CN105343269A - Chinese herb extract with anesthetic effect and preparation method thereof - Google Patents
Chinese herb extract with anesthetic effect and preparation method thereof Download PDFInfo
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- CN105343269A CN105343269A CN201510871623.0A CN201510871623A CN105343269A CN 105343269 A CN105343269 A CN 105343269A CN 201510871623 A CN201510871623 A CN 201510871623A CN 105343269 A CN105343269 A CN 105343269A
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- chinese medicine
- medicine extract
- zanthoxyli
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention provides a Chinese herb extract with an anesthetic effect. The Chinese herb extract comprises the following raw materials in parts by weight: 10-20 parts of pericarpium zanthoxyli, 15-25 parts of purple flower holly leaf, 10-20 parts of common cephalanoplos herb, 2-8 parts of pericarpium papaveris, 7-10 parts of chamomilia, 2-4 parts of radix zanthoxyli, 3-5 parts of ginseng and 0.5-1.5 parts of procaine. The Chinese herb extract has the benefits that the Chinese herb extract stresses the overall performance, not only has an anesthetic effect but also can relieve muscle pain caused by disappearance of anesthesia, and combines pericarpium zanthoxyli, purple flower holly leaf, common cephalanoplos herb, pericarpium papaveris, chamomilia, radix zanthoxyli, ginseng and procaine to achieve an extremely good anesthetic effect on patients requiring anesthesia.
Description
Technical field
The invention belongs to traditional Chinese medicine field, relate to a kind of Chinese medicine extract with anaesthetic effect and preparation method thereof.
Background technology
It is generally acknowledged, anesthesia is the reversibility function inhibitio of a kind of nervus centralis and (or) the peripheral nervous system produced by medicine or additive method, and the feature of this suppression mainly feels the forfeiture of the particularly pain sensation.Anesthesia (anesthesia) one etymology in Greek narkosis, as the term suggests, fiber crops be numbness benumb, liquor-saturated is drunk stupor.Therefore, the implication of anesthesia with medicine or additive method, entire patient or local is temporarily lost sensibility, and carries out operative treatment to reach painless object.Anesthesiology (anesthesiology) uses the rationale of relevant anesthesia, clinical knowledge and technology to eliminate corrective surgery pain, and guarantee patient safety is the science that operation creates good conditions.Now, anesthesiology to have become in clinical medicine a special independent educational project, mainly comprising the research of Clinical Anaesthesiology, emergency resuscitation medical science, Intensive care therapeutics, Diagnosis and Treatment of Pain and other relevant medical and mechanism thereof, is the comprehensive branch of learning of a research anesthesia, analgesia, emergency resuscitation and serious symptom medical science.
Wherein clinical anesthesia is the major part of modern anaesthesia.1. general anesthesia: general anesthesia refers to and enters in body by anesthetics by suction, vein, intramuscular injection or rectal perfusion, and central nervous system is suppressed, causes patient to realize and disappears and the process of the painless feel in the whole body.This anesthesia method is " sleeping state " as the saying goes, and feature is that patient realizes disappearance, and whole-body muscle relaxes, and experiences less than pain.The most frequently used general anesthesia mode is intubation and general anaesthesia, and feature adopts intravenous anesthetic or inhalation anesthetic to produce general anesthesia effect, and need circulation of qi promoting cannula in art, mechanical assistance is breathed.The process of intubation and general anaesthesia.This process comprises induction of anesthesia, anesthesia maintenance and recovery from anesthesia.So-called induction of anesthesia allows people transfer sleeping state to by clear-headed.After patient enters operating room, first by the open venous channel (transfusion of namely having an acupuncture treatment) of nurse, Anesthetist connects electrocardiogram, blood pressure, the monitorings such as blood oxygen saturation, mask oxygen-inspiration.Then, Anesthetist just can start induction of anesthesia.Anesthetist can give patient's intravenous injection general anesthetic or inhalation anesthesia gas, and patient upon administration 3 ~ 5 minutes awareness of defecation knows disappearance, enters sleep state by clear-headed.Under generalized anesthetic state; because consciousness, whole-body muscle do not relax; patient loses the strength of breathing; autonomous respiration can disappear usually, and therefore after patient enters general anesthesia state, Anesthetist can carry out tracheal intubation operation; namely the intubation instruments such as laryngoscope auxiliary under an endotracheal tube inserted the trachea of patient through the oral cavity of patient or nasal cavity; the