CN104873762A - Gallnut traditional Chinese medicine preparation for treating diabetes and preparation method - Google Patents

Abstract

The invention discloses a gallnut traditional Chinese medicine preparation for treating diabetes. The gallnut traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 30-50 parts of radix scrophulariae, 40-60 parts of white mulberry, 60-80 parts of sealwort, 100-120 parts of purslane, 70-90 parts of whole radix ophiopogonis, 130-150 parts of Chinese yam, 90-110 parts of fresh chrysopogon aciculatus, and 180-200 parts of gallnut. The gallnut traditional Chinese medicine preparation disclosed by the invention has the effects of promoting secretion of saliva or body fluid, clearing heat, nourishing yin to lessen fire and reducing blood glucose and blood fat, and has obvious curative effects to the symptoms, such as nephropathy, hepatic diseases, peripheral neuropathy and ischemic cerebrovascular diseases due to diabetes; the gallnut traditional Chinese medicine preparation is proper in compatibility of medicines, simple to prepare, high in safety property, free from any toxic and side effect and good in effect, and can be used for treating both symptoms and root causes of diabetes; and therefore, the gallnut traditional Chinese medicine preparation is worthy of being widely popularized and applied clinically.

Description

A kind of Galla Chinensis Chinese medicine preparation and preparation method for the treatment of diabetes

Technical field

The present invention relates to technical field of Chinese medicines, specifically a kind of Galla Chinensis Chinese medicine preparation and preparation method for the treatment of diabetes.

Background technology

The metabolic disease of diabetes to be one group with hyperglycemia be feature, hyperglycemia is then due to defect of insulin secretion or its biological agent is impaired causes, long-standing hyperglycemia during diabetes, causes various chronic lesion, the dysfunction of organizing particularly eye, kidney, heart, blood vessel, nerve.Diabetes are caused by heredity or diet unreasonable factor, and treat diabetes at present and mainly adopt insulinize and Drug therapy, long-time use Drug therapy can go down with Liver and kidney function, ischemic disease, the symptom such as actute infection, gastroenteropathy, therapeutic effect is not thorough, be easy to recurrence after healing, relative cost costly, not easily tackles the problem at its root, also occur the Chinese medicine preparation of some treatment diabetes in the market, but these preparation effects are also not bery desirable.

Summary of the invention

The object of the present invention is to provide and a kind ofly reduce blood glucose and the Galla Chinensis Chinese medicine preparation of effective treatment diabetes and preparation method, to solve the problem proposed in above-mentioned background technology.

For achieving the above object, the invention provides following technical scheme:

Treat a Galla Chinensis Chinese medicine preparation for diabetes, formed by the preparation of raw material of following weight portion: Radix Scrophulariae 30 ~ 50 parts, Morus alba skin 40 ~ 60 parts, Rhizoma Polygonati 60 ~ 80 parts, Herba Portulacae 100 ~ 120 parts, Radix Ophiopogonis herb 70 ~ 90 parts, Rhizoma Dioscoreae 130 ~ 150 parts, fresh Herba Commelinae Diffusae 90 ~ 110 parts, Galla Chinensis 180 ~ 200 parts.

The Galla Chinensis Chinese medicine preparation of described treatment diabetes, be made up of raw material medicine: Radix Scrophulariae 40 parts, Morus alba skin 50 parts, Rhizoma Polygonati 70 parts, Herba Portulacae 110 parts, Radix Ophiopogonis herb 80 parts, Rhizoma Dioscoreae 140 parts, fresh Herba Commelinae Diffusae 100 parts, Galla Chinensis 190 parts.

