation, sharp joint by repercussive.Control traumatic injury and rheumatic arthralgia, the clothes but single is steep in wine, or join other blood-activating and trauma-curing medicinals and the same usefulness of dispelling wind and removing obstruction in the collateral medicine.
" Japan hanako materia medica ": " end serious epistaxis, leukorrhagia, puerperal, blood was transported, the breast knot, menstruation is more than, hemorrhoidal hamorrhage, the hemorrhoid flaccidity, furuncle is controlled in evacuation of pus, lets out essence, and hematuria is pounced on the damage blood stasis.”
Compendium of Material Medica: " qualcomm meridian is controlled joint wind pain, the promoting the circulation of blood of invigorating blood circulation.”
Modern pharmacological research proof this product contains anthraquinones, as alizarin, rubican, black rubican etc.Can shorten the rabbit clotting time, certain anastalsis is arranged, rubican is with calcium ion combination in the blood, slight anticoagulation effect is arranged, and water extract has the effect of excited uterus, the Rubidate of Madder extract and synthetic, effect in increasing leukocyte is all arranged, Cyclohexapeptides in the Radix Rubiae has antitumor action, in addition, various bacteria and dermatophytes is had inhibitory action.
(8) Herba Ephedrae
Herba Ephedrae acrid in the mouth, little hardship, warm in nature, return lung, urinary bladder channel.The energy relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.Be used for anemofrigid cold.This product acrid in the mouth is dispersed, cold expelling warm in nature, and the master goes into lung and urinary bladder channel, the function loosing the interspaces of skin and muscles, saturating hair key, relieving the exterior syndrome by diaphoresis is the high product of relieving the exterior syndrome with drugs of pungent in flavor and warm in nature with dispersing wind and cold.Be used for the edema due to wind pathogen edema.Open lung qi on this product, following defeated bladder is the key medicine of lung qi dispersing diuresis.Ailment said due to cold or exposure is attacked table, and the edema of impairment of dispersing and descending function of the lung, dysuria have exterior syndrome concurrently.
In addition, get the logical effect that stagnates of Herba Ephedrae cold expelling, with controlling wind and cold arthromyodynia, carbuncle of yin nature, sucutaneous nodule.
" herbal classic ": " pyrexial malaria is delivered perspiration for main apoplexy, cold headache, and the steam that uncharms ends cough with dyspnea, removes cold and heat, and broken disease heavily fortified point gathers.”
This product main component is an ephedrine, and contains a small amount of pseudoephedrine, volatilization wet goods.Herba Ephedrae volatile oil has perspiration, and ephedrine can make the people's sweat gland secretion that is in the hot environment increase and speed.Herba Ephedrae volatile oil Emulsion has refrigeration function.Ephedrine and pseudoephedrine all have the effect of alleviating bronchial muscular spasm.
(9) Herba Spirodelae grass
Herba Spirodelae grass acrid in the mouth, cold in nature, return lung, urinary bladder channel.The energy relieving the exterior syndrome by diaphoresis, rash is antipruritic, inducing diuresis to remove edema.Be used for the wind heat exterior syndrome, fever without perspiration.This product is hot cold, and the light weight come-up has the lung qi dispersing diaphoresis, the merit of dispelling wind and heat pathogens.This product has the merit of dispelling wind for relieving itching again, often joins Herba Schizonepetae, Radix Saposhnikoviae, the Fructus Kochiae and is equal to usefulness.Be used for the edema dysuria.Can open suitable lung qi on this product and diaphoresis, but regulating fluid apssage and diuresis down so availablely control the dysuria wind heat exterior syndrome person that holds concurrently and be advisable, can singly use, or join Herba Ephedrae, Fructus Forsythiae, Exocarpium Benincasae and be equal to usefulness.
" herbal classic ": " main sudden high fever itching over the body, following aqueous vapor.”
" Bencao Congxin ": " wind is removed in diaphoresis, inducing diuresis to remove edema.”
