CN103356824B - Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof - Google Patents
Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof Download PDFInfo
- Publication number
- CN103356824B CN103356824B CN201310269964.1A CN201310269964A CN103356824B CN 103356824 B CN103356824 B CN 103356824B CN 201310269964 A CN201310269964 A CN 201310269964A CN 103356824 B CN103356824 B CN 103356824B
- Authority
- CN
- China
- Prior art keywords
- weight portions
- radix
- flos
- mixed powder
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine based narcotic drug used for a tooth extraction operation and a preparation method thereof. The traditional Chinese medicine based narcotic drug comprises the raw medicines as follows: flos rhododendri, rubia cordifolia, flos daturae, pentapetes phoeniceam, glaucescent fissistigma root, carbo of typhae pollen, membrana follicularis ovi, cutch, alangium chinense harms, illicium verum, stellaria media, honeysuckle, herb of pedunculoside and radix angelicae. The traditional Chinese medicine based narcotic drug provided by the invention is prepared based on traditional Chinese theory of traditional Chinese medicine, has the advantages of being free of toxic and side effect, good in effects on relieving pain and stopping bleeding, fast to come into effect and low in cost, does not need injection when in use; when in use, dental tweezers are operated to clamp a cotton ball to drop or apply the liquid medicine into a periodontal pocket of a tooth to be extracted; when the periodontium has no pain, the tooth extraction operation can be carried out; therefore, the feared state of mind of a patient, especially a child and the patient fearful of giving an injection or the patient fainting on acupuncture, can be quelled.
Description
Technical field
The present invention relates to technical field of Chinese medicines, relate in particular to a kind of Chinese drug anesthesia medicine for tooth pulling surgery and preparation method thereof.
Background technology
At present, the known dentistry exodontia Western medicine anesthesia injections that adopt more, many deciduous teeth change the patient that tooth, wisdom tooth, cacodontia need to be pulled out into, because fearing untoward reaction that injection causes as pale complexion, nervous, uncomfortable in chest, nauseating etc., can also there is shock in serious, and the postoperative hemorrhage having is more than, infection etc., and situation occurs, also has in addition anaphylaxis etc.These all fearness psychology and reaction happen occasionally, and bring a lot of troubles to the work of odontologist, make odontopathy patient feel painful deeply.
Summary of the invention
Technical problem to be solved by this invention is, overcome drawback and the deficiency of above-mentioned Western medicine anesthesia injection, utilize the traditional theory of Chinese medical science of China, a kind of pure Chinese medicinal preparation is provided, have no side effect, analgesic hemostatic is effective, instant effect, Chinese drug anesthesia medicine for tooth pulling surgery that cost is low and preparation method thereof.
For solving the problems of the technologies described above, the invention provides a kind of Chinese drug anesthesia medicine for tooth pulling surgery, its raw medicinal material comprises: Flos Rhododendri Mollis, charred RADIX RUBIAE, Flos Daturae, Herba Portulacae Grandiflorae, Radix Fissistigmatis Glaucescentis, Pollen Typhae carbon, Membrana Follicularis ovi, catechu, Radix Alangii, Fructus Anisi Stellati, Herba malachii aquatici, Flos Lonicerae, Ilex pedunculosa Miq and the Radix Angelicae Dahuricae.
Wherein, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material can be preferably: Flos Rhododendri Mollis 8～15 weight portions, charred RADIX RUBIAE 15～35 weight portions, Flos Daturae 10～30 weight portions, Herba Portulacae Grandiflorae 10～20 weight portions, Radix Fissistigmatis Glaucescentis 15～25 weight portions, Pollen Typhae carbon 10～25 weight portions, Membrana Follicularis ovi 15～25 weight portions, catechu 10～15 weight portions, Radix Alangii 10～30 weight portions, Fructus Anisi Stellati 20～35 weight portions, Herba malachii aquatici 15～25 weight portions, Flos Lonicerae 20～30 weight portions, Ilex pedunculosa Miq 15～30 weight portions and the Radix Angelicae Dahuricae 20～35 weight portions.
