CN115501289A - Traditional Chinese medicine composition and traditional Chinese medicine pad for relieving pain and bleeding and preparation method thereof - Google Patents
Traditional Chinese medicine composition and traditional Chinese medicine pad for relieving pain and bleeding and preparation method thereof Download PDFInfo
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- CN115501289A CN115501289A CN202211405557.4A CN202211405557A CN115501289A CN 115501289 A CN115501289 A CN 115501289A CN 202211405557 A CN202211405557 A CN 202211405557A CN 115501289 A CN115501289 A CN 115501289A
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- relieving pain
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Abstract
The invention discloses a traditional Chinese medicine composition for relieving pain and bleeding and a preparation method thereof, relates to the field of medicines, and solves the problems of poor product effect and high cost in the field of traditional analgesic traditional Chinese medicines and analgesic traditional Chinese medicine pads, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 25-45 parts of golden cypress, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of Chinese violet, 25-45 parts of platycodon grandiflorum, 25-45 parts of ligusticum wallichii, 25-45 parts of cassia twig and 22-24 parts of raw liquorice; the invention also relates to a preparation method of the traditional Chinese medicine composition and a preparation method of a traditional Chinese medicine pad based on the traditional Chinese medicine composition.
Description
Technical Field
The invention relates to the field of medicines, in particular to the field of traditional Chinese medicine compositions for relieving pain and bleeding.
Background
Pain and discomfort in patients after anorectal surgery are commonly treated with analgesic drugs, including oral and topical drugs, such as: the ibuprofen capsule is orally taken, the lidocaine gel is locally used, the potassium permanganate solution can be used for cleaning an anus incision by hip bath sometimes, most patients depend on psychology when using the analgesic, and most oral drugs and local analgesics have great liver and kidney functions and gastrointestinal stimulation.
Therefore, the analgesic medicinal pad appears after anorectal surgery in order to deal with the symptoms of pain and blood seepage, but the traditional Chinese medicinal pad is inconvenient to carry, is complex to use after a patient leaves home, is high in cost, needs to be changed in anorectal surgery or wound outpatient service, and brings inconvenience to the patient.
Therefore, the existing products in the field of analgesic traditional Chinese medicine and analgesic traditional Chinese medicine pads after anorectal surgery have poor effects and higher cost.
Disclosure of Invention
The invention aims to: in order to solve the problems of poor product effect and high cost of the traditional analgesic traditional Chinese medicine and the analgesic traditional Chinese medicine pad after anorectal surgery, the invention provides the traditional Chinese medicine composition for relieving pain and bleeding, the traditional Chinese medicine pad and the preparation method thereof.
The invention specifically adopts the following technical scheme for realizing the purpose:
a traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 25-45 parts of golden cypress, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of Chinese violet, 25-45 parts of platycodon grandiflorum, 25-45 parts of ligusticum wallichii, 25-45 parts of cassia twig and 22-24 parts of raw liquorice.
Optionally, the paint comprises the following components in parts by weight: 30 parts of golden cypress, 20 parts of mirabilite, 20 parts of alum, 20 parts of Chinese violet, 20 parts of platycodon grandiflorum, 20 parts of ligusticum wallichii, 20 parts of cassia twig and 30 parts of raw liquorice.
The invention also provides a preparation method of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps: weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition.
The invention also provides a preparation method of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps:
s1, filling a first preset amount of finished traditional Chinese medicine composition into a non-woven fabric bag, and sealing to prepare a medicine bag;
s2, placing the medicine bag into a medicine bag containing bag, and arranging a reinforcing component on the medicine bag containing bag to obtain the traditional Chinese medicine pad.
Optionally, the first predetermined amount is 3-5g.
The invention also provides application of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps:
s1, opening a reinforcing component of the traditional Chinese medicine pad and fixing the reinforcing component on underwear corresponding to the wound;
s2, dripping a second preset amount of normal saline on the medicine bag.
Optionally, the second predetermined amount is 2-3ml.
Optionally, the normal saline is 0.9% normal saline.
Optionally, the application of the traditional Chinese medicine pad for relieving pain and bleeding further comprises the following step of arranging a self-heating patch on one side of the underwear far away from the traditional Chinese medicine pad to heat the traditional Chinese medicine pad across the underwear.
The invention has the following beneficial effects:
1. according to the traditional Chinese medicine composition for relieving pain and bleeding, phellodendron bark has the functions of resisting bacteria and diminishing inflammation, mirabilite and alum have the functions of diminishing swelling and stopping bleeding, chinese violet has the functions of improving the immunity of a patient and improving the wound healing capacity, platycodon grandiflorum has the function of enhancing the antibacterial effect of the phellodendron bark, and ligusticum wallichii, cassia twig and raw licorice are matched to further relieve pain and stop bleeding, so that the effects of resisting bacteria and diminishing inflammation, stopping bleeding and relieving pain and promoting wound healing are realized from multiple dimensions.
