CN108272772A - A kind of surface surgical anesthesia facial mask - Google Patents
A kind of surface surgical anesthesia facial mask Download PDFInfo
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- CN108272772A CN108272772A CN201810173112.5A CN201810173112A CN108272772A CN 108272772 A CN108272772 A CN 108272772A CN 201810173112 A CN201810173112 A CN 201810173112A CN 108272772 A CN108272772 A CN 108272772A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Abstract
The invention discloses a kind of surface surgical anesthesia facial mask, the material of main part of the facial mask is face paper or facial mask cloth, and Chinese medical extract and local anaesthetics are impregnated on material of main part；The anesthetic composition is made of Olibanum extract, Myrrha extract, pepper extract, camomile extract, Flos Osmanthi Fragrantis extract, licorice, borneol, peppermint, lidocaine, totokaine.The surface surgical anesthesia facial mask of the present invention, is combined, hence it is evident that reduce the toxic reaction of lidocaine, totokaine dosage and its generation, while having the function of antibacterial, anti-inflammatory, detumescence using Chinese and Western；In addition, the facial mask can realize that local skin is anaesthetized in a short time, have the characteristics that rapid-action, effect by force and it is lasting, penetration power is strong, adverse reaction is few.
Description
Technical field
The invention belongs to field of medical technology, it is related to a kind of surface surgical anesthesia facial mask more particularly to during one kind contains
The facial mask of medicament extract and local anaesthetics ingredient.
Background technology
As society develops rapidly, life is more and more plentiful, and the hope that people pursue beauty is also increasingly stronger, especially
It is especially prominent for the beauty and shaping demand of fleshy exterior.Fleshy exterior beauty treatment means are mostly the method for radiating such as luminous energy, thermal energy, therewith band
Come the feeling of pain and burning sensation of skin, on the one hand influences the cosmetic surgery impression of party；On the other hand, pain can cause to work as thing
The automatic activity of people interferes the surgical work of lift face doctor, influences cosmetic outcome.
The existing control method for skin irritatin mainly carries out anaesthetic treatment by Western medicine anesthetic, some are smaller
Cosmetic surgery in order to it is cost-effective can reduce anesthesia survival dose or without anesthesia.However in the case where not anaesthetizing, lift face
Personage can not also be utilized post-operative recovery by the hardship of pain.
Oral or injecting anesthetic medicine, selectivity is poor, and effective dose is difficult to control, and adverse reaction, anaesthetic effect easily occurs
It is barely satisfactory, and the pain that injection is brought need to be endured.In addition, individual is different to the susceptibility of arcotic, it usually will appear anesthesia
Insufficient or overdose of anesthesia accident.
In addition, publication CN106367452A discloses a kind of preparation of the bacteria cellulose film with anesthesia function
Method, main technical schemes are by adding lidocaine hydrochloride injection into the fermentation medium of production bacteria cellulose
The bacteria cellulose film with anesthesia potency is prepared, it is raw to make it have good biocompatibility, anti-inflammatory, anesthesia potency etc.
Object activity.
Patent CN105213677A discloses a kind of Chinese medicinal film and preparation method thereof for surface anesthesia, by main body
Chinese drug anesthesia ingredient is impregnated on material；The Chinese drug anesthesia ingredient be by the dried venom of toads, dried pinellia, arisacma consanguineum schott, Pericarpium Zanthoxyli, borneol,
What camphor and peppermint were extracted, Chinese medical extract anesthesia facial mask can realize that local skin is anaesthetized in a short time, have
The features such as rapid-action, effect is lasting, penetration power is larger by force by force.
Patent CN103690515A discloses one kind towards laser therapy surface anesthesia film and preparation method thereof, using face
Film paper or facial mask cloth uniformly immerse anesthetic in facial mask as substrate, achieve the effect that uniformly to anaesthetize, at the same avoid nurse because
For malpractice caused by anesthetic coating unevenness.
And patent CN107375586A discloses a kind of Chinese medicinal film and preparation method thereof for surface anesthesia, sheep is paced up and downed
Footprint, iron sieve, datura flower, radix aconiti agrestis, Radix Astragali, Radix Angelicae Sinensis, dried pinellia, arisacma consanguineum schott, rhizoma typhonii, Chinese prickly ash, arabian jasmine root, Radix Notoginseng, calamus, ice
Piece, Radix Glycyrrhizae and peppermint, it is suitable by medicinal material compatibility, it brings out the best in each other, drug effect penetrability is strong, rapid-action, anesthesia duration is long, secure side
Just, without side-effects.
