CN105853651A - Traditional Chinese medicine ointment for local anesthetic and analgesic, as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine ointment for local anesthetic and analgesic, as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine ointment for local anesthetic and analgesic, as well as a preparation method and application thereof. The traditional Chinese medicine ointment is prepared from the following raw materials in parts by weight: 20-28 parts of polygala tenuifolia, 24-32 parts of denseleaf sedge, 1-8 parts of ardisia villosa, 18-26 parts of chamaenerion angustifolium and 10-18 parts of solanum lyratum. The preparation method comprises the following steps: grinding and screening ardisia villosa, extracting twice with absolute ethanol, and concentrating to obtain concentrate; grinding and screening polygala tenuifolia and denseleaf sedge, stirring with hydrogen peroxide aqueous solution, and filtering to obtain filtrate A; grinding and screening chamaenerion angustifolium and solanum lyratum, heating and stirring with an ethanol solution having a concentration of 75 percent, freezing, heating and stirring, and filtering to obtain filtrate B; and mixing, heating and stirring the concentrate, the filtrate A and the filtrate B. The traditional Chinese medicine ointment has the advantages of quick response, high local anesthetic efficacy, strong intranperative controllability, quick local anesthetic recovery, no toxic or side effect, good pain relieving and bleeding stopping effect, low cost and shock prevention, and is especially applicable to children and tooth to-be-extracted persons who are afraid of injection and fainting on acupuncture.
Description
Technical field
The present invention relates to pharmaceutical technology field, a kind of Chinese medicine ointment for local anesthesia pain relieving and its preparation method and application.
Background technology
In clinical operation, when anesthesia is to perform a surgical operation or carry out diagnostic test operation time for eliminate patient pain, ensure patient safety, create good
Good surgical condition and the various methods taked.Patient, when carrying out invasive diagnosis and checking with operation technique, can feel pain and discomfort, needs
With using local anesthetic topical anesthesia, or general anesthesia is used to make patient's swound.Operation or check that operation can cause patient's psychentonia and not
Good reflection occurs, as abdominal postoperative can cause Nausea and vomiting.Special posture (such as ventricumbent position, calculi position etc.), can increase patient's for a long time
Do not accommodate misery, therefore should make patient in environment comfortable, quiet, alleviate pessimal stimulation, keep as far as possible painless in the case of undergo surgery.Mesh
Before, clinical commonly used local anesthesia method is still injection lignocaine local infiltration, or the method for block nerves conduction carries out field block, or
Topical anesthesia is carried out by local anaesthetics pad pasting.The operation of existing anesthesia method is comparatively laborious, and anesthetic risks is higher, and anaesthetic effect is difficult to ensure that.
Change tooth in particular for many deciduous teeth, wisdom tooth, cacodontia need the patient that pulls out, use Western medicine anesthesia injection methods, because fearing injection more
Pain and the stress such as pale complexion, nervous, uncomfortable in chest, nauseating etc. that causes, severe one may result in haemophilia after shock, and the operation in patients having,
There is the situations such as infection, the anaphylaxis etc. that the most also local anaesthetics causes.These are all afraid of that psychology and reaction happen occasionally, to the work of clinician
Bring a lot of trouble, make dental patient feel painful deeply.
Summary of the invention
It is an object of the invention to provide that a kind of instant effect, local anesthesia usefulness is high, controllability is strong in art, have no side effect, analgesic hemostatic is effective,
Low cost, antishock Chinese medicine ointment for local anesthesia pain relieving and its preparation method and application, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine ointment for local anesthesia pain relieving, is made up of according to the raw material of weight portion following: Radix Polygalae 20-28 part, mountain Herba Verbenae 24-32
Part, Radix ardisiae villosae 1-8 part, Herba Epilobii Angustifoii 18-26 part, Herba Solani Lyrati 10-18 part.
As the further scheme of the present invention: the described Chinese medicine ointment for local anesthesia pain relieving, it is made up of according to the raw material of weight portion following: Radix Polygalae
22-26 part, mountain Herba Verbenae 26-30 part, Radix ardisiae villosae 3-6 part, Herba Epilobii Angustifoii 20-24 part, Herba Solani Lyrati 12-16 part.
As the further scheme of the present invention: the described Chinese medicine ointment for local anesthesia pain relieving, it is made up of according to the raw material of weight portion following: Radix Polygalae
24 parts, mountain Herba Verbenae 28 parts, Radix ardisiae villosae 5 parts, Herba Epilobii Angustifoii 22 parts, Herba Solani Lyrati 14 parts.