The Galla Chinensis Chinese medicine preparation of described treatment diabetes, concrete preparation process is as follows:

(1) get Radix Scrophulariae 40 parts, Rhizoma Polygonati 70 parts, Herba Portulacae 110 parts, Radix Ophiopogonis herb 80 parts, fresh Herba Commelinae Diffusae 100 parts, cleaning is dried, shearing length is 3 ~ 4cm, be ground into granule, add the distilled water of crude drug 10 ~ 12 times amount, and soak 4 ~ 6h at the temperature of 40 ~ 60 DEG C, continue to decoct 20min after being first fried boiling with high heat, and then slow fire boiling 3 ~ 5h, isolated by filtration obtains extracting solution; Again add the distilled water of 6 ~ 8 times amount, boil 2 ~ 3h, isolated by filtration obtains extracting solution; The last distilled water again adding 4 ~ 6 times amount, boil 1 ~ 2h, isolated by filtration obtains extracting solution; Merge three extracting solution and obtain extracting solution A;

(2) get fresh white Cortex Mori 50 parts, Rhizoma Dioscoreae 140 parts, shred after peeling, the distilled water adding 6 ~ 8 times amount heats 2 ~ 3h at 70 ~ 90 DEG C of temperature, and then naturally cool to 30 ~ 40 DEG C, isolated by filtration obtains extracting solution B;

(3) get fresh Galla Chinensis 190 parts, clean up and blend, then filter and extract Galla Chinensis stock solution, add the distilled water of Galla Chinensis stock solution 3 times, at 50 ~ 60 DEG C of temperature, heat 50 ~ 70min, cooled and filtered obtains liquor C;

(4) by extracting solution A, extracting solution B and liquor C according to volume ratio 1:1:2 mix homogeneously, namely obtain the Galla Chinensis Chinese medicine preparation of described treatment diabetes.

Instructions of taking: every day is early, middle and late respectively takes once, and a dose is 15ml, 15 days courses for the treatment of, manyly after taking medicine took effect at 20 ~ 25 days, and 3 ~ 4 courses for the treatment of cure.

The pharmacological action of the raw material of Chinese medicine selected by the present invention: Radix Scrophulariae: sweet in the mouth, hardship, property is put down, GUIXIN, lung meridian, supplementing QI and nourishing YIN, heat-clearing and toxic substances removing, cures mainly weakness, cough haematemesis after being ill, dizzy, lumbago is aching and limp, diabetes, seminal emission; Morus alba skin: cool in nature, sweet in the mouth, nontoxic, clearing away summer-heat, appetizing promote the production of body fluid, diuresis of relieving summer heat, treatment diabetes, oedema due to nephritis and hepatopathy jaundice; Rhizoma Polygonati: clearing away summer-heat, antipyretic, diuretic, cures mainly heatstroke, pyretic toxicity, quenches one's thirst, hypertension, nephropathy, diabetes, pain of joint muscle etc.; Herba Portulacae: heat-clearing and toxic substances removing, loose blood detumescence, diuresis of relieving summer heat; Radix Ophiopogonis herb: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, reduce blood glucose; Rhizoma Dioscoreae: sweet in the mouth, property is put down, invigorating spleen and reinforcing stomach, kidney nourishing and replenishing vital essence, lung benefiting cough-relieving, reduces blood glucose, anti-hepatic coma; Fresh Herba Commelinae Diffusae: lightly seasoned, cold in nature, the loose poison of the heat that disappears, reduces blood glucose, inducing diuresis for treating stranguria syndrome; Galla Chinensis: bitter, cold in nature, GUIXIN, liver, spleen, lung meridian, clearing away summer-heat, improving eyesight removing toxic substances, QI invigorating recover from fatigue, blood fat reducing, reduce blood glucose, solution labor clears away heart-fire, enhance metabolism.