The Chinese medicinal composition takes pure Chinese medicaments as raw materials, the raw materials have synergistic interaction, and the added phellodendron, chinese violet, platycodon grandiflorum, cassia twig and raw liquorice in the raw materials contain rich amino acid and active enzyme, so that the immunity can be improved, and the wound healing capacity of a patient is improved; berberine contained in the phellodendron amurense can effectively resist fungi, viruses and bacteria, so that the traditional Chinese medicine composition has good antibacterial and anti-inflammatory effects, and the added alum and the phellodendron amurense cooperate to enhance the hemostatic effect of the composition; furthermore, platycodin rich in platycodon grandiflorum is matched with berberine, so that the antibacterial effect of the berberine is enhanced; the rhizoma Ligustici Chuanxiong contains alkaloid ligustrazine, and liquiritigenin in Glycyrrhrizae radix is matched with cinnamaldehyde in ramulus Cinnamomi to enhance antibacterial, antiviral and analgesic effects of ramulus Cinnamomi. The traditional Chinese medicine composition has the advantages that the antibacterial and anti-inflammatory effects are realized through multiple dimensions, the effective components for resisting bacteria, diminishing inflammation and easing pain are formed through the cooperation of various components, the pain is effectively improved, the pain and the blood seepage of wounds after anorectal surgery are relieved, the pain of patients after the anorectal surgery is relieved, the time for the wounds to have pain, blood seepage and swelling is shortened, and a new medicine selection is provided for the clinical nursing of anorectal surgery wounds. Solves the problems of poor product effect and higher cost in the field of the traditional Chinese medicine for relieving pain after anorectal operation.
The traditional Chinese medicine composition for relieving pain and bleeding is an external medicine for relieving wound pain, bleeding and swelling after anorectal surgery, can replace excessive dependence of patients on oral and intramuscular injection analgesics after surgery, directly relieve pain, bleeding and swelling after surgery on local wounds, reduce toxic and side effects, and provide a safe and reliable new choice for clinical medication.
2. The preparation method of the traditional Chinese medicine pad for relieving pain and bleeding, which is disclosed by the invention, is simple, low in manufacturing cost and high in convenience. The traditional Chinese medicine composition is arranged in the non-woven fabric bag, so that medicines are concentrated and are not spilled out, the non-woven fabric bag is fixed in the medicine bag containing bag, the medicines are released slowly, the medicine pad is convenient to use due to the arrangement of the reinforcing component, and the efficiency of medicine absorption is enhanced.
3. The application of the traditional Chinese medicine pad for relieving pain and oozing blood provided by the invention is simple in use mode, extremely high in convenience, convenient to replace and enhanced in superiority. When needing to use this medicine pad, open and fix and consolidate the subassembly, fix the medicine pad in the position that close-fitting clothing corresponds the wound, instil into normal saline again and can realize using, after normal saline got into the cartridge bag, dissolve the traditional chinese medicine composition in the cartridge bag, make things convenient for the wound to see out from the non-woven fabrics bag of cartridge bag in by the wound absorption, convenient and fast is effective. After the use, remove the reinforcement subassembly, take off traditional chinese medicine pad from the underwear and take off, can change, it is also convenient to change.
Drawings
FIG. 1 is a diagram of a medicated pad for relieving pain and bleeding according to the present invention;
fig. 2 is a reference diagram of the application of a traditional Chinese medicine pad for relieving pain and bleeding.
1-medicine bag, 2-medicine bag containing bag, 3-reinforcing component, 4-underclothes and 5-heating patch or pressurizing patch.
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Detailed Description
After anorectal surgery is performed on a patient, pain and blood seepage of a wound can occur, and in order to relieve the pain of the patient during the surgery and shorten the time for pain, blood seepage and swelling of the wound, a medicine pad can be used.
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 25-45 parts of golden cypress, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of Chinese violet, 25-45 parts of platycodon grandiflorum, 25-45 parts of ligusticum wallichii, 25-45 parts of cassia twig and 22-24 parts of raw liquorice.
As can be understood, the added phellodendron bark is bitter in taste and cold in nature; the kidney, bladder and large intestine meridians are bitter and cold in nature, and have the effects of clearing heat, eliminating dampness, purging fire and detoxifying; more importantly, the phellodendron has an antibacterial effect, the antibacterial active component of the phellodendron is berberine, and the pharmacological effect of the phellodendron is similar to that of coptis chinensis; has strong inhibitory effect on fungi, red mould, staphylococcus aureus, pneumococcus, diphtheria bacillus, viridans streptococcus, dysentery bacillus (except Sonne), hemolytic streptococcus, meningococcus, vibrio cholerae, anthrax bacillus, etc., and also has inhibitory effect on Bacillus subtilis, bordetella pertussis, tetanus bacillus, etc.; therefore, the added phellodendron has the functions of resisting fungi, viruses and bacteria, so that the traditional Chinese medicine composition has obvious functions of resisting bacteria and diminishing inflammation.