Wherein, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Flos Rhododendri Mollis 10～13 weight portions, charred RADIX RUBIAE 20～30 weight portions, Flos Daturae 15～25 weight portions, Herba Portulacae Grandiflorae 15～20 weight portions, Radix Fissistigmatis Glaucescentis 20～25 weight portions, Pollen Typhae carbon 15～20 weight portions, Membrana Follicularis ovi 20～25 weight portions, catechu 10～13 weight portions, Radix Alangii 15～25 weight portions, Fructus Anisi Stellati 25～30 weight portions, Herba malachii aquatici 20～25 weight portions, Flos Lonicerae 25～30 weight portions, Ilex pedunculosa Miq 15～20 weight portions and the Radix Angelicae Dahuricae 25～35 weight portions.
Wherein, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Flos Rhododendri Mollis 12 weight portions, charred RADIX RUBIAE 26 weight portions, Flos Daturae 23 weight portions, Herba Portulacae Grandiflorae 17 weight portions, Radix Fissistigmatis Glaucescentis 21 weight portions, Pollen Typhae carbon 17 weight portions, Membrana Follicularis ovi 22 weight portions, catechu 11 weight portions, Radix Alangii 18 weight portions, Fructus Anisi Stellati 28 weight portions, Herba malachii aquatici 23 weight portions, Flos Lonicerae 27 weight portions, Ilex pedunculosa Miq 16 weight portions and the Radix Angelicae Dahuricae 31 weight portions.
Wherein, when the dosage form of described Chinese drug anesthesia medicine is tincture, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 90%;
Second step, in the mixed powder that the first step obtains, add the ethanol that the determining alcohol with respect to 4～8 times of the quality of described mixed powder is 85%～95%, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 4 ℃～6 ℃ standing 30～60 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 90～150 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
The 3rd step, gets mixed powder 80g～150g that second step obtains, and adds 60 degree～70 degree Chinese liquor 300ml～800ml, stirs it is dissolved, and soaks 20～40 hours, filters, and bottles standby.
Beneficial effect of the present invention: Chinese drug anesthesia medicine provided by the invention, utilize the traditional theory of Chinese medical science of China, have and have no side effect, analgesic hemostatic is effective, instant effect, the advantage that cost is low, does not need injection during use, only need take the photograph sub-folder by dentistry and hold cotton balls dip in liquid medicine and splash into or wipe and will have tooth pulled out in the periodontal pocket of tooth for several times, while detecting periodontal tissue's analgesia, can implement tooth pulling surgery, can effectively eliminate patient's the feared state of mind, particularly child, fear the exodontia person who has an injection and have a fainting spell during acupuncture treatment.
The specific embodiment
The invention provides a kind of Chinese drug anesthesia medicine for tooth pulling surgery, its raw medicinal material comprises: Flos Rhododendri Mollis, charred RADIX RUBIAE, Flos Daturae, Herba Portulacae Grandiflorae, Radix Fissistigmatis Glaucescentis, Pollen Typhae carbon, Membrana Follicularis ovi, catechu, Radix Alangii, Fructus Anisi Stellati, Herba malachii aquatici, Flos Lonicerae, Ilex pedunculosa Miq and the Radix Angelicae Dahuricae.
The herbal pharmacology of each raw medicinal material is as follows:
Flos Rhododendri Mollis: pungent, temperature; Very toxic.Return Liver Channel.Expelling wind and removing dampness, dissipating blood stasis analgesic therapy.For rheumatic arthralgia, traumatic injury, skin stubborn dermatitis.Tinea is controlled in external, decocts water rinsing the mouth and controls caries pain.
Charred RADIX RUBIAE: hardship, cold.Return Liver Channel.Removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.
Flos Daturae: pungent, temperature; Poisonous.Return lung, Liver Channel.Antiasthmatic-antitussive, analgesia, spasmolytic.For asthma and cough, coldness and pain in the epigastrium, rheumatic arthralgia, children's's intermittent infantile convulsion; Surgical anesthesia.