This product contains red grass element, vitexin, apiose, and the reseda flavin in addition, also contains materials such as potassium acetate, potassium chloride, iodine, bromine.Have heart tonifying diuresis and faint refrigeration function.
(10) Herba Taraxaci
Herba Taraxaci bitter in the mouth, sweet, cold in nature, return liver stomach warp.The energy heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation, dampness removing is treating stranguria.This product hardship is with drop-down, and is sweet with detoxifcation, and the double gas that stagnates that looses of cold energy heat clearing away is the good merchantable brand of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
" Newly Revised Canon of Materia Medica ": " housewife's human milk carbuncle.”
" Amplification on Materia Medica addendum ": " Detoxicating food-poisoning, the gas that stagnates that looses, the heat-transformation poison, the malignant boil tuberculosis that disappears furuncle is swollen.”
" book on Chinese herbal medicine is respectively wanted " " specially controlling carbuncle, treat poison, also is treating stranguria quality goods.”
This product contains taraxasterol, taraxacin, taraxacin etc.The public pod of Pu is to staphylococcus aureus, Hemolytic streptococcus has stronger inhibitory action, to Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi and card, his coccus etc. has certain inhibitory action, in addition, function of gallbladder promoting is still arranged, protect the liver, diuresis, be good for the stomach and laxative effective.Decoct also has the effect of excitating organism immunologic function.
(11) Herba Violae
Herba Violae bitter in the mouth, suffering, cold in nature, GUIXIN, Liver Channel.The energy heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation.Be used for the carbuncle furuncle, the acute mastitis acute appendicitis, erysipelas swells and ache.This product hardship is let out suffering and is loose, and the heat clearing away of cold energy is gone into conscience through blood system, so the energy heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation stagnates for controlling the warm blood heap soil or fertilizer over and around the roots, red and swollen heat pain, and the common drug of carbuncle sore tumefacting virus is its speciality to treat poison especially.With controlling carbuncle, treating skin ulcer, erysipelas etc., it is for oral administration singly to smash juice with bright product, with the slag external application.The product that also can join heat-clearing and toxic substances removing such as Flos Lonicerae, Herba Taraxaci, Flos Chrysanthemi Indici, as wuwei xiaodu drink, with controlling acute mastitis, normal and the same usefulness of Herba Taraxaci, it is for oral administration to fry in shallow oil soup, or with the slag external application, good effect is arranged all, and with controlling acute appendicitis, often and Radix Et Rhizoma Rhei, Caulis Sargentodoxae, Herba Hedyotidis Diffusae are equal to usefulness.
Compendium of Material Medica: " control all carbuncle carbuncle on the back, treat the skin ulcer scrofula, innominate toxic swelling, malignant boil.”
" book on Chinese herbal medicine justice ", " Herba Violae aims at carbuncle and treats the general medicine of poison." " right hot cool loosing swollen, and is longer than and brings down a fever.
This product contains glycoside, flavonoid.Tubercule bacillus, dysentery bacterium, staphylococcus aureus, streptococcus pneumoniae, dermatophytes and leptospira there is inhibitory action.In addition, effects such as analgesic, detumescence, antiinflammatory are still arranged.
(12) Fructus Chaenomelis
The Fructus Chaenomelis sour in the mouth, warm in nature, return liver, spleen channel, energy relaxing muscles and tendons and activating QI and blood in the collateral, dehumidifying stomach function regulating.Be used for rheumatic arthralgia, the contracture of muscle arteries and veins, beriberi swells and ache.This product has relaxing muscles and tendons and activating QI and blood in the collateral effect preferably, and the eliminating impediment that can dry, and is the key medicine of lingering pathogenic wind insensitive impediment, spasm of muscles and vessels.Control the muscular contracture stiffness of the nape, unable to move around is joined Olibanum, Myrrha, the Radix Rehmanniae with Fructus Chaenomelis, fries in shallow oil as Fructus Chaenomelis.