It can be understood that the mirabilite added in the invention is salty, bitter and cold. It enters stomach and large intestine meridians. Clearing away heat, removing dampness, removing blood stasis, dredging channels, relieving swelling, and treating sore. Can be used for treating excess heat accumulation, abdominal distension and constipation, phlegm stagnation, conjunctival congestion and nebula, erysipelas and carbuncle swelling, so that the traditional Chinese medicine composition has the effect of relieving pain by adding mirabilite into the composition.
It can be understood that the alum added in the invention is prepared by processing and refining sulfate mineral alunite, mainly contains hydrous aluminum potassium sulfate, has sour, astringent and cold properties, and enters lung, spleen, liver and large intestine channels, has the effects of detoxifying, killing parasites, eliminating dampness and relieving itching when being externally used, and is used for treating eczema, mange, rectocele, hemorrhoids and purulent otitis purulenta; the oral administration has effects of stopping bleeding, relieving diarrhea, and dispelling wind phlegm. The traditional Chinese medicine composition has the effect of stopping bleeding, has the synergistic effect by combining with the added mirabilite, and enhances the effects of relieving pain and stopping bleeding.
The Chinese violet added in the invention is rich in active enzyme, so that the synthesis of human immunoglobulin can be promoted, the immunity of human body can be enhanced, the disease resistance of human body can be obviously improved, the wound healing speed of patients can be enhanced, and the healing promoting effect of the Chinese medicinal composition can be further enhanced.
It is understood that the platycodon added in the present invention is the root of platycodon of the family platycodonaceae. Bitter, pungent and even. It enters lung meridian. Radix Platycodi is rich in various saponins, mainly platycodin. Radix Platycodi has effects of dispersing lung qi, eliminating phlegm, relieving sore throat, expelling pus, and promoting lung qi, and can be used for treating sore throat, aphonia, cough, purulent phlegm, etc. The platycodon grandiflorum has the effects of diffusing lung, eliminating phlegm, relieving sore throat and expelling pus, can promote lung qi to benefit chest, diaphragm and throat, and has a good phlegm eliminating effect, so that the platycodon grandiflorum is a main medicine for treating lung meridian qi, can treat cough with excessive phlegm, and can diffuse lung, eliminate phlegm, relieve cough and relieve sore throat no matter cold or heat. Balloonflower root, radix Platycodi, with the function of dispersing lung-qi and relieving sore throat, can be used for treating sore throat, aphonia, etc., and can be combined with each other according to symptoms regardless of deficiency or excess. Balloonflower root, radix Platycodi has the action of promoting lung qi to expel purulent phlegm caused by lung obstruction, such as cough, chest pain, expectoration, stinking smell, and pulmonary abscess. Because the lung is exterior-interior to the large intestine, and the balloonflower root has the function of promoting lung qi, it can indirectly dredge the intestines and stomach, and can be used for treating diarrhea and tenesmus.
It can be understood that the added ligusticum wallichii is the rhizome of the Umbelliferae ligusticum wallichii, is pungent and warm and enters liver, gallbladder and pericardium channels. The rhizoma Ligustici Chuanxiong contains alkaloid ligustrazine, volatile oil ligustilide, and fragrant alkene. Rhizoma Ligustici Chuanxiong has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. The rhizoma ligustici wallichii is matched with the safflower: chuan Xiong is good at activating blood and moving qi, relieving pain, ascending the head and descending the blood to the sea; safflower is good at activating blood and dredging channels, removing blood stasis and relieving pain. The combination of the two herbs can activate blood, move qi and alleviate pain strongly, so it is good at treating pain due to qi stagnation and blood stasis, especially cold.
