CN114288236A - Anesthetic ointment, preparation method and analgesic patch - Google Patents
Anesthetic ointment, preparation method and analgesic patch Download PDFInfo
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- CN114288236A CN114288236A CN202111538242.2A CN202111538242A CN114288236A CN 114288236 A CN114288236 A CN 114288236A CN 202111538242 A CN202111538242 A CN 202111538242A CN 114288236 A CN114288236 A CN 114288236A
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- extract
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- anesthetic
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- 230000003444 anaesthetic effect Effects 0.000 title claims abstract description 30
- 230000000202 analgesic effect Effects 0.000 title claims abstract description 14
- 239000002674 ointment Substances 0.000 title claims description 12
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000002562 thickening agent Substances 0.000 claims abstract description 8
- 239000000853 adhesive Substances 0.000 claims abstract description 7
- 230000001070 adhesive effect Effects 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- 239000003906 humectant Substances 0.000 claims abstract description 7
- 229940025300 lidocaine injection Drugs 0.000 claims abstract description 7
- 239000000419 plant extract Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 23
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- 244000103926 Chamaenerion angustifolium Species 0.000 claims description 14
- 235000008302 Chamaenerion angustifolium Nutrition 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 9
- 241001480177 Nymphaea alba Species 0.000 claims description 7
- 241001534869 Terminalia Species 0.000 claims description 7
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 6
- 229920002498 Beta-glucan Polymers 0.000 claims description 6
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
- -1 polydimethylsiloxane Polymers 0.000 claims description 6
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 6
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 229920000058 polyacrylate Polymers 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 244000025254 Cannabis sativa Species 0.000 claims description 2
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims description 2
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 235000009120 camo Nutrition 0.000 claims description 2
- 235000005607 chanvre indien Nutrition 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 239000011487 hemp Substances 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims 3
- 241000209128 Bambusa Species 0.000 claims 2
- 241001098499 Lanceolata Species 0.000 claims 2
- 241000288015 Bambusicola <bird> Species 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 abstract 1
- 230000008313 sensitization Effects 0.000 abstract 1
- 244000302661 Phyllostachys pubescens Species 0.000 description 10
- 235000003570 Phyllostachys pubescens Nutrition 0.000 description 10
- 230000003020 moisturizing effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 241000124033 Salix Species 0.000 description 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 3
- 229960004194 lidocaine Drugs 0.000 description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 241000720991 Illicium Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 229940068517 fruit extracts Drugs 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241001316058 Fabiana Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 240000007232 Illicium verum Species 0.000 description 1
- 235000008227 Illicium verum Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229940090044 injection Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses an anesthetic paste, a preparation method and an analgesic patch, wherein the anesthetic paste comprises the following components in parts by mass: 0.5-1.5% of acid-base regulator, 0.2-1% of adhesive, 20-25% of humectant, 0.5-1.5% of film-forming agent, 0.05-0.2% of thickening agent, 5-6% of plant extract, 40-60% of lidocaine injection with concentration of 4 wt%, and the balance of deionized water. The anesthetic paste provided by the invention has low sensitization when applied to skin.
Description
Technical Field
The invention belongs to the field of paste, and particularly relates to an anesthetic paste, a preparation method and an analgesic patch.
Background
The lidocaine emulsifiable paste is externally applied, which is the most commonly used analgesic mode of injection and photoelectric treatment at present, and has the advantages of quick response and obvious analgesic effect, but the existing compound lidocaine emulsifiable paste has higher incidence rate of skin anaphylactic reaction after the operation of a patient after the compound lidocaine emulsifiable paste is applied, thereby influencing the postoperative rehabilitation of the patient.
Disclosure of Invention
In order to solve the above technical problems, an object of the present invention is to provide a hemp paste which has a good anesthetic effect, has moisturizing and whitening properties on the skin, and has a low incidence of allergic reactions.
In order to achieve the purpose, the technical scheme of the invention is as follows: the anesthetic ointment comprises the following components in parts by mass: 0.5-1.5% of acid-base regulator, 0.2-1% of adhesive, 20-25% of humectant, 0.5-1.5% of film-forming agent, 0.05-0.2% of thickening agent, 5-6% of plant extract, 40-60% of lidocaine injection with concentration of 4 wt%, and the balance of deionized water.
In the technical scheme, the acid-base regulator is EDTA disodium; the adhesive is acrylate copolymer sodium; the film forming agent is glycerol polyacrylate.
In the technical scheme, the humectant comprises glycerol, propylene glycol, beta-glucan with the concentration of 0.4 wt% and sodium hyaluronate with the concentration of 1 wt%, and the mass ratio of the glycerol to the propylene glycol to the beta-glucan with the concentration of 0.4 wt% to the sodium hyaluronate with the concentration of 1 wt% is 10: 7: 3: 2.
in the technical scheme, the thickening agent is triethanolamine and methyl ether polydimethylsiloxane, and the mass ratio of the triethanolamine to the methyl ether polydimethylsiloxane is 1: 20.
in the technical scheme, the plant extracts comprise willow herb extracts, illicium simsii leaf extracts, terminalia faba fruit extracts, phyllostachys pubescens extracts and nymphaea alba extracts, and the mass ratio of the willow herb extracts, the illicium simsii leaf extracts, the terminalia faba fruit extracts, the phyllostachys pubescens extracts and the nymphaea alba extracts is 1: 2: 4: 2: 2.
in the technical scheme, the willow herb extract is one or more of willow herb, willow herb leaves and willow herb stems, and the phyllostachys pubescens extract is one or two of phyllostachys pubescens and phyllostachys pubescens stems.