Herba Portulacae Grandiflorae: light; Micro-hardship; Cold in nature.Heat-clearing and toxic substances removing; Dissipating blood stasis hemostasis.Main laryngopharynx swelling and pain; Furuncle; Eczema; Treating swelling and pain by traumatic injury; Burn and scald; Traumatic hemorrhage.
Radix Fissistigmatis Glaucescentis: temperature; Pungent puckery.Return Liver Channel.Wind-damp dispelling; Restore menstrual flow and invigorate blood circulation; Hemostasis.Main air pain of dampness syndrome; Menoxenia; Traumatic injury; Fracture; Traumatic hemorrhage.
Pollen Typhae carbon: sweet, flat.Return liver, pericardium channel.Hemostasis, blood stasis dispelling, treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Membrana Follicularis ovi: sweet in the mouth; Light; Property is put down.Return spleen; Stomach; Lung meridian.Nourishing YIN and clearing away lung-heat; Sore; Removing nebula; Synthetism.The main outer asthma of coughing; Pharyngalgia aphonia; Lymphoid tuberculosis; Ulcer being unable to heal; The raw cataracta of order; The vertigo; Trauma fracture.
Catechu: bitter, puckery, be slightly cold.Return lung meridian.Removing dampness promoting tissue regeneration and ulcer healing.For ulcer being unable to heal, eczema, aphtha, falls and flutters the pain of injury, traumatic hemorrhage.
Radix Alangii: acrid in the mouth; Bitter; Slightly warm in nature; Mild toxicity.Return liver; Kidney; Heart channel.Dispel the wind, dredging collateral, dissipating blood stasis, analgesia, and have anesthesia and relaxed muscle effect.Dispelling the wind and dampness pathogens pain, paralysis and numbness, heart failure, impairment caused by overstrain lumbago, traumatic injury.
Fructus Anisi Stellati: pungent, temperature.Return liver,kidney,spleen, stomach warp.Warming YANG to expel cold, regulating QI to relieve pain.For colic of cold type stomachache, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.
Herba malachii aquatici: sweet; Acid; Property is put down.Return liver; Stomach warp.Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main dyspnea and cough due to lung-heat; Dysentery; Carbuncle; Hemorrhoid; Toothache; Menoxenia; Infantile malnutrition.
Flos Lonicerae: sweet, cold.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Ilex pedunculosa Miq: bitter in the mouth; Puckery; Cool in nature.Return lung; Liver; Kidney; Large intestine channel.Expelling wind and removing dampness; Dissipating blood stasis hemostasis.Main air pain of dampness syndrome; Traumatic hemorrhage; Traumatic injury; Chapped skin; Cicatrix.The book on Chinese herbal medicine outline > > of < < Xinhua: there is the function of heat-clearing and toxic substances removing, hemostasis and pain-relieving, for traumatic hemorrhage, rheumatic arthritis, lumbago, traumatic injury, chapped skin, cicatrix.
The Radix Angelicae Dahuricae: pungent, temperature.Return stomach, large intestine, lung meridian.Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Wherein, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material can be preferably: Flos Rhododendri Mollis 8～15 weight portions, charred RADIX RUBIAE 15～35 weight portions, Flos Daturae 10～30 weight portions, Herba Portulacae Grandiflorae 10～20 weight portions, Radix Fissistigmatis Glaucescentis 15～25 weight portions, Pollen Typhae carbon 10～25 weight portions, Membrana Follicularis ovi 15～25 weight portions, catechu 10～15 weight portions, Radix Alangii 10～30 weight portions, Fructus Anisi Stellati 20～35 weight portions, Herba malachii aquatici 15～25 weight portions, Flos Lonicerae 20～30 weight portions, Ilex pedunculosa Miq 15～30 weight portions and the Radix Angelicae Dahuricae 20～35 weight portions.