other end of endotracheal tube connects anesthetic machine, by anesthetic machine by endotracheal tube to patient's delivering oxygen, help patient respiratory.After this namely enter anesthesia maintenance state, Anesthetist can continue inhalation anesthesia gas by anesthetic machine to patient, or by venous channel continuous infusion anaesthetic, makes patient continue to be in narcotism.Now just can start to have performed the operation.The length of whole anesthesia maintenance time, depends on the length of operating time.Operating time is long, and the anesthesia maintenance time is just long; Operating time is short, and the anesthesia maintenance time is also short.When terminating smoothly when performing the operation, Anesthetist can stop the use of anaesthetic, and namely patient enters the recovery from anesthesia phase.Along with the metabolism of anaesthetic in patient body is discharged, anaesthetic concentration reduces gradually.When anaesthetic bulk concentration is reduced to a certain degree time, patient just can recover autonomous respiration, and consciousness also can be regained consciousness, and now endotracheal tube can be extracted by Anesthetist, continues to patient mask's oxygen uptake, and absorbs oral secretion.When the autonomous respiration of patient recovers good, realize completely clear-headed, discriminate ability good, when vital sign is steady, namely reaches recovery from anesthesia from room standard, just can return to ward.General anesthesia is not all need to carry out tracheal intubation, mechanical ventilation.Some times are short and small, and noxious stimulation is little, simple operation technique and inspection operation, and such as abortion, gastrointestinal endoscopy etc., carry out intubation and general anaesthesia with regard to not needing, and can implement to retain autonomous respiration, but the general anesthesia that consciousness disappears.
2. local anesthesia: local anesthesia utilizes local anesthetic as procaine, lignocaine etc., is injected at corresponding site and spinal nerves, plexus nervorum or nerve trunk and the thinner peripheral termination of nerve is blocked, a certain position of health is temporarily lost sensibility.The feature of local anesthesia is exactly " locally " that anesthesia is confined to health, and the consciousness of patient is clear-headed.Conventional method comprises intravertebral anesthesia (retardance), nerve block, field block, local infiltration anesthesia and topical anesthesia etc.Intravertebral anesthesia is that local anesthetic is injected into intraspinal tube by thecal puncture, and that wherein injects subarachnoid space is called subarachnoid block or lumbar anesthesia, and that injects spinal epidural cavity is called retardation of external cavity of dura mater.Intravertebral anesthesia namely everybody " the half body anesthesia " that is commonly called as.Anesthetist can carry out operation at your back, and then you just feel that the lower part of the body is numb, and the pain sensation, sense of touch disappear.
Nerve block local anesthetic is expelled to health nerve trunk (clump) place, and the region making it arrange produces pain sensation conduction block, and conventional nerve block has cervical plexus block, brachial plexus block, femoral nerve block etc.Field block is then be injected in around operative site by local anesthetic, makes the teleneuron of operative region block and reach the object of anesthesia.Local infiltration anesthesia directly local anesthetic is injected to operative site, and be distributed in each layer tissue of whole field of operation equably, to block the conduction of pain, is the anesthesia that clinical minor operation is commonly used.Topical anesthesia is by local anesthetic strong for permeability spraying or is coated on the surface such as mucosa, conjunctiva to produce anesthetic action.
, as analgesic drug product such as injection morphine, pethidine etc., then there is the problem that analgesia time is short in traditional Postoperative Analgesia After method.Analgesic is lasting by analgesia pump, constant speed is injected in vivo; block the transmission pathway of pain; although it is short to overcome analgesia time; ease pain incomplete; the shortcoming of medication repeatedly; but because analgesia pump must rely on venous channel, be more suitable for for caesarean delivered puerpera, the puerpera for vaginal delivery then affects its normal activity.At present, China market has multiple anethetic products, be used for greatly medical, and price is higher, side effect is large, is rarely used in life and uses.Mostly containing hormone and synthetic medicament in its constituent of existing anethetic products, life-time service can bring harm in various degree to human body, therefore, the invention provides a kind of anesthetis not adding any antiseptic and other hormones, without any murder by poisoning composition, belonging to natural pure tcm product, is a kind of desirable local anesthesia product.