It is a further object of the present invention to provide the preparation method of a kind of Chinese medicine ointment for local anesthesia pain relieving, comprise the steps of:
1) being pulverized by Radix ardisiae villosae, cross 200 mesh sieves, the dehydrated alcohol adding its quality 7-8 times extracts 2 times, and extraction temperature is 62-65 DEG C, leaching
The time of carrying is 2.2-2.5h, merges lixiviating solution and is concentrated into the 32-35% of original volume, preparing concentrated solution；
2) Radix Polygalae, mountain Herba Verbenae are pulverized, cross 80 mesh sieves, add the aqueous hydrogen peroxide solution of the two quality 15-16 times, in aqueous hydrogen peroxide solution
The weight/mass percentage composition of hydrogen peroxide is 3-5%, stirs 1-1.2h, then stir process 30-35min at 45-47 DEG C at 15-20 DEG C, then at 60-62 DEG C
Lower heated and stirred processes 25-30min, heated and stirred 25-30min at then heating to 100-102 DEG C, crosses leaching filtrate A；
3) Herba Epilobii Angustifoii, Herba Solani Lyrati are pulverized, crossed 100 mesh sieves, add 75% ethanol solution of the two quality 8-9 times, heated and stirred at 75-78 DEG C
Process 50-60min, more freezing 1-1.2h at-10 DEG C, then heated and stirred processes 1.5-1.8h at 83-85 DEG C, crosses leaching liquor B；
4) concentrated solution, filtrate A are mixed with liquor B, then heated and stirred 30-35min at 88-90 DEG C, obtain Chinese medicine ointment.
It is yet another object of the invention to provide the application in preparation local anesthesia analgesic drug product of the described Chinese medicine ointment.
It is yet another object of the invention to provide the application in preparation dentistry narcotic analgesic medicine of the described Chinese medicine ointment.
Radix Polygalae has Fructus Alpiniae Oxyphyllae of calming the nerves, the function eliminated the phlegm, subside a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration
Not well, sore swollen toxin, breast swell and pain.
Mountain Herba Verbenae clearing away heat and promoting diuresis.Main stranguria；Burn and scald.
Radix ardisiae villosae has wind-damp dispelling, effect of promoting blood circulation and stopping pain.Being usually used in rheumatic arthralgia, cough is spitted blood, abdominal pain due to cold, traumatic injury, and ulcerative carbuncle swells
Pain etc..
Herba Epilobii Angustifoii restores menstrual flow and invigorates blood circulation, reducing swelling and alleviating pain.For menoxenia；Fracture, articular sprain are controlled in external.
Herba Solani Lyrati has effect of clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, is used for treating jaundice, edema, gonorrhea, cholecystitis, cholelithiasis, rheumatic arthritis
Deng disease.
Compared with prior art, the invention has the beneficial effects as follows:
The Chinese medicine ointment that the present invention prepares, under the synergism of each raw material, has controllability in instant effect, anesthesia usefulness height, art for local anesthesia
By force, art finish recover fast, have no side effect, analgesic hemostatic is effective, low cost, cost performance advantages of higher, postoperative can be in time by anaesthetic generation
Thanking and excrete, resisting the complication caused because of anesthesia has good curative effect, it is adaptable to internal medicine, surgery etc. need the operation of local anesthesia.Especially
Ground, the present invention, in terms of dentistry, need not injection during use, only need to instill with dental forceps clamping cotton balls dip in liquid medicine or wipe the tooth of tooth to be had tooth pulled out
In week bag for several times, when detecting periodontal tissue's analgesia, tooth pulling surgery can be implemented, it is possible to effectively eliminate the feared state of mind of patient, particularly child,
Fear the exodontia person having an injection and having a fainting spell during acupuncture treatment.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described reality
Executing example is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art exist
Do not make the every other embodiment obtained under creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine ointment for local anesthesia pain relieving, it is made up of according to the raw material of weight portion following: Radix Polygalae 20 parts,
Mountain Herba Verbenae 24 parts, Radix ardisiae villosae 1 part, Herba Epilobii Angustifoii 18 parts, Herba Solani Lyrati 10 parts.