Wherein, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Flos Rhododendri Mollis 10～13 weight portions, charred RADIX RUBIAE 20～30 weight portions, Flos Daturae 15～25 weight portions, Herba Portulacae Grandiflorae 15～20 weight portions, Radix Fissistigmatis Glaucescentis 20～25 weight portions, Pollen Typhae carbon 15～20 weight portions, Membrana Follicularis ovi 20～25 weight portions, catechu 10～13 weight portions, Radix Alangii 15～25 weight portions, Fructus Anisi Stellati 25～30 weight portions, Herba malachii aquatici 20～25 weight portions, Flos Lonicerae 25～30 weight portions, Ilex pedunculosa Miq 15～20 weight portions and the Radix Angelicae Dahuricae 25～35 weight portions.
Wherein, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Flos Rhododendri Mollis 12 weight portions, charred RADIX RUBIAE 26 weight portions, Flos Daturae 23 weight portions, Herba Portulacae Grandiflorae 17 weight portions, Radix Fissistigmatis Glaucescentis 21 weight portions, Pollen Typhae carbon 17 weight portions, Membrana Follicularis ovi 22 weight portions, catechu 11 weight portions, Radix Alangii 18 weight portions, Fructus Anisi Stellati 28 weight portions, Herba malachii aquatici 23 weight portions, Flos Lonicerae 27 weight portions, Ilex pedunculosa Miq 16 weight portions and the Radix Angelicae Dahuricae 31 weight portions.
Wherein, when the dosage form of described Chinese drug anesthesia medicine is tincture, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 90%;
Second step, in the mixed powder that the first step obtains, add the ethanol that the determining alcohol with respect to 4～8 times of the quality of described mixed powder is 85%～95%, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 4 ℃～6 ℃ standing 30～60 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 90～150 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
The 3rd step, gets mixed powder 80g～150g that second step obtains, and adds 60 degree～70 degree Chinese liquor 300ml～800ml, stirs it is dissolved, and soaks 20～40 hours, filters, and bottles standby.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1: tincture 1 prepared by the present invention
Get Flos Rhododendri Mollis 12g, charred RADIX RUBIAE 26g, Flos Daturae 23g, Herba Portulacae Grandiflorae 17g, Radix Fissistigmatis Glaucescentis 21g, Pollen Typhae carbon 17g, Membrana Follicularis ovi 22g, catechu 11g, Radix Alangii 18g, Fructus Anisi Stellati 28g, Herba malachii aquatici 23g, Flos Lonicerae 27g, Ilex pedunculosa Miq 16g and Radix Angelicae Dahuricae 31g;
Its preparation method comprises the following steps:
The first step, above-mentioned raw materials medical material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 2 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of mixed powder is at least 90%;
Second step, in the mixed powder that the first step obtains, add the ethanol that the determining alcohol with respect to 6 times of the quality of mixed powder is 90%, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 5 ℃ standing 40 hours, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 120 minutes, obtain the mixed powder of the micron particles of 2 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of mixed powder is at least 95%,
The 3rd step, gets the mixed powder 120g that second step obtains, and adds 60 degree Chinese liquor 700ml, stirs it is dissolved, and soaks 30 hours, filters, and bottles standby.
Tincture 2 prepared by embodiment 2 the present invention
Get Flos Rhododendri Mollis 10g, charred RADIX RUBIAE 23g, Flos Daturae 17g, Herba Portulacae Grandiflorae 15g, Radix Fissistigmatis Glaucescentis 24g, Pollen Typhae carbon 19g, Membrana Follicularis ovi 24g, catechu 13g, Radix Alangii 21g, Fructus Anisi Stellati 26g, Herba malachii aquatici 21g, Flos Lonicerae 25g, Ilex pedunculosa Miq 18g and Radix Angelicae Dahuricae 27g;
Its preparation method comprises the following steps:
The first step, above-mentioned raw materials medical material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 1 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of mixed powder is at least 90%;
Second step, in the mixed powder that the first step obtains, add the ethanol that the determining alcohol with respect to 8 times of the quality of mixed powder is 85%, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 6 ℃ standing 50 hours, adopt percolation with the speed of 1ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 100 minutes, obtain the mixed powder of the micron particles of 1 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of mixed powder is at least 95%,
The 3rd step, gets the mixed powder 90g that second step obtains, and adds 70 degree Chinese liquor 400ml, stirs it is dissolved, and soaks 24 hours, filters, and bottles standby.