" not Lu " " main arthralgia chiefly caused by damp pathogen pathogen, cholera is told down greatly, and convulsion is more than.”
" book on Chinese herbal medicine is just ": " Fructus Chaenomelis is held back with its acid with this person, and acid can be walked muscle, hold back and can take off admittedly, woody flavour just, so especially specially go into liver, beneficial muscle is walked blood.Treat weakness of the waist and knees, beriberi, tying-in institute is indispensable.”
Fructus Chaenomelis contains Saponin, flavonoid, vitamin C, malic acid, tartaric acid, the acid of structure rafter etc., in addition, also contains catalase, peroxidase, tannin etc.This product has obvious detumescence effect to zoopery arthritis, and the effect that relaxes gastrointestinal muscular spasm and limb muscle spasm is seemingly arranged.
Therapeutic mechanism of the present invention is:
Its effective ingredient directly arrives disease institute by Transdermal absorption during external washout with traditional Chinese herbs, and just " target organ " directly plays a role.Its effect is more much bigger than reaching disease institute role by internal metabolism after for oral administration, and decay is few, and after the Transdermal absorption, the performance drug effect enters the systemic blood circulation then, and through internal metabolism, liver detoxification excretes.Drug effect is direct, toxic and side effects is little, and this also is the advantage of external used medicine.
In the time of external washout with traditional Chinese herbs, can follow " determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs ", get final product according to " treatment based on differentiation of disease ", because congestion, swelling, pain symptom belong to the excess syndrome performance of " qi depression to blood stasis " after the wound for the part, whether exist " simulataneous insufficiency and excessive " to consider as for whole body, obviously influence can not take place to whole body in the sick institute because medicine goes directly.
Drug osmotic enters sanguimotor approach by skin absorbs two, one, sees through horny layer and epidermis and enters corium, absorbed by blood capillary to enter blood circulation, i.e. and epidermis approach, this is the main path that the medicine percutaneous absorbs.In this approach, medicine can pass corneocyte and arrive active epidermis, also can arrive active epidermis by the corneocyte gap.Because the corneocyte diffusional resistance is big, drug molecule mainly diffuses through horny layer by intercellular substance.The corneocyte gap is the multilamellar lipid bilayer that the lipoid molecule forms, and the hydrophilic segment bound water molecule of lipoid molecule forms the aqueous district, and the hydrocarbon chain of lipoid molecule partly forms hydrophobic region.The polar medicine molecule is through the infiltration of the aqueous district in corneocyte gap, but not the polar medicine molecule permeates via hydrophobic region.
Percutaneous another approach of medicine is percutaneous appendages, promptly by hair follicle, sebaceous gland and sweat gland.Medicine is faster than epidermis approach by the infiltration rate of skin appendages, but skin appendages has only about 0.1% at the shared area of skin surface, therefore is not the main path that the medicine percutaneous absorbs.When drug osmotic began, medicine at first was absorbed by the skin appendages approach, and after the medicine by the epidermis approach arrived blood circulation, the process of osmosis of medicine reached stable state, and then the effect of appendages approach can be left in the basket.Ionic drug and water-soluble macromolecule medicine are difficult to by being rich in the horny layer of lipoid, and the infiltration rate of epidermis approach is very slow, and then the appendages approach seems important.Skin appendages also is the percutaneous important channel of iontophoresis process intermediate ion type medicine.
Medicinal application to the skin after, at first from preparation, be discharged into skin surface, dissolved drug is distributed and is entered horny layer, diffuse through the interface that horny layer arrives active epidermis, medicament distribution enters the active epidermis of aqueous, continues diffusion and arrives corium, is absorbed by blood capillary to enter blood circulation.
