CN111150696B - After-sun repair emulsion and preparation method thereof - Google Patents
After-sun repair emulsion and preparation method thereof Download PDFInfo
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- CN111150696B CN111150696B CN202010112563.5A CN202010112563A CN111150696B CN 111150696 B CN111150696 B CN 111150696B CN 202010112563 A CN202010112563 A CN 202010112563A CN 111150696 B CN111150696 B CN 111150696B
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- roselle
- sun
- abelmoschus manihot
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- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a post-basking repair emulsion and a preparation method thereof, wherein the post-basking repair emulsion is prepared from the following components in parts by mass: c14～C221-5% of alkyl alcohol, 1-6% of glyceryl stearate, 5-15% of a post-basking repair composition, 1-10% of liquid oil, 1-5% of solid oil, 3-10% of aloe extract, 1-3% of radix paeoniae extract, 2-5% of polydimethylsiloxane, 0.01-0.5% of a thickening agent, 2-5% of an antioxidant, 0.01-0.5% of a preservative, 0.05-0.5% of a chelating agent and the balance of deionized water. The sunscreen lotion can be used for repairing the skin for more than 8 hours after being dried, and has the effects of reducing uncomfortable symptoms such as stabbing pain, erythema, desquamation and the like, inhibiting inflammatory reactions such as redness and swelling and the like, and remarkably removing free radicals.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a post-basking repair emulsion and a preparation method thereof.
Background
In hot summer, even if a tight sun-proof work is performed, the damage of sunlight cannot be completely avoided. After the skin is irradiated by ultraviolet rays, discomfort symptoms such as stabbing pain, erythema, desquamation, obvious burning sensation of an affected part, pruritus and the like can be caused; the water loss of the skin after the sun is serious, the barrier function is lost, and ultraviolet rays can promote cells to release various inflammatory mediums, so that dermal blood vessels are expanded, tissues are edematous, and inflammatory reaction is stimulated; meanwhile, ultraviolet rays invade the inside of the skin, and generate a large amount of oxygen ion free radicals inside and outside epidermal cells, so that abnormal cell activities are caused, and skin aging is promoted. Therefore, the method is very important for repairing the skin after the sun shines.
At present, for the after-sun repair of the skin, consumers prefer the plant extract, and the damaged skin after sun is repaired by utilizing various functional components contained in the plant extract. For example, chinese patent application CN110090191A discloses a post-basking repair composition and cosmetics thereof, wherein the post-basking repair composition is mainly prepared from plant extracts such as opuntia ficus-indica stem extract, chia seed extract, agave leaf extract, sunflower seed extract, artemisia umbellata extract, glycyrrhiza glabra root extract, and apple seed extract, and has the effects of calming and soothing skin, moisturizing, scavenging free radicals, inhibiting melanin generation, and the like; for example, the Chinese patent application CN108434036A discloses a witch hazel after-sun repairing composition which mainly comprises a white-flowered chrysanthemum flower extract, a white birch bark extract and a witch hazel extract, can realize synergistic effect, improve facial gloss, supplement water, remove red swelling and skin, increase pores and red blood streak, has high light stability, and can permanently repair and promote skin whitening. In practice, the two sunscreen repair compositions are mainly used for repairing the skin within 6-8 hours after the sun is cured, and the effect is greatly reduced when the sunscreen repair composition is used after more than 8 hours, so that the skin is seriously damaged.
Therefore, the cosmetics which can remarkably repair the skin after being sunburned for a long time, reduce uncomfortable symptoms such as stabbing pain, erythema and desquamation, inhibit inflammatory reaction such as red swelling and the like and remarkably remove free radicals are urgently needed to be provided.
Disclosure of Invention
Based on the above, the invention aims to provide the cosmetic which can remarkably repair the skin after being sunburned for a long time, reduce uncomfortable symptoms such as stabbing pain, erythema, desquamation and the like, inhibit inflammatory reaction such as red swelling and the like, and remarkably remove free radicals.
In order to achieve the purpose, the invention adopts the following technical scheme: the after-sun repair emulsion is prepared from the following components in parts by mass: c14～C221-5% of alkyl alcohol, 1-6% of glyceryl stearate, 5-15% of a post-basking repair composition, 1-10% of liquid oil, 1-5% of solid oil, 3-10% of aloe extract, 1-3% of radix paeoniae extract, 2-5% of polydimethylsiloxane, 0.01-0.5% of a thickening agent, 2-5% of an antioxidant, 0.01-0.5% of a preservative, 0.05-0.5% of a chelating agent and the balance of deionized water; the after-sun repair composition is composed of 15-25 parts of roselle extract, 10-20 parts of abelmoschus manihot extract and 1-5 parts of sodium caseinate.