Summary of the invention
Along with the development of Chinese Chinese medicine, people appreciate Chinese medicine gradually to be had anaesthetic effect disease therapeutic process and has no side effect, patient bears painful little, the advantage that cost is saved relatively, have the present situation of anaesthetic effect for existing doctor trained in Western medicine, an object of the present invention is to provide a kind of Chinese medicine extract with anaesthetic effect, has feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Have a Chinese medicine extract for anaesthetic effect, each raw material is as follows, is weight portion: Pericarpium Zanthoxyli 10-20, Ilex purpurea Hassk.[I.chinensis Sims 15-25, Herba Cirsii 10-20, Pericarpium Papaveris 2-8, Flos Matricariae chamomillae 7-10, Radix Zanthoxyli 2-4, Radix Ginseng 3-5, procaine 0.5-1.5.
Have a Chinese medicine extract for anaesthetic effect, preferred scheme, each raw material is as follows, is weight portion: Pericarpium Zanthoxyli 13-18, Ilex purpurea Hassk.[I.chinensis Sims 18-23, Herba Cirsii 13-18, Pericarpium Papaveris 4-6, Flos Matricariae chamomillae 8-9, Radix Zanthoxyli 2.5-3.5, Radix Ginseng 3.5-4.5, procaine 0.8-1.3.
Have a Chinese medicine extract for anaesthetic effect, better preferred scheme, each raw material is as follows, is weight portion: Pericarpium Zanthoxyli 15, Ilex purpurea Hassk.[I.chinensis Sims 20, Herba Cirsii 15, Pericarpium Papaveris 5, Flos Matricariae chamomillae 8.5, Radix Zanthoxyli 3, Radix Ginseng 4, procaine 1.
There is a preparation method for the Chinese medicine extract of anaesthetic effect, be prepared from primarily of following step:
1. Flos Matricariae chamomillae cleaned, smash to pieces, cross 100-140 mesh sieve, load in extraction kettle, in extraction kettle, pass into the CO that flow is 10-20L/h
2and extracting 2-5 hour, after extraction, gained camomile extract is collected in decompression;
2. be placed in marmite by Pericarpium Zanthoxyli, add the aqueous solution being mixed with rice vinegar, the ratio of rice vinegar and water is 1:3, boils 40-60 minute, and filter, filtrate is stand-by;
3. Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Radix Zanthoxyli and Radix Ginseng is first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 30-40 DEG C, soak 20-40 minute, take out filtering residue, filtering residue is rushed with cold water more stand-by;
4. by step 3. gained filtering residue be placed in porcelain container, add step 2. gained filtrate, decoct boiling 3-7 minute, filter, filtrate leaves standstill 20-40 hour, obtains supernatant;
5. by step 4. gained supernatant be placed in transparent vessel and add camomile extract and procaine, stir 10-20 minute clockwise with waddy, bottle and get final product.
The preparation method of above-mentioned Chinese medicine extract, 1. step crosses 110-130 mesh sieve, loads in extraction kettle, passes into the CO that flow is 13-18L/h in extraction kettle
2and extract 3-4 hour (preferred, cross 120 mesh sieves, load in extraction kettle, in extraction kettle, pass into the CO that flow is 15L/h
2and extract 3.5 hours).
The preparation method of above-mentioned Chinese medicine extract, 2. step boils 45-55 minute, filters (preferred, to boil 50 minutes, filter).
The preparation method of above-mentioned Chinese medicine extract, 3. step adds the warm water of 33-38 DEG C, soaks 25-35 minute (preferred, to add the warm water of 35 DEG C, soak 30 minutes).
The preparation method of above-mentioned Chinese medicine extract, 4. step decocts boiling 4-6 minute, filters, and filtrate leaves standstill 25-35 hour (preferred, decoct boiling 5 minutes, filter, filtrate leaves standstill 30 hours).
The preparation method of above-mentioned Chinese medicine extract, 5. step stirs 13-18 minute (preferred, to stir 15 minutes clockwise with waddy) clockwise with waddy.