Being pulverized by Radix ardisiae villosae, cross 200 mesh sieves, the dehydrated alcohol adding its quality 7 times extracts 2 times, and extraction temperature is 62 DEG C, extraction time
For 2.2h, merge lixiviating solution and be concentrated into the 32% of original volume, preparing concentrated solution.Radix Polygalae, mountain Herba Verbenae are pulverized, cross 80 mesh sieves, adds two
The aqueous hydrogen peroxide solution that person's mass is 15 times, the weight/mass percentage composition of the hydrogen peroxide in aqueous hydrogen peroxide solution is 3%, stirs 1h, then at 15 DEG C
Stir process 30min at 45 DEG C, then at 60 DEG C, heated and stirred processes 25min, then heats to heated and stirred 25min at 100 DEG C, filters
Take filtrate A.Herba Epilobii Angustifoii, Herba Solani Lyrati are pulverized, crossed 100 mesh sieves, adds the ethanol solution that volumetric concentration is 75% of the two quality 8 times, at 75 DEG C
Lower heated and stirred processes 50min, more freezing 1h at-10 DEG C, then at 83 DEG C, heated and stirred processes 1.5h, crosses leaching liquor B.By concentrated solution,
Filtrate A mixes with liquor B, then heated and stirred 30min at 88 DEG C, obtains Chinese medicine ointment.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine ointment for local anesthesia pain relieving, it is made up of according to the raw material of weight portion following: Radix Polygalae 28 parts,
Mountain Herba Verbenae 32 parts, Radix ardisiae villosae 8 parts, Herba Epilobii Angustifoii 26 parts, Herba Solani Lyrati 18 parts.
Being pulverized by Radix ardisiae villosae, cross 200 mesh sieves, the dehydrated alcohol adding its quality 8 times extracts 2 times, and extraction temperature is 65 DEG C, extraction time
For 2.5h, merge lixiviating solution and be concentrated into the 35% of original volume, preparing concentrated solution.Radix Polygalae, mountain Herba Verbenae are pulverized, cross 80 mesh sieves, adds two
The aqueous hydrogen peroxide solution that person's mass is 16 times, the weight/mass percentage composition of the hydrogen peroxide in aqueous hydrogen peroxide solution is 5%, stirs 1.2h, then at 20 DEG C
Stir process 35min at 47 DEG C, then at 62 DEG C, heated and stirred processes 30min, then heats to heated and stirred 30min at 102 DEG C, filters
Take filtrate A.Herba Epilobii Angustifoii, Herba Solani Lyrati are pulverized, crossed 100 mesh sieves, adds 75% ethanol solution of the two quality 9 times, at 78 DEG C at heated and stirred
Reason 60min, more freezing 1.2h at-10 DEG C, then at 85 DEG C, heated and stirred processes 1.8h, crosses leaching liquor B.By concentrated solution, filtrate A with
Liquor B mixes, then heated and stirred 35min at 90 DEG C, obtains Chinese medicine ointment.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine ointment for local anesthesia pain relieving, it is made up of according to the raw material of weight portion following: Radix Polygalae 22 parts,
Mountain Herba Verbenae 26 parts, Radix ardisiae villosae 3 parts, Herba Epilobii Angustifoii 20 parts, Herba Solani Lyrati 12 parts.
Being pulverized by Radix ardisiae villosae, cross 200 mesh sieves, the dehydrated alcohol adding its quality 7.5 times extracts 2 times, and extraction temperature is 63 DEG C, extraction time
For 2.3h, merge lixiviating solution and be concentrated into the 33% of original volume, preparing concentrated solution.Radix Polygalae, mountain Herba Verbenae are pulverized, cross 80 mesh sieves, adds two
The aqueous hydrogen peroxide solution that person's mass is 15.5 times, the weight/mass percentage composition of the hydrogen peroxide in aqueous hydrogen peroxide solution is 4%, stirs 1.1h, so at 18 DEG C
After at 46 DEG C stir process 32min, then at 61 DEG C heated and stirred process 28min, then heat to heated and stirred 28min at 101 DEG C, mistake
Leaching filtrate A.Herba Epilobii Angustifoii, Herba Solani Lyrati are pulverized, crossed 100 mesh sieves, adds 75% ethanol solution of the two quality 8.5 times, heat at 76 DEG C and stir
Mix process 55min, more freezing 1.1h at-10 DEG C, then heated and stirred processes 1.6h at 84 DEG C, crosses leaching liquor B.By concentrated solution, filtrate A
Mix with liquor B, then heated and stirred 32min at 89 DEG C, obtain Chinese medicine ointment.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine ointment for local anesthesia pain relieving, it is made up of according to the raw material of weight portion following: Radix Polygalae 26 parts,
Mountain Herba Verbenae 30 parts, Radix ardisiae villosae 6 parts, Herba Epilobii Angustifoii 24 parts, Herba Solani Lyrati 16 parts.
