Summary of the invention
The object of the present invention is to provide a kind of plaster of reducing swelling and alleviating pain, plaster treatment wound of the present invention swelling, blood stasis, pain successful, easy to use, side effect is little, deeply is subject to the welcome of extensive patients.
Technical solution of the present invention: a kind of plaster of reducing swelling and alleviating pain, formulated by the crude drug of following weight portion: Radix Angelicae Dahuricae 4-8, Radix Angelicae Sinensis 6-12, Radix Stephaniae Tetrandrae 6-12, Myrrha 6-12, Radix Angelicae Pubescentis 10-14, Olibanum 6-12, Herba Lycopodii 6-12, Rhizoma Homalomenae 10-14, Herba Taraxaci 10-14, Rhizoma Drynariae 8-10, Borneolum Syntheticum 8-10.Manufacture method: get Radix Angelicae Dahuricae 4-8 by above-mentioned weight portion, Radix Angelicae Sinensis 6-12, Radix Stephaniae Tetrandrae 6-12, Radix Angelicae Pubescentis 10-14, Herba Lycopodii 6-12, Rhizoma Homalomenae 10-14, Herba Taraxaci 10-14, Rhizoma Drynariae 8-10, add the water of 3-5 times of drug weight, and slow fire drags for slag after decocting 1 hour and becomes decoction; Add again Myrrha 6-12 in decoction, Olibanum 6-12, slow fire is heated to after medicine dissolves add Plumbum preparatium to make paste; Add again Borneolum Syntheticum 8-10 to stir, releasing fire-toxin; Then spreading out cloth adds the ointment 10-20 prepared and restrains into plaster.Subsides in one day one, 7 days courses for the treatment of.
The present invention's optimum weight ratio part being of filling a prescription: the Radix Angelicae Dahuricae 6, Radix Angelicae Sinensis 9, Radix Stephaniae Tetrandrae 9, Myrrha 9, Radix Angelicae Pubescentis 12, Olibanum 9, Herba Lycopodii 9, Rhizoma Homalomenae 12, Herba Taraxaci 12, Rhizoma Drynariae 9, Borneolum Syntheticum 9.
In the present invention's formula, the drug effect of each crude drug is:
The Radix Angelicae Dahuricae: acrid in the mouth is warm in nature, attaches to the lung and stomach meridians, and the loose wind that can induce sweat is sensible, pain relieving, dampness leukorrhagia stopping, detumescence and apocenosis.For affection of exogenous wind-cold, headache, nasal obstruction.For YANG MING headache, toothache, nasal sinusitis, rheumatic arthralgia.Anemofrigid-damp arthralgia, lumbar and back pain, normal and Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Clematidis are used together.This product energy detumescence and apocenosis, pain relieving.In addition, this product available skin rheumatism pruritus and venom controlled still.
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature.Return liver, the heart, spleen channel.Can enrich blood, invigorate blood circulation, regulating menstruation, pain relieving, intestine moistening.For blood deficiency, stasis and have cold coagulation concurrently, and traumatic injury, the pain card of wind-damp numbness.Chinese angelica blood supplementing is invigorated blood circulation, and the energy dispersing cold for relieving pain of holding concurrently again, therefore can be with the application of card compatibility.As control traumatic injury, often join Olibanum, Myrrha etc." the Jing Yue's complete work book on Chinese herbal medicine just ": ", therefore specially can enrich blood, its gas is light and hot, therefore again can promoting the circulation of blood for Radix Angelicae Sinensis, its sweet in the mouth and weighing.Invigorating middle warmer has, in row, benefit is arranged, the gas medicine in sincere blood, and also the panacea in blood is also." modern pharmacology research: Radix Angelicae Sinensis speeds blood flow rate to the acute microcirculation of rabbit pia mater encephali due to the intravenous injection high molecular dextran, the hemocyte depolymerization, fluidised form is improved.The equal little degree that can raise of sodium ferulate abdominal cavity or subcutaneous injection, show to be improved Peripheral Microcirculation and blood vessel dilating effect.Ferulic acid is the important component of Radix Angelicae Sinensis " the Wen Huahan stasis of blood ".