Acute toxicity testing:
40 of application NIH mices, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; The tincture 1 of embodiments of the invention 1 preparation is dissolved in water, (concentration is 4.45g crude drug/ml, maximum concentration) gavage, gavage volume is 2ml/kg (being that single-dose dosage is 8.9 crude drugs/kg), matched group gives equivalent normal saline, administration in one day 1 time, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tincture LD50=8.9 crude drug/kg/ day of the present invention.Chinese medicine clinical application amount of the present invention is 2.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.04g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 20g) oral administration gavage Chinese drug anesthesia medicine of the present invention is quantity 222 times.Therefore Chinese drug anesthesia medicine acute toxicity of the present invention is low, clinical drug safety.
Clinical experiment:
Case selection: get the 212 routine sufferers that in October, 2010～2013 derive from the court's exodontia patient year February, male's 124 examples, women's 88 examples, 9～52 years old age.Retained deciduous teeth 54 examples; Wound or odontopathy cause agomphiasis 68 examples that need to pull out; Undesirable root tooth 36 examples that a variety of causes forms; Impacted wisdom tooth 54 examples;
Anesthesia: isolation saliva, periodontal routine disinfection.With the tincture medicinal liquid that dental forceps clamping cotton balls dips in the embodiment of the present invention 1 preparation, splash in the periodontal pocket of the tooth of will having tooth pulled out and in nest hole for several times, approximately 1～3 minute, while detecting periodontal tissue's analgesia, can implement tooth pulling surgery.
The standard of curative effect evaluation: effective: painless or pain is very little in art, postoperative 2～5min can form good blood clot, without oozing of blood, edge of wound shrinks, the postoperative nothing inflammation that occurs together; Effective: in art, without obvious pain, postoperative 2～5min can form blood clot, visible a little oozing of blood of naked eyes, edge of wound is without obvious contraction, the postoperative nothing inflammation that occurs together; Invalid: in art, have obvious pain or hurt like hell, after postoperative medication 8min, clot forms not exclusively, and naked eyes are shown in obviously hemorrhage, or produces the inflammation that occurs together simultaneously.
Therapeutic outcome: in Table 1.
Anaesthetic effect statistics after table 1 tooth pulling surgery
Known according to table 1, Chinese drug anesthesia medicine of the present invention, analgesic hemostatic is effective, instant effect, the check statistics through postoperative 1 week, postoperative without infecting.
Model case:
Zhang, man, 22 years old.Because of lower front tooth the right the 4th class retained deciduous tooth, to outpatient service, seek medical advice, requiring doctor is that it is pulled out, and then inlays one, after diagnosis, agrees to pull out.Before operation, isolation saliva, periodontal routine disinfection.Then with the tincture medicinal liquid that dental forceps clamping cotton balls dips in the embodiment of the present invention 1 preparation, splash in the periodontal pocket of the tooth of will having tooth pulled out and in nest hole 6 times, approximately 2 minutes, detect periodontal tissue's analgesia, implement tooth pulling surgery.Painless in art, postoperative 4min forms good blood clot, and without oozing of blood, edge of wound shrinks, check after 1 week, and post-operative recovery is good, without hemorrhage, without pain, without occurring together inflammation.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (3)
1. the Chinese drug anesthesia medicine for tooth pulling surgery, it is characterized in that, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material is: Flos Rhododendri Mollis 8～15 weight portions, charred RADIX RUBIAE 15～35 weight portions, Flos Daturae 10～30 weight portions, Herba Portulacae Grandiflorae 10～20 weight portions, Radix Fissistigmatis Glaucescentis 15～25 weight portions, Pollen Typhae carbon 10～25 weight portions, Membrana Follicularis ovi 15～25 weight portions, catechu 10～15 weight portions, Radix Alangii 10～30 weight portions, Fructus Anisi Stellati 20～35 weight portions, Herba malachii aquatici 15～25 weight portions, Flos Lonicerae 20～30 weight portions, Ilex pedunculosa Miq 15～30 weight portions and the Radix Angelicae Dahuricae 20～35 weight portions,
The dosage form of described Chinese drug anesthesia medicine is tincture, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 90%;
Second step, in the mixed powder that the first step obtains, add the ethanol that the determining alcohol with respect to 4～8 times of the quality of described mixed powder is 85%～95%, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 4 ℃～6 ℃ standing 30～60 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 90～150 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
The 3rd step, gets mixed powder 80g～150g that second step obtains, and adds 60 degree～70 degree Chinese liquor 300ml～800ml, stirs it is dissolved, and soaks 20～40 hours, filters, and bottles standby.