Being pulverized by Radix ardisiae villosae, cross 200 mesh sieves, the dehydrated alcohol adding its quality 7.5 times extracts 2 times, and extraction temperature is 63 DEG C, extraction time
For 2.3h, merge lixiviating solution and be concentrated into the 33% of original volume, preparing concentrated solution.Radix Polygalae, mountain Herba Verbenae are pulverized, cross 80 mesh sieves, adds two
The aqueous hydrogen peroxide solution that person's mass is 15.5 times, the weight/mass percentage composition of the hydrogen peroxide in aqueous hydrogen peroxide solution is 4%, stirs 1.1h, so at 18 DEG C
After at 46 DEG C stir process 32min, then at 61 DEG C heated and stirred process 28min, then heat to heated and stirred 28min at 101 DEG C, mistake
Leaching filtrate A.Herba Epilobii Angustifoii, Herba Solani Lyrati are pulverized, crossed 100 mesh sieves, adds 75% ethanol solution of the two quality 8.5 times, heat at 76 DEG C and stir
Mix process 55min, more freezing 1.1h at-10 DEG C, then heated and stirred processes 1.6h at 84 DEG C, crosses leaching liquor B.By concentrated solution, filtrate A
Mix with liquor B, then heated and stirred 32min at 89 DEG C, obtain Chinese medicine ointment.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine ointment for local anesthesia pain relieving, it is made up of according to the raw material of weight portion following: Radix Polygalae 24 parts,
Mountain Herba Verbenae 28 parts, Radix ardisiae villosae 5 parts, Herba Epilobii Angustifoii 22 parts, Herba Solani Lyrati 14 parts.
Being pulverized by Radix ardisiae villosae, cross 200 mesh sieves, the dehydrated alcohol adding its quality 7.5 times extracts 2 times, and extraction temperature is 63 DEG C, extraction time
For 2.3h, merge lixiviating solution and be concentrated into the 33% of original volume, preparing concentrated solution.Radix Polygalae, mountain Herba Verbenae are pulverized, cross 80 mesh sieves, adds two
The aqueous hydrogen peroxide solution that person's mass is 15.5 times, the weight/mass percentage composition of the hydrogen peroxide in aqueous hydrogen peroxide solution is 4%, stirs 1.1h, so at 18 DEG C
After at 46 DEG C stir process 32min, then at 61 DEG C heated and stirred process 28min, then heat to heated and stirred 28min at 101 DEG C, mistake
Leaching filtrate A.Herba Epilobii Angustifoii, Herba Solani Lyrati are pulverized, crossed 100 mesh sieves, adds 75% ethanol solution of the two quality 8.5 times, heat at 76 DEG C and stir
Mix process 55min, more freezing 1.1h at-10 DEG C, then heated and stirred processes 1.6h at 84 DEG C, crosses leaching liquor B.By concentrated solution, filtrate A
Mix with liquor B, then heated and stirred 32min at 89 DEG C, obtain Chinese medicine ointment.
Comparative example 1
In addition to not containing mountain Herba Verbenae, its formula and preparation process are consistent with embodiment 5.
Comparative example 2
Containing only mountain Herba Verbenae, its preparation process is consistent with embodiment 5.
Embodiment 6 acute toxicity testing
Application NIH mice 40, SPF level, male and female half and half, body weight 16～20g, carry out acute toxicity test.Mice is randomly divided into two groups,
Often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；Chinese medicine ointment prepared by embodiments of the invention 5 is dissolved in water,
(concentration is 4.45g crude drug/ml, maximum concentration) gavage, gavage volume is 2ml/kg (i.e. unit dosage form is 8.9 crude drugs/kg), and matched group gives
Normal saline, is administered once for one day, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result table
Bright: to compare with matched group, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight
Increase the most normal.The Chinese medicine ointment LD50=8.9 crude drug/kg/ day of the Mouse oral gavage present invention.The Chinese medicine clinical application amount of the present invention is that 2.4g is raw
Medicine/day/people, adult's body weight is in terms of 60KG, and average dosage is 0.04g crude drug/kg/ day.By weighing machine: mice (average weight is in terms of 20g)
The dosis tolerata of the Chinese medicine ointment of the oral administration gavage present invention is 222 times of quantity.Therefore the Chinese medicine ointment acute toxicity of the present invention is low, clinical application
Safety.