Alkaloids substance quinine contained in Galla Chinensis in medicament of the present invention, have diuresis to invigorate blood circulation, anti-inflammatory antipyretic, the improving eyesight that clears away heart-fire effect, the Galla Chinensis glycoside contained and similar insulin material, the secretion of insulin can be promoted, have good blood sugar lowering, effect for reducing blood fat, long-term edible Galla Chinensis can effectively prevent diabetes; Citrulline contained in Morus alba skin can promote the formation of carbamide, thus has diuresis; Other medicament plays replenishing body fluid and clearing away heat pathogen, diuresis of relieving summer heat, reduce the effects such as blood glucose, various medicine coordinates combined effect, effectively can treat some common diseases such as nephropathy, hepatic disease, peripheral neuropathy and the ischemic cerebrovascular caused by diabetes and diabetes, it is suitable that reason joined by the medical material of medicament of the present invention, and make simple, security performance is high, without any side effects, to glycosuria condition of disease treating both the principal and secondary aspects of a disease, and effective, clinic wide popularization and application.

Detailed description of the invention

Embodiment 1

The Galla Chinensis Chinese medicine preparation for the treatment of diabetes

Raw material: be made up of raw material medicine, Radix Scrophulariae 30 parts, Morus alba skin 40 parts, Rhizoma Polygonati 60 parts, Herba Portulacae 100 parts, Radix Ophiopogonis herb 70 parts, Rhizoma Dioscoreae 130 parts, fresh Herba Commelinae Diffusae 90 parts, Galla Chinensis 180 parts.

Preparation process:

(1) get Radix Scrophulariae 30 parts, Rhizoma Polygonati 60 parts, Herba Portulacae 100 parts, Radix Ophiopogonis herb 70 parts, fresh Herba Commelinae Diffusae 90 parts, cleaning is dried, shearing length is 3 ~ 4cm, be ground into granule, add the distilled water of crude drug 12 times amount, and soak 5h at the temperature of 50 DEG C, continue to decoct 20min after being first fried boiling with high heat, and then slow fire boiling 4h, isolated by filtration obtains extracting solution; Again add the distilled water of 8 amounts, boil 3h, isolated by filtration obtains extracting solution; The last distilled water again adding 6 times amount, boil 2h, isolated by filtration obtains extracting solution; Merge three extracting solution and obtain extracting solution A;

(2) get fresh white Cortex Mori 40 parts, Rhizoma Dioscoreae 130 parts, shred after peeling, the distilled water adding 8 times amount heats 3h at 80 DEG C of temperature, then naturally cools to 30 DEG C, and isolated by filtration obtains extracting solution B;

(3) get fresh Galla Chinensis 180 parts, clean up and blend, then filter and extract Galla Chinensis stock solution, add the distilled water of Galla Chinensis stock solution 3 times, at 60 DEG C of temperature, heat 60min, cooled and filtered obtains liquor C;

(4) by extracting solution A, extracting solution B and liquor C according to volume ratio 1:1:2 mix homogeneously, namely obtain the Galla Chinensis Chinese medicine preparation of described treatment diabetes.

Embodiment 2

The Galla Chinensis Chinese medicine preparation for the treatment of diabetes

Raw material: be made up of raw material medicine, Radix Scrophulariae 40 parts, Morus alba skin 50 parts, Rhizoma Polygonati 70 parts, Herba Portulacae 110 parts, Radix Ophiopogonis herb 80 parts, Rhizoma Dioscoreae 140 parts, fresh Herba Commelinae Diffusae 100 parts, Galla Chinensis 190 parts.

Preparation process:

(1) get Radix Scrophulariae 40 parts, Rhizoma Polygonati 70 parts, Herba Portulacae 110 parts, Radix Ophiopogonis herb 80 parts, fresh Herba Commelinae Diffusae 100 parts, cleaning is dried, shearing length is 3 ~ 4cm, be ground into granule, add the distilled water of crude drug 12 times amount, and soak 5h at the temperature of 50 DEG C, continue to decoct 20min after being first fried boiling with high heat, and then slow fire boiling 4h, isolated by filtration obtains extracting solution; Again add the distilled water of 8 amounts, boil 3h, isolated by filtration obtains extracting solution; The last distilled water again adding 6 times amount, boil 2h, isolated by filtration obtains extracting solution; Merge three extracting solution and obtain extracting solution A;