It is understood that the cassia twig added in the present invention is a dried twig of cinnamomum cassia presl belonging to the family lauraceae. Pungent, sweet and warm. It enters heart, lung and bladder meridians. The main effective component of the cassia twig is volatile oil, and the main component of the cassia twig is cinnamaldehyde and the like. Ramulus Cinnamomi has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, tonifying yang, regulating qi, and calming the adverse-rising energy. It is pungent, sweet, warm in nature, can dispel cold, enters lung and bladder meridians, is good at dispersing yang qi, regulating ying-blood, and is helpful for defending the exterior, sweating and dispelling the pathogenic wind, and can be used for treating wind-cold exterior syndrome. It is pungent, warm and unblocking, has the actions of warming meridians and dispelling cold, and can be used to treat abdominal cold pain, amenorrhea due to blood cold, arthralgia of joint, etc. In addition, it is sweet and warm in nature and can warm spleen yang to help water transportation, and kidney yang to help bladder qi transformation, and can be used for treating phlegm retention, edema, etc., and it is sweet and warm in nature and can also help heart yang, promote blood circulation, smooth palpitation and adverse rise of qi, and can be used for treating palpitation and galloping-pong. Modern pharmacological research shows that the traditional Chinese medicine composition has the effects of relieving fever and cooling, has the abundant effects of calming, invigorating stomach, promoting urination, strengthening heart, inhibiting bacteria and viruses, easing pain, calming and the like, and can well improve the wound state of a patient after use and improve pain.
The added raw liquorice has the effects of tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the medicines.
The traditional Chinese medicine composition for relieving pain and bleeding takes pure traditional Chinese medicines as raw materials, cortex phellodendri has the functions of resisting bacteria and diminishing inflammation, mirabilite and alum have the functions of reducing swelling and stopping bleeding, herba violae has the functions of improving the immunity of a patient and improving the wound healing capability, radix platycodi has the function of enhancing the antibacterial effect of the cortex phellodendri, and the ligusticum chuanxiong hort, the cassia twig and the raw liquorice are matched to further relieve pain and stop bleeding, so that the effects of resisting bacteria and diminishing inflammation, stopping bleeding and relieving pain and promoting wound healing are realized from multiple dimensions.
The traditional Chinese medicine composition for relieving pain and bleeding has the advantages that the raw materials are synergistic, the phellodendron, the Chinese violet, the platycodon grandiflorum, the cassia twig and the raw liquorice added in the raw materials contain rich amino acid and active enzyme, the immunity can be improved, and the wound healing capacity of a patient is improved; berberine contained in the phellodendron amurense can effectively resist fungi, viruses and bacteria, so that the traditional Chinese medicine composition has good antibacterial and anti-inflammatory effects, and the added alum and the phellodendron amurense are synergistic to increase the hemostatic effect of the composition; furthermore, platycodin rich in platycodon grandiflorum is matched with berberine, so that the antibacterial effect of the berberine is enhanced; the rhizoma Ligustici Chuanxiong contains alkaloid ligustrazine, and liquiritigenin in Glycyrrhrizae radix is matched with cinnamic aldehyde in ramulus Cinnamomi, so as to enhance antibacterial, antiviral and analgesic effects of ramulus Cinnamomi. The traditional Chinese medicine composition performs antibiosis, antiphlogosis, hemostasis and analgesia through multiple dimensions, and various components are cooperated to form an effective component for antibiosis, antiphlogosis and analgesia, so that pain is effectively improved, analgesia, antiphlogosis and wound healing are promoted. Solves the problems of poor product effect and higher cost in the field of the traditional Chinese medicine for relieving pain after anorectal surgery.
The pharmaceutical composition has synergistic effect after reasonable compatibility, can effectively relieve pain and bleeding of wounds after anorectal surgery, relieve pain of patients after surgery, shorten time for pain, bleeding and swelling of wounds, and provide a new medication option for nursing of clinical anorectal surgery wounds.
The traditional Chinese medicine composition for relieving pain and bleeding is an external medicine for relieving wound pain, bleeding and swelling after anorectal surgery, can replace excessive dependence of patients on oral and intramuscular injection analgesics after surgery, directly relieves pain, bleeding and swelling after surgery on local wounds, reduces toxic and side effects, and provides a safe and reliable new choice for clinical medication.
In certain embodiments of the present invention, the composition comprises the following components in parts by weight: 30 parts of golden cypress, 20 parts of mirabilite, 20 parts of alum, 20 parts of Chinese violet, 20 parts of platycodon grandiflorum, 20 parts of ligusticum wallichii, 20 parts of cassia twig and 30 parts of raw liquorice.
The invention also provides a preparation method of the traditional Chinese medicine composition for relieving pain and bleeding, which comprises the following steps:
weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition.
Understandably, the preparation method of the traditional Chinese medicine pad is simple, low in manufacturing cost and high in convenience.
The invention also provides a preparation method of the traditional Chinese medicine pad for relieving pain and bleeding, which is shown in figure 1 and comprises the following steps:
s1, filling a first preset amount of finished traditional Chinese medicine composition into a non-woven fabric bag and sealing to prepare a medicine bag 1;
s2, placing the medicine bag 1 into the medicine bag containing bag 2, and arranging the reinforcing component 3 on the medicine bag containing bag 2 to obtain the traditional Chinese medicine pad.