The invention also aims to provide a method for preparing the ointment.
The other technical scheme of the invention is as follows: the preparation method of the ointment comprises the following steps:
step 1: uniformly mixing deionized water, an acid-base regulator, an adhesive, a film-forming agent and a humectant at 75-80 ℃, and uniformly mixing to obtain a mixture A;
step 2: cooling the mixture A obtained in the step 1 to 55-65 ℃, adding a thickening agent into the mixture A, uniformly mixing, and uniformly mixing to obtain a mixture B;
and step 3: cooling the mixture B obtained in the step 2 to below 40 ℃, adding plant extracts into the mixture B, uniformly mixing, and uniformly mixing to obtain a mixture C;
and 4, step 4: and (3) cooling the mixture C obtained in the step (3) to room temperature, adding 4 wt% of lidocaine injection into the mixture C, uniformly mixing, and uniformly mixing to obtain the ointment.
The invention also aims to provide the analgesic patch which has good analgesic effect and low skin allergy reaction rate.
The other technical scheme of the invention is as follows: an analgesic patch comprises a patch body, wherein the surface of one side of the patch body is uniformly coated with the anesthetic paste prepared by the preparation method of the anesthetic paste.
The invention has the beneficial effects that: the anaesthetic paste or the analgesic patch provided by the invention can be placed in a refrigerator for refrigeration before use, so that the anaesthetic paste or the analgesic patch (with facial mask moisturizing effect) can moisturize the face when in use (the cold compress can achieve the effect of relieving pain by contracting local blood vessels), in addition, the content can be reduced to contain a large amount of moisturizing components, so that the anaesthetic paste or the analgesic patch (with facial mask moisturizing effect) can moisturize the face when in use, the film agent is formed to ensure that the anaesthetic paste can form a layer of paste film on the surface of the skin after being smeared on the surface of the skin, so that the anaesthetic paste is uniformly distributed on the surface of the skin and is more beneficial to the moisturizing effect of the moisturizing agent, the thickening agent ensures the consistency of the anaesthetic paste to stabilize the physical shape of the anaesthetic paste, the pH regulator can chelate heavy metals in the anaesthetic paste and can automatically regulate the pH value of the anaesthetic paste to a proper range of the skin, the willow herb extract has the effects of diminishing inflammation and easing pain, the pseudostellera chamaejasme leaf extract has the effects of dissipating blood stasis and reducing swelling, the Terminalia faba fruit extract has the effect of resisting oxidation, and the phyllostachys pubescens extract and the nymphaea alba extract both have the effects of whitening and brightening.
Detailed Description
The principles and features of this invention are described below in conjunction with examples, which are set forth to illustrate, but are not to be construed to limit the scope of the invention.
Example 1
The embodiment provides an anesthetic paste which comprises the following components in parts by mass: 1% of disodium EDTA, 0.6% of acrylate copolymer sodium, 10% of glycerol, 7% of propylene glycol, 1% of glycerol polyacrylate, 3% of beta-glucan with the concentration of 0.4 wt%, 2% of sodium hyaluronate with the concentration of 1 wt%, 0.1% of triethanolamine, 2% of methyl ether polydimethylsiloxane, 0.5% of willow herb extract, 1% of illicium verum leaf extract, 2% of Terminalia fabiana fruit extract, 1% of Bodinieria longifolia extract and 1% of nymphaea alba extract, 50% of lidocaine injection with the concentration of 4 wt%, and the balance of deionized water.
The willow extract is one or more of willow, willow leaves and willow stems, and the phyllostachys pubescens extract is one or two of phyllostachys pubescens and phyllostachys pubescens stems.
Example 2
This example provides a method for preparing the ointment of example 1, including the following steps:
step 1: uniformly mixing deionized water, EDTA disodium, acrylate copolymer sodium, glycerol, propylene glycol, glycerol polyacrylate, beta-glucan with the concentration of 0.4 wt% and sodium hyaluronate with the concentration of 1 wt% at 75-80 ℃ to obtain a mixture A;
step 2: cooling the mixture A obtained in the step 1 to 55-65 ℃, adding triethanolamine and methyl ether polydimethylsiloxane into the mixture A, uniformly mixing, and uniformly mixing to obtain a mixture B;
and step 3: cooling the mixture B obtained in the step 2 to below 40 ℃, adding the pseudoanise leaf extract, the terminalia faba kernel fruit extract, the phyllostachys pubescens extract and the nymphaea alba extract into the mixture B, uniformly mixing, and uniformly mixing to obtain a mixture C;
and 4, step 4: and (3) cooling the mixture C obtained in the step (3) to room temperature, adding 4 wt% of lidocaine injection into the mixture C, uniformly mixing, and uniformly mixing to obtain the ointment.