However, finding in practical applications, above-mentioned existing Chinese medicine film or the plain film of dimension are Chinese medicine or single local anaesthetics, are being used
When, need to be coated with a thick layer of in skin surface, and need to be wrapped up with preservative film, and the topical application of drug time is up to 1h or more, Chinese medicine work it is slow,
Effect is poor, and there are poor compliances for local anaesthesia anesthesia, and will appear the adverse reactions such as rubescent, oedema, shouting pain, calcination, do not utilize art
After restore.
Invention content
Anaesthetic effect during operation on skin is bad, the deficiency more than adverse reaction it is an object of the invention to improving, and provides
A kind of surface surgical anesthesia facial mask.
Surface surgical anesthesia provided by the invention has soft form with facial mask, can be complete as common facial mask
It is attached to skin surface, action component transdermal penetration therein enters surface skin, and noninvasive administration, and administration process may be implemented
It has good selectivity, the localized skin surface anaesthetic effect for treating lift face is good.
In addition, the anesthesia facial mask can adjust application time, application area, operation consent root according to the difference of type of surgery
It is cut out according to anaesthetic skin area difference and anaesthetizes facial mask, you can efficiently, accurately anaesthetized, avoid other for oral administration or injection
The not accurate problem of the dosage of administration, scope control.
To achieve the above object, the present invention uses following technical scheme：
The present invention provides a kind of surface surgical anesthesia facial mask, the material of main part of the facial mask is face paper or facial mask
Cloth is impregnated with Chinese medical extract and local anaesthetics on the material of main part.
Further, in the surface surgical anesthesia facial mask, the Chinese medical extract includes Olibanum extract, does not have
Medicament extract.Used Olibanum extract is that the powdered mobility of yellow-white of the resin of olive subject plant Cattell Boswellia carterii carries
Produce product are taken, has the function of regulating qi and activating blood in the facial mask, analgesic therapy, chase after poison；Myrrh is olive subject plant Chinese violet tree
Commiphoramyrrha Engl or the dry resin for breathing out Chinese violet tree Commiphoramolmol Engl, be divided into natural myrrh with
Gum opoponax uses natural myrrh in of the invention, has effects that scattered blood stasis eliminatings, detumescence ding-tong in the facial mask.
It is further preferred that in the surface surgical anesthesia facial mask, the Chinese medical extract further includes that Chinese prickly ash carries
Take object, camomile extract.Effect that Chinese prickly ash has warm in pain, desinsection antipruritic in the facial mask；Chamomile can alleviate inflammation
And pain symptom, alleviate the effect of having a sleepless night caused by neurotic skin itch, the chamomile extraction employed in the facial mask
Object promoting qi circulation and relieving pain helps improve eczema, pimples, bleb, chronic eczema, hypersensitization skin and general allergic phenomena.
Further more, in the surface surgical anesthesia facial mask, the Chinese medical extract further includes that sweet osmanthus carries
Take object, licorice.Flos Osmanthi Fragrantis extract employed in the facial mask plays the effect of knot is broken in cold dispelling；Licorice has clear
Thermal detoxification, relieving spasm to stop pain, coordinating the drug actions of a prescription have the effect of corticoid sample, there is anti-inflammatory, anti-allergic effects.
It is further preferred that in the surface surgical anesthesia facial mask, the Chinese medical extract further include borneol,
Peppermint.Borneol can inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison；Peppermint has effects that dispelling wind and heat from the body, head clearing and promoting qi circulation and relieving pain, effect
In sensory nerve ending, feeling can be made to benumb, external application has anesthetic effect.
Using the above Chinese medical extract as main analgesic composition, being equipped with the facial mask of local anaesthetics can realize in a short time
The anesthesia of local fleshy exterior has the characteristics that rapid-action, effect is strong and lasting, penetration power is strong, and with anti-inflammatory, antiallergic effect, is not easy
There are the adverse reactions such as rubescent, oedema, calcination, is conducive to the progress of surface skin plastic aesthetic surgery.