(2) get fresh white Cortex Mori 50 parts, Rhizoma Dioscoreae 140 parts, shred after peeling, the distilled water adding 8 times amount heats 3h at 80 DEG C of temperature, then naturally cools to 30 DEG C, and isolated by filtration obtains extracting solution B;

(3) get fresh Galla Chinensis 190 parts, clean up and blend, then filter and extract Galla Chinensis stock solution, add the distilled water of Galla Chinensis stock solution 3 times, at 60 DEG C of temperature, heat 60min, cooled and filtered obtains liquor C;

(4) by extracting solution A, extracting solution B and liquor C according to volume ratio 1:1:2 mix homogeneously, namely obtain the Galla Chinensis Chinese medicine preparation of described treatment diabetes.

Embodiment 3

The Galla Chinensis Chinese medicine preparation for the treatment of diabetes

Raw material: be made up of raw material medicine, Radix Scrophulariae 50 parts, Morus alba skin 60 parts, Rhizoma Polygonati 80 parts, Herba Portulacae 120 parts, Radix Ophiopogonis herb 90 parts, Rhizoma Dioscoreae 150 parts, fresh Herba Commelinae Diffusae 110 parts, Galla Chinensis 200 parts.

Preparation process:

(1) get Radix Scrophulariae 50 parts, Rhizoma Polygonati 80 parts, Herba Portulacae 120 parts, Radix Ophiopogonis herb 90 parts, fresh Herba Commelinae Diffusae 110 parts, cleaning is dried, shearing length is 3 ~ 4cm, be ground into granule, add the distilled water of crude drug 12 times amount, and soak 5h at the temperature of 50 DEG C, continue to decoct 20min after being first fried boiling with high heat, and then slow fire boiling 4h, isolated by filtration obtains extracting solution; Again add the distilled water of 8 amounts, boil 3h, isolated by filtration obtains extracting solution; The last distilled water again adding 6 times amount, boil 2h, isolated by filtration obtains extracting solution; Merge three extracting solution and obtain extracting solution A;

(2) get fresh white Cortex Mori 60 parts, Rhizoma Dioscoreae 150 parts, shred after peeling, the distilled water adding 8 times amount heats 3h at 80 DEG C of temperature, then naturally cools to 30 DEG C, and isolated by filtration obtains extracting solution B;

(3) get fresh Galla Chinensis 200 parts, clean up and blend, then filter and extract Galla Chinensis stock solution, add the distilled water of Galla Chinensis stock solution 3 times, at 60 DEG C of temperature, heat 60min, cooled and filtered obtains liquor C;

(4) by extracting solution A, extracting solution B and liquor C according to volume ratio 1:1:2 mix homogeneously, namely obtain the Galla Chinensis Chinese medicine preparation of described treatment diabetes.

Embodiment 4

Clinical trial

(1) subjects: adopt the present invention to treat 100 routine patients altogether, wherein man 60 example, female 40 example; The oldest person 68 years old, age reckling 46 years old.

(2) Therapeutic Method: every day is early, middle and late respectively takes once, and a dose is 10ml, 7 days courses for the treatment of.

(3) standard is treated

Cure: diabetic symptom all disappears, health indices recovers normal on inspection.

Take a turn for the better: diabetic symptom obviously disappears, and indices recovers whole substantially on inspection.

Invalid: before and after medication, symptom is without change.

(4) therapeutic outcome: how to take effect at 10 ~ 15 days after taking medicine in the routine case of patient 100,3 ~ 4 courses for the treatment of cure; Wherein cure 75 examples, effective 20 examples, effective 2 examples, invalid 2 examples, total effective rate reaches 98%.

Model case:

(1) Qin, man, 50 years old, people was pacified in Anhui six, the frequent myasthenia of limbs of patient, does not have spirit, fat, suffering from diabetes, fatty liver, thick blood fat through looking into, cannot work, after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom is clearly better, basicly stable through sugar of having a blood test, glucose in urine, fatty liver symptom alleviates to some extent, and after taking 4 courses for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom disappears, stablize through sugar of having a blood test, glucose in urine, blood fat chemical examination is normal, and fatty liver symptom alleviates.