Preferably, the sunscreen emulsion is prepared from the following components in parts by mass: c14～C222-4% of alkyl alcohol, 2-5% of glyceryl stearate and dried5-10% of a repair composition, 5-10% of liquid oil, 2-5% of solid oil, 5-10% of an aloe extract, 1-3% of a peony root extract, 3-5% of polydimethylsiloxane, 0.05-0.3% of a thickening agent, 2-3% of an antioxidant, 0.01-0.3% of a preservative, 0.05-0.2% of a chelating agent and the balance of deionized water; the after-sun repair composition is composed of 20-25 parts of roselle extract, 10-15 parts of abelmoschus manihot extract and 2-5 parts of sodium caseinate.
Preferably, the sunscreen emulsion is prepared from the following components in parts by mass: c14～C222.5% of alkyl alcohol, 3% of glyceryl stearate, 10% of a post-basking repair composition, 5% of liquid oil, 3% of solid oil, 10% of aloe extract, 2% of radix paeoniae alba extract, 3.5% of polydimethylsiloxane, 0.2% of a thickening agent, 3% of an antioxidant, 0.01% of a preservative, 0.15% of a chelating agent and the balance of deionized water; the after-sun repair composition comprises 20 parts of roselle extract, 15 parts of abelmoschus manihot extract and 5 parts of sodium caseinate.
Preferably, the preparation method of the roselle extractive comprises the following steps:
naturally drying and crushing the roselle flower, adding 60-75% ethanol solution according to the weight volume ratio of 1 (20-100) g/ml, performing microwave treatment for 1-5 min at 300-500W, performing ultrasonic extraction for 15-60 min at 300-500W, filtering, and concentrating the filtrate to obtain the roselle flower.
Preferably, the density of the roselle extractive obtained after concentration is (1.02-1.15) g/cm3。
Preferably, the preparation method of the abelmoschus manihot extract comprises the following steps:
naturally drying and crushing the abelmoschus manihot, adding water according to the weight-volume ratio of 1 (5-20) g/ml, heating and refluxing for extraction for 1-2 h, filtering, adding water according to the weight-volume ratio of 1 (5-10) g/ml into filter residues, heating and refluxing for extraction for 1-2 h, filtering, combining the two filtrates, and concentrating to obtain the abelmoschus manihot extract.
Preferably, the density of the Hibiscus manihot extract obtained after concentration is (1.02-1.20) g/cm3。
Preferably, the liquid oil is isopropyl myristate or ethylhexyl palmitate; the solid oil is cetearyl alcohol.
Preferably, the thickener is xanthan gum or carbomer 940.
Preferably, the preservative is methylisothiazolinone or iodopropynyl butylcarbamate; the chelating agent is EDTA-2 Na; the antioxidant is vitamin E.
The invention also provides a method for preparing the after-sun repair cream, which is characterized by comprising the following steps:
A) c is to be14～C22Adding alkyl alcohol, glyceryl stearate, liquid oil, solid oil, polydimethylsiloxane and antioxidant into an oil phase pot, stirring and heating to 80-85 ℃, and preserving heat for later use;
B) adding deionized water into a water phase pot, adding a thickening agent while stirring, uniformly dispersing, adding the after-sun repair composition, the aloe extract, the peony root extract and the chelating agent, heating to 80-85 ℃, and preserving heat for 30min for later use;
C) filtering the material obtained in the step B), pumping into an emulsifying pot, adding the material prepared in the step A) while stirring, homogenizing and emulsifying for 3-10 min, slowly cooling to 40-45 ℃, adjusting the pH value of the material, adding a preservative, stirring uniformly, discharging after the detection is qualified, and filling.