The aquation of skin can change the permeability of skin.Behind covered with plastic film on the skin or ointment, hinder water evaporates, antiperspirant is put aside in skin, makes the horny layer aquation.The horny layer density of aquation reduces, and it is big that permeability becomes.So the immersion of certain hour can increase the absorption of medicine.After reaching certain hour, keratodermatitis dissolving can occur, destroy, and skin is caused damage, so can not ceaselessly carry out washout, must give the time of skin self-regeneration, adjustment.
For verifying therapeutic effect of the present invention, get 70 examples to the sprained ankle patient of age in 18-70 one full year of life, wherein male 40 examples, women 30 examples; 20～65 years old age, average 40 years old; The course of disease 1 day is to 1 week, average 3 days.70 routine patients are divided into treatment group (30 example) and control group A (20 example), matched group B (20 example) at random, and its age, the sex state of an illness do not have significant difference (P＞0.05).There are not fracture, dislocation in the X-ray film inspection; Pressure pain point is positioned at lower tibiofibula associating the place ahead, internal malleolus distally, foot tenderness, swelling, during function limitation, to its dispenser, gives the Chinese medicine granules washout during dispenser, and two doses of every days, respectively once, each 20 minutes, two weeks were a course of treatment sooner or later; The control group A example gives the decoction washout, and method is with the treatment group; Matched group B distills water temperature and washes, and method is the same.Each group is all carried out part massage, functional exercise simultaneously.Gather the every observation index of washout after 3 days, 7 days, 10 days, 14 days, carry out statistical analysis, the general test item of safety observation project (1): heart rate, pulse, breathing, blood pressure; (2) skin colour, quality change (3) acra blood fortune, sensation, activity situation; (4) routine blood test, liver, renal function, electrocardiogram.Health giving quality observation item (1) the swelling situation that disappears; (2) pain relief situation (3) functional rehabilitation situation (4) exercise recovery situation.
Main curative effect index classification and scoring
(1) swelling: measure the footpath variation of ankle joint level week.Calculate with mm.
(2) pain: divide level Four.
0=does not have tenderness, scores 40 fens;
The 1=mild tenderness has tenderness during weight, passive activity is not limited, scores 30 fens;
2=moderate tenderness has tenderness during weight, passive activity is slightly limited, scores 20 fens;
3=severe tenderness has tenderness during weight, and the escape of shrinking back, and passive activity is seriously limited, score 10.
(3) function: the sole of the foot is bent, the back of the body is stretched the scope summation (unit: °).
Efficacy assessment standard
With reference to " orthopaedics evaluation of clinical curative effect standard " Takakura ankle joint marking system.
Above-mentioned data are carried out statistical procedures:
Measurement data represents that with X ± S mean relatively adopts one way analysis of variance, and there is statistical significance P＜0.05.With statistical package SPSS10.0 as data processing tools.
Therapeutic outcome is analyzed
Before and after treatment group clinical symptoms and the sign treatment obvious change (P＜0.05) is arranged relatively; Also take an evident turn for the better after the every clinical indices treatment of matched group (P＜0.05).But three groups relatively, and treatment group and control group A do not have significant difference, and more all there were significant differences for treatment group, control group A and matched group B (P＜0.05).
The curative effect of swelling relatively reaches analysis
The analysis of table 1 pair swelling (X ± S)
*Respectively organizing data before the treatment does not have significant difference, and P＞0.05# test group and control group A can be alleviated limb swelling effectively, two groups of no significant differences of contrast, and P＞0.05 △ significantly is better than matched group B, P＜0.01 for two groups.
The curative effect of pain relatively reaches analysis
The analysis of table 2 pair pain (X ± s)
*Respectively organizing data before the treatment does not have that significant difference # test group can be alleviated limbs pain effectively and control group A does not have significant difference, and P＞0.05 △ significantly is better than matched group B, P＜0.01 for two groups.Wherein respectively organized no significant difference on the 7th day, may be relevant with repair in trauma mechanism.