(2) Lin, female, 52 years old, plant resources in Wenling people, patient suffers from diabetes, and with hypertension, coronary heart disease, takes Chinese medicine preparation of the present invention, after taking 1 course for the treatment of, hypertension, coronary heart disease are clearly better, and glucose in urine is basicly stable, after then taking 3 courses for the treatment of, hypertension, coronary heart disease symptom disappear, blood glucose held stationary.

(3) Zeng, man, 60 years old, people from Jiujiang, patient has a headache at ordinary times, dreaminess, weak all over, there is hyperglycemia medical history more than 2 years, take hypoglycemic medicine always, have no improvement, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention, the mental status is clearly better, and blood glucose declines to some extent, the state of an illness starts to take a turn for the better, and after taking 4 courses for the treatment of, blood glucose value drops to normal level, so far health is fine, glucostasis, without recurrence.

Claims (3)

1. treat the Galla Chinensis Chinese medicine preparation of diabetes for one kind, it is characterized in that, formed by the preparation of raw material of following weight portion: Radix Scrophulariae 30 ~ 50 parts, Morus alba skin 40 ~ 60 parts, Rhizoma Polygonati 60 ~ 80 parts, Herba Portulacae 100 ~ 120 parts, Radix Ophiopogonis herb 70 ~ 90 parts, Rhizoma Dioscoreae 130 ~ 150 parts, fresh Herba Commelinae Diffusae 90 ~ 110 parts, Galla Chinensis 180 ~ 200 parts.

2. the Galla Chinensis Chinese medicine preparation for the treatment of diabetes according to claim 1, it is characterized in that, be made up of raw material medicine: Radix Scrophulariae 40 parts, Morus alba skin 50 parts, Rhizoma Polygonati 70 parts, Herba Portulacae 110 parts, Radix Ophiopogonis herb 80 parts, Rhizoma Dioscoreae 140 parts, fresh Herba Commelinae Diffusae 100 parts, Galla Chinensis 190 parts.

3. the Galla Chinensis Chinese medicine preparation for the treatment of diabetes according to claim 1 and 2, is characterized in that, concrete preparation process is as follows:

(1) get Radix Scrophulariae 40 parts, Rhizoma Polygonati 70 parts, Herba Portulacae 110 parts, Radix Ophiopogonis herb 80 parts, fresh Herba Commelinae Diffusae 100 parts, cleaning is dried, shearing length is 3 ~ 4cm, be ground into granule, add the distilled water of crude drug 10 ~ 12 times amount, and soak 4 ~ 6h at the temperature of 40 ~ 60 DEG C, continue to decoct 20min after being first fried boiling with high heat, and then slow fire boiling 3 ~ 5h, isolated by filtration obtains extracting solution; Again add the distilled water of 6 ~ 8 times amount, boil 2 ~ 3h, isolated by filtration obtains extracting solution; The last distilled water again adding 4 ~ 6 times amount, boil 1 ~ 2h, isolated by filtration obtains extracting solution; Merge three extracting solution and obtain extracting solution A;

(2) get fresh white Cortex Mori 50 parts, Rhizoma Dioscoreae 140 parts, shred after peeling, the distilled water adding 6 ~ 8 times amount heats 2 ~ 3h at 70 ~ 90 DEG C of temperature, and then naturally cool to 30 ~ 40 DEG C, isolated by filtration obtains extracting solution B;

(3) get fresh Galla Chinensis 190 parts, clean up and blend, then filter and extract Galla Chinensis stock solution, add the distilled water of Galla Chinensis stock solution 3 times, at 50 ~ 60 DEG C of temperature, heat 50 ~ 70min, cooled and filtered obtains liquor C;

(4) by extracting solution A, extracting solution B and liquor C according to volume ratio 1:1:2 mix homogeneously, namely obtain the Galla Chinensis Chinese medicine preparation of described treatment diabetes.