Further, in the surface surgical anesthesia facial mask, the local anaesthetics be procaine, pramocaine,
It is one or more in cinchocaine, lidocaine, benzocainum, butanilicaine, totokaine, Amydricaine, prilocaine.Institute
It is preferably one or more in lidocaine, totokaine, prilocaine to state local anaesthetics；Anaesthetize mainly Chinese medicine analgesia in facial mask
Ingredient can obviously reduce the dosage of local anaesthetics, mitigates the reactions such as rubescent, oedema, shouting pain caused by arcotic, can also reduce allergy
The incidence of reaction.
Further, in the surface surgical anesthesia facial mask, following assisted group is also contained on the anesthesia facial mask
Point：Carboxymethyl cellulose, hydroxypropyl methyl cellulose, cyclodextrin, ethyl alcohol, propylene glycol, butanediol, glycerine, polyethylene glycol, 1-
Dodecyl-aza-cycloheptane alkane -2- ketone, ethyl-para-hydroxybenzoate, Tween-80, phosphoric acid, hydrochloric acid, sodium hydroxide, sodium bicarbonate,
It is one or more in sodium dihydrogen phosphate, disodium hydrogen phosphate.Anesthesia is mainly Chinese medicine analgesic composition with facial mask, and addition is suitable auxiliary
Material can improve the blending and physical stability of component, meanwhile, auxiliary element can effectively extend the pot-life of facial mask,
It avoids face-mask material that rotten deterioration occurs during preserving, influences to use.
Wherein, ethyl-para-hydroxybenzoate is added as preservative and is applied, and prevents bacteria breed, extends facial mask storage week
Phase.Tween 80 has solubilization, protection traditional Chinese medicine ingredients dispersibility and stability.Auxiliary element, traditional Chinese medicine ingredients, local anaesthetics are together
It prepares and infiltrates solution, on the material of main part for then infiltrating facial mask.
Hydroxypropyl methyl cellulose (HPMC) also known as hydroxypropyl methylcellulose, cellulose hydroxypropyl methyl ether, are with high-purity
Gossypin is raw material, etherified and obtained under alkaline condition, has the function of thickening, emulsification；HPMC has heat setting colloidality
Matter forms gel after the heating of product aqueous solution and is precipitated, and addition HPMC is conducive to the form control of film as auxiliary material, makes its structure more
Stablize, the rate of release action ingredient is more stablized, and the effect of surface local anaesthesia is good.
Glycerine, ethyl alcohol, polyethylene glycol all have good water-retaining property, have the function of moisturizing, moistening, can keep facial mask
In moisture stablize, keep the osmotic concentration of face-mask material in suitable range, avoid the dry of facial mask, improve facial mask
With the compatibility of skin, the using effect of facial mask is improved.Wherein ethyl alcohol is also used as solvent, improves the meltage of component, and have
Transdermal enhancing effect allows the action component in facial mask to be quickly absorbed by the skin.
Cyclodextrin is a kind of synthesizing water-solubility high-molecular compound, has caking property, hygroscopicity, solubilising or cohesion,
With excellent physiological compatibility.The solubility and solution rate of water-soluble undesirable drug in water, while and people can be improved
Body surface surface skin has compatibility extremely outstanding, can be effectively promoted anesthetic composition and enter skin corium through epidermis, realizes
Anesthesia potency.
Further, in the surface surgical anesthesia facial mask, the quality hundred of helper component in the infiltration solution
Divide ratio for hydroxypropyl methyl cellulose 0.01~10%, cyclodextrin 0.01~10%, ethyl alcohol 0.01~50%, propylene glycol 0.01~
10%, ethyl-para-hydroxybenzoate 0~0.2%, Tween-80 0.01~5%, Azone 0.01
~5%.
Specifically, as the usage ratio of helper component in the infiltration solution is：Contain hydroxypropyl first in per 100ml solution
Base 0.01~10g of cellulose, 0.01~10g of cyclodextrin, 0.01~50g of ethyl alcohol, 0.01~10g of propylene glycol, P-hydroxybenzoic acid
0~0.2g of ethyl ester, 0.01~5g of Tween-80,0.01~5g of Azone, pure water constant volume.Auxiliary
Ingredient has effects that certain filming function and promotes to permeate, but to play best anesthesia drug effect, need to accurately control various
The dosage of ingredient, it is only that the eurythmy of each auxiliary element is good, it could preferably play the effect of anaesthetizing facial mask.
Further, in the surface surgical anesthesia facial mask, the facial mask is will to contain Chinese medical extract and office
It is obtained in the infiltration solution material of main part of anaesthetic；Infiltrated on the facial mask filling amount of solution be 15~
30ml/ pieces.After the surface infiltration of facial mask, it can be preferably attached to skin surface, be conveniently fitted on skin and applied.