The pharmacological effect of each crude drug is respectively:
Pericarpium Zanthoxyli: the traditional Chinese medical science is thought, Pericarpium Zanthoxyli is warm in nature, acrid in the mouth, has warming spleen and stomach for dispelling cold, stomach invigorating dehumidifying, pain relieving parasite killing, removing toxic substances are regulated the flow of vital energy, effect of antipruritic raw meat of dispelling; Can be used for treating food stagnation, stop pain of joint muscle, coldness and pain in the epigastrium caused by drink, singultus, vomiting, wind-cold damp pathogen, have loose bowels, dysentery, ascarid, the disease such as pudendal pruritus.Warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, separates fish raw meat poison.Control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, cough with dyspnea, anemofrigid-damp arthralgia, has loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.
Herba Cirsii: wild Flos Carthami, spinule lid, thorn dish, cat Ji, blue or green field thistle, thousand needle grass, field thistle dish, field thistle, blue and green dish, luxuriant dish, rifle cutter dish, wild Flos Carthami, thorn angle dish, thorn angle bud, wood thorn Chinese mugwort, thorn stick dish, thorn spinoblast, assassinate grass, shepherd's purse shepherd's purse hair, little evil hen, thorn Radix Raphani, Herba Cirsii nurse, oriental dodartia herb, cattle jabs, thorn tip grass, saw saw grass (common rural area is used for feeding pigs) spinule lid, luxuriant bud (the ground call such as Northern Anhui), play bud (the ground call such as Southern Henan), thorn tooth dish ground calls such as () Henan Province are northern.Sweet, bitter, cold.GUIXIN, Liver Channel.Function with cure mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Herba Cirsii energy vasoconstrictive, shortening clotting time.All inhibitory action is had to Diplococcus pneumoniae, Hemolytic streptococcus, diphtheria corynebacterium, typhoid fever village bacterium, bacillus pyocyaneus, dysentery bacterium, staphylococcus aureus etc.Decoct or tincture have excitation to rabbit uterus.In addition, still there is function of gallbladder promoting, reduce the effect of blood cholesterol.
Ilex purpurea Hassk.[I.chinensis Sims: Ilex purpurea Hassk.[I.chinensis Sims is the plant belonging to Aquifoliaceae.Be distributed in various places on the south China the Changjiang river, be often grown in sparse woods.Its root, leaf all can pharmacy, and primary efficacy is heat-clearing and toxic substances removing; Promoting tissue regeneration and ulcer healing; Promoting blood circulation and hemostasis.The dilute aqueous solution that Ilex purpurea Hassk.[I.chinensis Sims is equivalent to crude drug 0.0125g/ml all has inhibitory action to bacillus pyocyaneus, escherichia coli, Bacillus typhi, shigella flexneri, Bacillus alcaligenes, bacillus subtilis, staphylococcus aureus.When aqueous solution be diluted to be equivalent to crude drug 0.0031g/ml time, inhibitory action is still had to staphylococcus aureus.
Pericarpium Papaveris: meridian distribution of property and flavor: flat; Sour, puckery; Return lung, large intestine, kidney channel; Poison function cure mainly: astringe the lung, astringing intestine to stop diarrhea, pain relieving.For chronic cough, chronic diarrhea, proctoptosis, epigastric pain.
Flos Matricariae chamomillae: the chamomile essential oil extract by Flos Matricariae chamomillae is also popular health protection and pharmaceutical preparation.Because Flos Matricariae chamomillae can help for sleep, alleviate inflammation and the pain symptom of patient, alleviate the effect of the insomnia caused by neurotic skin pruritus.Selected areas of China also has in a large amount of cultivation, in order to be used as medicine and tea making.Effect of the helpful sleep of Flos Matricariae chamomillae, alleviates inflammation and the pain symptom of patient, alleviates the insomnia caused by neurotic skin pruritus; Flos Matricariae chamomillae soothing effect is excellent, and can alleviate anxiety, anxiety, indignation and fear, people is loosened patience, feels happy and auspicious.Alleviate worry, make soul tranquil, helpful to insomnia.