It can be understood that the preparation method of the traditional Chinese medicine pad is simple, low in manufacturing cost and high in convenience. The traditional Chinese medicine composition is arranged in the non-woven fabric bag, so that the medicines are concentrated and are not spilled, the non-woven fabric bag is fixed in the medicine bag accommodating bag, the medicines are released slowly, the medicine pad is convenient to use due to the arrangement of the reinforcing component, and the absorption efficiency of the medicines is enhanced.
It should be noted that, in the actual production, before the traditional Chinese medicine composition is added into the non-woven fabric bag, the non-woven fabric bag and the medicine bag containing bag need to be sterilized and disinfected to avoid introducing bacteria and causing infection of patients.
In some embodiments of the invention, the medicine bag holding bag is made of soft skin-adhering materials such as non-woven fabrics and cotton, so that the wound of a patient is prevented from being further damaged in the using process, and the healing is promoted.
It should be noted that the reinforcement member may be provided in various ways. Optionally, set up the double faced adhesive tape on the one side of contact wound is kept away from to cartridge bag holding bag, when using traditional chinese medicine medicated pad, tear the double faced adhesive tape, put the bag with the cartridge bag and paste fixedly with the personal clothing, one side and the wound contact that cartridge bag holding bag did not set up the double faced adhesive tape, traditional chinese medicine in the cartridge bag holding bag can be through the contact with the wound, and the pain and the inflammation of diminishing are alleviated to the wound, has effectively alleviated the painful discomfort of patient's postoperative.
Further, the mode of setting up of reinforcing component can also be modes such as bandage, stay cord, magic subsides, realizes that traditional chinese medicine pad one side is fixed on the underwear, and the one side contacts with the wound in addition, carries out analgesia anti-inflammatory.
In certain embodiments of the present invention, the first predetermined amount is 3-5g. Specifically, the first preset amount is preferably 5g.
The invention also provides application of the traditional Chinese medicine pad for relieving pain and bleeding, which comprises the following steps:
s1, opening a reinforcing component of the traditional Chinese medicine pad and fixing the reinforcing component on underwear corresponding to a wound;
s2, dripping a second preset amount of normal saline on the medicine package.
The application of the traditional Chinese medicine pad is simple in use mode, extremely high in convenience, convenient to replace and high in superiority. When needing to use this medicine pad, open and fix and consolidate the subassembly, fix the medicine pad in the position that close-fitting clothing corresponds the wound, instil into normal saline again and can realize using, after normal saline got into the cartridge bag, dissolve the traditional chinese medicine composition in the cartridge bag, make things convenient for the wound to see out from the non-woven fabrics bag of cartridge bag in by the wound absorption, convenient and fast is effective. After the use, unload and consolidate the subassembly, take off traditional chinese medicine pad from the underwear and take off, can change, it is also convenient to change.
Similarly, the reinforcing member herein may be provided in various forms, such as double-sided tape, a strap, a string, a hook and loop fastener, etc. In a specific embodiment, the required reinforcement elements can be selected according to the actual needs.
Further, in some embodiments of the present invention, the reinforcing component can also pressurize the wound besides the function of fixing the traditional Chinese medicine pad on the underwear, so that the medicine on the medicine pad can be fully contacted with the wound, and the pain-relieving and inflammation-diminishing functions are more obvious.
In certain embodiments of the invention, the second predetermined amount is 2-3ml. In particular, the second predetermined amount is preferably 2ml.
In certain embodiments of the invention, the saline is 0.9% saline.
In some embodiments of the invention, the application of a traditional Chinese medicine pad for relieving pain and bleeding further comprises the step of arranging a heating patch or a pressurizing patch 5 on one side of the underwear 5 far away from the medicine containing bag 2 to heat the medicine pad through the underwear.
Understandably, through set up heating subsides 5 on one side of keeping away from traditional chinese medicine pad at close-fitting clothes, can be so that the wound can be mildly heated and heated for patient's painful uncomfortable feels can slow down, promotes the experience of patient postoperative and feels. The pressure patch 5 is arranged to pressurize the wound, so that the medicine on the medicine pad can be fully contacted with the wound, the effects of analgesia and anti-inflammation are more obvious, and the healing speed of the wound is increased.
Example 1
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 25 parts of phellodendron, 23 parts of mirabilite, 22 parts of alum, 25 parts of Chinese violet, 25 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 25 parts of cassia twig and 24 parts of raw liquorice. Weighing the golden cypress, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain a finished product of the traditional Chinese medicine composition 1.
Example 2
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 27 parts of phellodendron, 28 parts of mirabilite, 23 parts of alum, 27 parts of Chinese violet, 27 parts of platycodon grandiflorum, 27 parts of ligusticum wallichii, 27 parts of cassia twig and 23 parts of raw liquorice. Weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition 2.