The abelmoschus manihot extract prepared by the invention has obvious sedative and anti-inflammatory effects, and the roselle has obvious free radical scavenging effect, and the abelmoschus manihot extract and the roselle are combined to be used for preparing the cosmetic composition, so that the damaged skin after being exposed to the sun can be effectively repaired, and the effects of synergistic anti-inflammatory, detumescence and free radical scavenging are achieved. However, in practice, the roselle extractive contains more organic acid, and although the roselle extractive has certain myogenic effect, the roselle extractive is easy to stimulate the skin. Aiming at the problem, the inventor discovers through a great deal of creative work that the irritation of the hibiscus sabdariffa extract can be remarkably reduced by adding a certain amount of sodium caseinate and combining the hibiscus sabdariffa extract, and meanwhile, the sodium caseinate increases the compatibility of the hibiscus sabdariffa extract and the hibiscus sabdariffa extract, improves the bonding property of the composition and the skin, can remarkably improve the effects of sedation, anti-inflammation and free radical removal for a long time, and can achieve the remarkable repairing effect after being used after being damaged for 8 hours after being exposed to the sun.
Therefore, the invention has the following beneficial effects:
the after-sun repair emulsion provided by the invention has the main functional components of the roselle extract, the abelmoschus manihot extract and the sodium caseinate according to a certain proportion, and the synergistic effect of the roselle extract, the abelmoschus manihot extract and the sodium caseinate can reduce the irritation of organic acid in the roselle extract to skin, so that the effects of remarkably repairing the after-sun skin for a long time, reducing discomfort symptoms such as stabbing pain, erythema and desquamation, inhibiting inflammatory reactions such as redness and swelling and the like, and remarkably removing free radicals are achieved, and the effect of remarkably repairing after being used after being damaged for 8 hours after being sun-dried.
Detailed Description
The present invention will be described in further detail below with reference to specific embodiments of examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.
In the examples, the experimental methods used were all conventional methods unless otherwise specified, and the materials, reagents and the like used were commercially available without otherwise specified.
Example 1A post-basking repair composition
The after-sun repair composition comprises the following components in parts by weight: 20 parts of a roselle extract, 15 parts of a abelmoschus manihot extract and 5 parts of sodium caseinate.
The preparation method comprises the following steps:
s1, drying and pulverizing flos Hibisci Sabdariffae naturally, adding 75% ethanol solution at weight volume ratio of 1:50g/ml, treating with 450W microwave for 3min, performing 500W ultrasonic extraction for 45min, filtering, and concentrating the filtrate to obtain extract with density of 1.10g/cm3The Hibiscus sabdariffa extract of (1);
s2, naturally drying and crushing Abelmoschus manihot, adding water according to the weight-volume ratio of 1:20g/ml, heating and refluxing for extraction for 1.5h, filtering, adding water to filter residues according to the weight-volume ratio of 1:10g/ml, heating and refluxing for extraction for 1h, filtering, combining the two filtrates, concentrating to obtain the extract with the density of 1.15g/cm3Abelmoschus manihot (L.) MedicusAn extract;
s3, mixing the roselle extract obtained in the step S1, the abelmoschus manihot extract obtained in the step S2 and sodium caseinate in parts by weight.
Example 2A post-basking repair composition
The after-sun repair composition comprises the following components in parts by weight: 25 parts of roselle extractive, 10 parts of abelmoschus manihot extractive and 3 parts of sodium caseinate.
The preparation method comprises the following steps:
s1, drying and pulverizing the flowers of Hibiscus sabdariffa naturally, adding 60% ethanol solution according to the weight-volume ratio of 1:25g/ml, treating for 5min with 300W microwave, performing ultrasonic extraction for 15min with 500W, filtering, and concentrating the filtrate to obtain the extract with the density of 1.08g/cm3The Hibiscus sabdariffa extract of (1);
s2, naturally drying and crushing Abelmoschus manihot, adding water according to the weight-volume ratio of 1:10g/ml, heating and refluxing for extraction for 1.5h, filtering, adding water to filter residues according to the weight-volume ratio of 1:5g/ml, heating and refluxing for extraction for 1h, filtering, combining the two filtrates, concentrating to obtain the extract with the density of 1.12g/cm3The Abelmoschus manihot extract;
s3, mixing the roselle extract obtained in the step S1, the abelmoschus manihot extract obtained in the step S2 and sodium caseinate in parts by weight.
Example 3A post-basking repair composition
The after-sun repair composition comprises the following components in parts by weight: 15 parts of a roselle extract, 20 parts of a abelmoschus manihot extract and 1 part of sodium caseinate.