Radix Stephaniae Tetrandrae: inducing diuresis to remove edema, wind-expelling pain-stopping." Kaibao Bencao ": acrid in the mouth, hardship, flat, warm, nontoxic.Treat edema, swelling due to wind, go bladder heat, typhoid fever, and the cold and heat pathogen, apoplexy hands muscle spasm of the leg and foot, stopping leak, loose carbuncle, dislike knot, all snail scabies, worm skin ulcer, logical space between skin and muscles, sharp nine orifices.
Myrrha: bitter in the mouth, suffering, property is flat.GUIXIN, liver, spleen channel.The energy promoting blood circulation and stopping pain, detumescence and promoting granulation.This product effect is similar to Olibanum.Control that the traumatic injury stasis of blood is stagnant to swell and ache, the surgery ulcer sore pain, skin infection does not close up and all pains of the stagnant trusted subordinate of all stasis of bloods after bursting for a long time, and normal and Olibanum mutual reinforcement between are use.The difference of the two is that Olibanum is partial to circulation of qi promoting, stretches muscle, the relatively loose blood blood stasis dispelling of Myrrha.
Radix Angelicae Pubescentis: expelling pathogenic wind from the body surface; Removing damp and stopping pain." Bencao Jingshu ": Radix Angelicae Pubescentis, its main air incised wound pain relieving person that hits that trembles with fear, the institute that incised wound is wind and cold attacks, vim and vigour are stopped up and not all right, therefore its pain more, the bitter Gan Xinwen of Radix Angelicae Pubescentis, can ward off wind and cold, evil loose flesh table peace and, qi and blood circulation, therefore its pain is from only also.The renal mass person, kidney is long-pending, and kidney channel is the wind and cold visitor that takes advantage of a weak point in opponent's defence, and becomes renal mass, and this medicine originally enters the few the moon of foot, therefore control renal mass.Epilepsy and the Election all institute of ailment said due to cold or exposure become also, wind Qu Ze Epilepsy Election spontaneous recovery.Woman's hernia abdominal mass person, cold-damp is taken advantage of a weak point in opponent's defence due to middle kidney man also, bitter can dampness, temperature can be warded off cold, suffering can be dispersed, cold-damp is gone and the kidney peace, therefore main woman's hernia abdominal mass and is treated all harmful wind, hundred arthralgia wind without for a long time newly also.
Olibanum: the pain relieving of energy blood-activating and qi-promoting, detumescence and promoting granulation.For the external wounds traumatic injury, the skin infection carbuncle.This product can promoting blood circulation, removing blood stasis and relieving pain, the eliminating carbuncle of invigorating blood circulation again, and removing the necrotic tissue and promoting granulation, be the external wounds key medicine.Control that the traumatic injury stasis of blood is stagnant to swell and ache, normal and Myrrha, the compatibilities such as Sanguis Draxonis, as Anisodus carniolicoides C.Y.Wu et C.Chen.For all pain cards of stagnation of blood stasis.As trusted subordinate's stasis of blood pain, lump in the abdomen and rheumatic arthralgia etc.The hot loose temperature of this product is logical, can blood-activating and qi-promoting.Pain relieving, again can blood stasis dispelling stretch muscle and exempt from numbness, therefore control above-mentioned all cards.Control trusted subordinate's stasis of blood pain, lump in the abdomen, often join Radix Angelicae Sinensis, Radix Angelicae Pubescentis, the same use of Myrrha, as Huoluo Xiaoling Dan.Control anemofrigid-damp arthralgia, the limbs pain numbness, often join Qiang's Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae is equal to use, as " Medicine Comprehended " JUANBI TANG." not Lu ": " treat the edema due to wind pathogen poison swollen, remove bad odor.One treats the urticaria poison of itching." " property of medicine opinion ": " and the leading damage of knocking, trusted subordinate's blood stasis, traumatic fracture Japan and fall, muscles and bones stasis of blood pain, golden sword damages, unbearably painful." Compendium of Material Medica: loose blood detumescence, analgesic therapy granulation promoting." Olibanum invigorates blood circulation, the Myrrha blood that falls apart, all can the alleviating pain and detumescence granulation promoting, therefore two medicines are often held concurrently mutually and used." " Records of Tradition Chinese and Western Medicine in Combination ": ", for declaring logical internal organs, the key medicine of circulation meridians, therefore all pain of all heart stomach flank limbs joints all can be controlled it for Olibanum, Myrrha, two medicines use.The power that its ventilation is invigorated blood circulation, the kind anemofrigid-damp arthralgia of controlling, numb all over the body again, and extremity are unsuccessful and all skin infection are swollen aches, or its skin ulcer is not ached firmly.External be powder to apply skin infection, can removing toxic substances and promoting subsidence of swelling, granulation promoting relieves the pain.Though be the product of opening, unlikely wasting QI-blood, really good medicine is also.”