Example 3
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 40 parts of golden cypress, 24 parts of mirabilite, 24 parts of alum, 45 parts of Chinese violet, 45 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 45 parts of cassia twig and 24 parts of raw liquorice. Weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition 3.
Example 4
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 29 parts of phellodendron, 24 parts of mirabilite, 23 parts of alum, 40 parts of Chinese violet, 42 parts of platycodon grandiflorum, 42 parts of ligusticum wallichii, 45 parts of cassia twig and 23 parts of raw liquorice. Weighing the golden cypress, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain a finished product of the traditional Chinese medicine composition 4.
Example 5
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 43 parts of golden cypress, 23 parts of mirabilite, 23 parts of alum, 43 parts of Chinese violet, 43 parts of platycodon grandiflorum, 43 parts of ligusticum wallichii, 43 parts of cassia twig and 23 parts of raw liquorice. Weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition 5.
Example 6
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 44 parts of golden cypress, 23 parts of mirabilite, 23 parts of alum, 45 parts of Chinese violet, 45 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 45 parts of cassia twig and 24 parts of raw liquorice. Weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition 6.
Example 7
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 38 parts of golden cypress, 24 parts of mirabilite, 23 parts of alum, 36 parts of Chinese violet, 37 parts of platycodon grandiflorum, 38 parts of ligusticum wallichii, 39 parts of cassia twig and 23 parts of raw liquorice. Weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition 7.
Example 8
A traditional Chinese medicine composition for relieving pain and bleeding comprises the following components in parts by weight: 41 parts of golden cypress, 23 parts of mirabilite, 23 parts of alum, 42 parts of Chinese violet, 45 parts of platycodon grandiflorum, 45 parts of ligusticum wallichii, 45 parts of cassia twig and 24 parts of raw liquorice. Weighing the golden cypress, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain a finished product of the traditional Chinese medicine composition 7.
Test example 1 test subjects tested the efficacy of the present composition
1. Design of experiments
Experimental settings (1), (2), (3), (4), (5), (6), 6 treatment groups were:
the Chinese medicinal compositions of the embodiments 1 to 5 are respectively prepared into Chinese medicinal pads 1 to 5.
Treatment group 1: the traditional Chinese medicine composition 1 prepared in example 1 was used to prepare a traditional Chinese medicine pad 1.
Treatment group 2: the traditional Chinese medicine composition 2 prepared in example 2 was used to prepare a traditional Chinese medicine pad 2.
Treatment group 3: the traditional Chinese medicine composition 3 prepared in example 3 was used to prepare a traditional Chinese medicine pad 3.
Treatment group 4: the traditional Chinese medicine composition 4 prepared in example 4 was used to prepare a traditional Chinese medicine pad 4.
Treatment group 5: the traditional Chinese medicine composition 5 prepared in example 5 was used to prepare a traditional Chinese medicine pad 5.
Treatment group 6: a commercially available analgesic pad was used.
The herbal pads of treatment groups 1-6 were individually administered to 6 groups of subjects (1 patient per group), and the subjects' experiences after use were recorded. The subjects were patients who had undergone anorectal surgery in the anorectal department, and the test period was 7 days.
It should be noted that each test subject used two pads per day, and the application method was in accordance with the standard application method.
2. Test results and analysis
Each tester records the pain feeling of the wound and the self condition of the tester by self, and scores the wound, wherein the scoring standard is 10 points in total, the unconscious pain and the state are 1 point, the very poor pain and the mental state are 10 points, and the lower the score is, the lower the pain feeling is. The score results are shown in the following table.
TABLE 1 recording of the pain sensation of the wound and the condition of the test person
| Date of | Day | 1 | |
|
|
|
Day 6 | Day 7 |
| ① | 10 | 8 | 3 | 5 | 7 | 8 | 1 | |
| ② | 10 | 7 | 6 | 5 | 5 | 3 | 1 | |
| ③ | 10 | 8 | 7 | 5 | 4 | 3 | 3 | |
| ④ | 9 | 8 | 6 | 4 | 3 | 3 | 2 | |
| ⑤ | 10 | 9 | 6 | 5 | 4 | 4 | 4 | |
| ⑥ | 9 | 8 | 7 | 8 | 6 | 5 | 5 |
Referring to table 1, it can be seen that, when the herbal pads prepared in examples 1 to 5 of the present invention were used, the pain sensation of the wound was significantly reduced and the conditions thereof were significantly improved, whereas those of treatment group 6 used the commercially available herbal pads, which were poor in the effect of improving the pain sensation of the wound and the mental state.
Experimental example 2 pharmacodynamic experiment of the foot bath medicine for promoting animal wound healing
2.1 design of wound models
The mice were ICR mice, purchased from Dundao technologies, inc., and all were male, with a weight specification of 25-30g, and the weight was approximately 30-35g when tested after 5 days of free feeding.