The preparation method comprises the following steps:
s1, drying and pulverizing flos Hibisci Sabdariffae naturally, adding 75% ethanol solution at weight volume ratio of 1:100g/ml, treating with 500W microwave for 1min, performing ultrasonic extraction at 300W for 60min, filtering, and concentrating the filtrate to obtain extract with density of 1.11g/cm3The Hibiscus sabdariffa extract of (1);
s2, naturally drying and crushing Abelmoschus manihot, adding water according to the weight-volume ratio of 1:10g/ml, heating and refluxing for extraction for 1.5h, filtering, adding water to filter residue according to the weight-volume ratio of 1:5g/ml, heating and refluxing for extractionFiltering for 1 hr, mixing the filtrates, and concentrating to obtain extract with density of 1.14g/cm3The Abelmoschus manihot extract;
s3, mixing the roselle extract obtained in the step S1, the abelmoschus manihot extract obtained in the step S2 and sodium caseinate in parts by weight.
Example 4 post-basking repair emulsion
The preparation method comprises the following steps:
A) c is to be14～C22Adding alkyl alcohol, glyceryl stearate, isopropyl myristate, ethylhexyl palmitate, cetostearyl alcohol, polydimethylsiloxane and vitamin E into an oil phase pot, stirring and heating to 80-85 ℃, and keeping the temperature for later use;
B) adding deionized water into a water phase pot, adding carbomer 940 while stirring, dispersing uniformly, adding the after-sun repair composition, the aloe extract, the peony root extract and EDTA-2Na, heating to 80-85 ℃, and keeping the temperature for 30min for later use;
C) filtering the material obtained in the step B), pumping into an emulsifying pot, adding the material prepared in the step A) while stirring, homogenizing and emulsifying for 3-10 min, slowly cooling to 40-45 ℃, adjusting the pH value of the material, adding methylisothiazolinone, stirring uniformly, discharging after the detection is qualified, and filling.
Example 5 post-basking repair emulsion
The preparation method refers to example 4.
Example 6 post-basking repair emulsion
The preparation method refers to example 4.
Comparative example 1A composition
The difference from example 1 is that the composition of comparative example 1 is not added with roselle extract, and other parameters and operations refer to example 1.
Comparative example 2A composition
The difference from example 1 is that the composition of comparative example 2, in which the roselle extract was re-extracted, was directly subjected to ultrasonic extraction without microwave treatment, and other parameters and operations were as in example 1.
Comparative example 3A composition
The difference from example 1 is that the composition of comparative example 3 does not contain the abelmoschus manihot extract, and other parameters and operations refer to example 1.
Comparative example 4A composition
The difference from example 1 is that the malva neglecta extract in the composition of comparative example 4 is replaced with a witch hazel extract (available from biotechnology limited in new Tian of Shaanxi), and other parameters and operations refer to example 1.
Comparative example 5A composition
The difference from example 1 is that the composition of comparative example 5 does not contain sodium caseinate, and the other parameters and operations refer to example 1.
Comparative example 6A composition
The difference from example 1 is that the sodium caseinate in the composition of comparative example 6 was replaced by sodium lauryl sulfate, and other parameters and operations refer to example 1.
Experimental example 1 test of the after-Sun repair Effect of the composition
1. Experimental materials: the compositions prepared in examples 1 to 3 and comparative examples 1 to 6 were dissolved in water to prepare an aqueous solution having a content of 5% as a sample to be measured.
2. Subject: SD rats 300-350 g, half male and half female.
3. The experimental process comprises the following steps:
SD rats were randomly divided into a blank group, a model group, examples 1-3 groups, and comparative examples 1-6 groups, each group containing 20 rats. The back of the rat is unhaired 24 hours before the experiment, and the area is about 3 multiplied by 3cm2Except for the blank group, the skin of the back of the rat is molded by 2, 4-dinitrochlorobenzene in the other groups, the ultraviolet rays are used for irradiating for 12 hours, 0 hour and 8 hours after the molding is successful (the skin shows symptoms of dryness, desquamation, burning, stabbing pain, swelling, erythema and the like) are respectively coated on the unhairing area of the back of the rat by 0.5ml of the sample to be tested prepared in the examples 1 to 3 and the comparative examples 1 to 6, and the coating range is about 2.5 multiplied by 2.5cm2The blank group and the model group were replaced with deionized water, and the administration was performed once a day for 14 days, and the skin condition on the back of rats in each group was observed on day 15 and recorded according to the evaluation criteria in table 1, and the serum Histidine (HIS) concentration in the rat sample in each group was measured.