The curative effect comparison and analysis (table 3) of function
For preventing that too early active movement from influencing the damaged tissue reparation, so functional evaluation in treatment each measurement in 7 days, 14 days once.
(the bent °+back of the body of the sole of the foot is stretched a ° X ± S) in the analysis of table 3 pair function
*Treatment Qiangu group data do not have significant difference # test group and control group A can be improved limb function effectively, two groups of no significant differences of contrast, and P＞0.05 △ significantly is better than matched group B, P＜0.01 for two groups.
Monitoring to safety index
Three group of 70 routine patient's heart rate, blood pressure, breathing, pulse, routine blood test, liver, renal function electrocardiogram are all normal.
Clinical and experimental study proves, the present invention for the ankle joint wound after symptom, the sign of swelling obvious therapeutic action is arranged, effectively alleviating pain, eliminate swelling, improve function of joint, harmless to organizing, body is had no adverse effects.Granule carries, uses conveniently, and is reliable for effect, is worth clinical expansion.
The specific embodiment
Embodiment one:
Get the Radix Angelicae Dahuricae 4 grams, Radix Saposhnikoviae 6 grams, Radix Angelicae Sinensis 6 grams, Radix Achyranthis Bidentatae 6 grams, Myrrha 6 grams, Olibanum 6 grams, Radix Rubiae 6 grams, Herba Ephedrae 6 grams, Herba Spirodelae grass 10 grams, Herba Taraxaci 10 grams, Herba Violae 10 grams, Fructus Chaenomelis 12 grams, add suitable quantity of water and decoct secondary, each 1.5 hours, collecting decoction, staticly settled 24 hours, and filtered, under 50 ℃～60 ℃, filtrate is concentrated into the thick paste of relative density 1.4, get thick paste 40g, add starch 100g, medicinal dextrin 20g, an amount of in 2: 5: 1 ratios and ethanol, 12 mesh sieves are granulated, after 70 ℃ of dryings, granulate gets granule 150g, is distributed into every bag 50g and gets final product.
Embodiment two:
Get the Radix Angelicae Dahuricae 8 grams, Radix Saposhnikoviae 12 grams, Radix Angelicae Sinensis 12 grams, Radix Achyranthis Bidentatae 12 grams, Myrrha 12 grams, Olibanum 12 grams, Radix Rubiae 12 grams, Herba Ephedrae 12 grams, Herba Spirodelae grass 14 grams, Herba Taraxaci 14 grams, Herba Violae 14 grams, Fructus Chaenomelis 18 grams prepare granule by the method according to embodiment one then and get final product.
Embodiment three:
Get the Radix Angelicae Dahuricae 6 grams, Radix Saposhnikoviae 9 grams, Radix Angelicae Sinensis 9 grams, Radix Achyranthis Bidentatae 9 grams, Myrrha 9 grams, Olibanum 9 grams, Radix Rubiae 9 grams, Herba Ephedrae 9 grams, Herba Spirodelae grass 12 grams, Herba Taraxaci 12 grams, Herba Violae 12 grams, Fructus Chaenomelis 15 grams prepare granule by the method according to embodiment one then and get final product.
Embodiment four:
Get the Radix Angelicae Dahuricae 5 grams, Radix Saposhnikoviae 7 grams, Radix Angelicae Sinensis 7 grams, Radix Achyranthis Bidentatae 7 grams, Myrrha 7 grams, Olibanum 7 grams, Radix Rubiae 7 grams, Herba Ephedrae 7 grams, Herba Spirodelae grass 10 grams, Herba Taraxaci 10 grams, Herba Violae 10 grams, Fructus Chaenomelis 13 grams prepare granule by the method according to embodiment one then and get final product.