Embodiment 7 clinical experiment
Case selection: take the 400 example sufferers of exodontia patient, male 200 example, women 200 example, age 9～52 years old.Retained deciduous teeth 40 example；
Wound or odontopathy cause agomphiasis 120 example needing to pull out；Undesirable root tooth 120 example that a variety of causes is formed；Impacted wisdom tooth 120 example；It is randomly divided into 4
Group, respectively test group, contrast 1 group, contrast 2 groups, contrast 3 groups, often group patient's patient's condition is basically identical.
Anesthesia: isolation saliva, periodontal routine disinfection.Test group: dip in the Chinese medicines of the embodiment of the present invention 5 preparation with dental forceps clamping cotton balls
In plaster drop enters the periodontal pocket of tooth to be had tooth pulled out and in cavities for several times, about 1～3 minute, when detecting periodontal tissue's analgesia, hands of having tooth pulled out can be implemented
Art.Contrast 1 group: with dental forceps clamping cotton balls dip in comparative example 1 of the present invention preparation Chinese medicine ointment medicinal liquid instill tooth to be had tooth pulled out periodontal pocket in and nest
In hole for several times, about 1～3 minute, when detecting periodontal tissue's analgesia, tooth pulling surgery can be implemented.Contrast 2 groups: clamp cotton balls with dental forceps
Dip in comparative example 2 of the present invention preparation Chinese medicine ointment medicinal liquid instill tooth to be had tooth pulled out periodontal pocket in and cavities in for several times, about 1～3 minute, detect periodontal
During tissue analgesia, tooth pulling surgery can be implemented.Contrast 3 groups: dip in general anaesthesia medicinal liquid with dental forceps clamping cotton balls and instill the periodontal of tooth to be had tooth pulled out
Bag in and cavities in for several times, about 1～3 minute, when detecting periodontal tissue's analgesia, tooth pulling surgery can be implemented.
The standard of curative effect evaluation: effective: painless or pain is the least in art, postoperative 2～5min can form good blood clot, without oozing of blood, wound
Edge shrinks, postoperative without accompanying inflammation；Effective: without obvious pain in art, postoperative 2～5min can form blood clot, a little oozing of blood seen from naked eyes,
Edge of wound is without substantially shrinking, postoperative without accompanying inflammation；Invalid: to have obvious pain or hurt like hell in art, after postoperative 8min, clot is formed
Not exclusively, naked eyes are shown in the most hemorrhage, or produce accompanying inflammation simultaneously.
Therapeutic outcome: be shown in Table 1.
Anaesthetic effect statistics after table 1 tooth pulling surgery
According to table 1, test group compares with contrast 3 groups and understands, and the Chinese medicine ointment of the present invention is superior to from effective percentage and postoperative untoward reaction
Existing anaesthetic.Knowable to test group compares with contrast 1-2 group, the Chinese medicine ointment of the present invention is under the synergism of each raw material, and analgesic hemostatic is imitated
The best, instant effect, through the reviewing statistics of postoperative 1 week, postoperative without infecting, have no side effect.The Chinese medicine ointment of the present invention has the most progressive.
Model case:
Korea Spro, female, 28 years old.Because the retained deciduous tooth of second, the upper front tooth left side is sought medical advice to outpatient service, it is desirable to doctor pulls out for it, inlays one the most again,
After diagnosis, agree to pull out.Operation consent, isolates saliva, periodontal routine disinfection.Then the embodiment of the present invention 5 is dipped in dental forceps clamping cotton balls
In the Chinese medicine ointment of preparation instills the periodontal pocket of tooth to be had tooth pulled out and in cavities 2 times, about 2 minutes, detect periodontal tissue's analgesia, implement tooth pulling surgery.
In art painless, postoperative 3min forms good blood clot, and without oozing of blood, edge of wound shrinks, and checks after 1 week, and post-operative recovery is good, without hemorrhage,
Without pain, without accompanying inflammation.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and in the spirit without departing substantially from the present invention
Or in the case of basic feature, it is possible to realize the present invention in other specific forms.Which point therefore, no matter from the point of view of, embodiment all should be regarded as
Being exemplary, and be nonrestrictive, the scope of the present invention is limited by claims rather than described above, it is intended that will fall in power
All changes in the implication of the equivalency that profit requires and scope are included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only comprises an independent technology
Scheme, this narrating mode of description is only that for clarity sake those skilled in the art should be using description as an entirety, each embodiment
In technical scheme can also form, through appropriately combined, other embodiments that it will be appreciated by those skilled in the art that.