2. Chinese drug anesthesia medicine as claimed in claim 1, it is characterized in that, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material is: Flos Rhododendri Mollis 10～13 weight portions, charred RADIX RUBIAE 20～30 weight portions, Flos Daturae 15～25 weight portions, Herba Portulacae Grandiflorae 15～20 weight portions, Radix Fissistigmatis Glaucescentis 20～25 weight portions, Pollen Typhae carbon 15～20 weight portions, Membrana Follicularis ovi 20～25 weight portions, catechu 10～13 weight portions, Radix Alangii 15～25 weight portions, Fructus Anisi Stellati 25～30 weight portions, Herba malachii aquatici 20～25 weight portions, Flos Lonicerae 25～30 weight portions, Ilex pedunculosa Miq 15～20 weight portions and the Radix Angelicae Dahuricae 25～35 weight portions.
3. Chinese drug anesthesia medicine as claimed in claim 1, it is characterized in that, in described Chinese drug anesthesia medicine, the ratio of weight and number of each raw medicinal material is: Flos Rhododendri Mollis 12 weight portions, charred RADIX RUBIAE 26 weight portions, Flos Daturae 23 weight portions, Herba Portulacae Grandiflorae 17 weight portions, Radix Fissistigmatis Glaucescentis 21 weight portions, Pollen Typhae carbon 17 weight portions, Membrana Follicularis ovi 22 weight portions, catechu 11 weight portions, Radix Alangii 18 weight portions, Fructus Anisi Stellati 28 weight portions, Herba malachii aquatici 23 weight portions, Flos Lonicerae 27 weight portions, Ilex pedunculosa Miq 16 weight portions and the Radix Angelicae Dahuricae 31 weight portions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310269964.1A CN103356824B (en) | 2013-06-20 | 2013-06-20 | Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310269964.1A CN103356824B (en) | 2013-06-20 | 2013-06-20 | Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103356824A CN103356824A (en) | 2013-10-23 |
| CN103356824B true CN103356824B (en) | 2014-11-26 |
Family
ID=49359626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310269964.1A Expired - Fee Related CN103356824B (en) | 2013-06-20 | 2013-06-20 | Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103356824B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989813A (en) * | 2014-05-22 | 2014-08-20 | 李克伟 | Traditional Chinese medicinal anesthetic for dental operations and preparation method thereof |
| CN103977137A (en) * | 2014-05-22 | 2014-08-13 | 李克伟 | Epidermal anesthetic and preparation method thereof |
| CN104367733A (en) * | 2014-11-02 | 2015-02-25 | 颜政 | Traditional Chinese medicine anesthetic for tooth pulling surgery and preparation method thereof |
| CN105362681A (en) * | 2015-11-25 | 2016-03-02 | 邱成毅 | Medicine for surface anesthesia |
| CN105853651A (en) * | 2016-06-23 | 2016-08-17 | 郭建荣 | Traditional Chinese medicine ointment for local anesthetic and analgesic, as well as preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119980A (en) * | 2011-02-24 | 2011-07-13 | 张玉霞 | Chinese medicinal Hindu datura flower-manchurian wildginger compound skin surface infiltration anesthetic |
| CN102240352A (en) * | 2010-05-14 | 2011-11-16 | 张绍敏 | Narcotic powder for tooth extraction and preparation method thereof |
-
2013
- 2013-06-20 CN CN201310269964.1A patent/CN103356824B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240352A (en) * | 2010-05-14 | 2011-11-16 | 张绍敏 | Narcotic powder for tooth extraction and preparation method thereof |