TABLE 1 evaluation criteria for skin conditions
4. The experimental results are as follows: see tables 2-3.
TABLE 2 repair effect 0h after successful mold making
Note: in comparison to the set of models,*P<0.05，**P<0.01。
as can be seen from table 2, when the composition prepared in embodiments 1 to 3 of the present invention is applied to the damaged skin 0h after the successful molding, the HIS concentration can be significantly reduced, the inflammatory response can be alleviated, and the symptoms of dryness, desquamation, swelling, erythema, etc. of the damaged skin can be significantly improved; in comparative examples 1 to 6, the composition components or the composition obtained by the preparation method are respectively changed, so that the inflammation and skin conditions are improved to a certain extent, but the improvement effect is obviously inferior to that of the examples.
TABLE 3 repair effect 8h after successful mold making
Note: in comparison to the set of models,*P<0.05，**P<0.01。
as can be seen from table 3, when the composition prepared in embodiments 1 to 3 of the present invention is applied to the damaged skin 8 hours after the successful molding, the HIS concentration can be still significantly reduced, the inflammatory response can be alleviated, and the symptoms of dryness, desquamation, swelling, erythema, etc. of the damaged skin can be significantly improved; in comparative examples 1 to 6, the composition components are changed or the composition obtained by the preparation method has no significant influence on the HIS concentration, and the skin condition is improved poorly.
Experimental example 2 radical scavenging Effect test of composition
1. Experimental materials: the compositions prepared in examples 1 to 3 and comparative examples 1 to 6 were dissolved in water to prepare an aqueous solution having a content of 5% as a sample to be measured.
2. The experimental process comprises the following steps:
(1) hydroxyl radical scavenging experiments: adding 0.5ml of 0.75mmol/L o-diazaphenanthrene absolute ethanol solution into a stoppered test tube, respectively adding 2ml of 0.2mol/L phosphate buffer solution (pH 7.4) and 1ml of sample to be tested, mixing well, adding 0.5ml of 0.75mmol/L FeSO4·7H2O solution, mixing uniformly again, adding 0.5ml of concentrateH with a degree of 0.01% (v/v)2O2After reacting in a constant-temperature water bath at 37 ℃ for 60min, the absorbance value of each group of mixture solution is respectively measured at 536nm and is recorded as AxThe absorbance value is recorded as A by taking distilled water as a blank groupbReplacing H with distilled water2O2The absorbance values were measured as a lesion group and recorded as AnAccording to the formula: hydroxy radical scavenging rate ═ ax-An)/(Ab-An) X 100%, hydroxyl radical scavenging rate was calculated.
(2) DPPH free radical scavenging experiments: taking 3ml of 0.2mmol/L DPPH absolute ethanol solution, adding 1ml of sample to be measured, mixing, reacting at room temperature in a dark place for 30min, measuring the absorbance value at the wavelength of 517nm, and recording as Ax(ii) a Measuring absorbance value by using 3ml of absolute ethyl alcohol and 1ml of sample to be measured as blank control, and recording as Ab(ii) a The absorbance values were recorded as A by using 3ml of DPPH absolute ethanol solution and 1ml of absolute ethanol solution as control groupsnAccording to the formula: DPPH radical clearance rate ═ 1- (A)x-Ab)/An]X 100%, DPPH radical clearance was calculated.
3. The experimental results are as follows: see table 4.
TABLE 4 determination of radical scavenging Effect of the compositions
| Group of | Hydroxyl radical scavenging rate (%) | DPPH radical scavenging ratio (%) |
| Example 1 | 81.15 | 83.72 |
| Example 2 | 80.54 | 82.51 |
| Example 3 | 81.09 | 82.28 |
| Comparative example 1 | 29.32 | 26.47 |
| Comparative example 2 | 51.47 | 50.23 |
| Comparative example 3 | 45.74 | 43.91 |
| Comparative example 4 | 58.13 | 59.46 |
| Comparative example 5 | 56.22 | 55.35 |
| Comparative example 6 | 57.36 | 57.62 |
As can be seen from Table 4, the compositions prepared in the embodiments 1 to 3 of the present invention have hydroxyl radical and DPPH radical scavenging rates of more than 80%, and can significantly delay skin cell aging; in comparative examples 1-6, the hydroxyl radical and DPPH radical scavenging rate of the composition obtained by changing the composition components or the preparation method is obviously reduced.
Experimental example 3 skin irritation test with composition
1. Test materials: the compositions prepared in examples 1 to 3 and comparative examples 3 to 6.
2. Test subjects: healthy rabbits weigh 2.5-3 kg, and are half as male and female.
3. The test method comprises the following steps:
test methods refer to skin irritation/corrosion test of cosmetic hygiene norm (2007 edition), and the control is normal skin on the other side of the same test animal, and the scoring criteria are shown in table 5.