Radix Zanthoxyli: bitter in the mouth, pungent, property is put down.Gui Jing: return liver, stomach warp.Effect: blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling wind and removing obstruction in the collateral, removing toxic substances and promoting subsidence of swelling.Cure mainly: for injury from falling down, stomachache, toothache, rheumatic arthralgia, venom; Externally treating burns and scalds.
Radix Ginseng: weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.Radix Ginseng has excitation to central nervous system, and has inhibitory action on the contrary time a large amount of.Excitement and the process of inhibition of animal higher nervous activity can be strengthened.And energy enhancing body is to the adaptive capacity of all nonspecific stimulations, can reduce feeling of fatigue.
Procaine: procaine is local anesthetic.Clinical its hydrochlorate conventional, also known as " novocain ".White crystals or crystalline powder, soluble in water.Toxicity ratio cocaine is low.Add micro-epinephrine in injection, can action time be extended.For infiltration anesthesia, lumbar anesthesia, " block therapy " etc.Except over administration causes central nervous system and cardiovascular system reaction, accidental anaphylaxis, should make skin anaphylactic test before medication.Its metabolite aminobenzoic acid (PABA) can weaken the antibacterial efficacy of sulfonamides.Local anaesthetics.These product can make cell membrane stability, reduce its permeability to ion, and when neural impulse is reached, sodium, potassium ion can not pass in and out cell membrane and produce depolarization and action potential, thus produce local anesthetic action.The penetration power of these product to mucosa is poor, is unsuitable for topical anesthesia, but toxicity is little, and effect is certain, is applied to infiltration anesthesia.Also block anesthesia can be used, epidural anesthesia etc.
The beneficial effect of gained Chinese medicine extract of the present invention is: Chinese medicine extract of the present invention " more holistic ", both anaesthetic effect can be had, the myalgia brought after anesthesia disappears can be alleviated again, Pericarpium Zanthoxyli, Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Flos Matricariae chamomillae, Radix Zanthoxyli, Radix Ginseng and procaine being combined, having fabulous anesthesia curative effect to needing the patient of anesthesia.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1have a Chinese medicine extract for anaesthetic effect, each raw material is as follows, is weight portion (getting 10g for every part): Pericarpium Zanthoxyli 10, Ilex purpurea Hassk.[I.chinensis Sims 15, Herba Cirsii 10, Pericarpium Papaveris 2, Flos Matricariae chamomillae 7, Radix Zanthoxyli 2, Radix Ginseng 3, procaine 0.5.
Have the Chinese medicine extract of anaesthetic effect, preparation process is as follows:
1. Flos Matricariae chamomillae cleaned, smash to pieces, cross 100 mesh sieves, load in extraction kettle, in extraction kettle, pass into the CO that flow is 10L/h
2and extracting 2 hours, after extraction, gained camomile extract is collected in decompression;
2. be placed in marmite by Pericarpium Zanthoxyli, add the aqueous solution being mixed with rice vinegar, the ratio of rice vinegar and water is 1:3, boils 40 minutes, and filter, filtrate is stand-by;
3. Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Radix Zanthoxyli and Radix Ginseng is first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 30 DEG C, soak 20 minutes, take out filtering residue, filtering residue is rushed with cold water more stand-by;
4. by step 3. gained filtering residue be placed in porcelain container, add step 2. gained filtrate, decoct boiling 3 minutes, filter, filtrate leaves standstill 20 hours, obtains supernatant;
5. by step 4. gained supernatant be placed in transparent vessel and add camomile extract and procaine, stir 10 minutes clockwise with waddy, bottle and get final product.
model case one:wu XX, female, 40 years old, Licheng City, Jinan City, Shandong Province scholar, the eyelid cutis laxa of patient's unknown cause is sagging, sometimes blocks the visual field, carries out maintaining and treating with a lot of cosmetics and skin care products, without any effect, decide that eyelid surgery does in hospital, give to be applied in eyelid place with embodiment 1 gained Chinese medicine extract before corrective surgery and local anesthesia is carried out to patient, after 5 minutes, anesthesia onset, and the sensation also not occurring pain after anesthesia disappearance.
embodiment 2have a Chinese medicine extract for anaesthetic effect, each raw material is as follows, is weight portion (getting 10g for every part): Pericarpium Zanthoxyli 20, Ilex purpurea Hassk.[I.chinensis Sims 25, Herba Cirsii 20, Pericarpium Papaveris 8, Flos Matricariae chamomillae 10, Radix Zanthoxyli 4, Radix Ginseng 5, procaine 1.5.