Claims (5)
1. wound external-wash Chinese medicine preparation, it is characterized in that: its prescription restrains by weight and consists of, Radix Angelicae Dahuricae 4-8 gram, Radix Saposhnikoviae 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Radix Achyranthis Bidentatae 6-12 gram, Myrrha 6-12 gram, Olibanum 6-12 gram, Radix Rubiae 6-12 gram, Herba Ephedrae 6-12 gram, Herba Spirodelae grass 10-14 gram, Herba Taraxaci 10-14 gram, Herba Violae 10-14 gram, Fructus Chaenomelis 12-18 gram.
2. wound external-wash Chinese medicine preparation according to claim 1 is characterized in that: its prescription restrains by weight and consists of, the Radix Angelicae Dahuricae 4 grams, Radix Saposhnikoviae 6 grams, Radix Angelicae Sinensis 6 grams, Radix Achyranthis Bidentatae 6 grams, Myrrha 6 grams, Olibanum 6 grams, Radix Rubiae 6 grams, Herba Ephedrae 6 grams, Herba Spirodelae grass 10 grams, Herba Taraxaci 10 grams, Herba Violae 10 grams, Fructus Chaenomelis 12 grams.
3. wound external-wash Chinese medicine preparation according to claim 1 is characterized in that: its prescription restrains by weight and consists of, the Radix Angelicae Dahuricae 8 grams, Radix Saposhnikoviae 12 grams, Radix Angelicae Sinensis 12 grams, Radix Achyranthis Bidentatae 12 grams, Myrrha 12 grams, Olibanum 12 grams, Radix Rubiae 12 grams, Herba Ephedrae 12 grams, Herba Spirodelae grass 14 grams, Herba Taraxaci 14 grams, Herba Violae 14 grams, Fructus Chaenomelis 18 grams.
4. wound external-wash Chinese medicine preparation according to claim 1 is characterized in that: its prescription restrains by weight and consists of, the Radix Angelicae Dahuricae 6 grams, Radix Saposhnikoviae 9 grams, Radix Angelicae Sinensis 9 grams, Radix Achyranthis Bidentatae 9 grams, Myrrha 9 grams, Olibanum 9 grams, Radix Rubiae 9 grams, Herba Ephedrae 9 grams, Herba Spirodelae grass 12 grams, Herba Taraxaci 12 grams, Herba Violae 12 grams, Fructus Chaenomelis 15 grams.
5. the process for producing granula of the described wound external-wash Chinese medicine preparation of claim 1 is characterized in that: Radix Angelicae Dahuricae 4-8 is restrained Radix Saposhnikoviae 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Radix Achyranthis Bidentatae 6-12 gram, Myrrha 6-12 gram, Olibanum 6-12 gram, Radix Rubiae 6-12 gram, Herba Ephedrae 6-12 gram, Herba Spirodelae grass 10-14 gram, Herba Taraxaci 10-14 gram, Herba Violae 10-14 gram, Fructus Chaenomelis 12-18 gram, add suitable quantity of water and decoct secondary, each 1.5 hours, collecting decoction staticly settled 24 hours, filter, under 50 ℃～60 ℃, filtrate is concentrated into the thick paste of relative density 1.4, gets thick paste 40g, add starch 100g, medicinal dextrin 20g, an amount of in 2: 5: 1 ratios and ethanol, 12 mesh sieves are granulated, after 70 ℃ of dryings, and granulate, get granule 150g, be distributed into every bag 50g and get final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172660A (en) * | 1997-03-20 | 1998-02-11 | 张明根 | Liniment for neck, shoulder, waist and leg |
| CN1333028A (en) * | 2000-07-12 | 2002-01-30 | 赵树人 | External liniment for treating rheumatic arthritis |
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2006
- 2006-06-15 CN CNB200610044809XA patent/CN100394950C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172660A (en) * | 1997-03-20 | 1998-02-11 | 张明根 | Liniment for neck, shoulder, waist and leg |
| CN1333028A (en) * | 2000-07-12 | 2002-01-30 | 赵树人 | External liniment for treating rheumatic arthritis |
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| CN1895473A (en) | 2007-01-17 |
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