| CN102119980A (en) * | 2011-02-24 | 2011-07-13 | 张玉霞 | Chinese medicinal Hindu datura flower-manchurian wildginger compound skin surface infiltration anesthetic |
Non-Patent Citations (4)
| Title |
|---|
| 外用中药麻醉剂的发展与应用;孟阳;《北京中医》;20071130;第26卷(第11期);757-759 * |
| 孟阳.外用中药麻醉剂的发展与应用.《北京中医》.2007,第26卷(第11期),757-759. * |
| 王树荣.闹羊花与洋金花静脉复合麻醉90例报告.《人民军医》.1982,(第9期),37-38. * |
| 闹羊花与洋金花静脉复合麻醉90例报告;王树荣;《人民军医》;19821231(第9期);37-38 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103356824A (en) | 2013-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103356824B (en) | Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof | |
| CN101274024B (en) | Pharmaceutical compositions for curing toothache | |
| CN105056159A (en) | Medicine for treating parasitic diseases of pigs and preparation method thereof | |
| CN104721632A (en) | Clinical medical herbal anesthetic | |
| CN104623433A (en) | Traditional Chinese medicine for preventing postanesthesia shivering and preparation method of traditional Chinese medicine | |
| CN103990103A (en) | Medicine for local anaesthesia and preparation method of medicine | |
| CN105079420A (en) | Anesthesia ointment for wound surface and preparation method of anesthesia ointment | |
| CN104587206A (en) | Medicament for treating bedsore and preparation method of medicament | |
| CN103251754A (en) | Traditional Chinese medicine composition for treating bedsore | |
| CN103142727B (en) | Chinese herbal medicine composition for treating burning and scalding of human body | |
| CN102579607B (en) | Chinese medicine composition for treating acne | |
| CN105267516A (en) | Plaster for skin surface local anesthesia | |
| CN105343660A (en) | Traditional Chinese medicinal preparation for treating peripheral vertigo and preparation method of traditional Chinese medicinal preparation | |
| CN116942740B (en) | Traditional Chinese medicine composition for treating lumbar disc herniation and application thereof | |
| CN105853651A (en) | Traditional Chinese medicine ointment for local anesthetic and analgesic, as well as preparation method and application thereof | |
| CN115501289B (en) | Chinese medicinal composition and pad for relieving pain and blood permeation and preparation method thereof | |
| CN102552772B (en) | Traditional Chinese medicine used for treating chronic cough lung deficiency | |
| CN104606444A (en) | Traditional Chinese anesthesia medicine for tooth extraction and preparation method of traditional Chinese anesthesia medicine | |
| CN105998738A (en) | Traditional Chinese medicinal composition for treating night sweat | |
| CN105998504A (en) | Traditional Chinese medicinal narcotic preparation | |
| CN104887808A (en) | Periodontitis treatment traditional Chinese medicine preparation | |
| CN106038905A (en) | Narcotic analgesic and preparation method thereof | |
| CN105055886A (en) | Traditional Chinese medicine composite for treating both-qi-and-yin-deficiency type tuberculosis | |
| CN104984069A (en) | Traditional Chinese medicinal narcotic applied in painless abortion surgery, and preparation method thereof | |
| CN104740200A (en) | Traditional Chinese medicine spray for treating nasal obstruction caused by chronic nasosinusitis and preparation method of traditional Chinese medicine spray |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141126 Termination date: 20150620 |
|
| EXPY | Termination of patent right or utility model |