Have the Chinese medicine extract of anaesthetic effect, preparation process is as follows:
1. Flos Matricariae chamomillae cleaned, smash to pieces, cross 140 mesh sieves, load in extraction kettle, in extraction kettle, pass into the CO that flow is 20L/h
2and extracting 5 hours, after extraction, gained camomile extract is collected in decompression;
2. be placed in marmite by Pericarpium Zanthoxyli, add the aqueous solution being mixed with rice vinegar, the ratio of rice vinegar and water is 1:3, boils 60 minutes, and filter, filtrate is stand-by;
3. Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Radix Zanthoxyli and Radix Ginseng is first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 40 DEG C, soak 40 minutes, take out filtering residue, filtering residue is rushed with cold water more stand-by;
4. by step 3. gained filtering residue be placed in porcelain container, add step 2. gained filtrate, decoct boiling 7 minutes, filter, filtrate leaves standstill 40 hours, obtains supernatant;
5. by step 4. gained supernatant be placed in transparent vessel and add camomile extract and procaine, stir 20 minutes clockwise with waddy, bottle and get final product.
embodiment 3:have a Chinese medicine extract for anaesthetic effect, each raw material is as follows, is weight portion (getting 10g for every part): Pericarpium Zanthoxyli 13, Ilex purpurea Hassk.[I.chinensis Sims 18, Herba Cirsii 13, Pericarpium Papaveris 4, Flos Matricariae chamomillae 8, Radix Zanthoxyli 2.5, Radix Ginseng 3.5, procaine 0.8.
Have the Chinese medicine extract of anaesthetic effect, preparation process is as follows:
1. Flos Matricariae chamomillae cleaned, smash to pieces, cross 110 mesh sieves, load in extraction kettle, in extraction kettle, pass into the CO that flow is 13L/h
2and extracting 3 hours, after extraction, gained camomile extract is collected in decompression;
2. be placed in marmite by Pericarpium Zanthoxyli, add the aqueous solution being mixed with rice vinegar, the ratio of rice vinegar and water is 1:3, boils 45 minutes, and filter, filtrate is stand-by;
3. Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Radix Zanthoxyli and Radix Ginseng is first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 33 DEG C, soak 25 minutes, take out filtering residue, filtering residue is rushed with cold water more stand-by;
4. by step 3. gained filtering residue be placed in porcelain container, add step 2. gained filtrate, decoct boiling 4 minutes, filter, filtrate leaves standstill 25 hours, obtains supernatant;
5. by step 4. gained supernatant be placed in transparent vessel and add camomile extract and procaine, stir 13 minutes clockwise with waddy, bottle and get final product.
embodiment 4have a Chinese medicine extract for anaesthetic effect, each raw material is as follows, is weight portion (getting 10g for every part): Pericarpium Zanthoxyli 18, Ilex purpurea Hassk.[I.chinensis Sims 23, Herba Cirsii 18, Pericarpium Papaveris 6, Flos Matricariae chamomillae 9, Radix Zanthoxyli 3.5, Radix Ginseng 4.5, procaine 1.3.
Have the Chinese medicine extract of anaesthetic effect, preparation process is as follows:
1. Flos Matricariae chamomillae cleaned, smash to pieces, cross 130 mesh sieves, load in extraction kettle, in extraction kettle, pass into the CO that flow is 18L/h
2and extracting 4 hours, after extraction, gained camomile extract is collected in decompression;
2. be placed in marmite by Pericarpium Zanthoxyli, add the aqueous solution being mixed with rice vinegar, the ratio of rice vinegar and water is 1:3, boils 55 minutes, and filter, filtrate is stand-by;
3. Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Radix Zanthoxyli and Radix Ginseng is first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 38 DEG C, soak 35 minutes, take out filtering residue, filtering residue is rushed with cold water more stand-by;
4. by step 3. gained filtering residue be placed in porcelain container, add step 2. gained filtrate, decoct boiling 6 minutes, filter, filtrate leaves standstill 35 hours, obtains supernatant;
5. by step 4. gained supernatant be placed in transparent vessel and add camomile extract and procaine, stir 18 minutes clockwise with waddy, bottle and get final product.
model case two:liu XX, female, 29 years old, people from Liaocheng, Shandong Province, had the medical histories such as chronic cough, often vomiting, constipation, dysuria, abdominal operation, wound, previously there is hernia incarceration history, the abnormal bulge of abdominal part, has ascites, hepatosplenomegaly, has lump to give prominence to when standing, be diagnosed as abdominal external hernia through examination in hospital, doctor advised carries out tension-free hernioplasty.