TABLE 5 skin irritation response score
4. And (3) test results: see table 6.
Table 6 skin irritation test results (n ═ 5)
As can be seen from table 6, in the observation period, the skin of the tested rabbit does not have abnormal reactions such as erythema and edema, and other poisoning symptoms, and the highest stimulation index at each observation time point in the test is 0, which indicates that the after-sun repair composition has no irritation to the skin; whereas the compositions of comparative examples 3 to 6 had mild erythema and edema after 1 hour and were eliminated after 24 hours.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (5)
1. The after-sun repair emulsion is characterized by being prepared from the following components in parts by mass: c14~C221-5% of alkyl alcohol, 1-6% of glyceryl stearate, 5-15% of a post-basking repair composition, 1-10% of liquid oil, 1-5% of cetearyl alcohol, 3-10% of an aloe extract, 1-3% of a peony root extract, 2-5% of polydimethylsiloxane, 0.01-0.5% of a thickening agent, 2-5% of an antioxidant, 0.01-0.5% of a preservative, 0.05-0.5% of a chelating agent and the balance of deionized water; the after-sun repair composition comprises 15-25 parts of roselle extract, 10-20 parts of abelmoschus manihot extract and 1-5 parts of sodium caseinate, wherein the liquid oil is isopropyl myristate or ethylhexyl palmitate, and the preparation method of the roselle extract comprises the following steps:
naturally drying and crushing roselle flowers, adding 60-75% ethanol solution according to the weight volume ratio of 1 (20-100) g/ml, performing microwave treatment for 1-5 min at 300-500W, performing ultrasonic extraction for 15-60 min at 300-500W, filtering, and concentrating filtrate to obtain the roselle extractive, wherein the density of the roselle extractive obtained after concentration is (1.02-1.15) g/cm3;
The preparation method of the Abelmoschus manihot extract comprises the following steps:
naturally drying and crushing Abelmoschus manihot, adding water according to the weight-volume ratio of 1 (5-20) g/ml, heating, refluxing and extracting for 1-2 h, filtering, adding water to filter residues according to the weight-volume ratio of 1 (5-10) g/ml, heating, refluxing and extracting for 1-2 h, filtering, combining filtrates obtained in two times, and concentrating to obtain the Abelmoschus manihot extract, wherein the density of the Abelmoschus manihot extract obtained after concentration is (1.02-1.20) g/cm3。
2. The after-sun repair cream as claimed in claim 1, characterized by being prepared from the following components in parts by mass: c14~C222-4% of alkyl alcohol, 2-5% of glyceryl stearate, 5-10% of after-sun repair composition, 5-10% of liquid oil and whale2-5% of wax stearyl alcohol, 5-10% of aloe extract, 1-3% of peony root extract, 3-5% of polydimethylsiloxane, 0.05-0.3% of thickening agent, 2-3% of antioxidant, 0.01-0.3% of preservative, 0.05-0.2% of chelating agent and the balance of deionized water; the after-sun repair composition is composed of 20-25 parts of roselle extract, 10-15 parts of abelmoschus manihot extract and 2-5 parts of sodium caseinate.
3. The post-basking repair cream of claim 1 or 2 wherein the thickener is xanthan gum or carbomer 940.
4. The post-basking repair cream of claim 1 or 2, wherein the preservative is methylisothiazolinone or iodopropynyl butylcarbamate; the chelating agent is EDTA-2 Na; the antioxidant is vitamin E.
5. A method of preparing the after-sun repair cream according to any one of claims 1 to 4, comprising the steps of:
A) c is to be14~C22Adding alkyl alcohol, glyceryl stearate, liquid oil, cetearyl alcohol, polydimethylsiloxane and an antioxidant into an oil phase pot, stirring and heating to 80-85 ℃, and preserving heat for later use;
B) adding deionized water into a water phase pot, adding a thickening agent while stirring, uniformly dispersing, adding the after-sun repair composition, the aloe extract, the peony root extract and the chelating agent, heating to 80-85 ℃, and preserving heat for 30min for later use;
C) filtering the material obtained in the step B), pumping into an emulsifying pot, adding the material prepared in the step A) while stirring, homogenizing and emulsifying for 3-10 min, slowly cooling to 40-45 ℃, adjusting the pH value of the material, adding a preservative, stirring uniformly, discharging after the detection is qualified, and filling.
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