After a mouse is anesthetized by using 10% chloral hydrate according to the dose of 0.003mL/g, 2cm x 4cm body hair on the back is removed, the body hair is cleaned by normal saline, the body hair is sterilized by using 75% alcohol, and then a round whole layer of skin with the diameter of 1cm is cut at the position 2cm beside the two sides of the spinal column on the back of the mouse and is deep to the subcutaneous part (skin to muscular layer) without damaging fat and fascia on the spinal column or abdominal muscles, and the left side and the right side of the spinal column of the mouse are respectively cut. The postoperative wound was sterilized with 75% alcohol and covered with sterile gauze.
2.2 animal grouping and wound treatment
Mice were randomly divided into 6 groups of 6 mice after molding.
In experimental groups 1-4, the left wounds of four groups of mice were dropped with 0.2ml of a solvent (0.01M PH7.2 Tris hydrochloride buffer) as a control, the right wounds were given with the solutions of the Chinese medicinal composition prepared in examples 1-4, respectively, after a few minutes, the dropped liquid in the wounds were absorbed, dried, packed with sterile gauze, placed in a clean cage, raised in cages, given clean drinking water, and taken freely, and changed every day.
In the control group 5, 0.2ml of a solvent (0.01M PH7.2 tris (hydroxymethyl) aminomethane hydrochloride buffer solution) was dropped into the left wound and the right wound of the mouse, and after a few minutes, the liquid dropped into the wound was absorbed and dried, the wound was wrapped with a sterile gauze, and the wound was placed in a clean cage and raised in cages, and clean drinking water was given to the cage for free feeding and changing the dressing every day.
In the control group 6, 0.2ml of solvent (0.01M PH7.2 tris (hydroxymethyl) aminomethane hydrochloride buffer) was dropped into the left side wound of each mouse as a control, and 0.2ml of a commercially available Chinese medicinal composition was dropped into the right side wound, and a Mayinglong hemorrhoid ointment aqueous solution was selected, wrapped with sterile gauze after the liquid dropped into the wound was absorbed and dried for several minutes, and then placed in a clean cage for cage rearing, and given clean drinking water, and the mice were freely eaten and changed each day.
(1) The healing time of the left and right wounds of the experimental groups 1-4 and the left and right wounds of the control group 5 and 6 were recorded, respectively, and the average value of each group was recorded and calculated, and the results are shown in table 2.
(2) Wound healing rates were recorded for each group of mice respectively: the healing conditions of the wounds on the left side and the right side of the mouse are contrastively observed after 1,3,5,7, 10 and 15 days after the drug administration, the area of the wound surface is measured, and the healing rate is calculated. The healing rate = { (original wound area-present wound area) ÷ original wound area } × 100%. The average of each group was calculated and the results are shown in table 3.
2.3 test results and analysis
Table 2 mean wound healing time in groups of wounded mice
TABLE 3 average wound healing rates at different times for each group of wounded mice
Referring to table 2, it can be seen that in the mice of the control group 5, the left side wound and the right side wound are not applied with the traditional Chinese medicine composition of the present invention, and the healing time is 14 days to 15 days. The experimental groups 1 to 4 have an obvious effect of promoting the wound healing of the mouse after applying the traditional Chinese medicine composition prepared in the embodiments 1 to 5 of the present invention to the mouse, and specifically, the left side wound of the mouse of the experimental groups 1 to 4 is not applied with the traditional Chinese medicine composition of the present invention, the healing time is 13 days to 15 days, and the right side wound applied with the traditional Chinese medicine composition of the present invention is 9 days to 11 days, so that the application of the traditional Chinese medicine composition of the present invention can promote the wound healing, increase the wound healing speed, and effectively shorten the healing time of the wound. The traditional Chinese medicine composition has obvious effects of relieving pain, diminishing inflammation and promoting wound healing.
The healing time of the traditional Chinese medicine composition sold in the control group 6 is 12 days, which is shorter than that of the control group 5, but the traditional Chinese medicine composition is not as good as the experimental groups 1-4, and the traditional Chinese medicine composition has a better effect.
Referring to table 4, it can be seen that the left side wounds of the mice of experimental groups 1-4 healed significantly slower than the right side wounds, for example, on day 7, the left side wounds of the mice of experimental group 3 healed at 36.8%, while the right side wounds healed at 71.8%, and it can be seen that the right side wounds healed faster when the Chinese medicinal composition of the present invention is applied.
Comparing the experimental group with the control group, for example, the data of the comparative experimental group 4 and the control group 5 show that the left and right side wounds of the mice in the control group are very slow to recover, and the healing rate is only 67.1% at day 15, while the left side wound of the mice in the experimental group 4 is 65.7% and the right side wound of the mice in the experimental group 4 is 99.6% at day 15, which is higher than the healing rate of the control group 5.