Anaesthetize with embodiment 4 gained Chinese medicine extract before surgery, onset in 5 minutes, and postoperative also use embodiment 4 gained Chinese medicine extract, otch does not have pain, and wound healing is very good.
embodiment 5have a Chinese medicine extract for anaesthetic effect, each raw material is as follows, is weight portion (getting 10g for every part): Pericarpium Zanthoxyli 15, Ilex purpurea Hassk.[I.chinensis Sims 20, Herba Cirsii 15, Pericarpium Papaveris 5, Flos Matricariae chamomillae 8.5, Radix Zanthoxyli 3, Radix Ginseng 4, procaine 1.
Have the Chinese medicine extract of anaesthetic effect, preparation process is as follows:
1. Flos Matricariae chamomillae cleaned, smash to pieces, cross 120 mesh sieves, load in extraction kettle, in extraction kettle, pass into the CO that flow is 15L/h
2and extracting 3.5 hours, after extraction, gained camomile extract is collected in decompression;
2. be placed in marmite by Pericarpium Zanthoxyli, add the aqueous solution being mixed with rice vinegar, the ratio of rice vinegar and water is 1:3, boils 50 minutes, and filter, filtrate is stand-by;
3. Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Radix Zanthoxyli and Radix Ginseng is first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 35 DEG C, soak 30 minutes, take out filtering residue, filtering residue is rushed with cold water more stand-by;
4. by step 3. gained filtering residue be placed in porcelain container, add step 2. gained filtrate, decoct boiling 5 minutes, filter, filtrate leaves standstill 30 hours, obtains supernatant;
5. by step 4. gained supernatant be placed in transparent vessel and add camomile extract and procaine, stir 15 minutes clockwise with waddy, bottle and get final product.
experimental example:clinical data: 1, physical data
:in order to verify the effect of Chinese medicine extract of the present invention, from January, 2012 in January, 2014 in 4 hospitals, have chosen 400 examples needs the patient carrying out anaesthetizing to carry out the experiment (embodiment 5) of medicine, be divided into matched group and experimental group, matched group 200 people, experimental group 200 people
2, Therapeutic Method: experimental group before surgery and operation in or used after operation gained Chinese medicine extract of the present invention local anesthesia is carried out to patient, matched group carries out conventional Preoperative Method, carries out the medication of subcutaneous injection general anaesthesia to the patient undergone surgery.
3, criterion of therapeutical effect: effective: common sympton alleviates substantially is invalid: malaise symptoms is all unchanged.In order to verify the effect of Chinese medicine extract of the present invention, We conducted the experiment (embodiment 5) of medicine, and accurately statistics and mathematical analysis having been carried out to data.
Specific experiment result is as following table:
Table 1:
Between the operating period, patient's self-induction symptom is as shown in table 2:
Table 2:
Prove through clinical trial, use Chinese medicine extract of the present invention compared with other means with anaesthetic effect, rapid-action, treatment means is more comprehensive thoroughly, have no side effect between the operating period, prove through clinical trial, Chinese medicine extract effective percentage of the present invention is 99%, is a kind of medicine safely and effectively with anaesthetic effect.
Claims (9)
1. there is a Chinese medicine extract for anaesthetic effect, it is characterized in that: each raw material is as follows, is weight portion: Pericarpium Zanthoxyli 10-20, Ilex purpurea Hassk.[I.chinensis Sims 15-25, Herba Cirsii 10-20, Pericarpium Papaveris 2-8, Flos Matricariae chamomillae 7-10, Radix Zanthoxyli 2-4, Radix Ginseng 3-5, procaine 0.5-1.5.