Claims (6)
1. the Chinese medicine ointment for local anesthesia pain relieving, it is characterised in that be made up of according to the raw material of weight portion following: Radix Polygalae 20-28 part,
Mountain Herba Verbenae 24-32 part, Radix ardisiae villosae 1-8 part, Herba Epilobii Angustifoii 18-26 part, Herba Solani Lyrati 10-18 part.
Chinese medicine ointment for local anesthesia pain relieving the most according to claim 1, it is characterised in that be made up of according to the raw material of weight portion following:
Radix Polygalae 22-26 part, mountain Herba Verbenae 26-30 part, Radix ardisiae villosae 3-6 part, Herba Epilobii Angustifoii 20-24 part, Herba Solani Lyrati 12-16 part.
Chinese medicine ointment for local anesthesia pain relieving the most according to claim 1, it is characterised in that be made up of according to the raw material of weight portion following:
Radix Polygalae 24 parts, mountain Herba Verbenae 28 parts, Radix ardisiae villosae 5 parts, Herba Epilobii Angustifoii 22 parts, Herba Solani Lyrati 14 parts.
4. the preparation method of the Chinese medicine ointment being used for local anesthesia pain relieving as claimed in claim 1, it is characterised in that comprise the steps of:
1) being pulverized by Radix ardisiae villosae, cross 200 mesh sieves, the dehydrated alcohol adding its quality 7-8 times extracts 2 times, and extraction temperature is 62-65 DEG C, leaching
The time of carrying is 2.2-2.5h, merges lixiviating solution and is concentrated into the 32-35% of original volume, preparing concentrated solution；
2) Radix Polygalae, mountain Herba Verbenae are pulverized, cross 80 mesh sieves, add the aqueous hydrogen peroxide solution of the two quality 15-16 times, in aqueous hydrogen peroxide solution
The weight/mass percentage composition of hydrogen peroxide is 3-5%, stirs 1-1.2h, then stir process 30-35min at 45-47 DEG C at 15-20 DEG C, then at 60-62 DEG C
Lower heated and stirred processes 25-30min, heated and stirred 25-30min at then heating to 100-102 DEG C, crosses leaching filtrate A；
3) Herba Epilobii Angustifoii, Herba Solani Lyrati are pulverized, crossed 100 mesh sieves, add 75% ethanol solution of the two quality 8-9 times, heated and stirred at 75-78 DEG C
Process 50-60min, more freezing 1-1.2h at-10 DEG C, then heated and stirred processes 1.5-1.8h at 83-85 DEG C, crosses leaching liquor B；
4) concentrated solution, filtrate A are mixed with liquor B, then heated and stirred 30-35min at 88-90 DEG C, obtain Chinese medicine ointment.
5. the application in preparation local anesthesia analgesic drug product of the Chinese medicine ointment as described in claim 1-3 is arbitrary.
6. the application in preparation dentistry narcotic analgesic medicine of the Chinese medicine ointment as described in claim 1-3 is arbitrary.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686086A (en) * | 2018-07-12 | 2018-10-23 | 吕芳芳 | A kind of extraction local anesthetic and its preparation method and application |
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| CN101979029A (en) * | 2010-10-06 | 2011-02-23 | 阚景祥 | Chinese medicinal narcotic |
| CN103356824A (en) * | 2013-06-20 | 2013-10-23 | 侯天霞 | Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof |
| CN103877454A (en) * | 2014-04-19 | 2014-06-25 | 周洁璐 | Chinese traditional medicine plaster special for local anaesthesia and analgesia and preparation method of plaster |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101979029A (en) * | 2010-10-06 | 2011-02-23 | 阚景祥 | Chinese medicinal narcotic |
| CN103356824A (en) * | 2013-06-20 | 2013-10-23 | 侯天霞 | Traditional Chinese medicine based narcotic drug used for tooth extraction operation and preparation method thereof |
| CN103877454A (en) * | 2014-04-19 | 2014-06-25 | 周洁璐 | Chinese traditional medicine plaster special for local anaesthesia and analgesia and preparation method of plaster |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686086A (en) * | 2018-07-12 | 2018-10-23 | 吕芳芳 | A kind of extraction local anesthetic and its preparation method and application |
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Application publication date: 20160817 |