It is further preferred that in the surface surgical anesthesia facial mask, each Chinese medical extract in the infiltration solution
Olibanum extract, Myrrha extract, pepper extract, camomile extract, Flos Osmanthi Fragrantis extract, licorice, borneol, peppermint
Mass percent with local anaesthetics is 0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~
10：0.01~10：0.01~10：0.01~10；Preferably, the mass percent of each Chinese medical extract is 0.01~5:0.01~
5:0.01~5:0.01~5:0.01~5:0.01~5:0.01~5:0.01~5；More preferably, the matter of each Chinese medical extract
It is 0.01~3 to measure percentage:0.01~3:0.01~3:0.01~3:0.01~3:0.01~3:0.01~3:0.01~3.Tool
Body, as carried containing 0.01~10g Myrrha extracts, 0.01~10g Chinese prickly ashes in infiltration solution per 100ml in the infiltration solution
Take object, 0.01~10g camomile extracts, 0.01~10g Flos Osmanthi Fragrantis extracts, 0.01~10g licorices, 0.01~10g
Borneol, 0.01~10g peppermints, design the dosage of Chinese medical extract, can preferably control the content of auxiliary element, be conducive to group
Divide and plays a role.
Further more preferably, in the surface surgical anesthesia facial mask, local anaesthetics is in the infiltration solution
Lidocaine, totokaine composition.
Further more preferably, in the surface surgical anesthesia facial mask, local anaesthetics in the infiltration solution
Lidocaine, totokaine composition quality percentage are 0.01~10%；Preferably, local anaesthetics lidocaine, totokaine combination
Amount of substance percentage is 0.01~5%；Most preferably, local anaesthetics lidocaine, totokaine composition quality percentage are
0.01~3%.Specifically, as contained 0.01~10g lidocaines, Ding Ka in infiltration solution per 100ml in the infiltration solution
Cause.Chinese and Western combines the dosage for being substantially reduced local anaesthetics, mitigates the reactions such as rubescent, oedema, shouting pain caused by arcotic, can also reduce
Anaphylactoid incidence.
The present invention is had the following technical effect that compared with prior art using above-mentioned technical proposal：
A, the facial mask of surface anesthesia of the present invention, using common film paper/film cloth as substrate, by Chinese medical extract and office
Anaesthetic is scattered in infiltration solution, is uniformly coated in substrate, and action component transdermal penetration therein enters surface skin, is ensured
Action component rapid osmotic during use is uniformly anaesthetized, safe and efficient；Anaesthetic effect is good, noninvasive administration may be implemented, and give
Medicine process has good selectivity, and the localized skin surface anaesthetic effect for treating lift face meets well clinical fleshy exterior cosmetic surgery and controls
The requirement for the treatment of has medical and beauty treatment positive help；
B, infiltration solution is combined using Chinese and Western, can realize local fleshy exterior anesthesia in a short time, have rapid-action, effect
The features such as lasting, penetration power is strong by force, and there is anti-inflammatory, antiallergic effect, the adverse reactions such as rubescent, oedema, calcination are less prone to,
Conducive to the progress of surface skin plastic aesthetic surgery；
C, the facial mask of the surface anesthesia can adjust application time, application area, operation according to the difference of type of surgery
Preceding cut out according to anaesthetic skin area difference anaesthetizes facial mask, you can efficiently, is accurately anaesthetized；
It d, and can be to avoid other problems for oral administration or dosage of drug administration by injection, scope control not accurate；It can keep away simultaneously
It is long to exempt from the existing surface fiber crops cream topical application of drug time, poor compliance, and will appear the adverse reactions such as rubescent, oedema, shouting pain, calcination.
Specific implementation mode
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention,
But following embodiments are not intended to limit the scope of the invention.
1 facial mask of embodiment infiltration solution is formulated by following components dosage：
2 facial mask of embodiment infiltration solution is formulated by following components dosage：
3 facial mask of embodiment infiltration solution is formulated by following components dosage：
4 facial mask of embodiment infiltration solution is formulated by following components dosage：
5 facial mask of embodiment infiltration solution is formulated by following components dosage：
6 facial mask of embodiment infiltration solution is formulated by following components dosage：
7 facial mask of embodiment infiltration solution is formulated by following components dosage：
8 facial mask of embodiment infiltration solution is formulated by following components dosage：
Above-described embodiment 1-8 is contained to the infiltration filling master to facial mask of solution of Chinese medical extract and/or local anaesthetics respectively
In body material, the filling amount that solution is infiltrated on the facial mask is 15~30ml/ pieces, and the facial mask containing the infiltration solution can be more preferable
Be attached to skin surface, be conveniently fitted on skin and applied.