Herba Lycopodii: expelling wind and cold. dehumidifying detumescence, relaxing muscles and tendons and activating QI and blood in the collateral.Traumatic injury.This product is hot can manage it and fall apart with relaxing muscles and tendons and activating QI and blood in the collateral, and reducing swelling and alleviating pain, control traumatic injury, pain caused by ecchymoma, and the circulation promoting vein relaxing medicines such as polygamy Lignum Sappan, Eupolyphaga Seu Steleophaga, Flos Carthami, Semen Persicae, washout for oral administration all can.
Rhizoma Homalomenae: wind-damp dispelling; Relaxing muscles and tendons and activating QI and blood in the collateral; Pain relieving; Detumescence.The dispelling the wind and dampness pathogens arthralgia pain; Podomere acid is educated; The muscles and bones flaccidity is soft; Traumatic injury; Stomachache; The carbuncle skin ulcer is swollen.
Herba Taraxaci: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds." book on Chinese herbal medicine justice ": Herba Taraxaci, its property is refrigerant, controls all and treats skin ulcers, carbuncle and ulcer, all cards of red and swollen pyretic toxicity, can take and can apply, and quite has confirmedly, treats red and swollen hard piece, particularly prompt effect and control the acute mastitis breast.Aquatic foods person smashes the juice decoction being taken warmly, and dry person's decoction, also can control it simply, and must be indispensable in the side of boiling medicine this.
Rhizoma Drynariae: the kidney invigorating bone strengthening continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; The external treatment alopecia areata, vitiligo." herbal classic is continuous dredges ": " the main removing blood stasis of Rhizoma Drynariae (" Kaibao Bencao "), hemostasis, benefit are traumaticd fracture, and speech can not make stasis person be detained, and does not make the absurd row of turn-overs, and make up, traumatics fracture, as do not traumaticd fracture also.″
Borneolum Syntheticum: property, flavor; Hot, bitter, be slightly cold.Effect: loose stagnated fire, logical all keys, refreshment.Suppress staphylococcus aureus and colibacillary growth.The transdermal enhancing effect of Borneolum Syntheticum mainly at horny layer, can also increase intact skin and exfoliation skin thereof storage storehouse effect.Make the subcutaneous capillary expansion simultaneously, thereby make medicine be easy to enter blood circulation, and make the purpose of medicine performance treatment disease.
The therapeutic mechanism of Chinese medicine of the present invention is:
Chinese medicine external, its effect is more much bigger than after for oral administration, by internal metabolism, reaching disease institute role, and decay is few, and after Transdermal absorption, the performance drug effect, then enter the systemic blood circulation, and through internal metabolism, liver detoxification, excrete.Drug effect is direct, toxic and side effects is little, and this is also the advantage of external used medicine.
Medicine enters sanguimotor approach by skin permeation two kinds: the one, and see through horny layer and epidermis and enter corium, absorbed and enter blood circulation by blood capillary, this is the main path of percutaneous drug absorption.In this approach, medicine can arrive active epidermis through corneocyte, also can arrive active epidermis by the corneocyte gap.The polar medicine molecule is through the infiltration of the aqueous district in corneocyte gap, but not the polar medicine molecule permeates via hydrophobic region.The 2nd, percutaneous hair follicle, sebaceous gland and sweat gland.It is fast that the infiltration rate of this mode medicine is wanted, but skin follicle, the shared area of glandular orifice only have 0.1% left and right of skin, because of the right this mode main path that is not percutaneous drug absorption, but the shortcut absorbed by skin, when plaster is attached to affected part, at first medicine is absorbed by hair follicle, glandular orifice approach, and after the medicine by the epidermis approach arrives blood circulation, the effect of hair follicle, glandular orifice approach can be left in the basket.Ionic drug and water-soluble macromolecule medicine are mainly by hair follicle, glandular orifice skin permeation.Hair follicle, glandular orifice are also the percutaneous important channel of iontophoresis process intermediate ion type medicine.