2. the Chinese medicine extract with anaesthetic effect according to claim 1, is characterized in that: each raw material is as follows, is weight portion: Pericarpium Zanthoxyli 13-18, Ilex purpurea Hassk.[I.chinensis Sims 18-23, Herba Cirsii 13-18, Pericarpium Papaveris 4-6, Flos Matricariae chamomillae 8-9, Radix Zanthoxyli 2.5-3.5, Radix Ginseng 3.5-4.5, procaine 0.8-1.3.
3. the Chinese medicine extract with anaesthetic effect according to claim 1, is characterized in that: each raw material is as follows, is weight portion: Pericarpium Zanthoxyli 15, Ilex purpurea Hassk.[I.chinensis Sims 20, Herba Cirsii 15, Pericarpium Papaveris 5, Flos Matricariae chamomillae 8.5, Radix Zanthoxyli 3, Radix Ginseng 4, procaine 1.
4. the preparation method with the Chinese medicine extract of anaesthetic effect according to any one of claim 1-3, is characterized in that: step is as follows:
1. Flos Matricariae chamomillae cleaned, smash to pieces, cross 100-140 mesh sieve, load in extraction kettle, in extraction kettle, pass into the CO that flow is 10-20L/h
2and extracting 2-5 hour, after extraction, gained camomile extract is collected in decompression;
2. be placed in marmite by Pericarpium Zanthoxyli, add the aqueous solution being mixed with rice vinegar, the ratio of rice vinegar and water is 1:3, boils 40-60 minute, and filter, filtrate is stand-by;
3. Ilex purpurea Hassk.[I.chinensis Sims, Herba Cirsii, Pericarpium Papaveris, Radix Zanthoxyli and Radix Ginseng is first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 30-40 DEG C, soak 20-40 minute, take out filtering residue, filtering residue is rushed with cold water more stand-by;
4. by step 3. gained filtering residue be placed in porcelain container, add step 2. gained filtrate, decoct boiling 3-7 minute, filter, filtrate leaves standstill 20-40 hour, obtains supernatant;
5. by step 4. gained supernatant be placed in transparent vessel and add camomile extract and procaine, stir 10-20 minute clockwise with waddy, bottle and get final product.
5. the preparation method of Chinese medicine extract according to claim 4, is characterized in that: 1. step crosses 110-130 mesh sieve, loads in extraction kettle, passes into the CO that flow is 13-18L/h in extraction kettle
2and extract 3-4 hour (preferred, cross 120 mesh sieves, load in extraction kettle, in extraction kettle, pass into the CO that flow is 15L/h
2and extract 3.5 hours).
6. the preparation method of Chinese medicine extract according to claim 4, is characterized in that: 2. step boils 45-55 minute, filters (preferred, to boil 50 minutes, filter).
7. the preparation method of Chinese medicine extract according to claim 4, is characterized in that: 3. step adds the warm water of 33-38 DEG C, soaks 25-35 minute (preferred, to add the warm water of 35 DEG C, soak 30 minutes).
8. the preparation method of Chinese medicine extract according to claim 4, is characterized in that: 4. step decocts boiling 4-6 minute, filters, and filtrate leaves standstill 25-35 hour (preferred, decoct boiling 5 minutes, filter, filtrate leaves standstill 30 hours).
9. the preparation method of Chinese medicine extract according to claim 4, is characterized in that: 5. step stirs 13-18 minute (preferred, to stir 15 minutes clockwise with waddy) clockwise with waddy.
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| CN105902681A (en) * | 2016-06-08 | 2016-08-31 | 雷知雅 | Oral local anesthetic preparation and preparation method thereof |
| CN108272772A (en) * | 2018-03-02 | 2018-07-13 | 江苏朗沁科技有限公司 | A kind of surface surgical anesthesia facial mask |
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| CN101647917A (en) * | 2009-07-09 | 2010-02-17 | 蒋勇 | Traditional Chinese medicine externally-applied anaesthetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105902681A (en) * | 2016-06-08 | 2016-08-31 | 雷知雅 | Oral local anesthetic preparation and preparation method thereof |
| CN108272772A (en) * | 2018-03-02 | 2018-07-13 | 江苏朗沁科技有限公司 | A kind of surface surgical anesthesia facial mask |
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