The ointment provided by the embodiment can obviously reduce the incidence rate of skin allergy during the epidermal application.
Example 3
The embodiment provides an analgesic patch, which comprises a patch body, wherein the surface of one side of the patch body is uniformly coated with the anesthetic paste prepared by the method for preparing the anesthetic paste described in embodiment 2, and the coating weight of the anesthetic paste is 0.1-1g/cm2。
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (8)
1. The anesthetic ointment is characterized by comprising the following components in parts by mass: 0.5-1.5% of acid-base regulator, 0.2-1% of adhesive, 20-25% of humectant, 0.5-1.5% of film-forming agent, 0.05-0.2% of thickening agent, 5-6% of plant extract, 40-60% of lidocaine injection with concentration of 4 wt%, and the balance of deionized water.
2. The anesthetic paste of claim 1, wherein the pH adjusting agent is disodium EDTA; the adhesive is acrylate copolymer sodium; the film forming agent is glycerol polyacrylate.
3. The anesthetic paste as claimed in claim 1, wherein the humectant includes glycerin, propylene glycol, β -glucan at a concentration of 0.4 wt%, and sodium hyaluronate at a concentration of 1 wt%, and the mass ratio of the glycerin, the propylene glycol, the β -glucan at a concentration of 0.4 wt%, and the sodium hyaluronate at a concentration of 1 wt% is 10: 7: 3: 2.
4. the anesthetic paste as claimed in claim 1, wherein the thickener is triethanolamine and methyl ether polydimethylsiloxane, and the mass ratio of the triethanolamine to the methyl ether polydimethylsiloxane is 1: 20.
5. the anesthetic paste as claimed in claim 1, wherein the plant extracts include willow herb extract, pseudostellera lanceolata leaf extract, terminalia faberi fruit extract, bambusa bambusicola extract and nymphaea alba extract, and the mass ratio of the willow herb extract, pseudostella lanceolata leaf extract, terminalia faberi fruit extract, bambusa faberi extract and nymphaea alba extract is 1: 2: 4: 2: 2.
6. the hemp paste of claim 5, wherein the willow herb extract is a mixture of one or more of willow herb, willow herb leaves and willow herb stems, and the Bombarus procumbens extract is a mixture of one or two of Bombarus procumbens and Bombarus procumbens stems.
7. A method for preparing the ointment of any one of claims 1 to 6, comprising the steps of:
step 1: uniformly mixing deionized water, an acid-base regulator, an adhesive, a film-forming agent and a humectant at 75-80 ℃, and uniformly mixing to obtain a mixture A;
step 2: cooling the mixture A obtained in the step 1 to 55-65 ℃, adding a thickening agent into the mixture A, uniformly mixing, and uniformly mixing to obtain a mixture B;
and step 3: cooling the mixture B obtained in the step 2 to below 40 ℃, adding plant extracts into the mixture B, uniformly mixing, and uniformly mixing to obtain a mixture C;
and 4, step 4: and (3) cooling the mixture C obtained in the step (3) to room temperature, adding 4 wt% of lidocaine injection into the mixture C, uniformly mixing, and uniformly mixing to obtain the ointment.
8. An analgesic patch, which is characterized by comprising a patch body, wherein the surface of one side of the patch body is uniformly coated with the anesthetic paste prepared by the method for preparing the anesthetic paste according to claim 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111538242.2A CN114288236A (en) | 2021-12-15 | 2021-12-15 | Anesthetic ointment, preparation method and analgesic patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111538242.2A CN114288236A (en) | 2021-12-15 | 2021-12-15 | Anesthetic ointment, preparation method and analgesic patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114288236A true CN114288236A (en) | 2022-04-08 |
Family
ID=80967192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111538242.2A Pending CN114288236A (en) | 2021-12-15 | 2021-12-15 | Anesthetic ointment, preparation method and analgesic patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114288236A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188939A (en) * | 2014-08-20 | 2014-12-10 | 北京泰德制药股份有限公司 | Partial external patch containing lidocaine or pharmaceutical salts thereof |
| CN108272772A (en) * | 2018-03-02 | 2018-07-13 | 江苏朗沁科技有限公司 | A kind of surface surgical anesthesia facial mask |
| CN112691076A (en) * | 2021-01-05 | 2021-04-23 | 山东百奥生物医药有限公司 | Hypoallergenic soothing epidermal anesthesia cream and preparation method and application thereof |
-
2021
- 2021-12-15 CN CN202111538242.2A patent/CN114288236A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188939A (en) * | 2014-08-20 | 2014-12-10 | 北京泰德制药股份有限公司 | Partial external patch containing lidocaine or pharmaceutical salts thereof |
| CN108272772A (en) * | 2018-03-02 | 2018-07-13 | 江苏朗沁科技有限公司 | A kind of surface surgical anesthesia facial mask |
| CN112691076A (en) * | 2021-01-05 | 2021-04-23 | 山东百奥生物医药有限公司 | Hypoallergenic soothing epidermal anesthesia cream and preparation method and application thereof |
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Application publication date: 20220408 |