Swelling successful due to treatment by Chinese herbs wound of the present invention, easy to use, side effect is little.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described:
Embodiment 1: a kind of plaster of reducing swelling and alleviating pain, formula: Radix Angelicae Dahuricae 4-8, Radix Angelicae Sinensis 6-12, Radix Stephaniae Tetrandrae 6-12, Myrrha 6-12, Radix Angelicae Pubescentis 10-14, Olibanum 6-12, Herba Lycopodii 6-12, Rhizoma Homalomenae 10-14, Herba Taraxaci 10-14, Rhizoma Drynariae 8-10, Borneolum Syntheticum 8-10.Manufacture method: get Radix Angelicae Dahuricae 4-8 by above-mentioned weight ratio part, Radix Angelicae Sinensis 6-12, Radix Stephaniae Tetrandrae 6-12, Radix Angelicae Pubescentis 10-14, Herba Lycopodii 6-12, Rhizoma Homalomenae 10-14, Herba Taraxaci 10-14, Rhizoma Drynariae 8-10, add the water of 3-5 times of drug weight, and slow fire drags for slag after decocting 1 hour and becomes decoction; Add again Myrrha 6-12 in decoction, Olibanum 6-12, slow fire is heated to after medicine dissolves add Plumbum preparatium to make paste; Add again Borneolum Syntheticum 8-10 to stir, releasing fire-toxin; Then spreading out cloth adds the ointment 10-20 prepared and restrains into plaster.
Embodiment 2: a kind of plaster of reducing swelling and alleviating pain, the Radix Angelicae Dahuricae 6, Radix Angelicae Sinensis 9, Radix Stephaniae Tetrandrae 9, Myrrha 9, Radix Angelicae Pubescentis 12, Olibanum 9, Herba Lycopodii 9, Rhizoma Homalomenae 12, Herba Taraxaci 12, Rhizoma Drynariae 9, Borneolum Syntheticum 9.Manufacture method is with embodiment 1.
Clinical data
For verifying therapeutic effect of the present invention, 60 routine traumatic patients of hospitalization since 2009 are carried out to the clinical treatment contrast experiment, the patient all has muscular tissue swelling and the blood stasis phenomenon of close degree, and the age is at the traumatic patient of 16-70 one full year of life, average 46 years old; Male 32 examples wherein, female's 28 examples; Course of disease 1-8 days.60 routine patients are divided into to treatment group (30 example) and matched group (30 example) at random, and its age, the sex state of an illness are without significant difference, and the coincidence statistics requirement, have comparability.
1, Therapeutic Method
Treatment group: give plaster of the present invention, tip of the day, 7 days courses for the treatment of;
Matched group: distill water temperature and wash and smear with safflower oil afterwards, 7 days courses for the treatment of.
2, efficacy assessment standard
Carry out statistical analysis with reference to wound evaluation of clinical curative effect standard.Be divided into Three Estate: recovery from illness, produce effects, invalid.Recovery from illness: swelling is thoroughly disappeared, and pain disappears, movable without impact; Produce effects: swelling is obviously disappeared, pain relief; Invalid: swelling is disappeared not obvious, and pain does not alleviate.
3, therapeutic effect
First, second and third course of therapy situation of clinical treatment is carried out to observation analysis:
Treatment group: treat a course for the treatment of, 6 people that fully recover, account for 20%; Produce effects 20 people, account for 66.7%; Invalid 4 people, account for 13.3%.After two courses for the treatment of, 16 people that fully recover, account for 53.3%; Produce effects 14 people, account for 46.7%.After three courses for the treatment of, 26 people that fully recover, account for 86.6%; Produce effects 4 people, account for 13.4%.Total obvious effective rate 100%, cure rate 86.6%.
Matched group: treat a course for the treatment of, the recovery from illness nothing; Produce effects 21 people, account for 70%; Invalid 9 people, account for 30%.After two courses for the treatment of, 8 people that fully recover, account for 26.7%; Produce effects 16 people, account for 53.3%; Invalid 6 people, account for 20%.After three courses for the treatment of, 17 people that fully recover, account for 56.7%; Produce effects 13 people, account for 43.3%.Total obvious effective rate 100%, cure rate 56.7%.
Clinical and experimental study proves, the treatment group therapeutic effect is better than matched group, illustrates that swelling after plaster of the present invention is to wound, blood stasis symptom have obvious therapeutic action, effectively alleviating pain, eliminate swelling, application is convenient, reliable for effect, clinic is promoted.