Comparing the data of the control group 6 with the experimental group 3 and the control group 5, it can be seen that the traditional Chinese medicine composition of the control group 6 has a certain effect of promoting wound healing, for example, on day 15, the wound healing rate on the right side of the control group 6 reaches 84.9%, which is 67.1% higher than that of the control group 5; at this time, the healing rate of the right side of the experimental group 3 reaches 99.6%, which is higher than that of the control group 6, and thus, the traditional Chinese medicine composition has a better effect.
In conclusion, the traditional Chinese medicine composition for relieving pain and bleeding disclosed by the invention takes pure traditional Chinese medicines as raw materials, the raw materials have synergistic interaction, and the phellodendron, the Chinese violet, the platycodon grandiflorum, the cinnamomum wilsonii twig and the raw liquorice added in the raw materials contain rich amino acids and active enzymes, so that the immunity can be improved, and the wound healing capacity of a patient is improved; the berberine contained in the phellodendron amurense can effectively resist fungi, viruses and bacteria, so that the traditional Chinese medicine composition has good antibacterial and anti-inflammatory effects, and the added alum and the phellodendron amurense are cooperated to enhance the hemostatic effect of the composition; furthermore, platycodin rich in platycodon grandiflorum is matched with berberine, so that the antibacterial effect of the berberine is enhanced; the rhizoma Ligustici Chuanxiong contains alkaloid ligustrazine, and liquiritigenin in Glycyrrhrizae radix is matched with cinnamic aldehyde in ramulus Cinnamomi, so as to enhance antibacterial, antiviral and analgesic effects of ramulus Cinnamomi. The traditional Chinese medicine composition performs antibiosis and antiphlogosis through multiple dimensions, and the components are cooperated to form an effective component for antibiosis, antiphlogosis and analgesia, so that pain is effectively improved, analgesia, antiphlogosis and wound healing are promoted. Solves the problems of poor product effect and higher cost in the field of the traditional Chinese medicine for relieving pain after anorectal surgery.
Claims (9)
1. A traditional Chinese medicine composition for relieving pain and bleeding is characterized by comprising the following components in parts by weight: 25-45 parts of golden cypress, 22-24 parts of mirabilite, 22-24 parts of alum, 25-45 parts of Chinese violet, 25-45 parts of platycodon grandiflorum, 25-45 parts of ligusticum wallichii, 25-45 parts of cassia twig and 22-24 parts of raw liquorice.
2. The traditional Chinese medicine composition for relieving pain and bleeding according to claim 1, which is characterized by comprising the following components in parts by weight: 30 parts of golden cypress, 20 parts of mirabilite, 20 parts of alum, 20 parts of Chinese violet, 20 parts of platycodon grandiflorum, 20 parts of ligusticum wallichii, 20 parts of cassia twig and 30 parts of raw liquorice.
3. The preparation method of the traditional Chinese medicine composition for relieving pain and bleeding according to claim 1 or 2, which is characterized by comprising the following steps: weighing the phellodendron, the mirabilite, the alum, the Chinese violet, the platycodon grandiflorum, the ligusticum wallichii, the cassia twig and the raw liquorice according to the mass parts, mixing and grinding into fine powder to obtain the finished product of the traditional Chinese medicine composition.
4. The preparation method of the traditional Chinese medicine pad for relieving pain and oozing blood based on claim 3 is characterized by comprising the following steps:
s1, filling a first preset amount of finished traditional Chinese medicine composition into a non-woven fabric bag, and sealing to prepare a medicine bag;
s2, placing the medicine bag into a medicine bag containing bag, and arranging a reinforcing component on the medicine bag containing bag to obtain the traditional Chinese medicine pad.
5. The method for preparing a herbal cushion for relieving pain and promoting blood circulation according to claim 4, wherein the first predetermined amount is 3-5g.
6. The application of the traditional Chinese medicine pad for relieving pain and bleeding according to claim 4 is characterized by comprising the following steps:
s1, opening a reinforcing component of the traditional Chinese medicine pad and fixing the reinforcing component on underwear corresponding to the wound;
s2, dripping a second preset amount of normal saline on the medicine bag.
7. The use of a herbal pad according to claim 6, wherein the second predetermined amount is 2-3ml.
8. The use of the herbal cushion for relieving pain and bleeding according to claim 6, wherein the normal saline is 0.9% normal saline.
9. The use of a medicated pad for relieving pain and promoting blood circulation of claim 6, further comprising a step of providing a self-heating patch on the side of the undergarment away from the medicated pad to heat the pad across the undergarment.
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