Clinical evaluation
The surface surgical anesthesia facial mask that will need 49 patients for carrying out clinical treatment that the embodiment of the present invention 8 is respectively adopted
Clinical effectiveness verification is carried out, specifically, is divided within 18 periods between on 07 21st, 2017 on 01 02nd, 2018
Other to carry out clinical test at least 1 patient, specific test result is as shown in table 1 below.
Table 1 is Experimental comparison results：
By 1 test result of above-mentioned table it is found that when surface surgical anesthesia using the present invention carries out surgery anesthesia with facial mask, have
Efficiency up to 97% or more, and in 1-15min rapid-action, anesthesia uniformly, effect it is strong and persistently, the features such as penetration power is strong, peace
Complete quick, anaesthetic effect is good, noninvasive administration may be implemented, and administration process has good selectivity, and it is beautiful to be conducive to surface skin
Hold the progress of plastic operation.
Specific embodiments of the present invention are described in detail above, but it is intended only as example, the present invention is simultaneously unlimited
It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and
It substitutes also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by impartial conversion and
Modification, all should be contained within the scope of the invention.
Claims (10)
1. the material of main part of a kind of surface surgical anesthesia facial mask, the facial mask is face paper or facial mask cloth, which is characterized in that institute
It states and is impregnated with Chinese medical extract and local anaesthetics on material of main part.
2. surface surgical anesthesia facial mask according to claim 1, which is characterized in that the Chinese medical extract includes frankincense
Extract, Myrrha extract, pepper extract, camomile extract.
3. surface surgical anesthesia facial mask according to claim 2, which is characterized in that the Chinese medical extract further includes osmanthus
Flower extract, licorice, borneol, peppermint.
4. surface surgical anesthesia facial mask according to claim 1, which is characterized in that the local anaesthetics be procaine,
One kind in pramocaine, cinchocaine, lidocaine, benzocainum, butanilicaine, totokaine, Amydricaine, prilocaine
Or it is a variety of.
5. surface surgical anesthesia facial mask according to claim 1, which is characterized in that on the anesthesia facial mask also contain with
Lower helper component：Carboxymethyl cellulose, cyclodextrin, ethyl alcohol, propylene glycol, butanediol, glycerine, gathers hydroxypropyl methyl cellulose
Ethylene glycol, Azone, ethyl-para-hydroxybenzoate, Tween-80, phosphoric acid, hydrochloric acid, sodium hydroxide,
It is one or more in sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate.
6. surface surgical anesthesia facial mask according to claim 5, which is characterized in that helper component in the infiltration solution
Mass percent be hydroxypropyl methyl cellulose 0.01~10%, cyclodextrin 0.01~10%, ethyl alcohol 0.01~50%, the third two
Alcohol 0.01~10%, ethyl-para-hydroxybenzoate 0~0.2%, Tween-80 0.01~5%, 1- dodecyl-aza-cycloheptanes alkane-
2- ketone 0.01~5%.
7. surface surgical anesthesia facial mask according to claim 1, which is characterized in that the facial mask is will to be carried containing Chinese medicine
It takes and obtains in the infiltration solution material of main part of object and local anaesthetics；The filling amount of solution is infiltrated on the facial mask is
15~30ml/ pieces.
8. surface surgical anesthesia facial mask according to claim 7, which is characterized in that each Chinese medicine carries in the infiltration solution
Take object Olibanum extract, Myrrha extract, pepper extract, camomile extract, Flos Osmanthi Fragrantis extract, licorice, borneol,
The mass percent of peppermint and local anaesthetics is 0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~
10：0.01~10：0.01~10：0.01~10.
9. surface surgical anesthesia facial mask according to claim 7, which is characterized in that local anaesthetics is in the infiltration solution
Lidocaine, totokaine composition.
10. surface surgical anesthesia facial mask according to claim 9, which is characterized in that local anaesthetics in the infiltration solution
Lidocaine, totokaine composition quality percentage are 0.01~10%.
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